CO6592044A2 - Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedadese inmunes - Google Patents

Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedadese inmunes

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Publication number
CO6592044A2
CO6592044A2 CO12111688A CO12111688A CO6592044A2 CO 6592044 A2 CO6592044 A2 CO 6592044A2 CO 12111688 A CO12111688 A CO 12111688A CO 12111688 A CO12111688 A CO 12111688A CO 6592044 A2 CO6592044 A2 CO 6592044A2
Authority
CO
Colombia
Prior art keywords
bcl
apoptosis
selectivity
cancer
treatment
Prior art date
Application number
CO12111688A
Other languages
English (en)
Inventor
Milan Bruncko
Hong Ding
George Doherty
Steven W Elmore
Lisa A Hasvold
Laura Hexamer
Aaron R Kunzer
Robert A Mantei
William J Mcclellan
Cheol-Min Park
Andrew M Petros
Xiaohong Song
Andrew J Souers
Gerard M Sullivan
Zhi-Fu Tao
Gary T Wang
Xilu Wang
Le Wang
Michael D Wendt
Todd M Hansen
Chang H Park
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42481688&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6592044(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CO6592044A2 publication Critical patent/CO6592044A2/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica BcI-2.
CO12111688A 2009-12-04 2012-07-04 Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedadese inmunes CO6592044A2 (es)

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