CN216725529U - Device and system for applying an electric field to a subject's body - Google Patents
Device and system for applying an electric field to a subject's body Download PDFInfo
- Publication number
- CN216725529U CN216725529U CN202123308068.0U CN202123308068U CN216725529U CN 216725529 U CN216725529 U CN 216725529U CN 202123308068 U CN202123308068 U CN 202123308068U CN 216725529 U CN216725529 U CN 216725529U
- Authority
- CN
- China
- Prior art keywords
- electric field
- electrode patch
- subject
- applying
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Electrotherapy Devices (AREA)
Abstract
An apparatus and system for applying an electric field to a subject's body is provided. The device includes: a plurality of electrode patch assemblies, each electrode patch assembly comprising: a plurality of electrode patch units configured to be in contact with a plurality of respective body parts of a subject to apply an electric field to the plurality of respective body parts and to sense temperatures at the plurality of respective body parts; and a switching circuit electrically connected to the plurality of electrode patch units; and an adapter configured to transmit the plurality of alternating electric field signals generated by the electric field generator to the switching circuit in a respective electrode patch assembly of the plurality of electrode patch assemblies, the switching circuit in each electrode patch assembly configured to individually control electrical connection to the plurality of electrode patch cells to selectively transmit a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch cells.
Description
Technical Field
The present disclosure relates to Tumor electric field therapy (TTF) technology, and more particularly to devices and systems for applying an electric field to a subject's body.
Background
Tumor electric field therapy (TTF) is a method of preventing the formation of spindle microtubules and inhibiting the separation of intracellular organelles in the mitotic phase of some Tumor cells and inducing apoptosis in the mitotic phase by a low-intensity intermediate frequency (e.g., 100 to 300kHz) alternating electric field, thereby achieving the effect of Treating tumors.
Compared with traditional cancer treatment methods, TTF has an innovative mechanism of action. Some of the physiological properties of tumor cells, such as geometry and high frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting a directional force on intracellular polar particles (e.g., macromolecules and organelles). These processes may lead to physical disruption of the cell membrane and apoptosis. At the terminal stage of mitosis of the cell, the structural form of the cleavage furrow can cause uneven distribution of the electric field around the cell, and meanwhile, under the influence of TTF, the electric field intensity at the cleavage furrow is obviously enhanced, and the charged substances in the cell move to the cleavage furrow, so that the formation of the cell structure is interfered and even destroyed, and finally, the cell can fail to divide and go to apoptosis.
In the related art, TTF is delivered to a subject via a pair of electrode patches placed on the skin of the subject in close proximity to the tumor. The electrode patch comprises a plurality of electrode units arranged in an array form, and the electrode units are connected in series. Due to the application of the alternating electric field, the heat applied to the skin surface of the subject rises. When the skin surface temperature of the detected person exceeds the human body threshold temperature, low-temperature skin scald is easily caused. In order to grasp the temperature of the skin surface in real time, a plurality of temperature sensors are arranged on the electrode patch to detect the skin temperature of corresponding positions. In order to avoid low-temperature scald, when the temperature measured by the temperature sensor exceeds the human body threshold temperature, the whole electrode patch corresponding to the temperature sensor and the other electrode patch paired with the electrode patch are closed to block heat generation, and the heat on the surface of the skin is radiated and cooled through the external air. While the subject's skin surface temperature is thus controlled, the subject's treatment time can thus be reduced, reducing subject compliance.
Therefore, there is a need for devices and systems for applying an electric field to a subject's body that can timely disconnect elements of the transducer that are too hot without affecting the proper operation of other elements of the transducer.
SUMMERY OF THE UTILITY MODEL
It would be advantageous to provide a mechanism that alleviates, mitigates or even eliminates one or more of the above-mentioned problems.
According to an aspect of the present disclosure, there is provided a device for applying an electric field to a subject's body, usable with an electric field generator, comprising: a plurality of electrode patch assemblies, each electrode patch assembly comprising: a plurality of electrode patch units, each electrode patch unit being respectively configured to contact a corresponding body part of a subject to apply an electric field to the corresponding body part in contact and sense a temperature of the electrode patch unit; the switch circuit is electrically connected with the electrode patch units respectively; and an adaptor configured to transmit the plurality of alternating electric field signals generated by the electric field generator to a switching circuit in the plurality of electrode patch assemblies, the switching circuit in each electrode patch assembly configured to individually control electrical connection to the plurality of electrode patch units to selectively transmit a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch units.
Optionally, the patch assembly further comprises a plurality of first cables for electrically connecting the plurality of electrode patch assemblies to the adaptor, respectively.
Optionally, the plurality of first cables are configured to provide respective electric field signal paths to transmit the plurality of alternating electric field signals to the switching circuits in the plurality of electrode patch assemblies, respectively.
Optionally, the switching circuit in each electrode patch assembly comprises a multi-way switch electrically connected between a respective one of the first plurality of wires and the plurality of electrode patch units in that electrode patch assembly to individually control transmission of a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch units under control of the electric field generator.
Optionally, the plurality of first cables are further configured to provide respective temperature signal paths to transmit temperature signals from the electrode patch units of the plurality of electrode patch assemblies to the adaptor.
Optionally, each of the plurality of electrode patch units comprises: an electrode patch unit main body for attaching to a corresponding body part to apply an electric field to the corresponding body part; the temperature sensor is arranged on the electrode patch unit main body and used for sensing the temperature of the electrode patch unit main body at the corresponding body part; and a second cable electrically connecting the electrode patch unit body to the switching circuit in the electrode patch assembly, the switching circuit in each electrode patch assembly being configured such that a temperature signal from the temperature sensor in each electrode patch unit is transmitted to the adaptor, and a corresponding one of the plurality of alternating electric field signals is selectively transmitted to the plurality of electrode patch units in the electrode patch assembly.
Optionally, the electrode patch unit body includes: a backing; an electrical functional component attached to the backing and electrically connected to the second cable to receive a corresponding one of the plurality of alternating electric field signals; a support attached to the backing and surrounding the electrical functional component; and the pasting piece is attached to one side of the electric functional component and the support piece far away from the back lining and is used for being in contact with the corresponding body part so as to apply an electric field generated by one corresponding alternating electric field signal in the plurality of alternating electric field signals to the corresponding body part.
Optionally, the adhesive element comprises an electrically conductive hydrogel.
Optionally, the electrode patch unit body further comprises a heat shrink sleeve disposed at a connection of the electrical functional component and the second cable.
Optionally, each of the plurality of electrode patch units further comprises a second connector for mechanically and electrically connecting a second cable to a switching circuit electrically connected to the electrode patch unit.
Optionally, further comprising a third cable for electrically connecting the adaptor to the electric field generator.
Optionally, further comprising a third connector for mechanically and electrically connecting the third cable to the electric field generator.
According to another aspect of the present disclosure, there is provided a system for applying an electric field to a subject's body, comprising: an electric field generator; and the above-mentioned device.
These and other aspects of the disclosure will be apparent from and elucidated with reference to the embodiments described hereinafter.
Drawings
Further details, features and advantages of the disclosure are disclosed in the following description of exemplary embodiments, taken in conjunction with the accompanying drawings, in which:
fig. 1 is a schematic block diagram of an apparatus for use with an electric field generator in accordance with an exemplary embodiment;
FIG. 2 is a schematic block diagram of the electrode patch assembly shown in FIG. 1;
FIG. 3 is a schematic block diagram of the electrode patch unit body shown in FIG. 2;
fig. 4 is a schematic block diagram of an apparatus for use with an electric field generator according to another example embodiment;
FIG. 5 is a schematic block diagram of the internal structure of the adapter shown in FIG. 1;
FIG. 6 is a schematic circuit diagram of the adapter shown in FIG. 1;
FIG. 7 is a method flow diagram of a system for applying an electric field according to an exemplary embodiment;
FIG. 8 is a flowchart of an example process of controlling the switching circuits in the method of FIG. 7, according to an example embodiment; and is
Fig. 9 is a flowchart of an example process of controlling the switching circuits in the method of fig. 7, according to an example embodiment.
Detailed Description
Fig. 1 is a schematic block diagram of a device 100 for use with an electric field generator according to an exemplary embodiment. As shown in fig. 1, a device 100 for use with an electric field generator 110 includes a plurality of electrode patch assemblies 120 and an adaptor 130.
The electric field generator 110 is used to generate an effective medium-high frequency alternating voltage signal that suppresses tumor cells. In one example, the electric field generator 110 can have a built-in signal processor (not shown) for regulating the output amplitude of the alternating voltage signal based on, for example, temperature data acquired from the subject.
Each electrode patch assembly 120 includes a plurality of electrode patch units 122 and a switching circuit 124. Each electrode patch unit 122 is configured for contact with a plurality of respective body parts of the subject to apply an electric field to the plurality of respective body parts of the subject and to sense temperatures at the plurality of respective body parts.
The switching circuit 124 is electrically connected to the plurality of electrode patch units 122.
The adaptor 130 is configured to transmit the plurality of alternating electric field signals generated by the electric field generator 110 to the switching circuit in a respective one of the plurality of electrode patch assemblies 120.
In the apparatus 100, the switching circuitry 124 in each electrode patch assembly 120 is configured to individually control electrical connections to the plurality of electrode patch cells 122 to selectively transmit a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch cells 122. In some exemplary embodiments, a plurality of electrode patch units 122 are connected in parallel to a switching circuit 124. The electrode patch unit 122 is applied to the skin of the subject, thereby applying an alternating electric field to the tumor to perform tumor treatment.
In one example, the apparatus 100 further includes a plurality of first cables 140. The plurality of first cables 140 are used to electrically connect the plurality of electrode patch assemblies 120 to the adaptor 130, respectively. In one example, the plurality of first cables 140 are configured to provide respective electric field signal paths to transmit the plurality of alternating electric field signals to the switching circuits 124 in the plurality of electrode patch assemblies, respectively.
In some exemplary embodiments, the plurality of first cables 140 are further configured to provide respective temperature signal paths to transmit temperature signals from the electrode patch units 122 of the plurality of electrode patch assemblies 120 to the adaptor 130.
In one example, the first cable 140 is multi-core. For example, the first cable 140 may be a cable having 20-core copper wires and a shielding layer, wherein 9 cores correspond to a temperature signal path, 9 cores correspond to an electric field signal path, 1 core corresponds to a power supply VCC, and 1 core corresponds to a ground signal GND.
In summary, the apparatus 100 can individually control the electrode patch units 122 electrically connected to the switch circuit 124 through the switch circuit 124 to selectively apply the electric field to the corresponding body part. When the temperature signal corresponding to one electrode patch unit 122 exceeds the human body safety threshold, the electrode patch unit 122 can be independently disconnected through the switch circuit 124, so that the safety in the treatment process is ensured. At the same time, the other electrode patch units 122 continue to apply the electric field to other body parts. Therefore, the device 100 can ensure the treatment safety and increase the time of alternating electric field treatment, thereby improving the treatment effect.
In some exemplary embodiments, the apparatus 100 further comprises a plurality of first connectors 150. The plurality of first connectors 150 are used to mechanically and electrically connect the plurality of first cables 140 to the adaptor 130, respectively. In one example, the first connector may comprise a push-on spring connector to facilitate quick replacement between the first cable 140 and the adapter 130.
In some exemplary embodiments, the apparatus 100 further comprises a third cable 160. Third cable 160 is used to electrically connect adaptor 130 to electric field generator 110. In one example, the third cable 160 is a cable comprising 8-core copper wire and a shielding layer.
In some exemplary embodiments, the apparatus 100 further comprises a third connector 170. Third connector 170 is used to mechanically and electrically connect third cable 160 to electric field generator 110. In one example, the third connector 170 may comprise a push-on spring connector.
In summary, the device 100 including the first connector 150, the third cable 160, and the third connector 170 facilitates convenient application of the plurality of electrode patch assemblies 120 to the skin of the subject by the subject or caregiver, thereby avoiding obstruction due to the presence of the cable.
Fig. 2 is a schematic block diagram of the electrode patch assembly 120 shown in fig. 1. As shown in fig. 2, the electrode patch assembly 120 includes a switching circuit 124 and a plurality of electrode patch units 122. In one example, each electrode patch unit 122 includes an electrode patch unit body 210, a temperature sensor 220, and a second cable 230.
The electrode patch unit body 210 is for being attached at a corresponding body part of a plurality of corresponding body parts to apply an electric field to the corresponding body part.
The temperature sensor 220 is disposed on the electrode patch unit body 210 for sensing a temperature at the corresponding body part. In one example, the temperature sensor 220 may be a thermistor. For simplicity, one temperature sensor 220 is provided on the electrode patch unit main body 210 in fig. 2, but the present application is not limited thereto.
The second cable 230 electrically connects the electrode patch unit body 210 to the switching circuit 124 in the electrode patch assembly 120. In one example, the second cable 230 is multi-core. For example, the second cable may be a cable having 3-core copper conductors and a shielding layer, wherein 1 core corresponds to a temperature signal, 1 core corresponds to a power supply VCC, and 1 core corresponds to a ground signal GND. Each switching circuit 124 is configured such that a temperature signal from a respective temperature sensor 220 in the electrode patch assembly 120 is transmitted to the adaptor 130 and a corresponding one of the plurality of alternating electric field signals is selectively transmitted to the plurality of electrode patch units 122 in the electrode patch assembly 120.
In summary, by configuring the electrode patch assembly 120 in the manner shown in fig. 2, it is possible to simultaneously apply an electric field to a corresponding body part of a subject and sense a temperature signal. Accordingly, the switching circuit 124 can transmit the temperature signal sensed by the temperature sensor 220 at any time, while individually controlling whether the alternating electric field signal transmitted to the electrode patch assembly 120 is output to each electrode patch unit 122. Thus, the device having the electrode patch assembly 120 as shown in fig. 2 can be used to achieve real-time sensing of the temperature of the skin of the subject to ensure safety, and individually control the alternating electric field signal transmitted to each electrode patch unit 122 according to the sensed temperature, thereby improving the therapeutic effect.
In some exemplary embodiments, the electrode patch unit 122 further includes a second connector 240. The second connector 240 serves to mechanically and electrically connect the second cable 230 to the switching circuit 124 electrically connected with the electrode patch unit 122. In one example, the second connector 240 may comprise a push-type spring connector.
Fig. 3 is a schematic block diagram of the electrode patch unit body 210 shown in fig. 2. As shown in fig. 3, the electrode patch unit body 210 includes a backing 310, an electrical function assembly 320, a support 330, and an adhesive 340. In one example, the backing 310 includes an adhesive layer.
The electrical functional component 320 is attached to the backing 310 and is electrically connected to the second cable 230 to receive a corresponding one of the plurality of alternating electric field signals.
The support 330 is affixed to the backing 310 and surrounds the electrical functional component 320.
The adhesive member 340 is attached to the electrical function assembly 320 and the side of the support member 330 away from the backing 310 for contacting the corresponding body part to apply an electric field generated by a corresponding one of the plurality of alternating electric field signals to the corresponding body part. In one example, a side of the electrical function assembly 320 facing the adhesive element 340 can conduct an alternating electric field.
In one example, the adhesive member 340 comprises a conductive hydrogel, which can increase the attaching comfort of the electrical functional component 320 on the skin of the human body, and can also serve as a conductive medium for applying the alternating electric field established by the electrical functional component 320 to the tumor site of the subject.
In some exemplary embodiments, the electrode patch unit body 210 further includes a heat shrink 350. A heat shrink 350 is provided at the connection of the electrical functional component 320 and the second cable 230.
In some exemplary embodiments, the temperature signals sensed by the plurality of electrode patch assemblies 120 are analog signals, and therefore analog-to-digital conversion of the temperature signals is required for subsequent operations. Fig. 4 is a schematic block diagram of an apparatus 400 for use with an electric field generator 410, according to another example embodiment. As shown in fig. 4, the device 400 includes an adapter 420 and a plurality of electrode patch assemblies 430. The electric field generator 410 provides a plurality of ac voltage signals for tumor treatment and determines whether the current temperature exceeds a threshold value to regulate the output of the ac voltage signals.
The electrode patch assembly 430 includes a plurality of electrode patch units and a switching circuit 440. Each electrode patch unit includes an electrical functional component, e.g., E1, E2 … En, and a temperature sensor, e.g., T1, T2 … Tn. In one example, the temperature sensors T1, T2 … Tn may employ thermistors. The thermistor can be flexibly configured to contact the body part due to its small size, and the temperature of the contacted body part can be determined by measuring its voltage value. It will be understood that only one electrode patch assembly 430 is shown in fig. 2 for clarity of illustration, but the disclosure is not so limited.
In one example, the adapter 420 includes an analog-to-digital converter 450 and a signal processor 460.
The analog-to-digital converter 450 is configured to convert the temperature signal to digital data. In one example, analog-to-digital converter 450 may select an analog-to-digital conversion integrated circuit with a communication protocol (e.g., SPI, I)2C, etc.) for digitizing the collected temperature signals for processing by the signal processor 460.
The signal processor 460 is configured to calculate a corresponding temperature value based on the digital data. In one example, the signal processor 460 is electrically connected to the analog-to-digital converter 450 and receives digital data. In one example, the signal processor 460 may select an integrated circuit (e.g., a single chip, an FPGA, etc.) with data operation storage to calculate a plurality of temperature values based on digital data. In other examples, the signal processor 460 may also employ a processor (e.g., STM32F103 series MCU) with a built-in analog-to-digital converter and a serial communication protocol to simplify the circuit structure.
In some exemplary embodiments, adaptor 420 also includes serial communication circuitry 470. Serial communications circuit 470 is configured to serially transmit the respective temperature values to electric field generator 410. In one example, serial communication circuit 470 may select an integrated circuit (e.g., RS232, RS485, etc.) with a serial communication protocol for transmitting the plurality of temperature values.
In some exemplary embodiments, each temperature sensor T1, T2 … Tn in the electrode patch assembly 430 may directly transmit the temperature signal of the temperature sensor in parallel to the analog-to-digital converter 450. For example, the n temperature sensors in the electrode patch assembly 430, the positive side copper lead (TC1, TC2 … TCn) of each thermal sensor is electrically connected in parallel to the analog-to-digital converter 450. In some exemplary embodiments, the positive side copper leads of each thermistor (TC1, TC2, TC3, etc.) may be electrically connected in parallel to the analog-to-digital converter 450 through the first connector 422.
In some exemplary embodiments, adaptor 420 further includes a buffer 480. The buffer 480 is electrically connected between the switching circuit 440 and the analog-to-digital converter 450 to transmit the temperature signal from each electrode patch unit in the plurality of electrode patch assemblies to the analog-to-digital converter 450.
In one example, buffer 480 includes a plurality of inputs electrically connected to respective ones of a plurality of temperature sensors; and a plurality of output terminals electrically connected to respective ones of the plurality of input terminals of the analog-to-digital converter 450. In some exemplary embodiments, the positive side copper wires (TC1, TC2 … TC3, etc.) of each temperature sensor may be coupled in parallel to the multiple inputs of buffer 480 through first connector 422, and the common terminals of the temperature sensors are cascaded to be coupled in common to adaptor 420.
In some exemplary embodiments, the buffer 480 may be formed using an operational amplifier circuit for isolating the front-stage signal to protect the back-end analog-to-digital converter 450. In one example, buffer 480 may employ a voltage follower circuit.
In one example, the ac electric field signal 490 may be transmitted through the adaptor 420, the switching circuit 440, and to the various electrical functional components E1, E2 … En.
In one example, the switch circuit 440 may include multi-way switches S1, S2 … Sn. The multiplexing switches S1, S2 … Sn are electrically connected between a respective one (not shown) of a plurality of first cables (not shown) and the plurality of electrode patch units in the electrode patch assembly 430 to individually control transmission of a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch units under control of the electric field generator 410.
In one example, the multiplexing switches S1, S2 … Sn are electrically connected to the electrical functional components E1, E2 … En of each electrode patch unit in the electrode patch assembly 430, respectively. When each switch is turned off, the ac electric field signal 490 is conducted to the corresponding electrical functional component. If the switch is in the open state, the AC electric field signal cannot be conducted to the corresponding electrical functional component. In one example, the switches of the switching circuit 440 are solid state relays or power transistors. It should be noted that the circuit configuration of the switch circuit 440 is not limited to the one shown in fig. 4.
In some exemplary embodiments, the switching states of the switching circuit 440 are controlled by a signal processor 460 in the commutator 420. The parallel transmission of the multiple paths of alternating current electric field signals can be realized by independently controlling the on and off of each path of alternating current electric field signal.
In some exemplary embodiments, the analog signal acquisition input and the common (GND) are both coupled into the buffer 480. The buffer 480 is connected to the switch circuit 440 via a first connector (e.g., the first connector 150 in fig. 1), and is further connected to the corresponding electrical functional components E1 and E2 … En via the second connectors 432 of the plurality of electrode patch units. The 1 electrode patch unit contains 1 electrical functional component, at least 1 temperature sensor (e.g., thermistor T1). The number of cells within a first cable (e.g., first cable 140 of fig. 1) may need to be increased in response to the number of thermistors added. The 1 thermistor T1 includes a positive terminal copper conductor TC1 and a common terminal copper conductor GND of the 1 thermistor.
In some exemplary embodiments, the device 400 may contain 4 sets of electrode patch assemblies, each set containing at least 9 electrical functional components and 9 thermistors. The positive terminal of the thermistor is coupled in parallel to the buffer 480 through a second cable (not shown), a second connector 432, a switching circuit 440, a first cable (not shown), and a first connector 422. The common terminal GND of the thermistor is cascaded and then connected to the adaptor 420 through a second cable (not shown), a second connector 432, a switching circuit 440, a first cable (not shown) and a first connector 422. The electric field generator 410 is conducted to the adaptor 420 through the third connector 412 and the third cable (not shown), and then connected to the multi-way switches S1 and S2 … Sn in the switch circuit 440 through the first connector 422 and the first cable (not shown). The multi-way switches S1 and S2 … Sn are connected together to receive ac electric field signals at one end close to the first cable (not shown) and the first connector 422, and connected to the multi-electric-function modules E1 and E2 … En at the other end far from the first cable (not shown) and the first connector 422 through the second connector 432 and the second cable (not shown), respectively.
Fig. 5 is a schematic block diagram of the internal structure of the adaptor 130 shown in fig. 1. As shown in fig. 5, the third cable 510 is a cable including 8-core copper wires and a shielding layer. Wherein 8 core copper conductors correspond 8 signals, are respectively: the system comprises a power supply VCC, a ground GND, a serial data transmitting terminal TX, a serial data receiving terminal RX, an alternating voltage signal X1, an alternating voltage signal X2, an alternating voltage signal Y1 and an alternating voltage signal Y2. An electric field generator (not shown) is coupled to the converter 130 via a third connector 520 and a third cable 510. The power supplies VCC and ground GND shown in fig. 5 are connected. The dotted terminals of the alternating voltage signals X1, X2, Y1 and Y2 are connected. The power VCC, ground GND and ac voltage signals in the adaptor 130 are all electrically connected to the plurality of electrode patch assemblies through corresponding wires in the first connector ports X1, X2, Y1 and Y2.
In the example of fig. 5, the adaptor 130 includes a buffer 530, an analog-to-digital converter 540, a signal processor 550, and a serial communication circuit 560. In this example, the signal processor 550 may have an analog-to-digital converter 540 built in. In other examples, serial communication circuit 560 may also be built into signal processor 550 to simplify circuit configuration. In other examples, analog-to-digital converter 540, serial communication circuit 560, and signal processor 550 may be separate from each other.
In some embodiments, the first connector ports X1, X2, Y1, Y2 include VCC, GND and corresponding X1, X2, Y1, Y2 ac field signal paths 570. The ac electric field signal path 570 includes 9 wires for transmitting ac electric field signals. Temperature signal path 580 is also included in each of first connector ports X1, X2, Y1, and Y2. Temperature signal path 580 includes 9 wires for transmitting temperature signals. The supply Voltage (VCC), common Ground (GND) and alternating current electric field signal path 570 and temperature signal path 580 in the commutator 130 are each passed into the respective electrode patch assemblies through the first connector ports X1, X2, Y1, Y2. The 9 temperature signals in the 4 sets of electrode patch assemblies are reversely transmitted to the buffer 530 through the first connector ports X1, X2, Y1 and Y2, then transmitted to the analog-to-digital converter 540 to be converted into digital signals, then transmitted to the signal processor 550 to be calculated and stored, and finally transmitted to the serial communication circuit 560 (for example, an integrated circuit RS232 with a serial communication protocol) by the signal processor 550, and the RS232 transmits the data to the electric field generator through the third cable 510 and the third adaptor 520.
Fig. 6 is a schematic circuit diagram of the adaptor 130 shown in fig. 1. Like reference numerals in fig. 6 and fig. 1 denote like elements, which are not described again.
The adaptor 130 includes an analog-to-digital converter 610, a signal processor 620, and a serial communication circuit 630. In this example, analog-to-digital converter 610 and serial communication circuit 630 are shown separate from signal processor 620, but as previously described, in some embodiments, signal processor 620 may have analog-to-digital converter 610 and serial communication circuit 630 built in to simplify the circuit structure.
As shown in FIG. 6, the positive terminals of a plurality of temperature sensors (e.g., thermistors T1-T9) are electrically connected in parallel to the input port of analog-to-digital converter 610. In some exemplary embodiments, the commutator 130 further includes a voltage regulator VCC and a plurality of precision resistors R1-R9. A plurality of precision resistors R1-R9 are electrically connected between the voltage regulator VCC and respective ones of the plurality of thermistors T1-T9. For example, a precision resistor R1 is connected between the voltage regulator VCC and the thermistor T1. In some exemplary embodiments, converter 130 further includes a buffer 640. In one example, the plurality of outputs of the buffer 640 are also electrically connected to respective ones of a plurality of precision resistors R1-R9.
The change of the thermistor resistance value can be synchronously caused by the change of the temperature, and the precision resistor R is connectedSAnd a voltage stabilizer VCC, the thermistor and the precision resistor are equivalent to two resistors which are connected in series for voltage division. Resistance value R of thermistorTAnd voltage VRTSatisfies the following relationship:
VRT＝VCC×(RT/(RT+RS))
wherein R isTIs the resistance value of the thermistor at a temperature T (K)SIs the precise resistance value connected with the thermistor.
It can be seen that when the thermistor resistance R isTThe collected voltage V is decreased when the resistance value is decreased due to the increase of the temperatureRTAnd also decreases. Due to the voltage VRTFor analog, it is converted into digital data by the analog-to-digital converter 430. The signal processor 440 calculates a current temperature value based on the digital data, wherein the thermistor resistance value RTAnd a voltage VRTThe relationship between them satisfies:
wherein R isNAt a rated temperature TN(K) The thermistor resistance at time, T target temperature (K) temperature in Kelvin, B thermistor coefficient, e constant (2.71828), e.g., using a 3.3V power supply (VCC), and B3380 thermistor, R at 25 deg.CNAt 10K, at a collected voltage VRTR obtained at 1.5022VTAbout 8355.88ohm, while the target T was calculated to be 29.8 ℃. In one example, analog-to-digital conversionThe device 430 adopts a 12-bit analog-to-digital conversion chip, the minimum measurable voltage is about 0.8056mV under the power supply voltage of 3.3V, the corresponding temperature minimum resolution is about 0.03 ℃, and the accuracy of the measurable temperature value is high. In addition, 4 sets of 36-path thermistors T1, T2 and the like transmit voltage signals to the analog-to-digital converter 610 in parallel, the voltage signals are processed by the signal processor 620 and then transmitted through the serial communication circuit 630, and the transmission rate is improved.
There is also provided, in accordance with some exemplary embodiments of the present disclosure, a system for applying an electric field to a subject's body, including: an electric field generator (e.g., electric field generator 110 or 410) and an apparatus 100 or 400 as described above with respect to fig. 1-6.
Fig. 7 is a flow chart of a method 700 for a system for applying an electric field according to an example embodiment. The method 700 is described below in connection with the example of fig. 1 (where the system includes the electric field generator 110 and the apparatus 100). As shown in fig. 7, method 700 includes steps 710 and 720.
At step 710, a plurality of temperature values are received by the electric field generator from the device, the plurality of temperature values being respectively indicative of temperatures sensed by the electrode patch units in the plurality of electrode patch assemblies.
At step 720, each switching circuit in the plurality of electrode patch assemblies is controlled by the electric field generator based on the plurality of temperature values to selectively transmit a corresponding alternating electric field signal of the plurality of alternating electric field signals to each electrode patch cell in the plurality of electrode patch assemblies.
Fig. 8 is a flowchart of an example process of controlling the switching circuits in the method 700 of fig. 7, according to an example embodiment. As shown in fig. 8, controlling each switching circuit in the plurality of electrode patch assemblies (step 720) includes steps 810 through 830.
At step 810, a first temperature value of the plurality of temperature values is compared to a temperature threshold, the first temperature value being indicative of a temperature of a first body part of the plurality of respective body parts.
At step 820, in response to the first temperature value being greater than the temperature threshold, control a first switch circuit of the switch circuits to cease transmission of a corresponding one of the plurality of alternating electric field signals to an electrode patch unit of the plurality of electrode patch assemblies corresponding to the first body site.
At step 830, in response to the first temperature value not being greater than the temperature threshold, control the first switching circuit to maintain transmission of a corresponding one of the plurality of alternating electric field signals to an electrode patch unit corresponding to the first body site.
Fig. 9 is a flowchart for controlling the switching circuits in the method 700 of fig. 7 according to another exemplary embodiment. As shown in fig. 9, controlling each of the switching circuits in the plurality of electrode patch assemblies (step 720) further includes steps 910 to 930.
At step 910, a second temperature value of the plurality of temperature values, different from the first temperature value, is compared to a temperature threshold, the second temperature value being indicative of a temperature of a second body part of the plurality of respective body parts.
At step 920, in response to the second temperature value being greater than the temperature threshold, controlling a second switch circuit of the switch circuits to stop transmission of a corresponding one of the plurality of alternating electric field signals to an electrode patch unit of the plurality of electrode patch assemblies corresponding to the second body part.
At step 930, in response to the second temperature value not being greater than the temperature threshold, control the second switching circuit to maintain transmission of a corresponding one of the plurality of alternating electric field signals to the electrode patch unit corresponding to the second body part.
The temperature threshold is set in the range of 37-41 ℃, and can be set according to the experience of the examinee.
In summary, the system with the device 100 or 400 has the advantage that 4 sets of electrode patch assemblies form two sets of alternating electric field signals (e.g., X1, X2, Y1, Y2 in fig. 4) with different directions. Alternating current electric field signals on each group of 9 electrode patch units are independently controlled, and temperature collection on each electrode patch unit is also independent, so that temperature measurement and an electric field application area are refined. Further described in conjunction with the control method 700 and fig. 4, the switch S1 controls the ac electric field signal at E1, the T1 detects the temperature at E1, and so on, the switch Sn controls the ac electric field signal at En, and the Tn detects the temperature at En. Therefore, when the temperature of a certain area exceeds the threshold value, the switch Sn can be opened to enable the AC electric field signal of the path to be zero, no extra heat is generated due to the absence of the holding of the electric field, and the switch Sn can be closed again after the temperature is reduced to a certain voltage to enable the voltage of the electric field of the path to be recovered. The control of the multi-path alternating current electric field signals is not interfered with each other, the influence of the turn-off of the single-path alternating current electric field signals on the whole electric field intensity is small, the strength applied by the electric field in unit area is optimized, and the treatment effect is improved.
While the disclosure has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative and exemplary and not restrictive; the present disclosure is not limited to the disclosed embodiments. Variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed subject matter, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word "comprising" does not exclude other elements or steps than those listed, the indefinite article "a" or "an" does not exclude a plurality, and the term "a plurality" means two or more. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.
Claims (13)
1. A device for applying an electric field to a subject's body, usable with an electric field generator, comprising:
a plurality of electrode patch assemblies, each electrode patch assembly comprising:
a plurality of electrode patch units, each of the electrode patch units being respectively configured to contact a corresponding body part of a subject to apply an electric field to the corresponding body part in contact and to sense a temperature of the electrode patch unit; and
the switch circuit is electrically connected with the plurality of electrode patch units respectively; and
an adaptor configured to transmit a plurality of alternating electric field signals generated by the electric field generator to a switching circuit in the plurality of electrode patch assemblies, wherein the switching circuit in each electrode patch assembly is configured to individually control electrical connections to the plurality of electrode patch cells to selectively transmit a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch cells.
2. The apparatus for applying an electric field to a subject's body of claim 1, further comprising a plurality of first cables for electrically connecting the plurality of electrode patch assemblies to the adapter, respectively.
3. The apparatus for applying an electric field to a subject's body of claim 2, wherein the plurality of first cables are configured to provide respective electric field signal paths to transmit the plurality of alternating electric field signals to the switching circuits in the plurality of electrode patch assemblies, respectively.
4. The apparatus for applying an electric field to a body of a subject of claim 3, wherein the switching circuit in each electrode patch assembly includes a multi-way switch electrically connected between a respective one of the plurality of first wires and the plurality of electrode patch units in that electrode patch assembly to individually control transmission of a corresponding one of the plurality of alternating electric field signals to the plurality of electrode patch units under control of the electric field generator.
5. The apparatus for applying an electric field to a subject's body of claim 3, wherein the plurality of first cables are further configured to provide respective temperature signal paths to transmit temperature signals from each electrode patch unit of the plurality of electrode patch assemblies to the adapter.
6. The apparatus for applying an electric field to a subject's body according to any one of claims 1 to 5, wherein each of the plurality of electrode patch units comprises:
an electrode patch unit body for attaching to the corresponding body part to apply an electric field to the corresponding body part;
the temperature sensor is arranged on the electrode patch unit main body and used for sensing the temperature of the electrode patch unit main body; and
a second cable electrically connecting the electrode patch unit to a switching circuit in the electrode patch assembly,
wherein the switching circuitry in each electrode patch assembly is configured such that a temperature signal from the temperature sensor in each electrode patch unit is transmitted to the adaptor and the corresponding one of the plurality of alternating electric field signals is selectively transmitted to the plurality of electrode patch units in that electrode patch assembly.
7. The apparatus for applying an electric field to a subject's body as defined in claim 6, wherein the electrode patch unit body includes:
a backing;
an electrical functional component affixed to the backing and electrically connected with the second cable to receive a corresponding one of the plurality of alternating electric field signals;
a support affixed to the backing and surrounding the electrical functional component; and
an adhesive member affixed to the electrical functional component and the side of the support member distal from the backing for contacting the respective body part to apply an electric field to the respective body part generated by the corresponding one of the plurality of alternating electric field signals.
8. The apparatus for applying an electric field to a subject's body as in claim 7, wherein the adhesive comprises a conductive hydrogel.
9. The apparatus for applying an electric field to a subject's body of claim 7, wherein the electrode patch unit body further comprises a heat shrink sleeve disposed at a connection of the electrical functional component and the second cable.
10. The apparatus for applying an electric field to a subject's body of claim 6, wherein each of the plurality of electrode patch units further comprises a second connector for mechanically and electrically connecting the second cable to a switching circuit electrically connected thereto.
11. The device for applying an electric field to a subject's body according to any one of claims 1 to 5, further comprising a third cable for electrically connecting the adaptor to the electric field generator.
12. The apparatus for applying an electric field to a subject's body of claim 11, further comprising a third connector for mechanically and electrically connecting the third cable to the electric field generator.
13. A system for applying an electric field to a subject's body, comprising:
an electric field generator; and
the device of any one of claims 1-12.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123308068.0U CN216725529U (en) | 2021-12-24 | 2021-12-24 | Device and system for applying an electric field to a subject's body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123308068.0U CN216725529U (en) | 2021-12-24 | 2021-12-24 | Device and system for applying an electric field to a subject's body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216725529U true CN216725529U (en) | 2022-06-14 |
Family
ID=81939281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123308068.0U Active CN216725529U (en) | 2021-12-24 | 2021-12-24 | Device and system for applying an electric field to a subject's body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216725529U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115845260A (en) * | 2022-12-30 | 2023-03-28 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, electrode plate thereof and temperature detection method |
| CN116271523A (en) * | 2022-12-30 | 2023-06-23 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, electrode sheet identification method, tumor electric field treatment system and treatment equipment |
| CN117180617A (en) * | 2023-10-09 | 2023-12-08 | 深圳奥派森生物电磁科技有限公司 | Electrode and system for electric field therapy |
| WO2024140855A1 (en) * | 2022-12-30 | 2024-07-04 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, electric field treatment system, and control method |
-
2021
- 2021-12-24 CN CN202123308068.0U patent/CN216725529U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115845260A (en) * | 2022-12-30 | 2023-03-28 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, electrode plate thereof and temperature detection method |
| CN116271523A (en) * | 2022-12-30 | 2023-06-23 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, electrode sheet identification method, tumor electric field treatment system and treatment equipment |
| CN116271523B (en) * | 2022-12-30 | 2024-03-29 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, electrode sheet identification method, tumor electric field treatment system and treatment equipment |
| WO2024140855A1 (en) * | 2022-12-30 | 2024-07-04 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, electric field treatment system, and control method |
| CN115845260B (en) * | 2022-12-30 | 2024-07-05 | 江苏海莱新创医疗科技有限公司 | Tumor electric field treatment system, electrode plate thereof and temperature detection method |
| CN117180617A (en) * | 2023-10-09 | 2023-12-08 | 深圳奥派森生物电磁科技有限公司 | Electrode and system for electric field therapy |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN216725529U (en) | Device and system for applying an electric field to a subject's body | |
| CN114288550A (en) | Device and system for applying electric field to body of subject and temperature control method thereof | |
| US12029898B2 (en) | Arrays for delivering tumor treating fields (TTFields) with selectively addressable sub-elements | |
| EP3500334B1 (en) | Temperature measurement in arrays for delivering ttfields | |
| EP4212203A1 (en) | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors | |
| CN114177527A (en) | Device and system for applying an electric field to a subject's body | |
| CN219128011U (en) | Electrode plate and electric field treatment system | |
| CN116046198B (en) | Electrode plate, electrode plate temperature detection method and tumor electric field treatment system | |
| CN219071822U (en) | Electric field therapy system | |
| CN115920230A (en) | Electrode plate, electric field treatment system and control method | |
| CN216603803U (en) | Device and system for applying an electric field to a subject's body | |
| CN216497040U (en) | Electric field generator and device for applying an electric field to a subject | |
| CN114099964A (en) | Electric field generator, device for applying electric field to subject and temperature control method thereof | |
| CN221014192U (en) | Electroencephalogram acquisition and transcranial electric stimulation system and equipment | |
| CN117085250A (en) | Electroencephalogram acquisition and transcranial electric stimulation system and equipment | |
| CN117861065A (en) | Electrode patch and electrical stimulation device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |