CR10383A - Derivados triazolopirazina. - Google Patents

Derivados triazolopirazina.

Info

Publication number
CR10383A
CR10383A CR10383A CR10383A CR10383A CR 10383 A CR10383 A CR 10383A CR 10383 A CR10383 A CR 10383A CR 10383 A CR10383 A CR 10383A CR 10383 A CR10383 A CR 10383A
Authority
CR
Costa Rica
Prior art keywords
triazolopirazine
derivatives
compounds
formula
relates
Prior art date
Application number
CR10383A
Other languages
English (en)
Inventor
Jingrong Jean Cui
Jacqui Elizabeth Hoffman
Lei Jia
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Hong Shen
Michelle Bich Tran-Dube
Hengmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR10383A publication Critical patent/CR10383A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La invencion se refiere a compuestos de formula I o una sal farmaceuticamente aceptable de los mismos, en la que R1, R2, R3 y R4 son como se definen en esta invencion. La invencion tambien se refiere a composiciones farmaceuticas que contienen los compuestos de formula I y a procedimientos de tratamiento de trastornos hiperproliferativos en un mamifero mediante administracion de los compuestos de formula I.
CR10383A 2006-05-11 2008-10-21 Derivados triazolopirazina. CR10383A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79996606P 2006-05-11 2006-05-11
US89323107P 2007-03-06 2007-03-06

Publications (1)

Publication Number Publication Date
CR10383A true CR10383A (es) 2008-11-11

Family

ID=38441445

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10383A CR10383A (es) 2006-05-11 2008-10-21 Derivados triazolopirazina.

Country Status (32)

Country Link
US (2) US7732604B2 (es)
EP (1) EP2018383B1 (es)
JP (1) JP4377962B2 (es)
KR (1) KR101099161B1 (es)
CN (1) CN101443331A (es)
AP (1) AP2008004674A0 (es)
AR (1) AR060994A1 (es)
AT (1) ATE532785T1 (es)
AU (1) AU2007251283A1 (es)
BR (1) BRPI0711809A2 (es)
CA (1) CA2651363C (es)
CR (1) CR10383A (es)
EA (1) EA016204B1 (es)
EC (1) ECSP088871A (es)
ES (1) ES2376913T3 (es)
GE (1) GEP20115174B (es)
GT (1) GT200700039A (es)
HN (1) HN2007015177A (es)
IL (1) IL194813A0 (es)
MA (1) MA30411B1 (es)
ME (1) MEP36508A (es)
MX (1) MX2008014399A (es)
NL (1) NL2000613C2 (es)
NO (1) NO20085060L (es)
NZ (1) NZ572361A (es)
PE (1) PE20080067A1 (es)
RS (1) RS20080533A (es)
TN (1) TNSN08445A1 (es)
TW (1) TWI346115B (es)
UY (1) UY30334A1 (es)
WO (1) WO2007132308A1 (es)
ZA (1) ZA200809020B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198448B2 (en) * 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
US20110039856A1 (en) * 2007-11-29 2011-02-17 Pfizer Inc. Polymorphs of a c-met/hgfr inhibitor
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
CA2716898A1 (en) * 2008-02-27 2009-09-03 Takeda Pharmaceutical Company Limited Compound having 6-membered aromatic ring
CA2717034A1 (en) * 2008-02-28 2009-09-03 Pascal Furet Imidazo[1,2-b]pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
US8598184B2 (en) * 2008-03-03 2013-12-03 Tiger Pharmatech Protein kinase inhibitors
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
EP2298731A4 (en) * 2008-06-25 2011-09-21 Takeda Pharmaceutical AMIDE COMPOUND
DE102008037790A1 (de) 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
EP2356116A1 (en) 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
EP2381777A4 (en) 2008-12-12 2012-08-08 Ariad Pharma Inc AZAINDOL DERIVATIVES AS KINASEHEMMER
US8586599B2 (en) 2008-12-22 2013-11-19 Merck Patent Gmbh Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
JOP20190230A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
SI2435443T1 (sl) * 2009-05-28 2013-12-31 Vertex Pharmaceuticals Incorporated Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
AU2010283806A1 (en) * 2009-08-12 2012-03-01 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
KR20120089463A (ko) 2009-08-20 2012-08-10 노파르티스 아게 헤테로시클릭 옥심 화합물
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose
WO2011079804A1 (en) * 2009-12-31 2011-07-07 Hutchison Medipharma Limited Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor
TWI423974B (zh) * 2010-02-11 2014-01-21 Hutchison Medipharma Ltd 三氮唑並吡啶和三氮唑並吡嗪化合物及其組合物和應用
WO2011143646A1 (en) 2010-05-14 2011-11-17 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
WO2011145035A1 (en) * 2010-05-17 2011-11-24 Indian Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
CN102532141A (zh) 2010-12-08 2012-07-04 中国科学院上海药物研究所 [1,2,4]***并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途
US20140088114A1 (en) 2011-05-16 2014-03-27 OSI Pharmaceuticals ,LLC Fused bicyclic kinase inhibitors
EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
CN102516263B (zh) * 2011-10-25 2015-04-08 南方医科大学 一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
CN102503959B (zh) * 2011-10-25 2015-04-08 南方医科大学 一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
CN103204844A (zh) * 2012-01-17 2013-07-17 上海艾力斯医药科技有限公司 氨基杂芳基化合物及其制备方法与应用
CA2865719C (en) 2012-03-30 2020-09-22 Rhizen Pharmaceuticals Sa Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
CA2868202C (en) 2012-04-03 2021-08-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
US20150051210A1 (en) 2012-04-03 2015-02-19 Novartis Ag Tyrosine Kinase Inhibitor Combinations and their Use
CN104109166B (zh) * 2013-04-17 2017-06-20 上海医药集团股份有限公司 喹啉类化合物、其制备方法、中间体、药物组合物和应用
WO2014174478A1 (en) 2013-04-26 2014-10-30 Novartis Ag Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
EP3053923B1 (en) * 2013-09-30 2018-04-11 Korea Research Institute of Chemical Technology Triazolopyrazine derivatives as tyrosin kinase inhibitors
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
JP2018123059A (ja) * 2015-06-10 2018-08-09 石原産業株式会社 1−シクロプロピルエチルアミン又はその塩の製造方法
CA3217238A1 (en) 2015-07-20 2017-01-26 Genzyme Corporation Colony stimulating factor-1 receptor (csf-1r) inhibitors
WO2017049711A1 (zh) 2015-09-24 2017-03-30 上海海聚生物科技有限公司 喹啉类衍生物、其药物组合物、制备方法及应用
CN106928232B (zh) * 2015-12-31 2019-07-09 上海医药集团股份有限公司 喹啉类化合物及其盐的晶型、制备方法、组合物与应用
EA201892075A1 (ru) 2016-03-15 2019-04-30 Оризон Дженомикс, С.А. Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
US11091489B2 (en) 2016-06-20 2021-08-17 Novartis Ag Crystalline forms of a triazolopyrimidine compound
KR20180092096A (ko) 2017-02-08 2018-08-17 에이비온 주식회사 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법
CN108570053A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元并六元杂环化合物、制备方法、中间体、组合和应用
CN108276418A (zh) * 2018-03-20 2018-07-13 北京凯恩梅格医药科技有限公司 化合物、含有该化合物的药用组合物及其用途
EP3893872A4 (en) 2018-12-14 2022-08-10 Beta Pharma, Inc. COMPOUNDS SUBSTITUTED BY ORGANOPHOSPHORUS AS C-MET INHIBITORS AND THEIR THERAPEUTIC USES
EP4267573A1 (en) 2020-12-23 2023-11-01 Genzyme Corporation Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
GB9520822D0 (en) 1995-10-11 1995-12-13 Wellcome Found Therapeutically active compounds
ES2186908T3 (es) 1996-07-13 2003-05-16 Glaxo Group Ltd Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas.
TR199900048T2 (xx) 1996-07-13 1999-04-21 Glaxo Group Limited Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
IL148718A0 (en) * 1999-09-17 2002-09-12 Abbott Gmbh & Co Kg Pyrazolopyrimidines as therapeutic agents
BRPI0412003A (pt) * 2003-07-02 2006-08-15 Sugen Inc arilmetil triazol e imidazopirazinas como inibidores de c-met
JP2007504243A (ja) 2003-09-03 2007-03-01 ニューロジェン・コーポレーション 5−アリール−ピラゾロ[4,3−d]ピリミジン類、ピリジン類、ピラジン類及び関連化合物
US9672526B2 (en) 2012-03-13 2017-06-06 American Express Travel Related Services Company, Inc. Systems and methods for tailoring marketing
US10884952B2 (en) 2016-09-30 2021-01-05 Intel Corporation Enforcing memory operand types using protection keys

Also Published As

Publication number Publication date
NZ572361A (en) 2012-02-24
ECSP088871A (es) 2008-12-30
EP2018383B1 (en) 2011-11-09
IL194813A0 (en) 2009-08-03
GEP20115174B (en) 2011-03-10
US20070265272A1 (en) 2007-11-15
EA200870423A1 (ru) 2009-04-28
GT200700039A (es) 2008-06-02
ES2376913T3 (es) 2012-03-20
EP2018383A1 (en) 2009-01-28
NO20085060L (no) 2008-12-03
AP2008004674A0 (en) 2008-12-31
TW200804384A (en) 2008-01-16
AR060994A1 (es) 2008-07-30
HN2007015177A (es) 2010-06-09
TWI346115B (en) 2011-08-01
CA2651363C (en) 2011-07-12
RS20080533A (en) 2009-09-08
AU2007251283A1 (en) 2007-11-22
JP4377962B2 (ja) 2009-12-02
UY30334A1 (es) 2008-01-02
MX2008014399A (es) 2008-11-27
PE20080067A1 (es) 2008-03-10
EA016204B1 (ru) 2012-03-30
JP2009536636A (ja) 2009-10-15
ATE532785T1 (de) 2011-11-15
MA30411B1 (fr) 2009-05-04
ZA200809020B (en) 2009-12-30
KR101099161B1 (ko) 2011-12-27
WO2007132308A1 (en) 2007-11-22
CA2651363A1 (en) 2007-11-22
BRPI0711809A2 (pt) 2011-12-06
TNSN08445A1 (fr) 2010-04-14
US20100105656A1 (en) 2010-04-29
NL2000613C2 (nl) 2007-11-20
US7732604B2 (en) 2010-06-08
KR20090006187A (ko) 2009-01-14
MEP36508A (en) 2011-02-10
CN101443331A (zh) 2009-05-27

Similar Documents

Publication Publication Date Title
CR10383A (es) Derivados triazolopirazina.
ECSP055867A (es) Derivados de pirrolopirimidina
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
ECSP056134A (es) Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3
ATE430744T1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
CR10027A (es) Nuevos derivados de pirrol fusionado
UY29963A1 (es) Compuestos terapéuticos: piridinas y pirazinas como andamios
WO2007138472A3 (en) Triazolopyridazine derivatives
TR201906123T4 (tr) P13 kinazı ve mtor inhibitörleri olarak triazin bileşikleri.
CR11568A (es) Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de mtor quinasa y pi3 quinasa y su sintesis
CO6470846A2 (es) Derivados aminobut´ricos sustituidos como inhibidores de neprilisina
UY30438A1 (es) Derivados n-sustituidos de 5-halo-4-[2-alquil-1-sustituidos-1h-imidazol-5-il]pirimidin-2-amina, composiciones-procesos para su preparacion y usos
ECSP11011560A (es) Derivados amino-propiónicos sustituidos como inhibidores de neprilisina
UY30500A1 (es) Compuestos de azabencimidazolilo
GT200600518A (es) Derivados de pirimidina
DK2074120T3 (da) Tropan-forbindelser
BRPI0915084B8 (pt) composto, e, composição farmacêutica
ECSP099177A (es) Derivados de quinazolinona e isoquinolinona
UY30411A1 (es) Derivados sustituidos del acetato de 2,3,4,-tetrahidroimidazo-[1,5-a]-pirimidin-6-amina, composiciones farmacéuticas y aplicaciones
UY31638A1 (es) Furo[3,2-c]piridina y tieno[3,2-c]piridinas
TW200626158A (en) Naphthaline derivatives
TW200637817A (en) 5-aminoindole derivatives
RS53613B1 (en) COMPOUNDS, COMPOSITIONS, AND PROCEDURES FOR TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHY
DE602005010744D1 (de) Piperazinylpyridinderivate als mittel gegen adipositas
GT200900309A (es) Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)