CO6160294A2 - Purinas como inhibidores pkc-teta - Google Patents

Purinas como inhibidores pkc-teta

Info

Publication number
CO6160294A2
CO6160294A2 CO09039704A CO09039704A CO6160294A2 CO 6160294 A2 CO6160294 A2 CO 6160294A2 CO 09039704 A CO09039704 A CO 09039704A CO 09039704 A CO09039704 A CO 09039704A CO 6160294 A2 CO6160294 A2 CO 6160294A2
Authority
CO
Colombia
Prior art keywords
alkyl
chosen
nr5r6
substituted
condition
Prior art date
Application number
CO09039704A
Other languages
English (en)
Inventor
Irina Neagu
Andrew Roughton
Koc-Kan Ho
David Diller
Jui-Hsiang Chan
Celia Kingsbury
Michael Ohlmeyer
Neeltje Miranda Teerhuis
Jacobus Cornelis Wijkmans
Lommerse Johannes Petrus Maria
Original Assignee
Organon Nv
Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Pharmacopeia Llc filed Critical Organon Nv
Publication of CO6160294A2 publication Critical patent/CO6160294A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

1.- Un compuesto! o su sal, representado por la Fórmula I,en donde: R1 se escoge de alquilo C1-C4, carbociclilo, carbociclilo sustituido, y en dondeR4 se escoge de cicloalquilo, cicloalquilalquilo, arilo, arilalquilo, heteroarilo, y heteroarilalquilo, en donde R4 puede ser sustituido, con una condición que cuando R4 es un heleroarilo, R4 no se une por vía de un heteroátomo al carbono del metileno que lleva el grupo Z; y Z se escoge de -H y alquilo C1-C4; R2 se escoge de -(alquilo C2-C7)-NR5R6, -(alquilo C0-C4)-R7-R8, y -(alquilo C0-C4)-C(O)-(alquilo C0-C4)-R7-R8, en donde R7 es ciclilo, con una condición que cuando R7 es un heterociclilo, un nitrógeno de purina de la Fórmula I unido a R2 no se une a un heteroátomo de R7 directamente o por vía de un grupo metileno; R8 se escoge de -(alquilo (C0-C4)-NR5R6, y -C(O)-(alquilo (C0-C4)-NR5R6, y, cuando R7 es heterociclilo nitrogenoso, R8 puede ser adicionalmente -H, con una condición que cuando R7 es un heterociclilo y R8 es -(alquilo C0-C4)- NR5R6, un heteroátomo de R7 no se une a -NR5R6 directamente o por vía de un grupo metileno; R5 y R6 se escogen independientemente de -H y alquilo C1-C4; y R3 se escoge de alquilo C1-C6, arilo, arilo sustituido, arilalquilo, arilalalquilo sustituido, heteroarilo y heteroarilo sustituido; con una condición que cuando R3 es fenilo y R2 es piperidin-4- iI-etilo, R1 no es ciclopropilo.
CO09039704A 2006-10-20 2009-04-20 Purinas como inhibidores pkc-teta CO6160294A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85339606P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
CO6160294A2 true CO6160294A2 (es) 2010-05-20

Family

ID=39111415

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09039704A CO6160294A2 (es) 2006-10-20 2009-04-20 Purinas como inhibidores pkc-teta

Country Status (17)

Country Link
US (1) US20110046131A1 (es)
EP (1) EP2078019A2 (es)
JP (1) JP2010507581A (es)
KR (1) KR20090075854A (es)
CN (1) CN101657453B (es)
AU (1) AU2007309167A1 (es)
BR (1) BRPI0717435A2 (es)
CA (1) CA2666940A1 (es)
CO (1) CO6160294A2 (es)
EC (1) ECSP099342A (es)
IL (1) IL198080A0 (es)
IN (1) IN2009CN02154A (es)
MX (1) MX2009004154A (es)
NO (1) NO20091597L (es)
RU (1) RU2009118963A (es)
WO (1) WO2008051826A2 (es)
ZA (1) ZA200902640B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090281075A1 (en) * 2006-02-17 2009-11-12 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
EP1991547A2 (en) * 2006-03-09 2008-11-19 Pharmacopeia, Inc. 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders
JP2009541332A (ja) * 2006-06-23 2009-11-26 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用法
JP2013512245A (ja) * 2009-11-24 2013-04-11 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 脂肪酸合成酵素阻害剤としてのアザベンズイミダゾール
WO2011094290A1 (en) * 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
CN103209695A (zh) 2010-09-15 2013-07-17 弗·哈夫曼-拉罗切有限公司 氮杂苯并噻唑化合物、组合物及应用方法
WO2013041539A1 (en) * 2011-09-20 2013-03-28 F. Hoffmann-La Roche Ag Imidazopyridine compounds, compositions and methods of use
CA2958704A1 (en) * 2014-08-25 2016-03-03 University Of Canberra Compositions for modulating cancer stem cells and uses therefor
WO2018143403A1 (ja) * 2017-02-03 2018-08-09 国立大学法人東北大学 複素環化合物
SG11202004167XA (en) * 2017-11-08 2020-06-29 Epiaxis Therapeutics Pty Ltd Immunogenic compositions and uses therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE69824632T2 (de) * 1997-11-12 2005-06-09 Mitsubishi Chemical Corp. Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten
CA2484631A1 (en) * 2002-05-13 2003-11-27 Merck & Co., Inc. Phenyl substituted imidazopyridines and phenyl substituted benzimidazoles
JP2004217582A (ja) * 2003-01-16 2004-08-05 Abbott Japan Co Ltd ９ｈ−プリン誘導体
CA2577588C (en) * 2004-10-29 2013-09-10 Tibotec Pharmaceuticals Ltd. Hiv inhibiting bicyclic pyrimidine derivatives
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
KR101362621B1 (ko) * 2005-02-16 2014-02-13 아스트라제네카 아베 화합물
WO2006091737A1 (en) * 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
EP1991547A2 (en) * 2006-03-09 2008-11-19 Pharmacopeia, Inc. 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders

Also Published As

Publication number Publication date
CN101657453B (zh) 2013-06-12
WO2008051826A2 (en) 2008-05-02
ZA200902640B (en) 2010-05-26
US20110046131A1 (en) 2011-02-24
RU2009118963A (ru) 2010-11-27
IN2009CN02154A (es) 2015-08-07
JP2010507581A (ja) 2010-03-11
NO20091597L (no) 2009-07-14
CA2666940A1 (en) 2008-05-02
AU2007309167A1 (en) 2008-05-02
KR20090075854A (ko) 2009-07-09
EP2078019A2 (en) 2009-07-15
IL198080A0 (en) 2009-12-24
BRPI0717435A2 (pt) 2014-03-18
ECSP099342A (es) 2009-06-30
WO2008051826A3 (en) 2008-10-02
MX2009004154A (es) 2009-09-09
CN101657453A (zh) 2010-02-24

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