CO2017003830A2 - Compuestos de piridina - Google Patents
Compuestos de piridinaInfo
- Publication number
- CO2017003830A2 CO2017003830A2 CONC2017/0003830A CO2017003830A CO2017003830A2 CO 2017003830 A2 CO2017003830 A2 CO 2017003830A2 CO 2017003830 A CO2017003830 A CO 2017003830A CO 2017003830 A2 CO2017003830 A2 CO 2017003830A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- hydrogen atom
- alkyl group
- different
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
La presente invención se refiere a un compuesto o una sal farmacológicamente aceptable del mismo que tiene una excelente actiividad inhibidora de fosfatasa alcalina no específica a tejido. El presente invento proporciona un compuesto representado por la fórmula (I), en donde R1 representa un átomo de hidrógeno, un grupo alquilo C1-6 opcionalmente sustituido, o similar, R2 y R3 son los mismos o diferentes y cada uno representan un átomo de hidrógeno, un grupo alquilo C1-6 opcionalmente sustituido, o similar , R4 y R5 son iguales o diferentes y cada uno representan un átomo de hidrógeno, un grupo alquilo C1-6 opcionalmente sustituido, o similar, R6 representa un átomo de hidrógeno o similar, cada R7 puede ser igual o diferente y puede representar cada uno un grupo alcoxilo C1-6 opcionalmente sustituido osimilar, X representa -CH =, -C(-R7 )=, o -N =, y m representa 1 a 4, o una sal farmacológicamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562190145P | 2015-07-08 | 2015-07-08 | |
| PCT/US2016/041345 WO2017007943A1 (en) | 2015-07-08 | 2016-07-07 | Pyrido-oxazinone derivatives as tnap inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017003830A2 true CO2017003830A2 (es) | 2017-08-31 |
Family
ID=57045381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0003830A CO2017003830A2 (es) | 2015-07-08 | 2017-04-20 | Compuestos de piridina |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US9920068B2 (es) |
| EP (1) | EP3319970B1 (es) |
| JP (1) | JP6666928B2 (es) |
| KR (1) | KR102590067B1 (es) |
| CN (1) | CN107207527B (es) |
| AU (1) | AU2016291163B2 (es) |
| CA (1) | CA2962795C (es) |
| CO (1) | CO2017003830A2 (es) |
| CY (1) | CY1122477T1 (es) |
| DK (1) | DK3319970T3 (es) |
| ES (1) | ES2754480T3 (es) |
| HK (1) | HK1253572A1 (es) |
| HR (1) | HRP20192121T1 (es) |
| HU (1) | HUE046994T2 (es) |
| IL (1) | IL251005B (es) |
| LT (1) | LT3319970T (es) |
| MX (1) | MX2017003822A (es) |
| MY (1) | MY185558A (es) |
| NZ (1) | NZ729387A (es) |
| PH (1) | PH12018500066A1 (es) |
| PL (1) | PL3319970T3 (es) |
| PT (1) | PT3319970T (es) |
| RS (1) | RS59594B1 (es) |
| RU (1) | RU2715704C2 (es) |
| SG (1) | SG11201701378WA (es) |
| SI (1) | SI3319970T1 (es) |
| TW (1) | TWI702220B (es) |
| WO (1) | WO2017007943A1 (es) |
| ZA (1) | ZA201701783B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201829417A (zh) * | 2016-12-23 | 2018-08-16 | 日商第一三共股份有限公司 | 氧氮呯化合物 |
| KR102480808B1 (ko) * | 2016-12-23 | 2022-12-22 | 다이이찌 산쿄 가부시키가이샤 | Ｔｎａｐ 저해 활성을 갖는 술폰아미드 화합물 |
| KR20210080416A (ko) | 2018-10-23 | 2021-06-30 | 다이이찌 산쿄 가부시키가이샤 | 바이아릴 유도체 |
| CN114085911B (zh) * | 2022-01-19 | 2022-05-17 | 珠海圣美生物诊断技术有限公司 | 一种检测肿瘤细胞或肿瘤细胞碎片的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810795A (en) | 1982-09-30 | 1989-03-07 | A. H. Robins Company, Incorporated | Certain 2,5 and 2,5,6-di- and tri-substituted nicotinic acid intermediates |
| CA2352612A1 (en) | 1998-11-27 | 2000-06-08 | Hideo Fukui | Pharmaceuticals |
| US6410520B2 (en) * | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| JP2009500442A (ja) | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| EP2433496A1 (en) | 2007-05-08 | 2012-03-28 | Burnham Institute for Medical Research | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification |
| US9458147B2 (en) * | 2012-02-22 | 2016-10-04 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as TNAP inhibitors |
-
2016
- 2016-07-07 HU HUE16775006A patent/HUE046994T2/hu unknown
- 2016-07-07 AU AU2016291163A patent/AU2016291163B2/en active Active
- 2016-07-07 LT LT16775006T patent/LT3319970T/lt unknown
- 2016-07-07 KR KR1020177010518A patent/KR102590067B1/ko active IP Right Grant
- 2016-07-07 CN CN201680006507.5A patent/CN107207527B/zh active Active
- 2016-07-07 SG SG11201701378WA patent/SG11201701378WA/en unknown
- 2016-07-07 MX MX2017003822A patent/MX2017003822A/es active IP Right Grant
- 2016-07-07 PL PL16775006T patent/PL3319970T3/pl unknown
- 2016-07-07 PT PT167750066T patent/PT3319970T/pt unknown
- 2016-07-07 DK DK16775006T patent/DK3319970T3/da active
- 2016-07-07 MY MYPI2017700569A patent/MY185558A/en unknown
- 2016-07-07 JP JP2017556523A patent/JP6666928B2/ja active Active
- 2016-07-07 CA CA2962795A patent/CA2962795C/en active Active
- 2016-07-07 TW TW105121542A patent/TWI702220B/zh active
- 2016-07-07 EP EP16775006.6A patent/EP3319970B1/en active Active
- 2016-07-07 NZ NZ729387A patent/NZ729387A/en unknown
- 2016-07-07 SI SI201630466T patent/SI3319970T1/sl unknown
- 2016-07-07 RU RU2017117179A patent/RU2715704C2/ru active
- 2016-07-07 ES ES16775006T patent/ES2754480T3/es active Active
- 2016-07-07 RS RS20191522A patent/RS59594B1/sr unknown
- 2016-07-07 WO PCT/US2016/041345 patent/WO2017007943A1/en active Application Filing
- 2016-07-07 US US15/314,887 patent/US9920068B2/en active Active
-
2017
- 2017-03-07 IL IL251005A patent/IL251005B/en active IP Right Grant
- 2017-03-13 ZA ZA2017/01783A patent/ZA201701783B/en unknown
- 2017-04-06 US US15/481,151 patent/US9879032B2/en active Active
- 2017-04-20 CO CONC2017/0003830A patent/CO2017003830A2/es unknown
-
2018
- 2018-01-05 PH PH12018500066A patent/PH12018500066A1/en unknown
- 2018-01-18 US US15/874,768 patent/US10221195B2/en active Active
- 2018-10-08 HK HK18112777.4A patent/HK1253572A1/zh unknown
-
2019
- 2019-11-27 CY CY20191101247T patent/CY1122477T1/el unknown
- 2019-11-27 HR HRP20192121TT patent/HRP20192121T1/hr unknown
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