CO2017011245A2 - Conjugados proteína-polisacárido de estreptococo grupo b, métodos para producir conjugados, composiciones inmunógenas que comprenden conjugados y sus usos - Google Patents

Conjugados proteína-polisacárido de estreptococo grupo b, métodos para producir conjugados, composiciones inmunógenas que comprenden conjugados y sus usos

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Publication number
CO2017011245A2
CO2017011245A2 CONC2017/0011245A CO2017011245A CO2017011245A2 CO 2017011245 A2 CO2017011245 A2 CO 2017011245A2 CO 2017011245 A CO2017011245 A CO 2017011245A CO 2017011245 A2 CO2017011245 A2 CO 2017011245A2
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Colombia
Prior art keywords
conjugates
gbs
polysaccharide
methods
group
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CONC2017/0011245A
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English (en)
Inventor
Jianxin Gu
Rajesh Kumar Kainthan
Avvari Krishna Prasad
Annaliesa Sybil Anderson
Bhalla Amardeep Singh Bhupender
Robert G K Donald
Kathrin Ute Jansen
Lakshmi Khandke
Jin-Hwan Kim
Paul Liberator
Mark Edward Ruppen
Ingrid Lea Scully
Suddham Singh
Cindy Xudong Yang
Original Assignee
Pfizer
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Application filed by Pfizer filed Critical Pfizer
Publication of CO2017011245A2 publication Critical patent/CO2017011245A2/es

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    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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Abstract

La invención se refiere a conjugados inmunógenos proteína-polisacárido que comprenden un polisacárido capsular (CP) de Streptococcus agalactiae, denominado comúnmente estreptococo grupo B (GBS), y una proteína portadora, en donde CP se selecciona del grupo que consiste en los serotipos Ia, Ib, II, III, IV, V, VI, VII, VIII y IX, y en donde CP tiene un nivel de ácido siálico mayor de alrededor de 60 %. La invención también se refiere a métodos para obtener los conjugados y las composiciones inmunógenas que comprenden los conjugados. La invención también se refiere a composiciones inmunógenas que comprenden conjugados proteína-polisacárido, en donde los conjugados comprenden un CP de GBS serotipo IV y al menos un serotipo adicional. Asimismo, la invención se refiere a métodos para inducir una respuesta inmunitaria en sujetos contra GBS y/o para reducir o prevenir la enfermedad por GBS invasivo en sujetos usando las composiciones descritas en la presente. Los anticuerpos resultantes se pueden usar para tratar o prevenir la infección por GBS mediante inmunoterapia pasiva.
CONC2017/0011245A 2015-05-04 2017-11-01 Conjugados proteína-polisacárido de estreptococo grupo b, métodos para producir conjugados, composiciones inmunógenas que comprenden conjugados y sus usos CO2017011245A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562156500P 2015-05-04 2015-05-04
US201562237813P 2015-10-06 2015-10-06
US201562237820P 2015-10-06 2015-10-06
US201662319539P 2016-04-07 2016-04-07
PCT/IB2016/052455 WO2016178123A1 (en) 2015-05-04 2016-04-29 Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof

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CO2017011245A2 true CO2017011245A2 (es) 2018-03-28

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US (4) US10226525B2 (es)
EP (1) EP3292146A1 (es)
JP (3) JP6948951B2 (es)
KR (2) KR102143534B1 (es)
CN (2) CN114010775A (es)
AU (2) AU2016258284C1 (es)
BR (1) BR112017022776A2 (es)
CA (1) CA2928602A1 (es)
CO (1) CO2017011245A2 (es)
IL (2) IL255106B2 (es)
MX (1) MX368897B (es)
MY (1) MY182282A (es)
NZ (1) NZ736238A (es)
PE (2) PE20220774A1 (es)
PH (1) PH12017501898A1 (es)
RU (1) RU2692923C2 (es)
SA (1) SA517390274B1 (es)
SG (2) SG11201708242YA (es)
TW (2) TWI807252B (es)
WO (1) WO2016178123A1 (es)
ZA (1) ZA201807203B (es)

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