AR104935A1 - Formas cristalinas de un inhibidor de histona deacetilasa - Google Patents
Formas cristalinas de un inhibidor de histona deacetilasaInfo
- Publication number
- AR104935A1 AR104935A1 ARP160101702A ARP160101702A AR104935A1 AR 104935 A1 AR104935 A1 AR 104935A1 AR P160101702 A ARP160101702 A AR P160101702A AR P160101702 A ARP160101702 A AR P160101702A AR 104935 A1 AR104935 A1 AR 104935A1
- Authority
- AR
- Argentina
- Prior art keywords
- deacetilasa
- histona
- inhibitor
- crystal forms
- crystal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Una forma cristalina de 2-((2-clorofenil)(fenil)amino)-N-(7-(hidroxiamino)-7-oxoheptil)pirimidin-5-carboxamida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562172629P | 2015-06-08 | 2015-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR104935A1 true AR104935A1 (es) | 2017-08-23 |
Family
ID=56178492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160101702A AR104935A1 (es) | 2015-06-08 | 2016-06-08 | Formas cristalinas de un inhibidor de histona deacetilasa |
Country Status (6)
Country | Link |
---|---|
US (1) | US10464906B2 (es) |
EP (1) | EP3303306B1 (es) |
JP (1) | JP6816036B2 (es) |
AR (1) | AR104935A1 (es) |
TW (1) | TW201718516A (es) |
WO (1) | WO2016200919A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013158984A1 (en) | 2012-04-19 | 2013-10-24 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
JP6873053B2 (ja) | 2015-06-08 | 2021-05-19 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | タンパク質脱アセチル化阻害剤の製造方法 |
TW201803594A (zh) * | 2016-06-09 | 2018-02-01 | 達納-法伯癌症協會 | Hdac抑制劑與bet抑制劑之使用方法及醫藥組合 |
JP7100018B2 (ja) | 2016-08-08 | 2022-07-12 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストンデアセチラーゼ6阻害剤及びcd20阻害抗体の薬学的組み合わせならびにその使用 |
EP3544600A4 (en) | 2016-11-23 | 2020-06-17 | Acetylon Pharmaceuticals, Inc. | PHARMACEUTICAL COMBINATIONS WITH A HISTONE DEACETYLAS INHIBITOR AND A PROGRAMMED DEATH LIGAND-1 (PD-L1) INHIBITOR AND METHOD FOR USE THEREOF |
Family Cites Families (51)
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US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
CA2404002A1 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2002074298A1 (fr) | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de production d'il-6 |
US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
ES2294190T3 (es) | 2001-11-01 | 2008-04-01 | Janssen Pharmaceutica N.V. | Derivados de amida como inhibidores de la glucogeno sintasa quinasa 3-beta. |
US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US7381825B2 (en) | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
JP4993374B2 (ja) | 2004-04-05 | 2012-08-08 | メルク エイチディーエーシー リサーチ エルエルシー | ヒストン脱アセチル化酵素インヒビタープロドラッグ |
CA2601706C (en) | 2005-03-22 | 2016-09-20 | Dana-Farber Cancer Institute, Inc. | Treatment of protein degradation disorders |
US20070155730A1 (en) | 2005-08-26 | 2007-07-05 | Methylgene, Inc. | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase |
CN101400362B (zh) | 2006-02-14 | 2016-10-12 | 哈佛大学校长及研究员协会 | 双官能组蛋白去乙酰化酶抑制剂 |
WO2007130429A2 (en) | 2006-05-03 | 2007-11-15 | The President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
WO2007144341A1 (en) | 2006-06-12 | 2007-12-21 | Vrije Universiteit Brussel | Differentiation of rat liver epithelial cells into hepatocyte-like cells |
ES2288802B1 (es) | 2006-07-07 | 2008-12-16 | Universidad De Granada | Nuevos derivados de ftalimida como inhibidores de las histonas desacetilasas. |
KR101433629B1 (ko) | 2006-09-11 | 2014-08-27 | 쿠리스 인코퍼레이션 | 아연 결합 부분을 함유한 티로신 키나아제 억제제 |
WO2009104696A1 (ja) | 2008-02-19 | 2009-08-27 | 株式会社アーネストメディスン | 身体機能の回復に有用な経口又は経腸組成物 |
AU2009274549B2 (en) | 2008-07-23 | 2014-05-01 | Dana-Farber Cancer Institute, Inc. | Deacetylase inhibitors and uses thereof |
US8716326B2 (en) | 2009-05-15 | 2014-05-06 | Korea Research Institute Of Chemical Technology | Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same |
US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
WO2011084991A2 (en) | 2010-01-08 | 2011-07-14 | President And Fellows Of Harvard College | Fluorinated hdac inhibitors and uses thereof |
DK2526093T3 (en) * | 2010-01-22 | 2016-11-14 | Acetylon Pharmaceuticals Inc | Reverse amide compounds as proteindeacetylasehæmmere and methods of use thereof |
AU2011255281A1 (en) | 2010-05-21 | 2013-01-10 | Sloan-Kettering Institute For Cancer Research | Selective HDAC inhibitors |
WO2012018499A2 (en) | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
KR20130115300A (ko) | 2010-11-16 | 2013-10-21 | 에이스틸론 파마수티컬스 인코포레이티드 | 단백질 탈아세틸화 효소 억제제로서 피리미딘 하이드록시 아미드 화합물 및 그의 사용방법 |
JP6169076B2 (ja) | 2011-07-20 | 2017-07-26 | ザ ジェネラル ホスピタル コーポレイション | 骨疾患の処置のためのヒストン脱アセチル化酵素6選択的阻害剤 |
WO2013158984A1 (en) | 2012-04-19 | 2013-10-24 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
JP2015533173A (ja) | 2012-10-12 | 2015-11-19 | トラスティース・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | タンパク質脱アセチル化酵素阻害剤としてのピリミジンヒドロキシアミド化合物およびその使用方法 |
US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
US9139583B2 (en) | 2013-02-01 | 2015-09-22 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
US9096549B2 (en) | 2013-02-01 | 2015-08-04 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
WO2014197471A1 (en) | 2013-06-03 | 2014-12-11 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase ( hdac) biomarkers in multiple myeloma |
EP3046559A4 (en) | 2013-09-20 | 2017-03-22 | Acetylon Pharmaceuticals, Inc. | Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor |
ES2929576T3 (es) | 2013-10-08 | 2022-11-30 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama |
JP2016536354A (ja) | 2013-10-10 | 2016-11-24 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | 非ホジキンリンパ腫を治療するための、hdac阻害剤単独またはbtk阻害剤との組み合わせ |
ES2862126T3 (es) | 2013-10-10 | 2021-10-07 | Acetylon Pharmaceuticals Inc | Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa |
ES2818933T3 (es) | 2013-10-10 | 2021-04-14 | Acetylon Pharmaceuticals Inc | Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin |
CR20160200A (es) | 2013-10-11 | 2016-08-29 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona desacetilasa y fármacos inmunomoduladores |
JP2016534069A (ja) | 2013-10-24 | 2016-11-04 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | Hdac6阻害剤での多嚢胞性疾患の治療 |
EP3076973B1 (en) | 2013-12-03 | 2020-04-29 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase inhibitors and immunomodulatory drugs |
ES2936812T3 (es) | 2013-12-20 | 2023-03-22 | Acetylon Pharmaceuticals Inc | Biomarcadores de histona desacetilasa 6 (HDAC6) en mieloma múltiple |
US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
US20150359794A1 (en) | 2014-06-13 | 2015-12-17 | Buck Institute For Research On Aging | Impairment of the large ribosomal subunit protein rpl24 by depletion or acetylation |
MX2017000307A (es) | 2014-07-07 | 2017-11-23 | Acetylon Pharmaceuticals Inc | Tratamiento de leucemia con inhibidores de histona deacetilasa. |
EP3204006A4 (en) | 2014-10-08 | 2018-04-04 | Regenacy Pharmaceuticals, LLC | Induction of gata2 by hdac1 and hdac2 inhibitors |
US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
WO2016090230A1 (en) | 2014-12-05 | 2016-06-09 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds for treating peripheral neuropathy |
CN107835810A (zh) | 2014-12-12 | 2018-03-23 | 瑞格纳西制药有限公司 | 作为hdac1/2抑制剂的哌啶衍生物 |
WO2016168647A1 (en) | 2015-04-17 | 2016-10-20 | Acetylon Pharmaceuticals Inc. | Treatment of neuroblastoma with histone deacetylase inhibotrs |
US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
JP6873053B2 (ja) | 2015-06-08 | 2021-05-19 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | タンパク質脱アセチル化阻害剤の製造方法 |
-
2016
- 2016-06-08 EP EP16731454.1A patent/EP3303306B1/en active Active
- 2016-06-08 TW TW105118206A patent/TW201718516A/zh unknown
- 2016-06-08 US US15/176,788 patent/US10464906B2/en active Active
- 2016-06-08 JP JP2017563542A patent/JP6816036B2/ja active Active
- 2016-06-08 AR ARP160101702A patent/AR104935A1/es unknown
- 2016-06-08 WO PCT/US2016/036422 patent/WO2016200919A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP6816036B2 (ja) | 2021-01-20 |
EP3303306A1 (en) | 2018-04-11 |
JP2018516946A (ja) | 2018-06-28 |
US10464906B2 (en) | 2019-11-05 |
US20170001965A1 (en) | 2017-01-05 |
EP3303306B1 (en) | 2020-02-12 |
WO2016200919A1 (en) | 2016-12-15 |
TW201718516A (zh) | 2017-06-01 |
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Legal Events
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FB | Suspension of granting procedure |