CO2020012360A2 - Anticuerpos multiespecíficos y utilización de los mismos - Google Patents
Anticuerpos multiespecíficos y utilización de los mismosInfo
- Publication number
- CO2020012360A2 CO2020012360A2 CONC2020/0012360A CO2020012360A CO2020012360A2 CO 2020012360 A2 CO2020012360 A2 CO 2020012360A2 CO 2020012360 A CO2020012360 A CO 2020012360A CO 2020012360 A2 CO2020012360 A2 CO 2020012360A2
- Authority
- CO
- Colombia
- Prior art keywords
- multispecific antibodies
- hla
- bind
- formulations
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente invención se refiere a anticuerpos multiespecíficos que se unen a HLA-G, y a un antígeno activador de células T, a su preparación, y a formulaciones y métodos de utilización de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18168053 | 2018-04-18 | ||
PCT/EP2019/060008 WO2019202041A1 (en) | 2018-04-18 | 2019-04-17 | Multispecific antibodies and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020012360A2 true CO2020012360A2 (es) | 2020-10-30 |
Family
ID=62025743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0012360A CO2020012360A2 (es) | 2018-04-18 | 2020-09-30 | Anticuerpos multiespecíficos y utilización de los mismos |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210147554A1 (es) |
EP (1) | EP3781594A1 (es) |
JP (2) | JP2021521785A (es) |
KR (1) | KR20210005639A (es) |
CN (1) | CN111989343B (es) |
AR (1) | AR115052A1 (es) |
AU (1) | AU2019256744A1 (es) |
BR (1) | BR112020021111A2 (es) |
CA (1) | CA3095547A1 (es) |
CL (1) | CL2020002539A1 (es) |
CO (1) | CO2020012360A2 (es) |
IL (1) | IL277559A (es) |
MA (1) | MA52285A (es) |
MX (1) | MX2020010946A (es) |
PE (1) | PE20210517A1 (es) |
PH (1) | PH12020500667A1 (es) |
SG (1) | SG11202009692SA (es) |
TW (1) | TW201945394A (es) |
WO (1) | WO2019202041A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20211604A1 (es) | 2018-07-09 | 2021-08-23 | Five Prime Therapeutics Inc | Anticuerpos de union a ilt4 |
CN113528448B (zh) * | 2020-04-14 | 2023-01-24 | 同济大学 | 一种人胚胎干细胞的构建方法 |
IL298867A (en) * | 2020-06-11 | 2023-02-01 | Tizona Therapeutics | Combines bispecific immune cells with binding specificity for HLA-G and another antigen |
JP2023536818A (ja) * | 2020-07-29 | 2023-08-30 | ヤンセン バイオテツク,インコーポレーテツド | Hla-g抗原結合ドメインを含むタンパク質及びそれらの使用 |
KR20230120665A (ko) * | 2020-12-17 | 2023-08-17 | 에프. 호프만-라 로슈 아게 | 항-hla-g 항체 및 이의 용도 |
US20220306747A1 (en) * | 2021-03-24 | 2022-09-29 | China Medical University Hospital | Anti-tumor antigen nanobody and nucleic acid encoding sequence thereof, and uses of the same |
US11795227B2 (en) * | 2021-03-24 | 2023-10-24 | Shine-On Biomedical Co., Ltd. | Immunomodulation and anti-tumor-related nanobody and nucleic acid encoding sequence thereof, and uses of the same |
CN113398253B (zh) * | 2021-05-14 | 2023-01-24 | 北京化工大学 | β2微球蛋白聚集抑制剂 |
CA3221568A1 (en) * | 2021-05-26 | 2022-12-01 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor to target hla-g-positive cancers |
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CN107074933B (zh) | 2014-10-24 | 2021-03-19 | 豪夫迈·罗氏有限公司 | 基于vh-vl域间角的抗体人源化 |
US20190119385A1 (en) * | 2015-03-27 | 2019-04-25 | University Of Southern California | Hla-g as a novel target for car t-cell immunotherapy |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
-
2019
- 2019-04-16 AR ARP190101003A patent/AR115052A1/es unknown
- 2019-04-17 PE PE2020001543A patent/PE20210517A1/es unknown
- 2019-04-17 WO PCT/EP2019/060008 patent/WO2019202041A1/en unknown
- 2019-04-17 BR BR112020021111-7A patent/BR112020021111A2/pt not_active Application Discontinuation
- 2019-04-17 MA MA052285A patent/MA52285A/fr unknown
- 2019-04-17 EP EP19718695.0A patent/EP3781594A1/en active Pending
- 2019-04-17 SG SG11202009692SA patent/SG11202009692SA/en unknown
- 2019-04-17 JP JP2020557212A patent/JP2021521785A/ja active Pending
- 2019-04-17 CN CN201980026851.4A patent/CN111989343B/zh active Active
- 2019-04-17 MX MX2020010946A patent/MX2020010946A/es unknown
- 2019-04-17 AU AU2019256744A patent/AU2019256744A1/en not_active Abandoned
- 2019-04-17 TW TW108113353A patent/TW201945394A/zh unknown
- 2019-04-17 KR KR1020207033026A patent/KR20210005639A/ko not_active Application Discontinuation
- 2019-04-17 CA CA3095547A patent/CA3095547A1/en not_active Abandoned
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2020
- 2020-09-23 IL IL277559A patent/IL277559A/en unknown
- 2020-09-30 CO CONC2020/0012360A patent/CO2020012360A2/es unknown
- 2020-10-01 CL CL2020002539A patent/CL2020002539A1/es unknown
- 2020-10-15 PH PH12020500667A patent/PH12020500667A1/en unknown
- 2020-10-16 US US17/072,549 patent/US20210147554A1/en active Pending
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2023
- 2023-02-27 JP JP2023028123A patent/JP2023081898A/ja active Pending
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JP2023081898A (ja) | 2023-06-13 |
MA52285A (fr) | 2021-02-24 |
CL2020002539A1 (es) | 2021-01-22 |
JP2021521785A (ja) | 2021-08-30 |
WO2019202041A1 (en) | 2019-10-24 |
CA3095547A1 (en) | 2019-10-24 |
IL277559A (en) | 2020-11-30 |
CN111989343A (zh) | 2020-11-24 |
PH12020500667A1 (en) | 2021-07-26 |
KR20210005639A (ko) | 2021-01-14 |
TW201945394A (zh) | 2019-12-01 |
EP3781594A1 (en) | 2021-02-24 |
US20210147554A1 (en) | 2021-05-20 |
BR112020021111A2 (pt) | 2021-02-17 |
SG11202009692SA (en) | 2020-11-27 |
CN111989343B (zh) | 2023-12-26 |
AU2019256744A1 (en) | 2020-11-19 |
AR115052A1 (es) | 2020-11-25 |
MX2020010946A (es) | 2020-11-09 |
PE20210517A1 (es) | 2021-03-17 |
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