CO2021004160A2 - Formas mórficas de los inhibidores del factor d del complemento - Google Patents

Formas mórficas de los inhibidores del factor d del complemento

Info

Publication number
CO2021004160A2
CO2021004160A2 CONC2021/0004160A CO2021004160A CO2021004160A2 CO 2021004160 A2 CO2021004160 A2 CO 2021004160A2 CO 2021004160 A CO2021004160 A CO 2021004160A CO 2021004160 A2 CO2021004160 A2 CO 2021004160A2
Authority
CO
Colombia
Prior art keywords
inhibitors
complement factor
morphic forms
compound
forms
Prior art date
Application number
CONC2021/0004160A
Other languages
English (en)
Inventor
Avinash P Phadke
Akihiro Hashimoto
Wei Ma
Lee M Katrincic
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of CO2021004160A2 publication Critical patent/CO2021004160A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención proporciona formas estables y altamente cristalinas del Compuesto 1 y Compuesto 2 de los inhibidores del factor D del Complemento para una eficacia farmacéutica terapéutica y una estabilidad de la forma de dosificación ventajosas.
CONC2021/0004160A 2018-09-06 2021-04-06 Formas mórficas de los inhibidores del factor d del complemento CO2021004160A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862727954P 2018-09-06 2018-09-06
PCT/US2019/050073 WO2020051538A1 (en) 2018-09-06 2019-09-06 Morphic forms of complement factor d inhibitors

Publications (1)

Publication Number Publication Date
CO2021004160A2 true CO2021004160A2 (es) 2021-04-30

Family

ID=69723293

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0004160A CO2021004160A2 (es) 2018-09-06 2021-04-06 Formas mórficas de los inhibidores del factor d del complemento

Country Status (11)

Country Link
US (1) US11814363B2 (es)
EP (1) EP3847174A4 (es)
JP (1) JP2021536511A (es)
KR (1) KR20210057086A (es)
CN (1) CN112839945A (es)
AU (1) AU2019336238A1 (es)
BR (1) BR112021004263A2 (es)
CA (1) CA3111810A1 (es)
CO (1) CO2021004160A2 (es)
MX (1) MX2021002640A (es)
WO (1) WO2020051538A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4346830A1 (en) * 2021-05-28 2024-04-10 Alexion Pharmaceuticals, Inc. Use of complement factor d inhibitor for treatment of geographic atrophy secondary to age-related macular degeneration
CA3233486A1 (en) * 2021-09-30 2023-04-06 Jun LOU Compound as inhibitor of complement factor d, and pharmaceutical composition and use thereof
WO2023158772A1 (en) 2022-02-21 2023-08-24 Teva Pharmaceuticals International Gmbh Solid state forms of danicopan and process thereof
CN115872925B (zh) * 2023-02-22 2023-09-29 山东莱福科技发展有限公司 一种6-溴-3-甲基吡啶-2-胺的制备方法

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Also Published As

Publication number Publication date
US11814363B2 (en) 2023-11-14
US20230094124A1 (en) 2023-03-30
CN112839945A (zh) 2021-05-25
EP3847174A1 (en) 2021-07-14
KR20210057086A (ko) 2021-05-20
JP2021536511A (ja) 2021-12-27
EP3847174A4 (en) 2022-06-15
MX2021002640A (es) 2021-07-16
WO2020051538A1 (en) 2020-03-12
AU2019336238A1 (en) 2021-04-08
BR112021004263A2 (pt) 2021-05-25
CA3111810A1 (en) 2020-03-12

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