CO4820396A1 - Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol - Google Patents

Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol

Info

Publication number
CO4820396A1
CO4820396A1 CO97015089A CO97015089A CO4820396A1 CO 4820396 A1 CO4820396 A1 CO 4820396A1 CO 97015089 A CO97015089 A CO 97015089A CO 97015089 A CO97015089 A CO 97015089A CO 4820396 A1 CO4820396 A1 CO 4820396A1
Authority
CO
Colombia
Prior art keywords
formula
lower alkyl
trisdehidro
colecalci
dihidroxi
Prior art date
Application number
CO97015089A
Other languages
English (en)
Inventor
Bernard Michael Hennessy
Jerome Anthony Iacobelli
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4820396A1 publication Critical patent/CO4820396A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Un compuesto de fórmulaen donde R es hidroxilo y R1 es H2 ó CH2 , ó R es hidrógeno ó flúor y R1 es CH2 . Un procedimiento para la preparación de un compuesto de fórmula I, como se ha descrito en la reivindicación 1, el cual comprende la eliminación de los grupos protectores sililo de un diol o triol correspondientemente sililados, de fórmula I, siendo de preferencia los grupos sililados protectores Si (R4 , R5 R6 ), en donde R4 y R6 son alquilo inferior y R5 es alquilo inferior, arilo o aril-alquilo inferior, y la eliminación del grupo sililo protector se efectúa convenientemente mediante la reacción con una sal de flúor en un disolvente orgánico polar.
CO97015089A 1996-03-21 1997-03-20 Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol CO4820396A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1380996P 1996-03-21 1996-03-21

Publications (1)

Publication Number Publication Date
CO4820396A1 true CO4820396A1 (es) 1999-07-28

Family

ID=21761865

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97015089A CO4820396A1 (es) 1996-03-21 1997-03-20 Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol

Country Status (30)

Country Link
EP (1) EP0796843B1 (es)
JP (1) JP2801587B2 (es)
KR (1) KR100240541B1 (es)
CN (1) CN1110477C (es)
AR (1) AR006315A1 (es)
AT (1) ATE240941T1 (es)
AU (1) AU708679B2 (es)
BR (1) BR9701404A (es)
CA (1) CA2199893C (es)
CO (1) CO4820396A1 (es)
CZ (1) CZ85897A3 (es)
DE (1) DE69722064T2 (es)
DK (1) DK0796843T3 (es)
ES (1) ES2198512T3 (es)
HR (1) HRP970162A2 (es)
HU (1) HUP9700609A3 (es)
ID (1) ID16285A (es)
IL (1) IL120469A0 (es)
MA (1) MA26423A1 (es)
MX (1) MX9702139A (es)
NO (1) NO971217L (es)
NZ (1) NZ314424A (es)
PE (1) PE42998A1 (es)
PL (1) PL319070A1 (es)
PT (1) PT796843E (es)
SG (1) SG70589A1 (es)
TR (1) TR199700219A2 (es)
TW (1) TW444001B (es)
YU (1) YU10397A (es)
ZA (1) ZA972302B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US6331642B1 (en) 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
KR101285720B1 (ko) * 2012-03-02 2013-07-19 주식회사 유니크메디케어 여드름 개선용 조성물
KR102493627B1 (ko) 2015-11-26 2023-01-31 코웨이 주식회사 호르데닌을 유효성분으로 함유하는 피부암 예방 또는 치료용 약학 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater

Also Published As

Publication number Publication date
NO971217L (no) 1997-09-22
PE42998A1 (es) 1998-08-11
CA2199893A1 (en) 1997-09-21
JPH107651A (ja) 1998-01-13
KR970065495A (ko) 1997-10-13
IL120469A0 (en) 1997-07-13
CZ85897A3 (cs) 1998-04-15
TR199700219A3 (tr) 1997-10-21
ES2198512T3 (es) 2004-02-01
EP0796843B1 (en) 2003-05-21
SG70589A1 (en) 2000-02-22
CA2199893C (en) 2008-02-05
ID16285A (id) 1997-09-18
TR199700219A2 (xx) 1997-10-21
ZA972302B (en) 1997-09-22
HUP9700609A2 (hu) 1998-07-28
NZ314424A (en) 1998-07-28
MX9702139A (es) 1998-04-30
TW444001B (en) 2001-07-01
KR100240541B1 (ko) 2000-01-15
AR006315A1 (es) 1999-08-25
NO971217D0 (no) 1997-03-17
DE69722064T2 (de) 2004-04-08
HRP970162A2 (en) 1998-04-30
BR9701404A (pt) 1998-11-03
DK0796843T3 (da) 2003-09-15
PT796843E (pt) 2003-09-30
PL319070A1 (en) 1997-09-29
HU9700609D0 (en) 1997-05-28
EP0796843A2 (en) 1997-09-24
HUP9700609A3 (en) 1999-03-01
MA26423A1 (fr) 2004-12-20
ATE240941T1 (de) 2003-06-15
AU708679B2 (en) 1999-08-12
CN1110477C (zh) 2003-06-04
DE69722064D1 (de) 2003-06-26
AU1513597A (en) 1997-09-25
YU10397A (sh) 1999-07-28
JP2801587B2 (ja) 1998-09-21
CN1172793A (zh) 1998-02-11
EP0796843A3 (en) 1999-04-14

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