CO5700793A2 - Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores de los receptores del gaba y/o farmacos anticonvulsivos - Google Patents
Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores de los receptores del gaba y/o farmacos anticonvulsivosInfo
- Publication number
- CO5700793A2 CO5700793A2 CO05113620A CO05113620A CO5700793A2 CO 5700793 A2 CO5700793 A2 CO 5700793A2 CO 05113620 A CO05113620 A CO 05113620A CO 05113620 A CO05113620 A CO 05113620A CO 5700793 A2 CO5700793 A2 CO 5700793A2
- Authority
- CO
- Colombia
- Prior art keywords
- zimbamate
- group
- therapeutic agent
- agents
- pharmaceutically acceptable
- Prior art date
Links
- 102000005915 GABA Receptors Human genes 0.000 title abstract 2
- 108010005551 GABA Receptors Proteins 0.000 title abstract 2
- 230000002082 anti-convulsion Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 4
- 239000000651 prodrug Substances 0.000 abstract 4
- 229940002612 prodrug Drugs 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 229940124597 therapeutic agent Drugs 0.000 abstract 4
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 2
- ZJQHPWUVQPJPQT-UHFFFAOYSA-N muscimol Chemical compound NCC1=CC(=O)NO1 ZJQHPWUVQPJPQT-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 thiagabine Chemical compound 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 abstract 1
- FJIKWRGCXUCUIG-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3h-1,4-benzodiazepin-2-one Chemical compound O=C([C@H](O)N=1)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1Cl FJIKWRGCXUCUIG-HNNXBMFYSA-N 0.000 abstract 1
- VSWBSWWIRNCQIJ-GJZGRUSLSA-N (R,R)-asenapine Chemical compound O1C2=CC=CC=C2[C@@H]2CN(C)C[C@H]2C2=CC(Cl)=CC=C21 VSWBSWWIRNCQIJ-GJZGRUSLSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 abstract 1
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 abstract 1
- VMIYHDSEFNYJSL-UHFFFAOYSA-N Bromazepam Chemical compound C12=CC(Br)=CC=C2NC(=O)CN=C1C1=CC=CC=N1 VMIYHDSEFNYJSL-UHFFFAOYSA-N 0.000 abstract 1
- UMSGKTJDUHERQW-UHFFFAOYSA-N Brotizolam Chemical compound C1=2C=C(Br)SC=2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl UMSGKTJDUHERQW-UHFFFAOYSA-N 0.000 abstract 1
- WYCLKVQLVUQKNZ-UHFFFAOYSA-N Halazepam Chemical compound N=1CC(=O)N(CC(F)(F)F)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 WYCLKVQLVUQKNZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 abstract 1
- MWQCHHACWWAQLJ-UHFFFAOYSA-N Prazepam Chemical compound O=C1CN=C(C=2C=CC=CC=2)C2=CC(Cl)=CC=C2N1CC1CC1 MWQCHHACWWAQLJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 abstract 1
- PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 abstract 1
- SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 abstract 1
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 abstract 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 abstract 1
- 229960004538 alprazolam Drugs 0.000 abstract 1
- 229960003036 amisulpride Drugs 0.000 abstract 1
- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960004372 aripiprazole Drugs 0.000 abstract 1
- 229960005245 asenapine Drugs 0.000 abstract 1
- 239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
- 229960000794 baclofen Drugs 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 229960002729 bromazepam Drugs 0.000 abstract 1
- 229960003051 brotizolam Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- CXOXHMZGEKVPMT-UHFFFAOYSA-N clobazam Chemical compound O=C1CC(=O)N(C)C2=CC=C(Cl)C=C2N1C1=CC=CC=C1 CXOXHMZGEKVPMT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001403 clobazam Drugs 0.000 abstract 1
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 abstract 1
- 229960003120 clonazepam Drugs 0.000 abstract 1
- 229960004170 clozapine Drugs 0.000 abstract 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 abstract 1
- 229960003529 diazepam Drugs 0.000 abstract 1
- CDCHDCWJMGXXRH-UHFFFAOYSA-N estazolam Chemical compound C=1C(Cl)=CC=C(N2C=NN=C2CN=2)C=1C=2C1=CC=CC=C1 CDCHDCWJMGXXRH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002336 estazolam Drugs 0.000 abstract 1
- 229960002200 flunitrazepam Drugs 0.000 abstract 1
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 229960002158 halazepam Drugs 0.000 abstract 1
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 abstract 1
- 229960001848 lamotrigine Drugs 0.000 abstract 1
- 229960004391 lorazepam Drugs 0.000 abstract 1
- 229960004033 lormetazepam Drugs 0.000 abstract 1
- 229960005017 olanzapine Drugs 0.000 abstract 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 abstract 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004535 oxazepam Drugs 0.000 abstract 1
- 229960002036 phenytoin Drugs 0.000 abstract 1
- 229960004856 prazepam Drugs 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- IBALRBWGSVJPAP-HEHNFIMWSA-N progabide Chemical compound C=1C(F)=CC=C(O)C=1C(=N/CCCC(=O)N)/C1=CC=C(Cl)C=C1 IBALRBWGSVJPAP-HEHNFIMWSA-N 0.000 abstract 1
- 229960002752 progabide Drugs 0.000 abstract 1
- 229960004431 quetiapine Drugs 0.000 abstract 1
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 abstract 1
- 229960004181 riluzole Drugs 0.000 abstract 1
- 229960001534 risperidone Drugs 0.000 abstract 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 abstract 1
- 229960000652 sertindole Drugs 0.000 abstract 1
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 abstract 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 abstract 1
- 229960003188 temazepam Drugs 0.000 abstract 1
- 229960004394 topiramate Drugs 0.000 abstract 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 abstract 1
- 229960003386 triazolam Drugs 0.000 abstract 1
- 229940102566 valproate Drugs 0.000 abstract 1
- 229960005318 vigabatrin Drugs 0.000 abstract 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 abstract 1
- 229960000607 ziprasidone Drugs 0.000 abstract 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Una composición farmacéutica, para usar en el tratamiento de un estado clínico psiquiátrico seleccionado del grupo que consta de un trastorno de ansiedad, un trastorno o estado clínico psicótico, o un trastorno del estado de ánimo, resistentes a los tratamientos, en un mamífero, que comprende: (i) un primer agente terapéutico que es un agente antipsicótico atípico, y (ii) un segundo agente terapéutico seleccionado del grupo que consta de agentes moduladores de los receptores del GABA, agentes anticonvulsivos y benzodiazepinas, en la que las cantidades de (i) y (ii) son conjuntamente efectivas para tratar dicho estado clínico psiquiátrico.2.- La composición farmacéutica según la reivindicación 1, en la que el primer agente terapéutico se selecciona del grupo que consta de olanzapina, aripiprazol, clozapina, risperidona, sertindol, quetiapina, amisulprida, asenapina y ziprasidona, o una sal farmacéuticamente aceptable o uno de sus profármacos o una sal farmacéuticamente aceptable de dicho profármaco; y el segundo agente terapéutico se selecciona del grupo que consta de muscimol, progabida, riluzol, baclofeno, gabapentina, vigabatrina, tiagabina, lamotrigina, pregabalina, topiramato, diazepam, lorazepam, clonazepam, oxazepam, clorazepato dipotásico, clorazepato, clordiazepóxido, mediazepam, flurazepam, clobazam, ni trazepam, flunitrazepam, estazolam, bromazepam, alprazolam, lormetazepam, temazepam, brotizolam, triazolam, clordiazepam, halazepam, prazepam, valproato, feni toína, carbamazapina, felbamato, levetiracetam, zonisamnida, metoximida, oxicarbazepina, nemotrizina, etosuximida, o una sal farmacéuticamente aceptable o uno de sus profármacos o una sal farmacéuticamente aceptable de dicho profármaco.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47118803P | 2003-05-16 | 2003-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700793A2 true CO5700793A2 (es) | 2006-11-30 |
Family
ID=33452430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05113620A CO5700793A2 (es) | 2003-05-16 | 2005-11-09 | Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores de los receptores del gaba y/o farmacos anticonvulsivos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050004106A1 (es) |
| EP (1) | EP1633400A2 (es) |
| JP (1) | JP2006528676A (es) |
| KR (1) | KR20060011873A (es) |
| CN (1) | CN1791430A (es) |
| AU (1) | AU2004237951A1 (es) |
| BR (1) | BRPI0410271A (es) |
| CA (1) | CA2525366A1 (es) |
| CL (1) | CL2004001046A1 (es) |
| CO (1) | CO5700793A2 (es) |
| MX (1) | MXPA05012317A (es) |
| NO (1) | NO20055172L (es) |
| RU (1) | RU2005135454A (es) |
| TW (2) | TW200509932A (es) |
| WO (1) | WO2004100992A2 (es) |
| ZA (1) | ZA200509252B (es) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ332762A (en) | 1996-07-24 | 2000-09-29 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
| US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
| DK2316456T3 (en) | 2003-04-29 | 2017-09-11 | Orexigen Therapeutics Inc | Compositions for affecting weight loss comprising an opioid antagonist and bupropion |
| PL1626721T3 (pl) | 2003-05-23 | 2017-05-31 | Otsuka Pharmaceutical Co., Ltd. | Pochodne karbostyrylu i stabilizatory nastroju do leczenia zaburzeń nastroju |
| US20070190129A1 (en) * | 2003-09-02 | 2007-08-16 | Pfizer Inc. | Sustained release dosage forms of ziprasidone |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| EP1734955A2 (en) * | 2004-01-13 | 2006-12-27 | Duke University | Compositions of an anticonvulsant and an antipsychotic drug for affecting weigt loss |
| BRPI0507250A (pt) * | 2004-01-29 | 2007-06-26 | Pfizer Prod Inc | combinações para tratar desordens do snc |
| US20050171088A1 (en) * | 2004-01-30 | 2005-08-04 | Astrazeneca Ab | Treatment of psychoses with dibenzothiazepine antipsychotic |
| GB0405200D0 (en) * | 2004-03-08 | 2004-04-21 | Pfizer Ltd | Combinations comprising alpha-2-delta ligands |
| CA2565154A1 (en) * | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
| EP1871363A4 (en) * | 2005-03-30 | 2009-01-21 | Genpharm Inc | COMBINED STAGE PROCESS FOR PHARMACEUTICAL COMPOSITIONS |
| HUE050758T2 (hu) | 2005-04-05 | 2021-01-28 | Univ Yale | Glutamátmoduláló szerek mentális rendellenességek kezelésére |
| US20080305161A1 (en) * | 2005-04-13 | 2008-12-11 | Pfizer Inc | Injectable depot formulations and methods for providing sustained release of nanoparticle compositions |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| BRPI0611322A2 (pt) * | 2005-05-31 | 2010-08-31 | Orexigen Therapeutics Inc | métodos e composicões para controlar distúrbios psicóticos |
| US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
| EP1948238B1 (en) * | 2005-11-10 | 2013-08-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for the treatment of addiction and other neuropsychiatric disorders |
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- 2004-05-03 KR KR1020057021723A patent/KR20060011873A/ko not_active Application Discontinuation
- 2004-05-03 JP JP2006530635A patent/JP2006528676A/ja not_active Withdrawn
- 2004-05-03 AU AU2004237951A patent/AU2004237951A1/en not_active Abandoned
- 2004-05-03 BR BRPI0410271-1A patent/BRPI0410271A/pt not_active IP Right Cessation
- 2004-05-03 CN CNA2004800133741A patent/CN1791430A/zh active Pending
- 2004-05-03 MX MXPA05012317A patent/MXPA05012317A/es unknown
- 2004-05-03 WO PCT/IB2004/001517 patent/WO2004100992A2/en active Application Filing
- 2004-05-03 RU RU2005135454/15A patent/RU2005135454A/ru unknown
- 2004-05-03 EP EP04730897A patent/EP1633400A2/en not_active Withdrawn
- 2004-05-13 CL CL200401046A patent/CL2004001046A1/es unknown
- 2004-05-14 TW TW093113733A patent/TW200509932A/zh unknown
- 2004-05-14 US US10/845,826 patent/US20050004106A1/en not_active Abandoned
- 2004-05-14 TW TW096117149A patent/TW200735873A/zh unknown
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- 2005-11-09 CO CO05113620A patent/CO5700793A2/es not_active Application Discontinuation
- 2005-11-15 ZA ZA200509252A patent/ZA200509252B/xx unknown
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| AU2004237951A1 (en) | 2004-11-25 |
| WO2004100992A3 (en) | 2005-01-20 |
| ZA200509252B (en) | 2007-09-26 |
| TW200509932A (en) | 2005-03-16 |
| NO20055172L (no) | 2005-12-13 |
| BRPI0410271A (pt) | 2006-05-16 |
| CA2525366A1 (en) | 2004-11-25 |
| CL2004001046A1 (es) | 2005-03-28 |
| KR20060011873A (ko) | 2006-02-03 |
| US20050004106A1 (en) | 2005-01-06 |
| EP1633400A2 (en) | 2006-03-15 |
| TW200735873A (en) | 2007-10-01 |
| CN1791430A (zh) | 2006-06-21 |
| JP2006528676A (ja) | 2006-12-21 |
| WO2004100992A2 (en) | 2004-11-25 |
| NO20055172D0 (no) | 2005-11-03 |
| MXPA05012317A (es) | 2006-01-30 |
| RU2005135454A (ru) | 2006-06-27 |
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