CN217479466U - Multifunctional driving device for biochip all-in-one machine - Google Patents

Multifunctional driving device for biochip all-in-one machine Download PDF

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CN217479466U
CN217479466U CN202221686094.9U CN202221686094U CN217479466U CN 217479466 U CN217479466 U CN 217479466U CN 202221686094 U CN202221686094 U CN 202221686094U CN 217479466 U CN217479466 U CN 217479466U
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reactor
hole
transmission
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driving
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孙悦
陈立波
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Fist Shanghai Biotechnology Co ltd
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Fist Shanghai Biotechnology Co ltd
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The utility model provides a multi-functional drive arrangement for biochip all-in-one, the biochip all-in-one is including hybridization portion and recognition portion, and hybridization portion is equipped with at least one reactor, is equipped with the biochip in the reactor, drive arrangement includes drive assembly, first driving medium and second driving medium, and drive assembly alternative transmission drive to first driving medium and second driving medium, and first driving medium and second driving medium all link up with the reactor, and the pressure is exerted to reactor inside when first driving medium is driven to remove, makes the liquid discharge in the outside liquid quilt suction reactor or messenger's reactor, drives the reactor when the second driving medium is driven to remove and shifts between hybridization reaction district and recognition district, and recognition portion reads the result of reactor. The utility model discloses can realize for reactor imbibition and flowing back, the reactor after the drive reaction is accomplished simultaneously removes and acquires the subassembly for the picture and shoot, provides reliable structure for biochip hybridization and the integration of result recognition.

Description

Multifunctional driving device for biochip all-in-one machine
Technical Field
The utility model belongs to the technical field of biochip, specifically be a multi-functional drive arrangement for biochip all-in-one.
Background
A biochip hybridization instrument is an analytical instrument which is generally used in the biological field, and a nucleic acid molecular hybridization technology is adopted to detect whether a genome to be detected contains a known gene sequence. When the hybridization instrument is used, liquid (hybridization liquid, binding liquid, sample liquid and the like) needs to be put into the hybridization instrument for reaction, and the reaction result can be judged according to the color and the state after the reaction. In the prior art, in order to improve the detection efficiency of the hybridization instrument, a plurality of driving components are arranged, and each component in the hybridization instrument can be driven to act so as to move the chip to a station at a corresponding stage. However, the larger number of driving components makes the hybridization apparatus complicated and bulky.
SUMMERY OF THE UTILITY MODEL
The above-mentioned problem to prior art exists, the utility model aims at providing a multi-functional drive arrangement for biochip all-in-one, drive arrangement can realize for reactor imbibition and flowing back, and the reactor after the drive reaction is accomplished simultaneously removes and acquires the subassembly with the confession picture and shoot, and same drive arrangement has assembled multiple functions, need not to be equipped with many sets of driving motor and satisfies different functions, has simplified the structure of biochip all-in-one, has reduced the volume and the cost of biochip all-in-one, provides reliable structure for the integrated structure of biochip hybridization and result recognition.
In order to realize the purpose, the utility model discloses the technical scheme who adopts is:
the utility model provides a multi-functional drive arrangement for biochip all-in-one, the biochip all-in-one includes hybridization portion and recognition portion, and hybridization portion is equipped with at least one reactor, is equipped with the biochip in the reactor, drive arrangement includes drive assembly, first driving medium and second driving medium, and drive assembly alternative transmission drives to first driving medium and second driving medium, and first driving medium and second driving medium all link up with the reactor, and the first driving medium is exerted pressure to reactor inside when being driven to remove, makes in the external liquid quilt suction reactor or make the liquid in the reactor discharge, drives the reactor when the second driving medium is driven to remove and shifts between hybridization reaction district and recognition district, and recognition portion reads the result of the reactor that gets into the recognition district.
As a further improvement of the above technical solution:
the first transmission piece comprises at least one piston, each reactor corresponds to one piston, two through holes communicated with the inner containing cavity are formed in the reactor, the pistons move in one through hole or an extension hole of the through hole, and external liquid is sucked into the reactor through the other through hole in the reactor or liquid in the reactor is discharged through the other through hole.
The second transmission part comprises a sealing pressing strip, the reactor is connected with the sealing pressing strip, and the driving assembly can be connected with the sealing pressing strip or cut off the connection with the sealing pressing strip.
The sealing pressing strip comprises a pressing strip body and a first transverse block located on the pressing strip body, at least one through hole is formed in the first transverse block, when the reactor is connected with the sealing pressing strip, the through hole in the first transverse block is communicated with the inside of the reactor, and one end of a piston is located in the through hole in the first transverse block.
Still be equipped with the horizontal block two on the layering body, horizontal block one and the parallel interval arrangement of horizontal block two, horizontal block one is located the below of horizontal block two, is equipped with at least one through-hole on the horizontal block two, through-hole on the horizontal block one and the through-hole on the horizontal block two are the central line altogether, and first driving piece still includes at least one spring, and the spring is located between horizontal block one and the horizontal block two, cup joints outside the piston, and the top of horizontal block one is connected to the one end of spring, the one end that is located between horizontal block one and the horizontal block two of piston is connected to the other end.
The driving assembly comprises a second motor, a total driving assembly, a driving plate and a reactor lifting driving assembly, the reactor lifting driving assembly is installed on the driving plate, the second motor transmits driving to the driving plate through the total driving assembly, the driving plate drives the reactor lifting driving assembly to ascend or descend, and the reactor lifting driving assembly can be connected with or disconnected from the sealing pressing strip.
Reactor lift drive assembly includes magnet mount, electro-magnet, connecting rod and return spring, and the magnet mount is installed on the driving plate, and the electro-magnet is installed on the magnet mount, and return spring's one end is connected the magnet mount is connected to connecting rod, the other end, can produce the effort to the connecting rod of metal material after the electro-magnet circular telegram, and the drive connecting rod removes, makes the connecting rod insert in the connecting hole of seting up on the layering body of sealing strip, and return spring is stretched simultaneously, after the electro-magnet outage, the connecting rod returns under return spring's spring action, breaks away from the contact with the sealing strip.
The driving assembly further comprises at least one driving rod, one end of the driving rod is fixedly connected with the driving plate, the other end of the driving rod is suspended downwards, and the driving rod can contact and press the piston downwards when descending.
The front and rear panels of the reactor are transparent, through which the interior volume of the reactor can be observed and photographed.
The reactor is provided with a needle tube which is communicated with the inner cavity of the reactor and is used for sucking or discharging liquid.
The beneficial effects of the utility model are that: drive arrangement can realize for reactor imbibition and flowing back, and the reactor after the drive reaction is accomplished simultaneously removes and acquires the subassembly with the confession picture and shoot, and same drive arrangement has assembled multiple functions, need not to be equipped with many sets of driving motor and satisfies different functions, has simplified the structure of biochip all-in-one, has reduced the volume and the cost of biochip all-in-one, provides reliable structure for the integration of biochip hybridization and result recognition.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Fig. 2 is a schematic diagram of a reactor and syringe configuration according to an embodiment of the present invention.
Fig. 3 is a schematic structural view of the sealing bead according to an embodiment of the present invention.
Fig. 4 is a schematic view of a drive plate, reactor lift drive assembly, and a plurality of drive rods according to an embodiment of the present invention.
Detailed Description
The following describes in detail embodiments of the present invention with reference to the accompanying drawings. It should be understood that the description herein is provided for illustration and explanation of the invention and is not intended to limit the invention.
Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
The utility model provides a multi-functional drive arrangement for biochip all-in-one, as shown in fig. 1 ~ 4, the biochip all-in-one includes hybridization portion and recognition portion, and the biochip setting is in reactor 1, and reactor 1 detachably installs in the all-in-one, and reactor 1 hybridizes with liquid in the hybridization reaction zone of hybridization portion, and the recognition portion is used for reading the biochip's that gets into in the reactor 1 in the recognition zone result. The driving device is arranged in the integrated machine and transmits pressure to the reactor 1, so that external liquid is sucked into the reactor 1 or liquid in the reactor 1 is discharged; the driving means also drives the reaction vessel 1 so that the reaction vessel 1 is transferred between the hybridization reaction zone and the reading zone.
The hybridization part is provided with a liquid containing component 2, a liquid transferring component 3, a reactor frame 4 and a thermal block 5.
Liquid containing assembly 2 is used for containing liquid, and liquid containing assembly 2 is provided with a plurality of grooves. The recess is used for placing the test tube that is equipped with liquid, can place at least one test tube on the recess, can place multiple liquid on every recess promptly.
The liquid transferring component 3 is connected with and drives the liquid containing component 2 to move. Further, the liquid containing assembly 2 is driven to reciprocate linearly. Specifically, the pipetting assembly 3 comprises a first motor and a first linear guide rail. The liquid containing assembly 2 is installed on the linear guide rail I, the motor I transmits and drives the liquid containing assembly 2 through the linear guide rail I, so that the liquid containing assembly 2 linearly reciprocates, and the linear moving direction of the liquid containing assembly 2 is parallel to the arrangement direction of various liquids on the groove.
The reactor 1 is provided with an internal cavity, and the biochip is arranged in the internal cavity. The reactor 1 is connected with a needle tube 1 ', preferably, the reactor 1 is fixedly connected with the needle tube 1', one end of the needle tube 1 'is connected with the reactor 1, the other end of the needle tube is suspended, and an internal channel of the needle tube 1' is communicated with an internal cavity of the reactor 1. The front and rear panels of the reactor 1 are transparent and are arranged opposite to each other. The inner cavity of the reactor 1 can be observed or shot through the front panel or the rear panel, and during shooting, the light can be emitted from the rear panel, and the shooting can be carried out from the front panel. The upper end of the reactor 1 'is provided with a through hole which is communicated with the inner cavity of the reactor 1'.
The reactor frame 4 is used for installing and supporting the reactor 1, a plurality of installation positions for installing the reactor 1 are arranged on the reactor frame 4, hollow parts are arranged on the installation positions, and the installation positions are arranged in a row at intervals. The upper end of the reactor frame 4 is also provided with a plurality of through holes which are respectively communicated with the plurality of installation positions. The reactors 1 are detachably mounted in mounting locations, one reactor 1 being mountable in each mounting location. The reactor frame 4 is positioned above the liquid containing assembly 2. After the reactor 1 is arranged on the reactor frame 4, the reactor 1 is clamped into the installation position, the inner cavity of the reactor 1, the through hole at the upper end of the reactor 1 and the through hole at the upper end of the reactor frame 4 are communicated in sequence, and a sealing ring can be arranged at the joint of the upper end of the reactor 1 and the reactor frame 4 in order to improve the tightness of the communicated channel. The transparent front panel and the transparent rear panel of the reactor 1 are right opposite to the hollow part of the reactor frame 4, so that the front panel and the rear panel of the reactor 1 are not shielded by the reactor frame 4, and a subsequent shooting and reading part can read the state of the accommodating cavity in the reactor 1. In particular, the reactor 1 is snapped into the installation site from the side of the reactor frame 4. The overhanging opening end of the needle tube 1 ' is downward, the needle tube 1 ' extends out of the bottom of the reactor frame 4, and the lower ends of the needle tubes 1 ' of a plurality of reactors 1 on a plurality of installation positions are respectively connected with the liquid containing assembly 2.
The thermal block 5 is used to heat the reactor 1 to react the liquid in the reactor 1. The hot block 5 is provided with an internal cavity, the upper end of the hot block 5 is provided with an opening, the lower end of the hot block 5 is provided with a plurality of holes communicated with the internal cavity at intervals, the reactor frame 4 can be put into or taken away from the interior of the hot block 5 from the upper end of the hot block 5, and when the reactor frame 4 is placed in the hot block 5, the needle tubes 1' of the plurality of reactors 1 on the reactor frame 4 respectively penetrate through the plurality of holes at the lower end of the hot block 5 and then extend out of the hot block 5. I.e. the reactor frame 4 is placed directly in the thermoblock 5 without connecting the two by means of connecting members. The outside of the hot block 5 is coated with a heating film, the heating film is connected with an external power supply through an electric wire to realize heating of the heating film, and heat is transferred to liquid in the reactor 1 through the hot block 5. Preferably, the top of the reactor frame 4 is higher than the top of the thermoblock 5 when the reactor frame 4 is placed on the thermoblock 5.
The driving device comprises a driving assembly, a first transmission piece and a second transmission piece.
The second transmission part is a sealing pressing strip 6, the sealing pressing strip 6 is detachably connected to the upper end of the reactor frame 4, and the upper end face of the reactor frame 4 is attached to the lower end face of the sealing pressing strip 6 after connection. The sealing batten 6 comprises a batten body 61, and a first transverse block 62 and a second transverse block 63 which are positioned on the same surface of the batten body 61. The first transverse block 62 and the second transverse block 63 are arranged in parallel at intervals, and the first transverse block 62 is positioned below the second transverse block 63. Be equipped with a row of through-hole of a plurality of parallel interval arrangements on the horizontal piece 62, be equipped with a row of through-hole of a plurality of parallel interval arrangements on the horizontal piece two 63, a plurality of through-holes on the horizontal piece one 62 respectively with a plurality of through-holes on the horizontal piece two 63 on same straight line. The number of the through holes on the first transverse block 62, the number of the through holes on the second transverse block 63 and the number of the installation positions on the reactor frame 4 are equal. Preferably, the aperture of the through hole on the first cross block 62 is equal to the aperture of the through hole on the second cross block 63. When the sealing pressing strip 6 is connected with the reactor frame 4, the first transverse block 62 is attached to the reactor frame 4, and the plurality of through holes in the first transverse block 62 are respectively communicated with the plurality of through holes in the upper end of the reactor frame 4. In order to improve the sealing performance of the communicated channel, a sealing ring can be arranged at the joint of the sealing pressing strip 6 and the reactor frame 4. The pressing strip body 61 is further provided with blind hole-shaped connecting holes, and the connecting holes and the first cross blocks 62 are respectively located on two side faces of the pressing strip body 61.
The first transmission member comprises at least one piston 71 and at least one spring. One end of the piston 71 is provided with a stopper, the outside diameter of which is larger than that of the piston 71. The outer diameter of the piston 71 is not larger than the aperture of the through hole on the first cross block 62 of the sealing pressing strip 6, and the outer diameter of the limiting head of the piston 71 is larger than the aperture of the through hole on the first cross block 62 and the aperture of the through hole on the second cross block 63. The piston 71 can extend into the through hole in the first cross block 62, and the circumferential surface of the piston 71 is attached to the wall of the through hole, so that the piston 71 can seal one end of the through hole in the first cross block 62. One end of the piston 71, which is far away from the limiting head, extends into the through hole in the first cross block 62, and the other end of the piston is located between the first cross block 62 and the second cross block 63, namely, the limiting head is located between the first cross block 62 and the second cross block 63, and the limiting head cannot extend into the through hole in the first cross block 62 or the through hole in the second cross block 63. The pistons 71 respectively extend into the through holes in the first cross block 62, and the pistons 71, the through holes in the first cross block 62 and the through holes in the second cross block 63 respectively share a center line. The spring is located between the first cross block 62 and the second cross block 63 and sleeved outside the piston 71, and specifically, one end of the spring is connected with the top of the first cross block 62, and the other end of the spring is connected with the limiting head of the piston 71.
The driving assembly comprises a second motor 81, a module fixing plate 82, a total transmission assembly, a transmission plate 84, a reactor lifting transmission assembly 86 and a plurality of transmission rods 85.
The general transmission assembly is arranged on the module fixing plate 82, the transmission plate 84 is connected with the general transmission assembly, and the second motor 81 transmits and drives the transmission plate 84 through the general transmission assembly, so that the transmission plate 84 ascends or descends.
In this embodiment, the total transmission assembly includes a second slider, a second slide rail, and a second linear guide 83. The second linear guide rail 83 comprises a guide rail seat, a screw rod and a nut connecting block, the screw rod is rotatably installed on the guide rail seat, the screw rod is perpendicular to the horizontal plane and is arranged, the nut connecting block is in threaded connection with the screw rod, and when the screw rod rotates, the screw rod drives the nut connecting block to move on the guide rail seat along the length direction of the screw rod. The slide rail is equipped with two, and slide rail and lead screw parallel arrangement, slide rail arrange on module fixed plate 82, and two slide rails are arranged respectively in the both sides of lead screw. The slide blocks are two and are respectively arranged on the two slide rails in a sliding manner. One end of the transmission plate 84 is connected with the nut connecting block and the two sliding blocks at the same time, the nut connecting block drives the transmission plate 84 to move synchronously, and the two sliding blocks are used for guiding the movement of the transmission plate 84, so that the movement of the transmission plate 84 is more stable and stable.
A plurality of transmission rods 85 are arranged in a row in parallel at intervals, one end of each transmission rod 85 is fixedly connected to the transmission plate 84, and the other end of each transmission rod 85 is suspended downwards. The number of the transmission rods 85 is the same as the number of the pistons 71. The outer diameter of the transmission rod 85 is not larger than the aperture of the through hole on the second transverse block 63. The transmission rods 85 are respectively concentric with the through holes on the second transverse block 63. When the transmission plate 84 descends, the transmission rods 85 are driven to descend and respectively pass through the through holes in the second cross block 63, then the transmission rods respectively contact one ends of the limiting heads of the pistons 71, when the transmission rods 85 continuously descend, the pistons 71 in contact with the transmission rods can be pressed downwards, and the springs are compressed. When the transmission rod 85 ascends, the piston 71 is driven to ascend by the spring due to the action of the spring, and when the transmission rod 85 ascends and enters the through hole in the second cross block 63, the piston 71 is separated from the contact with the transmission rod 85 and stops ascending because the limiting head of the piston 71 cannot enter the through hole in the second cross block 63.
The reactor lifting transmission assembly 86 includes a magnet holder, an electromagnet, a connecting rod, and a return spring. The magnet holder is fixedly mounted on the bottom surface of the driving plate 84. The electromagnet is arranged on the magnet fixing frame, and the connecting rod is arranged on the magnet fixing frame through a return spring. The electromagnet is connected in a circuit, and the electromagnet can produce acting force to the connecting rod made of metal materials after being electrified, so that the connecting rod is driven to move, and the connecting rod is inserted into the connecting hole in the pressing strip body 61 of the sealing pressing strip 6. When the electromagnet is powered off, the connecting rod returns under the elastic force of the return spring, and the connecting rod is withdrawn from the sealing pressing strip 6 and is separated from the contact with the sealing pressing strip 6.
The recognition part is provided with a picture acquisition component, and the picture acquisition component shoots the reactor 1 after reaction and transmits shooting information to a control system electrically connected with the reactor.
The utility model discloses a working process does:
when it is desired to draw the liquid in the liquid containing assembly 2 into the reactor 1: first, the second motor 81 is started, so that the power of the second motor 81 is transmitted to the transmission plate 84 through the second linear guide rail 83, at this time, the circuit connected with the electromagnet is in a disconnected state, and the connecting rod of the reactor lifting transmission assembly 86 is not connected with the sealing pressing strip 6. The transmission plate 84 is driven to descend by the second linear guide rail 83, the transmission rods 85 on the transmission plate 84 respectively extend into and penetrate through the through holes on the second cross block 63, when the transmission rods 85 respectively contact the pistons 71 and then descend continuously, the pistons 71 are pressed, the pistons 71 respectively descend along the through holes on the first cross block 62, and at the moment, springs outside the pistons 71 are compressed. As the piston 71 descends, the through holes below the piston 71 on the first cross block 62 and the gas in the cavity of the reactor 1 are discharged outwards. Then, the second motor 81 is started reversely, so that the power of the second motor 81 is transmitted to the transmission plate 84 through the second linear guide rail 83, the transmission plate 84 is driven by the second linear guide rail 83 to ascend, the piston 71 is not pressed any more, the piston 71 ascends under the elastic force of the spring until the limit head of the piston 71 contacts the bottom of the second cross block 63, and cannot ascend any more, and the spring is still in a compressed state at the moment, so that the current state of the piston 71 is stably maintained. During the ascending of the piston 71, the liquid in the liquid containing assembly 2 is sucked into the cavity of the reactor 1 through the needle tube 1', similar to the principle of an injector. The drive plate 84 continues to rise to the initial position.
When liquid in the reactor 1 needs to be discharged into the liquid containing assembly 2, the circuit connected with the electromagnet is in an off state at the moment, the second motor 81 is started to drive the transmission plate 84 to descend, the transmission rods 85 on the transmission plate 84 extend into and penetrate through the through holes on the second cross block 63 respectively to contact and press the pistons 71, and the pistons 71 descend along the through holes on the first cross block 62 respectively to discharge waste liquid in the reactor 1. The second motor 81 is started in reverse to raise the driving plate 84 to the initial position.
When the reaction of the liquid in the reactor 1 is completed, the state in the cavity of the reactor needs to be photographed: first, the circuit of the electromagnet is turned on, and at this time, the connection hole of the sealing bead 6 is aligned with the connection rod of the reactor lift transmission assembly 86 on the transmission plate 84 in the initial position. After the electromagnet is electrified, acting force is generated between the electromagnet and the connecting rod, the connecting rod is driven to be inserted into the connecting hole in the pressing strip body 61 of the sealing pressing strip 6, and the electromagnet is kept electrified. Then, the second motor 81 is started, the power of the second motor 81 is transmitted to the transmission plate 84 through the second linear guide rail 83, the transmission plate 84 is driven to ascend by the second linear guide rail 83 to drive the connecting rod on the transmission plate 84 to ascend, the connecting rod drives the sealing pressing strip 6, the reactor frame 4 and the reactor 1 to ascend synchronously, the reactor frame 4 leaves the hot block 5 until the reactor 1 is exposed and is located at the same height as the picture acquisition assembly, and at the moment, the transparent side face of the reactor 1 faces the picture acquisition assembly. Next, the picture taking assembly takes a picture of the reactor 1. After shooting is finished, the motor II 81 is started reversely, the transmission plate 84 and the connecting rod are driven to descend, the connecting rod drives the sealing pressing strip 6, the reactor frame 4 and the reactor 1 to descend synchronously, and the reactor frame 4 enters and is supported on the hot block 5 again. And finally, the circuit where the electromagnet is located is disconnected, the acting force of the electromagnet on the connecting rod disappears, the connecting rod returns under the action of the return spring, and the connecting rod is withdrawn from the connecting hole in the sealing pressing strip 6 and is separated from the sealing pressing strip 6.
Finally, it must be said here that: the above embodiments are only used for further detailed description of the technical solutions of the present invention, and the technical solutions of the present invention are not understood to be limited to the protection scope of the present invention, and some non-essential improvements and adjustments made by those skilled in the art according to the above-mentioned contents of the present invention all belong to the protection scope of the present invention.

Claims (10)

1. A multifunctional driving device for a biochip integrated machine is characterized in that the biochip integrated machine comprises a hybridization part and a reading part, the hybridization part is provided with at least one reactor (1), a biochip is arranged in the reactor (1), the driving device comprises a driving assembly, a first transmission piece and a second transmission piece, the driving assembly selects to transmit and drive to the first transmission piece and the second transmission piece, the first transmission piece and the second transmission piece are both connected with the reactor (1), the first transmission piece applies pressure to the inside of the reactor (1) when being driven to move, so that external liquid is sucked into the reactor (1) or liquid in the reactor (1) is discharged, the second transmission piece drives the reactor (1) to transfer between the hybridization reaction area and the reading area when being driven to move, and the reading part reads the result of the reactor (1) entering the reading area.
2. The drive device according to claim 1, characterized in that: the first transmission piece comprises at least one piston (71), each reactor (1) corresponds to one piston (71), two through holes communicated with the inner containing cavity are formed in the reactors (1), and the pistons (71) move in one through hole or an extension hole of the through hole, so that external liquid is sucked into the reactors (1) through the other through hole in the reactors (1) or liquid in the reactors (1) is discharged through the other through hole.
3. The drive device according to claim 2, characterized in that: the second transmission part comprises a sealing pressing strip (6), the reactor (1) is connected with the sealing pressing strip (6), and the driving assembly can be connected with the sealing pressing strip (6) or cut off the connection with the sealing pressing strip (6).
4. The drive device according to claim 3, characterized in that: sealing pressing strip (6) include layering body (61) and be located transverse block (62) on layering body (61), are equipped with at least one through-hole on transverse block (62), and when sealing pressing strip (6) were connected in reactor (1), the through-hole on transverse block (62) and the inside intercommunication of reactor (1), and piston (71) one end is located the through-hole on transverse block (62).
5. The drive device according to claim 4, characterized in that: still be equipped with horizontal piece two (63) on layering body (61), horizontal piece one (62) and horizontal piece two (63) parallel interval arrangement, horizontal piece one (62) are located the below of horizontal piece two (63), be equipped with at least one through-hole on horizontal piece two (63), through-hole on horizontal piece one (62) and the through-hole on horizontal piece two (63) common center line, first driving piece still includes at least one spring, the spring is located between horizontal piece one (62) and horizontal piece two (63), cup joint outside piston (71), the top of horizontal piece one (62) is connected to the one end of spring, the one end that is located between horizontal piece one (62) and horizontal piece two (63) of piston (71) is connected to the other end.
6. The drive device according to any one of claims 3 to 5, wherein: the driving assembly comprises a second motor (81), a total driving assembly, a driving plate (84) and a reactor lifting driving assembly (86), the reactor lifting driving assembly (86) is installed on the driving plate (84), the second motor (81) transmits and drives the driving plate (84) through the total driving assembly, the driving plate (84) drives the reactor lifting driving assembly (86) to ascend or descend, and the reactor lifting driving assembly (86) can be connected with the sealing pressing strip (6) or cut off the connection with the sealing pressing strip (6).
7. The drive device according to claim 6, characterized in that: reactor lift drive assembly (86) include magnet mount, electro-magnet, connecting rod and return spring, and the magnet mount is installed on driving plate (84), and the electro-magnet is installed on the magnet mount, and return spring's one end is connected the magnet mount is connected to connecting rod, the other end, can produce the effort to the connecting rod of metal material after the electro-magnet circular telegram, and the drive connecting rod removes, makes the connecting rod insert in the connecting hole of seting up on layering body (61) of sealing strip (6), and return spring is stretched simultaneously, after the electro-magnet outage, the connecting rod returns under return spring's the spring action, breaks away from the contact with sealing strip (6).
8. The drive device according to claim 6, characterized in that: the driving assembly further comprises at least one transmission rod (85), one end of the transmission rod (85) is fixedly connected with the transmission plate (84), the other end of the transmission rod (85) is suspended downwards, and the transmission rod (85) can contact and press down the piston (71) when descending.
9. The drive device according to claim 1, characterized in that: the front panel and the rear panel of the reactor (1) are transparent, and the inner cavity of the reactor (1) can be observed and photographed through the front panel and the rear panel.
10. The drive device according to claim 1, characterized in that: the reactor (1) is provided with a needle tube (1 '), the needle tube (1 ') is communicated with the inner cavity of the reactor (1), and liquid is sucked or discharged through the needle tube (1 ').
CN202221686094.9U 2022-05-24 2022-07-01 Multifunctional driving device for biochip all-in-one machine Active CN217479466U (en)

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CN202210571062 2022-05-24
CN2022105710622 2022-05-24

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CN202221685861.4U Active CN217479473U (en) 2022-05-24 2022-07-01 Biochip all-in-one with picture acquisition mechanism
CN202221701458.6U Active CN217614815U (en) 2022-05-24 2022-07-01 Imbibition drain of hybridization apparatus
CN202221685960.2U Active CN217479439U (en) 2022-05-24 2022-07-01 Reactor supporting and heating device of hybridization instrument
CN202210774571.5A Pending CN116410843A (en) 2022-05-24 2022-07-01 Biochip all-in-one
CN202221686094.9U Active CN217479466U (en) 2022-05-24 2022-07-01 Multifunctional driving device for biochip all-in-one machine
CN202221686107.2U Active CN217628334U (en) 2022-05-24 2022-07-01 Biological chip all-in-one machine

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CN202221685861.4U Active CN217479473U (en) 2022-05-24 2022-07-01 Biochip all-in-one with picture acquisition mechanism
CN202221701458.6U Active CN217614815U (en) 2022-05-24 2022-07-01 Imbibition drain of hybridization apparatus
CN202221685960.2U Active CN217479439U (en) 2022-05-24 2022-07-01 Reactor supporting and heating device of hybridization instrument
CN202210774571.5A Pending CN116410843A (en) 2022-05-24 2022-07-01 Biochip all-in-one

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CN116410843A (en) 2023-07-11
CN217614815U (en) 2022-10-21
CN217479473U (en) 2022-09-23
CN217628334U (en) 2022-10-21
CN217479439U (en) 2022-09-23

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