CO6361855A2 - Derivados de 7-hidroxi-benzoimidazol-4-il-,etanona e inhibidores de cinasa que enlaza pdz que contienen los mismos - Google Patents

Derivados de 7-hidroxi-benzoimidazol-4-il-,etanona e inhibidores de cinasa que enlaza pdz que contienen los mismos

Info

Publication number
CO6361855A2
CO6361855A2 CO11060496A CO11060496A CO6361855A2 CO 6361855 A2 CO6361855 A2 CO 6361855A2 CO 11060496 A CO11060496 A CO 11060496A CO 11060496 A CO11060496 A CO 11060496A CO 6361855 A2 CO6361855 A2 CO 6361855A2
Authority
CO
Colombia
Prior art keywords
benzoimidazol
same
derivatives
etanona
hidroxi
Prior art date
Application number
CO11060496A
Other languages
English (en)
Inventor
Yo Matsuo
Ryuji Ohsawa
Shoji Hisada
Yingfu Li
Joel R Walker
Feryan Ahmed
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of CO6361855A2 publication Critical patent/CO6361855A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere a derivados de 7-hidroxi-benzoimidazol-4-il-metanona de fórmula (I), y una sal farmacéuticamente aceptable, hidrato, solvato, o isómero de los mismos:para inhibir la actividad de PBK, un método para la preparación de los mismos, y una composición farmacéutica que contiene los mismos como ingrediente activo.
CO11060496A 2008-10-30 2011-05-17 Derivados de 7-hidroxi-benzoimidazol-4-il-,etanona e inhibidores de cinasa que enlaza pdz que contienen los mismos CO6361855A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10980108P 2008-10-30 2008-10-30

Publications (1)

Publication Number Publication Date
CO6361855A2 true CO6361855A2 (es) 2012-01-20

Family

ID=42129188

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11060496A CO6361855A2 (es) 2008-10-30 2011-05-17 Derivados de 7-hidroxi-benzoimidazol-4-il-,etanona e inhibidores de cinasa que enlaza pdz que contienen los mismos

Country Status (14)

Country Link
US (1) US20110263566A1 (es)
EP (1) EP2364087A4 (es)
JP (1) JP2012507525A (es)
KR (1) KR20110079847A (es)
CN (1) CN102271514A (es)
AU (1) AU2009310310A1 (es)
BR (1) BRPI0919977A2 (es)
CA (1) CA2741988A1 (es)
CO (1) CO6361855A2 (es)
IL (1) IL212544A0 (es)
MX (1) MX2011004414A (es)
RU (1) RU2011121665A (es)
WO (1) WO2010051085A1 (es)
ZA (1) ZA201103964B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2057187B1 (en) 2006-08-10 2016-12-28 Oncotherapy Science, Inc. Genes and polypeptides relating to breast cancers
EP2309855A4 (en) * 2008-07-30 2012-06-27 Oncotherapy Science Inc BENZIMIDAZOLE DERIVATIVES AND GLYCOGEN SYNTHASE KINASE-3-BETA INHIBITORS CONTAINING THE SAME
US20110301146A1 (en) * 2008-11-20 2011-12-08 Oncotherapy Science, Inc. Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives
CN101619058A (zh) * 2009-01-08 2010-01-06 上海交通大学 一种苯并咪唑-4-酰胺型衍生物
US9556117B2 (en) * 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
CN105017221B (zh) * 2014-04-30 2019-05-28 中国医学科学院药物研究所 苯并咪唑衍生物及其制法和药物组合物与用途
CN107847497B (zh) * 2015-07-30 2021-03-30 第一三共株式会社 用于成人t细胞白血病/淋巴瘤的治疗和/或预防剂
JP6009135B1 (ja) * 2015-07-30 2016-10-19 第一三共株式会社 成人ｔ細胞白血病リンパ腫の治療及び／又は予防剤
WO2019124608A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 4'-(p-톨루엔설포닐아미도)-4-하이드록시칼콘을 유효성분으로 함유하는 류마티스 관절염 예방 또는 치료용 약학 조성물
CN109320461B (zh) * 2018-12-12 2020-02-07 迪嘉药业集团有限公司 一种替米沙坦中间体的制备方法
SG11202110742TA (en) 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
US20040002524A1 (en) * 2002-06-24 2004-01-01 Richard Chesworth Benzimidazole compounds and their use as estrogen agonists/antagonists
WO2004065370A1 (en) * 2003-01-23 2004-08-05 Crystalgenomics, Inc. Glycogen synthase kinase 3beta inhibitor, composition and process for the preparation thereof

Also Published As

Publication number Publication date
EP2364087A1 (en) 2011-09-14
ZA201103964B (en) 2012-02-29
EP2364087A4 (en) 2012-05-30
AU2009310310A2 (en) 2011-10-06
AU2009310310A1 (en) 2010-05-06
IL212544A0 (en) 2011-06-30
BRPI0919977A2 (pt) 2015-08-25
JP2012507525A (ja) 2012-03-29
RU2011121665A (ru) 2012-12-10
KR20110079847A (ko) 2011-07-08
CN102271514A (zh) 2011-12-07
US20110263566A1 (en) 2011-10-27
CA2741988A1 (en) 2010-05-06
MX2011004414A (es) 2011-06-21
WO2010051085A1 (en) 2010-05-06

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