CN217479439U

CN217479439U - Reactor supporting and heating device of hybridization instrument

Info

Publication number: CN217479439U
Application number: CN202221685960.2U
Authority: CN
Inventors: 孙悦; 陈立波
Original assignee: Fist Shanghai Biotechnology Co ltd
Current assignee: Fist Shanghai Biotechnology Co ltd
Priority date: 2022-05-24
Filing date: 2022-07-01
Publication date: 2022-09-23
Anticipated expiration: 2032-07-01
Also published as: CN116410843A; CN217614815U; CN217479473U; CN217628334U; CN217479466U

Abstract

The utility model provides a reactor of hybridization appearance supports heating device is equipped with biochip in the reactor, the hybridization appearance includes the casing, it installs in the casing to support heating device, support heating device and include reactor frame and the heating element who is used for heating reactor, and reactor detachably installs on reactor frame, and heating element includes the hot briquetting, and the hot briquetting is equipped with inside appearance chamber, and hot briquetting upper end opening, reactor frame can follow the upper end of hot briquetting and get into or leave the hot briquetting inside, and hot briquetting slidable ground sets up, and the hot briquetting slides to stretching out the casing or returning the casing. The utility model discloses the reactor is put in the thermoblock through the reactor frame, and the thermoblock supports reactor and reactor frame simultaneously to the reactor heating, makes hybridization appearance inner structure compacter.

Description

Reactor supporting and heating device of hybridization instrument

Technical Field

The utility model belongs to the technical field of hybridization appearance, specifically be a reactor of hybridization appearance supports heating device.

Background

The hybridization instrument is an analytical instrument which is generally used in the biological field, and adopts the nucleic acid molecular hybridization technology to detect whether the genome to be detected contains a known gene sequence. When the device is used, liquid (hybridization liquid, binding liquid, sample liquid and the like) needs to be put into the hybridization instrument and put into the biochip for reaction, and the reaction result can be judged according to the color and the state after the reaction. The above reaction process generally needs heating, and if the space in the hybridization instrument where the biochip is located is integrally heated, the heating space is large, the heating efficiency is low, and the energy conservation is not facilitated. Meanwhile, the biochip is externally put into the hybridization apparatus, and is taken out of the hybridization apparatus after the reaction is completed, which causes difficulty in fixing and optimizing the heating apparatus.

SUMMERY OF THE UTILITY MODEL

In view of the above problems in the prior art, the object of the present invention is to provide a supporting and heating device for a hybrid instrument, in which a reactor is placed in a hot block through a reactor frame, the thermal block heats the reactor and supports the reactor and the reactor frame at the same time, the heating component does not need to occupy an independent space independently, so that the internal structure of the hybridization instrument is more compact, the reactor is put into and taken out by utilizing the reactor supporting component, the reactor supporting component is manually driven, the operation is simple and convenient, the reactor frame extends out of the shell for the operation of putting into or taking out of the reactor, after the reactor frame retracts into the shell, the spring wire is matched with the limiting part to stably keep the reactor frame at a set position, the thermal block and the reactor frame synchronously move to directly place the reactor frame into the thermal block or take the reactor frame out of the thermal block, the electric wire of the heating film outside the thermal block is positioned in the spring wire, and the electric wire is better protected and does not interfere with the action of other parts.

In order to realize the purpose, the utility model discloses the technical scheme who adopts is:

the utility model provides a reactor of hybridization appearance supports heating device, is equipped with the biochip in the reactor, the hybridization appearance includes the casing, support heating device and install in the casing, support heating device and include reactor frame and the heating element who is used for heating reactor, reactor detachably installs on reactor frame, and heating element includes the thermoblock, and the thermoblock is equipped with inside appearance chamber, and thermoblock upper end opening, reactor frame can follow the upper end of thermoblock and get into or leave the thermoblock inside, and thermoblock slidable ground sets up, and the thermoblock slides to stretching out the casing or returning the casing.

As a further improvement of the above technical solution:

the heating assembly further comprises an electric wire and a heating film, the heating film is coated outside the heat block, and the heating film is connected with an external power supply through the electric wire.

The device further comprises a reactor supporting assembly, the reactor supporting assembly comprises two first sliding blocks and two first sliding rails, the first sliding rails are fixedly mounted in the shell, the two sliding rails are arranged on the two sides of the heat block at intervals in parallel, the first sliding rails are perpendicular to the heat block, the first sliding blocks are slidably arranged on the first sliding rails, and the two ends of the heat block are connected with and supported on the first sliding blocks respectively.

The reactor supporting component also comprises a handle, and two ends of the handle are respectively connected with and supported on the first two sliding blocks or two ends of the hot block.

The reactor supporting assembly further comprises two spring wires which are arranged in parallel at intervals, one end of each spring wire is connected in the shell, and the other end of each spring wire is connected with one end of one sliding block or one end of the thermal block.

The electrical wires are located within the spring wires.

One end of the shell, which is far away from the handle, is provided with a limiting part for limiting a limiting position of the sliding block, when the sliding block I contacts the limiting part, the sliding block I can not move continuously, and at the moment, the spring wire is in a stretching state.

A row of installation positions are arranged on the reactor frame at intervals, and each installation position is detachably provided with a reactor.

The lower end of the reactor is connected with a needle tube, the needle tube is communicated with the inner cavity of the reactor, and the upper end of the reactor is provided with a through hole communicated with the inner cavity.

The lower end of the hot block is provided with a plurality of holes communicated with the inner containing cavity at intervals, and when the reactor frame is placed in the hot block, the needle tube at the lower end of the reactor on the reactor frame penetrates through the hole at the lower end of the hot block and then extends out of the hot block.

The beneficial effects of the utility model are that: the reactor is placed in the thermal block through the reactor frame, the thermal block heats the reactor and simultaneously supports the reactor and the reactor frame, the heating assembly does not need to independently occupy an independent space, the internal structure of the hybridization instrument is more compact, the reactor is placed in and taken out through the reactor supporting assembly, the reactor supporting assembly is manually driven, the operation is simple and convenient, the reactor frame extends out of the shell for placing the reactor or taking the reactor out, after the reactor frame retracts back to the shell, the spring wire is matched with the limiting part to stably keep the reactor frame at a set position, the thermal block and the reactor frame synchronously move to directly place the reactor frame in the thermal block or take the reactor frame out of the thermal block, the electric wire of the heating film outside the thermal block is positioned in the spring wire, and the electric wire is better protected without interfering the actions of other components.

Drawings

Fig. 1 is an external view of an embodiment of the present invention.

Fig. 2 is a schematic view of the structure of the present invention with the outer casing removed.

Fig. 3 is a schematic view of the handle structure of fig. 2 with the handle removed.

Fig. 4 is a schematic view of the structure of fig. 3 with the heat block removed.

Fig. 5 is a schematic structural diagram of a thermal block according to an embodiment of the present invention.

Fig. 6 is a schematic diagram of a reactor frame according to an embodiment of the present invention.

Fig. 7 is a schematic structural diagram of a reaction module according to an embodiment of the present invention.

Fig. 8 is a schematic structural view of the sealing bead according to an embodiment of the present invention.

Fig. 9 is a schematic view of the driving plate, the driving rod and the reactor lift driving assembly according to an embodiment of the present invention.

Detailed Description

The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings. It is to be understood that the description of the embodiments herein is for purposes of illustration and explanation only and is not intended to limit the invention.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

A supporting and heating device for a reactor of a hybridization instrument is shown in figures 1-9, and the hybridization instrument comprises a shell 1, a liquid containing assembly 2, a liquid transferring assembly 3, a reaction assembly 4, a supporting and heating device for the reactor, a sealing pressing strip 7, a piston assembly, a lifting transmission assembly 10 for the reactor, a driving assembly and a shooting assembly, wherein the liquid containing assembly, the liquid transferring assembly 3, the reaction assembly 4 and the supporting and heating device for the reactor are installed in the shell 1.

Flourishing liquid subassembly 2 is used for placing the test tube that holds liquid, moves liquid subassembly 3 and connects and drive flourishing liquid subassembly 2 and remove.

Reaction unit 4 is equipped with at least one group, and reaction unit 4 includes needle pipe 401 and reactor 402, and reactor 402 is equipped with inside and holds the chamber, and the biochip setting is held in the inside of reactor 402 holds the chamber, and the one end of needle pipe 401 is connected on reactor 402, the other end overhang, and needle pipe 401 internal passage and reactor 402 contain the intracavity intercommunication. The front and rear panels of the reactor 402 are transparent and are positioned opposite each other. The interior volume of the reactor 402 can be viewed or photographed through a front panel or a back panel. The upper end of the reactor 402 is provided with a through hole which is communicated with the inner cavity of the reactor 402.

The reactor support heating apparatus comprises a reactor frame 5, a heating assembly and a reactor support assembly 8. The reactor frame 5 is used for installing and supporting the reaction components 4, a plurality of installation positions for installing the reaction components 4 are arranged on the reactor frame 5, and the installation positions are arranged in a row in parallel at intervals. The upper end of the reactor frame 5 is also provided with a plurality of through holes which are respectively communicated with the plurality of installation positions. The reaction block 4 is detachably mounted on the mounting site. The reactor frame 5 is positioned above the liquid containing assembly 2. After the reaction assembly 4 is installed on the reactor frame 5, the reactor 402 is clamped into the installation position, the inner cavity of the reactor 402, the through hole at the upper end of the reactor 402 and the through hole at the upper end of the reactor frame 5 are sequentially communicated, and in order to improve the sealing property of the communicated channel, a sealing ring can be arranged at the joint of the upper end of the reactor 402 and the reactor frame 5. In particular, the reaction modules 4 are snapped into the mounting position from the side of the reactor frame 5. The transparent front panel and the transparent rear panel of the reactor 402 are not shielded by the reactor rack 5, and the corresponding reactor rack 5 is hollowed out for the subsequent shooting assembly to shoot. The open end of the needle tube 401 faces downwards, the needle tube 401 extends out of the bottom of the reactor frame 5, and the lower ends of the needle tubes 401 of the reaction components 4 on a plurality of installation positions are connected with the liquid testing and holding component 2. By the action of the subsequent piston assembly and drive assembly, the liquid in the liquid containing assembly 2 can be sucked into the reactor 402 through the needle tube 401.

The heating assembly is used to heat the reactor 402 of the reaction assembly 4 to provide temperature conditions for the reaction in the reactor 402. The heating assembly includes a thermal block 601, a heating film, an electrical wire, and a temperature sensor. The hot block 601 is provided with an internal cavity, the upper end of the hot block 601 is open, and the lower end of the hot block 601 is provided with a plurality of holes communicated with the internal cavity at intervals, the reactor frame 5 can be placed into the hot block 601 from the upper end of the hot block 601, and meanwhile, the needle tubes 401 of the reaction assemblies 4 on the reactor frame 5 respectively penetrate through the plurality of holes at the lower end of the hot block 601 and then extend out of the hot block 601. I.e. the reactor frame 5 is placed directly in the thermoblock 601 without connecting the two by means of connecting members. Both ends of the thermal block 601 are supported in the case 1. I.e. the reactor vessel frame 5 is not supported directly in the housing 1 but in the housing 1 by means of the thermoblock 601. The outside of the hot block 601 is coated with a heating film, the heating film is connected with an external power supply through a wire to heat the heating film, and heat is transferred to the liquid in the reactor 402 through the hot block 601. When the reactor frame 5 is placed on the thermal block 601, the top of the reactor frame 5 is higher than the top of the thermal block 601. A temperature sensor is provided in the case 1 for detecting the temperature of the thermal block 601 and transmitting the detected temperature to a control system electrically connected thereto.

The reactor support assembly 8 is used to bring or retract the reactor frame 5 out of or into the housing 1. The reactor support assembly 8 includes a pull 801, two slide blocks one 802, two slide rails one 803, and two spring wires 804. Two first sliding rails 803 are arranged on two sides of the thermal block 601 at intervals in parallel, and the first sliding rails 803 and the thermal block 601 are perpendicular to each other. The first slide rail 803 is fixedly installed in the housing 1, and the first slide block 802 can slide linearly along the first slide rail 803. The two ends of the thermal block 601 are respectively connected and supported on the two first sliding blocks 802. The two ends of the handle 801 are respectively connected and supported on the two sliding blocks one 802 or the two ends of the thermal block 601. When the handle 801 is pulled, the thermal block 601 and the reactor frame 5 are linearly moved by the two sliding blocks one 802, so that they synchronously extend out of the housing 1 or retract back into the housing 1.

In order to allow the reactor frame 5 to be accurately retracted to the initial position and stably held, two spring wires 804 are provided. Two spring wires 804 are arranged in parallel at intervals, one end of each spring wire 804 is connected in the shell 1, and the other end of each spring wire 804 is connected with one end of a sliding block-802 or a thermal block 601. One end of the shell 1, which is far away from the handle 801, is provided with a limiting part for limiting the limit position of the sliding block-802, the spring wire 804 is in a stretching state, when the reactor frame 5 and the thermal block 601 are pulled out, the stretching length of the spring wire 804 is increased, when the reactor frame 5 and the thermal block 601 are retracted to the set position, the spring wire 804 is blocked by the limiting part to continue to retract, and at the moment, the spring wire 804 is still in the stretching state, so that the reactor frame 5 and the thermal block 601 can be stably and reliably located at the set position. Preferably, the electrical wires of the heating assembly are located within the spring wires 804, i.e. the spring wires 804 serve the dual function of energizing the thermal block 601 and stabilizing the position of the reactor frame 5.

The sealing pressing strip 7 is detachably connected with the upper end of the reactor frame 5, and the upper end face of the reactor frame 5 is attached to the lower end face of the sealing pressing strip 7 after connection. The sealing batten 7 comprises a batten body 701, and a first transverse block 702 and a second transverse block 703 which are positioned on the same surface of the batten body 701. The first transverse block 702 and the second transverse block 703 are arranged in parallel at intervals, and the first transverse block 702 is positioned below the second transverse block 703. A plurality of parallel through holes are arranged in a row at intervals on the first transverse block 702, a plurality of parallel through holes are arranged in a row at intervals on the second transverse block 703, and the plurality of through holes on the first transverse block 702 and the plurality of through holes on the second transverse block 703 are on the same straight line. The number of the through holes on the first transverse block 702, the number of the through holes on the second transverse block 703 and the number of the installation positions on the reactor frame 5 are equal. Preferably, the aperture of the through hole on the first cross block 702 is equal to the aperture of the through hole on the second cross block 703. When the sealing pressing bar 7 is connected with the reactor frame 5, the plurality of through holes on the first cross block 702 are respectively communicated with the plurality of through holes at the upper end of the reactor frame 5. In order to improve the tightness of the communicated channel, a sealing ring can be arranged at the joint of the sealing pressing strip 7 and the reactor frame 5. The pressing strip body 701 is further provided with a blind hole-shaped connecting hole, and the connecting hole and the first cross block 702 are respectively located on two side faces of the pressing strip body 701. When the pull handle 801 is pulled, the thermal block 601, the reactor frame 5 and the sealing bead 7 move together.

The piston assembly includes a plurality of pistons 901 and a plurality of springs. One end of the piston 901 is provided with a stopper, the outer diameter of which is larger than the outer diameter of the piston 901. The outer diameter of the piston 901 is not larger than the aperture of the through hole on the first cross block 702 of the sealing pressing strip 7, and the outer diameter of the limiting head of the piston 901 is larger than the aperture of the through hole on the first cross block 702 and the aperture of the through hole on the second cross block 703. The piston 901 can extend into the through hole in the first cross block 702 and the circumferential surface of the piston 901 can abut against the wall of the through hole, so that the piston 901 can seal one end of the through hole in the first cross block 702. One end of the piston 901, which is far away from the limiting head, extends into the through hole of the first cross block 702, and the other end of the piston is located between the first cross block 702 and the second cross block 703, that is, the limiting head is located between the first cross block 702 and the second cross block 703, and the limiting head cannot extend into the through hole of the first cross block 702 or the through hole of the second cross block 703. The pistons 901 respectively extend into the through holes in the first cross block 702, and the pistons 901, the through holes in the first cross block 702 and the through holes in the second cross block 703 respectively share a center line. The springs are respectively sleeved on the pistons 901, are located between the first cross block 702 and the second cross block 703 and are sleeved outside the pistons 901, and specifically, one end of each spring is connected with the top of the first cross block 702, and the other end of each spring is connected with the limiting head of the piston 901.

The reactor lifting transmission assembly 10 comprises a magnet fixing frame, an electromagnet, a connecting rod and a return spring. The electromagnet is arranged on the magnet fixing frame, and the connecting rod is arranged on the magnet fixing frame through a return spring. After the electromagnet is electrified, acting force can be generated on the connecting rod made of metal materials, the connecting rod is driven to move, the connecting rod is inserted into the connecting hole in the pressing strip body 701 of the sealing pressing strip 7, the driving assembly drives the magnet fixing frame to lift, the sealing pressing strip 7 and the reactor frame 5 are driven to lift through the connecting rod, and the reactor frame 5 can be separated from the hot block 601 after lifting. When the electromagnet is powered off, the connecting rod returns under the elastic force of the return spring, and the connecting rod is withdrawn from the sealing pressing strip 7 and is separated from the contact with the sealing pressing strip 7.

The driving assembly is adapted to engage and drive the piston assembly to move so as to draw or expel fluid into or out of the reaction assembly 4. Meanwhile, the driving assembly can also drive the sealing pressing strip 7 and the reactor frame 5 to lift.

The driving assembly comprises a second motor, a module fixing plate 1102, a second linear guide 1103, a driving plate 1104 and a plurality of driving rods 1105. The module fixing plate 1102 is fixedly installed in the housing 1, the second linear guide 1103 is installed on the module fixing plate 1102, the transmission plate 1104 is connected to the second linear guide 1103, and the second motor transmits drive to the transmission plate 1104 through the second linear guide 1103, so that the transmission plate 1104 ascends or descends.

A plurality of drive links 1105 are spaced in parallel in a row, with one end of the drive links 1105 fixedly attached to the drive plate 1104 and the other end cantilevered downwardly. The number of drive rods 1105 is the same as the number of pistons 901. The outer diameter of the driving rod 1105 is not larger than the aperture of the through hole on the second cross block 703. The transmission rods 1105 are respectively concentric with the through holes on the second cross block 703. When the transmission plate 1104 descends, the transmission rods 1105 are driven to descend and respectively pass through the through holes in the second cross block 703, then respectively contact one ends of the limiting heads of the pistons 901, when the transmission rods 1105 continue to descend, the pistons 901 in contact with the transmission rods can be pressed down, and the springs are compressed. When the transmission rod 1105 ascends, the piston 901 is driven by the spring to ascend due to the action of the spring, and when the transmission rod 1105 enters the through hole on the second cross block 703, the piston 901 is separated from the contact with the transmission rod 1105 because the limit head of the piston 901 cannot enter the through hole on the second cross block 703.

The magnet fixing frame of the reactor lifting transmission assembly 10 is fixedly installed on the bottom surface of the transmission plate 1104, that is, the reactor lifting transmission assembly 10 is driven by the driving assembly to ascend or descend.

The shooting component shoots the reacted reaction component 4 and transmits shooting information to a control system electrically connected with the shooting component.

All the motors, the shooting assembly, the circuit switch where the electromagnet is located and the circuit switch where the heating film of the hot block 601 is located are electrically connected with an external control system.

The utility model discloses a working process does:

firstly, pulling the handle 801, the handle 801 drives the thermal block 601 or the sliding block I802, so that the thermal block 601 moves along the sliding rail I803 through the sliding block I802 and moves out of the shell 1, and meanwhile, the thermal block 601 drives the reactor frame 5 placed on the thermal block I, the sealing pressing strip 7 connected with the reactor frame 5 and the piston assembly on the sealing pressing strip 7 to synchronously extend out.

Then, the sealing pressing bar 7 and the reactor frame 5 connected with the sealing pressing bar are taken out, and the plurality of reaction assemblies 4 are respectively clamped from the side surfaces of the reactor frame 5, so that the reaction assemblies 4 are stably installed on the installation positions of the reactor frame 5, and the needle tubes 401 downwardly overhang and extend out of the bottom of the reactor frame 5.

Finally, the reactor frame 5 with the reaction components 4 installed and the sealing pressing strips 7 are placed in the hot block 601, the reactor frame 5 faces downwards, and the plurality of needle tubes 401 respectively penetrate through the plurality of holes in the lower end of the hot block 601 and extend out of the hot block 601. The retraction handle 801 and the spring wire 804 drive the first sliding block 802, the thermal block 601, the reactor frame 5 and the sealing pressing strip 7 to retract to the initial position, and the initial position is stably maintained under the action of the tension of the spring wire 804 and is blocked by the limiting part.

After the reactor 402 is installed, liquid is put into the liquid containing assembly 2, and the liquid in the liquid containing assembly 2 is sucked into the reactor 402. And starting the second motor, so that the power of the second motor is transmitted to the transmission plate 1104 through the second linear guide rail 1103, at the moment, the circuit connected with the electromagnet is in a disconnected state, and the connecting rod of the reactor lifting transmission assembly 10 is not connected with the sealing pressing strip 7. The driving plate 1104 is driven to descend by the second linear guide 1103, the driving rods 1105 on the driving plate 1104 respectively extend into and pass through the through holes on the second cross block 703, after the driving rods 1105 respectively contact the pistons 901, the pistons 901 are pressed, the pistons 901 respectively descend along the through holes on the first cross block 702, and at the moment, the springs outside the pistons 901 are compressed. As the piston 901 descends, the through holes below the piston 901 on the first cross block 702 and the gas in the cavity of the reactor 402 are exhausted outwards. Then the second motor is started in a reverse direction, so that the power of the second motor is transmitted to the transmission plate 1104 through the second linear guide 1103, the transmission plate 1104 is driven by the second linear guide 1103 to ascend, the piston 901 ascends under the action of the elastic force of the spring until the limit head of the piston 901 contacts the bottom of the second cross block 703, and the piston 901 cannot ascend continuously. During the process of raising the piston 901, the liquid in the liquid containing assembly 2 is sucked into the cavity of the reactor 402 through the needle tube 401, similar to the principle of an injector. The drive plate 1104 continues to rise to the initial position.

In the process, the reactor 402 is heated. The circuit of the heating film outside the heat block 601 is conducted, the heating film is electrified and heated, and heat is transferred to the reactor 402 in the heat block 601 through the heat block 601, so that reaction conditions are provided. During the reaction, the temperature of the thermal block 601 is detected by a temperature sensor. When the detected temperature of the hot block 601 is larger than the set range, the controller controls the circuit where the heating film is located to be disconnected, and the hot block 601 stops heating; when the detected temperature of the thermal block 501 is smaller than the set range, the controller controls the circuit where the heating film is located to be communicated, and the heating film is heated to raise the temperature.

After the reaction is complete, each reactor 402 is photographed and the photographed pictures or videos are saved. First, the circuit of the electromagnet is turned on, and at this time, the connection hole on the sealing bead 7 is aligned with the connection rod of the reactor lift transmission assembly 10 on the transmission plate 1104 in the initial position. After the electromagnet is electrified, acting force is generated between the electromagnet and the connecting rod, the connecting rod is driven to be inserted into the connecting hole in the pressing strip body 701 of the sealing pressing strip 7, and the electromagnet is kept electrified. Then, the second motor is started, the power of the second motor is transmitted to the transmission plate 1104 through the second linear guide 1103, the transmission plate 1104 is driven to ascend by the second linear guide 1103, the connection rod on the transmission plate 1104 is driven to ascend, the connection rod drives the sealing pressing strip 7, the reactor frame 5 and the reaction assembly 4 to ascend synchronously, and the reactor frame 5 leaves the hot block 601 until the reactor 402 is exposed and is located at the same height as the shooting assembly for shooting. Then, the second motor is started reversely, the transmission plate 1104 and the connecting rod are driven to descend, the connecting rod drives the sealing pressing strip 7, the reactor frame 5 and the reaction assembly 4 to descend synchronously, and the reactor frame 5 enters and is supported on the hot block 601 again. And finally, the circuit where the electromagnet is located is disconnected, the acting force of the electromagnet on the connecting rod disappears, the connecting rod returns under the action of the return spring, and the connecting rod is withdrawn from the connecting hole in the sealing pressing strip 7 and is separated from the connection with the sealing pressing strip 7.

After the shooting is finished, the reaction assembly 4 can be dismantled, and a new reaction assembly 4 is installed according to the method.

Finally, it is necessary to explain here: the above embodiments are only used for further detailed description of the technical solutions of the present invention, and the technical solutions of the present invention are not understood to be limited to the protection scope of the present invention, and some non-essential improvements and adjustments made by those skilled in the art according to the above-mentioned contents of the present invention all belong to the protection scope of the present invention.

Claims

1. A reactor supporting and heating device of a hybridization instrument is characterized in that a biochip is arranged in a reactor (402), the hybridization instrument comprises a shell (1), the supporting and heating device is installed in the shell (1), the supporting and heating device comprises a reactor frame (5) and a heating assembly for heating the reactor (402), the reactor (402) is detachably installed on the reactor frame (5), the heating assembly comprises a heat block (601), the heat block (601) is provided with an internal containing cavity, the upper end of the heat block (601) is opened, the reactor frame (5) can enter or leave the interior of the heat block (601) from the upper end of the heat block (601), the heat block (601) is slidably arranged, and the heat block (601) slides to extend out of the shell (1) or retract into the shell (1).

2. The apparatus of claim 1, wherein: the heating assembly further comprises an electric wire and a heating film, the heating film is coated outside the heat block (601), and the heating film is connected with an external power supply through the electric wire.

3. The apparatus of claim 2, wherein: the device also comprises a reactor supporting component (8), wherein the reactor supporting component (8) comprises two first sliding blocks (802) and two first sliding rails (803), the first sliding rails (803) are fixedly installed in the shell (1), the two first sliding rails (803) are parallelly arranged on two sides of the hot block (601) at intervals, the first sliding rails (803) and the hot block (601) are perpendicular to each other, the first sliding blocks (802) are slidably arranged on the first sliding rails (803), and two ends of the hot block (601) are respectively connected and supported on the first sliding blocks (802).

4. The apparatus of claim 3, wherein: the reactor supporting assembly (8) further comprises a handle (801), and two ends of the handle (801) are respectively connected and supported on the two first sliding blocks (802) or two ends of the thermal block (601).

5. The apparatus of claim 4, wherein: the reactor supporting assembly (8) further comprises two spring wires (804), the two spring wires (804) are arranged in parallel at intervals, one end of each spring wire (804) is connected into the shell (1), and the other end of each spring wire is connected with one end of one sliding block I (802) or one end of the thermal block (601).

6. The apparatus of claim 5, wherein: the wires are located within spring wires (804).

7. The apparatus of claim 5, wherein: one end of the shell (1) far away from the handle (801) is provided with a limiting part for limiting the limit position of the first sliding block (802), when the first sliding block (802) contacts the limiting part, the first sliding block (802) cannot move continuously, and at the moment, the spring wire (804) is in a stretching state.

8. The apparatus of claim 1, wherein: a row of mounting positions are arranged on the reactor frame (5) at intervals, and each mounting position is detachably provided with a reactor (402).

9. The apparatus of claim 8, wherein: the lower end of the reactor (402) is connected with a needle tube (401), the needle tube (401) is communicated with the inner cavity of the reactor (402), and the upper end of the reactor (402) is provided with a through hole communicated with the inner cavity.

10. The apparatus of claim 9, wherein: the lower end of the hot block (601) is provided with a plurality of holes communicated with the inner containing cavity at intervals, and when the reactor frame (5) is placed in the hot block (601), the needle tube (401) at the lower end of the reactor (402) on the reactor frame (5) passes through the hole at the lower end of the hot block (601) and then extends out of the hot block (601).