CO5721001A2 - Derivados sustituidos de morfolina y tiomorfolina - Google Patents

Derivados sustituidos de morfolina y tiomorfolina

Info

Publication number
CO5721001A2
CO5721001A2 CO06091597A CO06091597A CO5721001A2 CO 5721001 A2 CO5721001 A2 CO 5721001A2 CO 06091597 A CO06091597 A CO 06091597A CO 06091597 A CO06091597 A CO 06091597A CO 5721001 A2 CO5721001 A2 CO 5721001A2
Authority
CO
Colombia
Prior art keywords
cycloalkyl
ilo
alky
halo
alkyl
Prior art date
Application number
CO06091597A
Other languages
English (en)
Inventor
Tornoe Christian Wenzel
Mario Rottlander
Nikolay Khanzhin
Andrea Ritzen
William Patrick Watson
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37730781&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5721001(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of CO5721001A2 publication Critical patent/CO5721001A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

1.- Un derivado sustituido de morfolina o tiomorfolina de formula general Ien el cualq es 0 o 1;W es O o S;X es CO;Z es O;R1 se selecciona del grupo formado por halogeno, ciano, alqu(en/in)iIo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)iIo C3-8-alqu(en/in)iIo C1-6, halo-alqu(en/in)iIo C1-6, halo-cicloalqu(en)iIo C3-8, halo-cicloalqu(en)ilo C3-8-alqu(en/in)ilo C1-6, alqu(en/in)iIoxi C1-6, cicloalqu(en)iloxi C3-8 y cicloalqu(en)ilo C3-8-alqu(en/in)iIoxi C1-6;R2 se selecciona del grupo formado por halogeno, ciano, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)ilo C3-8-alqu(en/in)ilo C1-6, halo-alqu(en/in)ilo C1-6, halo-cicloalqu(en)ilo C3-8, halo-cicloalqu(en)ilo C3-8-alqu(en/in)ilo C1-6, alqu(en/in)iloxi C1-6, cicloalqu(en)iloxi C3-8, cicloalqu(en)ilo C3-8-alqu(en/in)iIoxi C1-6, el fenilo sustituido en forma opcional y el piridilo sustituido en forma opcional; en los que el fenilo y el piridilo estan sustituidos en forma opcional con uno o mas sustituyentes que son, en forma independiente, halogeno, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8 o cicloalqu(en)iIo C3-8-alqu(en/in)ilo C1-6;R3 se selecciona del grupo formado por alqu(en/in)ilo C1-10, cicloalqu(en)ilo C3-8, cicloalqu(en)ilo C3-8-alqu(en/in)ilo C1-6, Ar-alqu(en/in)ilo C1-6, Ar-cicloalqu(en)ilo C3-8, Ar-cicloalqu(en)ilo C3-8-alqu(en/in)iIo C1-6 y Ar; ycada uno de R4, R5, R6 y R7 se selecciona en forma independiente del grupo formado por hidrogeno y Ar;como base libre o sus sales.
CO06091597A 2004-03-12 2006-09-12 Derivados sustituidos de morfolina y tiomorfolina CO5721001A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200400412 2004-03-12

Publications (1)

Publication Number Publication Date
CO5721001A2 true CO5721001A2 (es) 2007-01-31

Family

ID=37730781

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06091597A CO5721001A2 (es) 2004-03-12 2006-09-12 Derivados sustituidos de morfolina y tiomorfolina

Country Status (32)

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US (6) US7501414B2 (es)
EP (3) EP1727809B8 (es)
JP (1) JP5006184B2 (es)
KR (2) KR20120136422A (es)
CN (2) CN1930138A (es)
AR (1) AR049784A1 (es)
AT (2) ATE398112T1 (es)
AU (1) AU2005221762B2 (es)
BR (1) BRPI0508570B8 (es)
CA (1) CA2559397C (es)
CO (1) CO5721001A2 (es)
CY (2) CY1110392T1 (es)
DE (2) DE602005016849D1 (es)
DK (2) DK1727809T3 (es)
EA (1) EA015120B1 (es)
EG (1) EG25344A (es)
ES (2) ES2306087T3 (es)
HK (1) HK1172618A1 (es)
HR (1) HRP20090685T1 (es)
IL (1) IL177859A (es)
MY (2) MY147786A (es)
NO (1) NO337161B1 (es)
NZ (1) NZ549133A (es)
PL (2) PL1947093T3 (es)
PT (2) PT1947093E (es)
RS (2) RS50606B (es)
SG (1) SG151254A1 (es)
SI (2) SI1947093T1 (es)
TW (2) TWI349666B (es)
UA (2) UA102517C2 (es)
WO (1) WO2005087754A1 (es)
ZA (2) ZA200607286B (es)

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DE602005007474D1 (en) 2008-07-24
IL177859A (en) 2013-02-28
CA2559397A1 (en) 2005-09-22
KR20120136422A (ko) 2012-12-18
AR049784A1 (es) 2006-09-06
ES2334076T3 (es) 2010-03-04
US7501414B2 (en) 2009-03-10
CN1930138A (zh) 2007-03-14
KR101411204B1 (ko) 2014-06-23
UA90670C2 (en) 2010-05-25
EP1947093B1 (en) 2009-09-23
US20090137571A1 (en) 2009-05-28
IL177859A0 (en) 2006-12-31
JP2007528880A (ja) 2007-10-18
EP2138487A1 (en) 2009-12-30
DE602005016849D1 (de) 2009-11-05
US7632835B2 (en) 2009-12-15
BRPI0508570B1 (pt) 2018-11-21
KR20060128004A (ko) 2006-12-13
DK1727809T3 (da) 2008-09-29
TW200811121A (en) 2008-03-01
ATE398112T1 (de) 2008-07-15
DK1947093T3 (da) 2010-02-01
CY1110392T1 (el) 2015-04-29
US8012962B2 (en) 2011-09-06
HK1172618A1 (zh) 2013-04-26
BRPI0508570B8 (pt) 2021-05-25
ZA200709718B (en) 2008-09-25
HRP20090685T1 (hr) 2010-02-28
TW200533359A (en) 2005-10-16
PL1947093T3 (pl) 2010-02-26
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US20100063033A1 (en) 2010-03-11
EA015120B1 (ru) 2011-06-30
MY147786A (en) 2013-01-31
CN102516204B (zh) 2016-01-20
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PL1727809T3 (pl) 2008-11-28
NO337161B1 (no) 2016-02-01
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JP5006184B2 (ja) 2012-08-22
AU2005221762B2 (en) 2011-06-09
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EA200601686A1 (ru) 2007-02-27
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US20090143369A1 (en) 2009-06-04
SI1727809T1 (sl) 2008-10-31
PT1947093E (pt) 2009-12-22

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