CO6690744A2 - Formulación de polvo seco que comprende un inhibidor de fosfodiesterasa - Google Patents
Formulación de polvo seco que comprende un inhibidor de fosfodiesterasaInfo
- Publication number
- CO6690744A2 CO6690744A2 CO13019325A CO13019325A CO6690744A2 CO 6690744 A2 CO6690744 A2 CO 6690744A2 CO 13019325 A CO13019325 A CO 13019325A CO 13019325 A CO13019325 A CO 13019325A CO 6690744 A2 CO6690744 A2 CO 6690744A2
- Authority
- CO
- Colombia
- Prior art keywords
- dry powder
- powder formulation
- phosphodiesterase inhibitor
- relates
- formulation
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se relaciona con una formulación farmacéutica en la forma de un polvo seco inhalable que comprende partículas de un inhibidor de fosfodiesterasa-4 como ingrediente activo. La invención también se relaciona con el proceso para preparar la formulación y con su uso en la prevención y/o el tratamiento de una enfermedad respiratoria tal como asma y EPOC.La presente invención se relaciona con Una formulación de polvo seco inhalable, CARACTERIZADA PORQUE comprende, como ingrediente activo, partículas micronizadas de un compuesto de la fórmula general (I) como el enantiómero (-),
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10171748 | 2010-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6690744A2 true CO6690744A2 (es) | 2013-06-17 |
Family
ID=43262631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13019325A CO6690744A2 (es) | 2010-08-03 | 2013-02-01 | Formulación de polvo seco que comprende un inhibidor de fosfodiesterasa |
Country Status (36)
Country | Link |
---|---|
US (2) | US9132121B2 (es) |
EP (2) | EP2600830B1 (es) |
JP (1) | JP6004233B2 (es) |
KR (1) | KR101805958B1 (es) |
CN (2) | CN103052379A (es) |
AR (1) | AR082443A1 (es) |
AU (1) | AU2011287711B2 (es) |
BR (1) | BR112013002506A2 (es) |
CA (1) | CA2807256C (es) |
CL (1) | CL2013000293A1 (es) |
CO (1) | CO6690744A2 (es) |
CY (1) | CY1120605T1 (es) |
DK (1) | DK2600830T3 (es) |
EA (2) | EA027692B1 (es) |
ES (1) | ES2664175T3 (es) |
GE (1) | GEP20156343B (es) |
HR (1) | HRP20180717T1 (es) |
HU (1) | HUE037620T2 (es) |
IL (1) | IL224517B (es) |
LT (1) | LT2600830T (es) |
MA (1) | MA34449B1 (es) |
ME (1) | ME03022B (es) |
MX (1) | MX346424B (es) |
MY (1) | MY179703A (es) |
NO (1) | NO2600830T3 (es) |
NZ (1) | NZ606548A (es) |
PE (2) | PE20171256A1 (es) |
PL (1) | PL2600830T3 (es) |
PT (1) | PT2600830T (es) |
RS (1) | RS57061B1 (es) |
SG (1) | SG187258A1 (es) |
SI (1) | SI2600830T1 (es) |
TR (1) | TR201807012T4 (es) |
UA (1) | UA112296C2 (es) |
WO (1) | WO2012016889A2 (es) |
ZA (1) | ZA201300870B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
US8293489B2 (en) | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
KR101803121B1 (ko) | 2010-08-03 | 2017-11-29 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제를 포함하는 약학적 제제 |
JP2014518203A (ja) | 2011-06-06 | 2014-07-28 | キエスィ ファルマチェウティチ エス.ピー.エー. | ホスホジエステラーゼ阻害剤としての1−フェニル−2−ピリジニルアルキルアルコール誘導体 |
CN111904962A (zh) | 2012-11-08 | 2020-11-10 | 理森制药股份公司 | 含有PDE4抑制剂和PI3 δ或双重PI3 δ-γ激酶抑制剂的药物组合物 |
ES2744542T3 (es) * | 2013-03-15 | 2020-02-25 | Robert I Henkin | Inhibidores de fosfodiesterasa para tratar trastornos gustativos y olfativos |
US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
JP6458957B2 (ja) | 2013-10-22 | 2019-01-30 | チエシ ファルマスティスィ エス.ピー.エー. | Pde4阻害剤の製造方法 |
GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
CN104800192A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入粉雾剂及制备方法 |
CN106233141B (zh) | 2014-02-18 | 2018-08-21 | 罗伯特·I·汉金 | 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物 |
EA201692456A1 (ru) * | 2014-07-09 | 2017-08-31 | Арвен Иладж Санайи Ве Тиджарет А.Ш. | Способ получения составов для ингаляции |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
US10583085B2 (en) * | 2017-05-17 | 2020-03-10 | Chiesi Farmaceutici S.P.A. | Carrier particles for dry powder formulations for inhalation |
KR101859752B1 (ko) * | 2017-09-13 | 2018-05-21 | 심원 | 조립식 열 저장 운반장치 |
KR101859750B1 (ko) * | 2017-09-13 | 2018-05-21 | 제일에스엠피(주) | 고정식 열 저장 운반장치 |
WO2023117985A1 (en) | 2021-12-21 | 2023-06-29 | Chiesi Farmaceutici S.P.A. | Dry powder formulations filled in an inhaler with improved resistance to humidity |
WO2023208982A1 (en) | 2022-04-27 | 2023-11-02 | Chiesi Farmaceutici S.P.A. | Crystal form of a pde4 inhibitor |
WO2024027901A1 (en) | 2022-08-02 | 2024-02-08 | Chiesi Farmaceutici S.P.A. | Predictive biomarker of clinical response to a pde4 inhibitor |
WO2024062007A1 (en) * | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
WO2024062005A1 (en) * | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
WO2024062006A1 (en) * | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19841248A1 (de) | 1997-09-12 | 1999-04-29 | Fraunhofer Ges Forschung | Demonstrationseinrichtung in Form eines Lebewesens |
DE59801018D1 (de) | 1997-09-16 | 2001-08-16 | Trench Switzerland Ag Basel | Spannungsteiler |
HUP0200185A3 (en) | 1999-03-05 | 2006-07-28 | Chiesi Farma Spa | Improved powdery pharmaceutical compositions for inhalation |
PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
US7744855B2 (en) | 2000-06-27 | 2010-06-29 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
EP1386630B1 (en) | 2002-07-31 | 2006-05-17 | CHIESI FARMACEUTICI S.p.A. | Powder inhaler |
DE10255387A1 (de) * | 2002-11-28 | 2004-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Tiotropium-haltige Pulverformulierung für die Inhalation |
GB0326632D0 (en) * | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
EP1891001B1 (en) * | 2005-06-06 | 2010-05-05 | F. Hoffmann-Roche AG | SULFONAMIDE DERIVATIVES USEFUL AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTl) INHIBITORS |
GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
EP2070913A1 (en) * | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
KR101803121B1 (ko) | 2010-08-03 | 2017-11-29 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제를 포함하는 약학적 제제 |
JP2014518203A (ja) | 2011-06-06 | 2014-07-28 | キエスィ ファルマチェウティチ エス.ピー.エー. | ホスホジエステラーゼ阻害剤としての1−フェニル−2−ピリジニルアルキルアルコール誘導体 |
JP6458957B2 (ja) | 2013-10-22 | 2019-01-30 | チエシ ファルマスティスィ エス.ピー.エー. | Pde4阻害剤の製造方法 |
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2011
- 2011-07-27 CA CA2807256A patent/CA2807256C/en active Active
- 2011-07-27 SI SI201131448T patent/SI2600830T1/en unknown
- 2011-07-27 HU HUE11741172A patent/HUE037620T2/hu unknown
- 2011-07-27 PE PE2017001245A patent/PE20171256A1/es unknown
- 2011-07-27 NZ NZ606548A patent/NZ606548A/en unknown
- 2011-07-27 DK DK11741172.8T patent/DK2600830T3/en active
- 2011-07-27 EP EP11741172.8A patent/EP2600830B1/en active Active
- 2011-07-27 EA EA201690541A patent/EA027692B1/ru unknown
- 2011-07-27 MY MYPI2013000339A patent/MY179703A/en unknown
- 2011-07-27 PE PE2013000155A patent/PE20130601A1/es active IP Right Grant
- 2011-07-27 ME MEP-2018-101A patent/ME03022B/me unknown
- 2011-07-27 MA MA35635A patent/MA34449B1/fr unknown
- 2011-07-27 TR TR2018/07012T patent/TR201807012T4/tr unknown
- 2011-07-27 SG SG2013008107A patent/SG187258A1/en unknown
- 2011-07-27 CN CN2011800382903A patent/CN103052379A/zh active Pending
- 2011-07-27 PT PT117411728T patent/PT2600830T/pt unknown
- 2011-07-27 EP EP17176635.5A patent/EP3246016A1/en active Pending
- 2011-07-27 LT LTEP11741172.8T patent/LT2600830T/lt unknown
- 2011-07-27 GE GEAP201112988A patent/GEP20156343B/en unknown
- 2011-07-27 CN CN201710259305.8A patent/CN106890165A/zh active Pending
- 2011-07-27 PL PL11741172T patent/PL2600830T3/pl unknown
- 2011-07-27 EA EA201390049A patent/EA024922B1/ru unknown
- 2011-07-27 AU AU2011287711A patent/AU2011287711B2/en active Active
- 2011-07-27 WO PCT/EP2011/062872 patent/WO2012016889A2/en active Application Filing
- 2011-07-27 RS RS20180394A patent/RS57061B1/sr unknown
- 2011-07-27 JP JP2013522202A patent/JP6004233B2/ja active Active
- 2011-07-27 KR KR1020137002872A patent/KR101805958B1/ko active IP Right Grant
- 2011-07-27 MX MX2013001172A patent/MX346424B/es active IP Right Grant
- 2011-07-27 ES ES11741172.8T patent/ES2664175T3/es active Active
- 2011-07-27 UA UAA201302607A patent/UA112296C2/uk unknown
- 2011-07-27 NO NO11741172A patent/NO2600830T3/no unknown
- 2011-07-27 BR BR112013002506A patent/BR112013002506A2/pt not_active Application Discontinuation
- 2011-08-02 AR ARP110102782 patent/AR082443A1/es not_active Application Discontinuation
- 2011-08-02 US US13/195,885 patent/US9132121B2/en active Active
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2013
- 2013-01-30 CL CL2013000293A patent/CL2013000293A1/es unknown
- 2013-01-31 IL IL224517A patent/IL224517B/en active IP Right Grant
- 2013-02-01 CO CO13019325A patent/CO6690744A2/es unknown
- 2013-02-01 ZA ZA2013/00870A patent/ZA201300870B/en unknown
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2015
- 2015-08-07 US US14/820,939 patent/US9308200B2/en active Active
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2018
- 2018-03-09 CY CY181100288T patent/CY1120605T1/el unknown
- 2018-05-09 HR HRP20180717TT patent/HRP20180717T1/hr unknown
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