CR20120346A - DERIVADOS DE SULFONAMIDA COMO AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2 PARA EL TRATAMIENTO DE CÁNCER Y ENFERMEDADES INMUNES - Google Patents
DERIVADOS DE SULFONAMIDA COMO AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2 PARA EL TRATAMIENTO DE CÁNCER Y ENFERMEDADES INMUNESInfo
- Publication number
- CR20120346A CR20120346A CR20120346A CR20120346A CR20120346A CR 20120346 A CR20120346 A CR 20120346A CR 20120346 A CR20120346 A CR 20120346A CR 20120346 A CR20120346 A CR 20120346A CR 20120346 A CR20120346 A CR 20120346A
- Authority
- CR
- Costa Rica
- Prior art keywords
- bcl
- selectivity
- cancer treatment
- immune diseases
- sulfonamide derivatives
- Prior art date
Links
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 title abstract 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000006907 apoptotic process Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108700000711 bcl-X Proteins 0.000 abstract 1
- 102000055104 bcl-X Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract
Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
Applications Claiming Priority (1)
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US12/631,404 US8563735B2 (en) | 2008-12-05 | 2009-12-04 | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
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CR20120346A true CR20120346A (es) | 2012-09-03 |
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ID=42481688
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CR20120346A CR20120346A (es) | 2009-12-04 | 2012-06-25 | DERIVADOS DE SULFONAMIDA COMO AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2 PARA EL TRATAMIENTO DE CÁNCER Y ENFERMEDADES INMUNES |
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CN (1) | CN102947285B (es) |
AR (2) | AR076945A1 (es) |
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BR (1) | BR112012013457A2 (es) |
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CL (1) | CL2012001422A1 (es) |
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DO (1) | DOP2012000153A (es) |
EC (1) | ECSP12012017A (es) |
ES (1) | ES2609607T3 (es) |
GT (1) | GT201200172A (es) |
HK (1) | HK1177201A1 (es) |
IL (1) | IL220129A (es) |
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