CN207036852U - A kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system - Google Patents
A kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system Download PDFInfo
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- CN207036852U CN207036852U CN201720793410.5U CN201720793410U CN207036852U CN 207036852 U CN207036852 U CN 207036852U CN 201720793410 U CN201720793410 U CN 201720793410U CN 207036852 U CN207036852 U CN 207036852U
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Abstract
The utility model belongs to immune detection analysis field, more particularly to a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system, including shell and mainframe, it is characterized in that mainframe top is fixed with chip card storage dish and sample pipe dish, centrifugation reaction tray is provided between chip card storage dish and sample pipe dish, centrifuges and is provided with loading system and purging system between reaction tray and sample pipe dish；Centrifugation reaction tray is provided with Systems for optical inspection on mainframe, mainframe is internally provided with control system and motor, the motor drive ic card storage dish, centrifuges reaction tray, sample pipe dish, the rotation of loading system.The full-automatic micro-fluidic chip fluorescence immunoassay detecting system can fundamentally realize full-automation, the requirement of multisample, high flux, quick detection.
Description
Technical field
The utility model belongs to immune detection analysis field, and in particular to a kind of full-automatic micro-fluidic chip fluorescence immunoassay inspection
Examining system.
Background technology
The detecting system of immunoassay can be divided into according to the method difference of immunoassay it is a variety of, as immunochromatographiassays assays instrument,
ELISA instrument, chemical illumination immunity analysis instrument etc..
With application of micro-fluidic chip (microfluidic chips) technology in fields such as medical science, life sciences,
The MCA of chip and other function element are integrated on several square centimeters of substrate, by the stream in microchannel
Body is controlled, and to realize the micro-total analysis system of the multiple functions such as sample introduction, dilution, mixing, reaction, separation, detection, is had
Miniaturization, integrated, analyze speed is fast, reagent consumes the remarkable advantage such as few.At present, micro-fluidic chip is applied to immune detection
Analysis field.
In recent years, in order to adapt to multisample, quick detection, manual operation is reduced, is released one after another various full-automatic micro-fluidic
Detector, but these self-reacting devices are only the reduction of manual operation, have liberated labour, and the subjectivity eliminated in experiment is missed
Difference, do not realize the requirement of multisample, high flux, quick detection fundamentally.
Therefore, develop a kind of convenient, fast, high flux, high sensitivity, it is integrated it is high, be adapted to industrialized production it is complete from
Dynamic micro-fluidic chip immune detection system is current urgent problem to be solved.
The content of the invention
In order to solve the above problems, the utility model provides a kind of full-automatic micro-fluidic chip fluorescence immunoassay detection system
System, can fundamentally realize full-automation, the requirement of multisample, high flux, quick detection.
What the purpose of this utility model was realized in：A kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system, bag
Shell and mainframe are included, mainframe top is provided with chip card storage dish and sample pipe dish, chip card storage dish and sample pipe dish
Between be provided with centrifugation reaction tray, centrifuge and be provided with loading system, purging system between reaction tray and sample pipe dish；On mainframe
Centrifugation reaction tray is provided with Systems for optical inspection, mainframe is internally provided with control system and motor, and the motor drives
Dynamic chip card storage dish, centrifuges reaction tray, sample pipe dish, the rotation of loading system.
The chip card storage dish, centrifuges reaction tray, sample pipe dish, and loading system passes through rotary shaft and motor respectively
It is connected；The chip card storage dish is internally provided with electric pushrod, and one or more can be placed by being provided with chip card storage dish
The neck of chip card the storage box；The outside of each chip card the storage box is provided with bar code information, each chip card the storage box bottom
It is provided with the outlet of chip detection card；There are one or more chip necks, the size and core of chip neck in the centrifugation reaction tray
Piece detection card matches.
The neck of the chip card the storage box is arranged in half journal axle of chip card storage dish, each two chip card the storage box
Neck between angle it is equal, multiple chips detection card, the chip card the storage box can be placed inside chip card the storage box up and down
It is directly installed in chip card storage dish.
The chip detection card carries the micro-fluidic chip of bar code information for a strip, is arranged in order on chip detection card
Have loading slot, fluorescence probe groove, reaction detection groove and a waste liquid tank, and connection loading slot, fluorescence probe groove, reaction detection groove and
The microchannel of waste liquid tank；The fluorescence probe groove solidifies fluorescence probe microballoon antibody or antigen in advance, and reaction detection groove is solid in advance
Change capture magnetic bead microballoon antibody or antigen；The micro-fluidic chip only has loading slot to be communicated by well with the external world, remaining groove
It is closing；When the chip detection card is placed, waste liquid tank one end is close to the center of chip card storage dish.
The centrifugation reaction tray is internally provided with electric pushrod, centrifuges and one or more cores are set in half journal axle of reaction tray
Piece neck, chip neck are provided with the interface for the chip detection card launched for the outlet at bottom of receiving chip card the storage box；It is described
When chip detection card is placed, loading slot one end is close to the center of centrifugation reaction tray；The centrifugation reaction tray bottom is fixed with annular
Magnet coil, the position of annular magnet coil is corresponding with the position of the upper reaction detection groove of chip detection card, and loop coil is powered
When produce magnetic field, for adsorb chip detection card reaction detection groove in micro- magnetic bead.
The sample disc is motor-driven rotatable disc structure specimen holder, can place multiple detection samples simultaneously
Pipe.
The loading system include sample needle, sample-adding needle rack, sample needle service sink, sample needle by be loaded needle rack with
Mainframe is connected, and sample-adding needle rack is provided with rotating device, and rotating device drives sample needle in sample pipe dish, centrifugation reaction tray
Move back and forth between sample needle service sink；The sample needle service sink is embedded in mainframe surface.
The Systems for optical inspection includes optical transmitting set, optical receiver, optical filter, optical-electrical converter and corresponding fixed dress
Put.
The purging system, which includes cleaning needle, cleaning needle rack, cleaning fluid bottle, cleaning fluid volume induction installation and fluid path, leads
Pipe, cleaning needle are connected by fluid path conduit with cleaning fluid bottle, and the cleaning fluid bottle is placed in outside mainframe.
The immune detection system also includes barcode scanner, and described barcode scanner is that one-dimension code or two-dimensional code scanning fill
Put, for scanning outside chip card the storage box and the bar code information on chip detection card surface, the bar code information include name of product,
Lot number, standard curve.
Compared with prior art, innovative point of the present utility model and advantage are.
（1）Full intellectualized operation, operator need to only load sample cell in sample disc, without being manually loaded, cleaning, incubating
Educate.
（2）All reagents solidify in chip in advance, save the use of a large amount of test tubes of conventional reagents box, and save repeatedly
Sampling operation.
（3）Sample needs sample amount few, and single index only needs 5-10ul.
（4）The totally-enclosed system of micro-fluidic chip, no cross contamination are free from environmental pollution.
（5）Detection project is optionally combined, and detection time is short, can be completed in 10 minutes multiple chips multisample or it is more because
Son detects simultaneously, realizes the quick and high flux of detection.
（6）Homogeneous reaction system makes testing result high sensitivity（10-15mol/ml）, high precision（CV ＜ 5%）, high repeat
Property（CV ＜ 5%）.
Brief description of the drawings
Fig. 1：Full-automatic micro-fluidic chip immune detection system structural representation.
Fig. 2：Full-automatic micro-fluidic chip immune detection system main frame structure schematic diagram.
Fig. 3：Chip gripper storage dish structural representation.
Fig. 4：Chip card the storage box knot illustrates composition.
Fig. 5：Chip detects card structure schematic diagram.
Fig. 6：Centrifuge reaction tray structural representation.
Fig. 7：Centrifuge reaction tray polycrystalline substance schematic diagram.
Fig. 8：Sample cell dish structure schematic diagram.
Fig. 9：Systems for optical inspection fundamental diagram.
Figure 10：Loading system structural representation.
Figure 11：Purging system structural representation.
In figure, 1：Shell；2：Mainframe；3：Chip card storage dish；4：Centrifuge reaction tray；5：Sample pipe dish；6.1：Chip
Electric pushrod inside card storage dish；6.2：Centrifuge electric pushrod inside reaction tray；7：Loading system；8：Purging system；9：Optics
Detecting system；10：Motor；11：The neck of chip card the storage box；12：Chip card the storage box；13：Chip detection card；131：Sample-adding
Groove；132：Fluorescence probe groove；133：Reaction detection groove；134：Waste liquid tank；14：Annular magnet coil；15：Sample needle；16：Sample-adding
Needle rack；16.1：Rotating device；17：Sample needle service sink；18：Cleaning needle；19：Clean needle rack；20：Cleaning fluid bottle；21：
Cleaning fluid volume induction installation；22：Fluid path conduit.
Embodiment
The utility model is described further below in conjunction with the accompanying drawings, the utility model is not limited to following instance.
Embodiment 1.
As illustrated, a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system, including shell 1 and mainframe 2, main frame
The top of frame 2 is provided with chip card storage dish 3 and sample pipe dish 5, and centrifugation is provided between chip card storage dish 3 and sample pipe dish 5
Reaction tray 4, centrifuge and be provided with loading system 7, purging system 8 between reaction tray 4 and sample pipe dish 5；On mainframe 2 correspond to from
Heart reaction tray 4 is provided with Systems for optical inspection 9, and mainframe 2 is internally provided with control system and motor 10, the driving chip of motor 10
Card storage dish 3, centrifuge reaction tray 4, sample pipe dish 5, the rotation of loading system 7.
Chip card storage dish 3, centrifuges reaction tray 4, sample pipe dish 5, and loading system 7 passes through rotary shaft and motor respectively
10 are connected；Chip card storage dish 3 is internally provided with electric pushrod 6.1, and at least one energy is provided with chip card storage dish 3 and is placed
The neck 11 of one or more chip card the storage box 12；The outside of each chip card the storage box 12 is provided with bar code information, each
The bottom of chip card the storage box 12 is provided with the outlet of chip detection card 13；There are one or more chip necks, core in centrifugation reaction tray 4
The size of piece neck matches with chip detection card 13.
The neck 11 of chip card the storage box is arranged in half journal axle of chip card storage dish 3, each two chip card the storage box
Neck 11 between angle it is equal, the inside of chip card the storage box 12 can place multiple chips detection cards 13 up and down；Or chip card is deposited
Storage box 11 is directly installed in chip card storage dish 3.
Chip detection card 13 is the micro-fluidic chips that a strip carries bar code information, is arranged in sequence with loading slot 131, glimmering
Light probe groove 132, reaction detection groove 133 and waste liquid tank 134, and the microchannel being connected with each other；The fluorescence probe groove 132 is pre-
First solidify fluorescence probe microballoon antibody or antigen, solidification captures magnetic bead microballoon antibody or antigen to reaction detection groove 133 in advance；Miniflow
Control chip only has loading slot 131 to be communicated by well with the external world, and remaining groove is closing；When chip detection card 13 is placed,
The one end of waste liquid tank 134 is close to the center of chip card storage dish.
Centrifugation reaction tray 4 is internally provided with electric pushrod 6.2, centrifuges and one or more is set in half journal axle of reaction tray 4
Chip neck, chip neck are provided with the chip launched for the outlet at bottom of receiving chip card the storage box 12 and detect connecing for card 13
Mouthful；When chip detection card 13 is placed, the one end of loading slot 131 is close to the center of centrifugation reaction tray 4；Centrifugation reaction tray 4 bottom is fixed
There is an annular magnet coil 14, the position of reaction detection groove 133 is relative on the position of annular magnet coil 14 and chip detection card 13
Should, annular magnet coil 14 produces magnetic field when being powered, for adsorbing in chip detection 13 reaction detection grooves of card 133 micro- magnetic bead.
Sample disc 5 is motor-driven rotatable disc structure specimen holder, can place multiple detection sample cells simultaneously.
Loading system includes sample needle 15, sample-adding needle rack 16, sample needle service sink 17, and sample needle 15 passes through sample needle branch
Frame 16 is connected with mainframe 2, and sample-adding needle rack 16 is provided with rotating device 16.1, and the motion of rotating device 16.1 drives sample needle
15 move back and forth between sample pipe dish 5, centrifugation reaction tray 4 and sample needle service sink 17, and sample needle service sink 17 is embedded in master
The surface of frame 2.
Optical system includes optical transmitting set, optical receiver, optical filter, optical-electrical converter and corresponding fixing device.
Purging system includes cleaning needle 18, cleaning needle rack 19, cleaning fluid bottle 20, cleaning fluid volume induction installation 21, fluid path
Conduit 22, cleaning needle are connected by fluid path conduit 22 with cleaning fluid bottle 20, and cleaning fluid volume induction installation 21 controls cleaning needle 20
Washing lotion amount.
The immune detection system also includes barcode scanner, and barcode scanner is one-dimension code or two-dimensional code scanning device, is used
In scanning chip card the storage box 12 outer surface, the bar code information of chip detection card 13, the bar code information includes name of product, criticized
Number, standard curve etc..
Embodiment 2.
8 kinds of chip detection cards are made respectively for 8 kinds of common tumor markers antigens（1. AFP, 2. cancer embryo
Antigens c EA, 3. total prostate specific antigen t-PSA, 4. f-PSA f-PSA, 5. dermoid cancer resists
Former SCC, 6. glycogen antigen 125,7. glycogen antigen 1 5-3,8. glycogen antigen 1 9-9.
Each chip detection 13 surface spray printing one-dimension codes of card, contain product related information, including name of product, lot number etc..
Every kind of chip detection card 13 is fitted into 1 chip card the storage box 12 for 8 totally.
The outer surface spray printing Quick Response Code of chip card the storage box 12, the relevant information of the product is inside loaded with, including：Name of product,
Lot number, standard curve etc..
Full-automatic micro-fluidic chip immune detection system detection method comprises the following steps.
（1）Chip card the storage box 12 is fixed on the neck 11 in chip card storage dish, barcode scanner automatically scanning
The bar code information of the outer surface of chip-stored box 12, it is loaded into operating system.
（2）With the bar code information on external barcode scanner scanning measuring samples pipe, operating system is loaded into, bar code information is most
Contain sample number into spectrum and project to be checked less, sample cell is inserted in sample pipe dish 5, is automatically rotated to specific assignment sampling position.
（3）According to project information to be checked, system chooses the chips of chip card storage dish 3 detection card 13 automatically, and chip card is deposited
Electric pushrod 6.1 inside storage disk is released chip detection card 13 to centrifugation reaction tray from the bottom of chip-stored box 12 and blocked accordingly
In groove, and scan the bar code information on chip detection card 13, standard curve corresponding to selection.
（4）The rotating device 16.1 being loaded on needle rack 16 drives sample needle 15 to quantify pipette samples 10ul in the sample,
It is added in the well of corresponding chip detection card 13, motor driving centrifugation reaction disc spins, rotating speed 300rpm, centrifugation is anti-
Answer 5 minutes, sample is driven into fluorescence probe groove 132 and reaction detection groove 133 respectively, thing to be checked is micro- with mark fluorescent respectively
Specific immune response occurs for ball antibody 1 and capture magnetic bead microballoon antibody 2, forms " fluorescent microsphere-antibody 1- Ag-Abs 2-
The double-antibody sandwich magnetic composite of magnetic bead microballoon ".
Sample needle 15 is cleaned after adding a sample in sample needle service sink 17, then carries out next sampling, sample-adding.
（5）After reaction terminates, annular magnet coil 14 is powered, and produces magnetic field, and magnetic composite is attracted to reaction detection
The bottom of groove 133, motor driving centrifugation reaction tray 4 rotate, rotating speed 1200rpm, centrifuged 1 minute, by non-magnetic compounds solution
Centrifuge into the waste liquid tank 134 of chip detection card.
（6）Magnetic field is disconnected, cleaning fluid 50ul, 300rpm centrifugation 2 minutes is added by well, cleans magnetic composite,
Magnet coil 14 is powered, and produces magnetic field, and magnetic composite is attracted to the bottom of reaction detection groove 133, and motor driving centrifugation is anti-
Disc spins are answered, rotating speed 1200rpm, are centrifuged 1 minute, by the waste liquid tank 134 of non-magnetic compounds solution centrifugal to chip, are disconnected
Magnetic field.
The surplus of cleaning fluid in the automatic sensing cleaning fluid bottle 20 of cleaning fluid volume induction installation 21, when surplus is less than lower limit
When, automatic alarm, it is replaced and cleaned liquid bottle 20.
（7）Detection, light irradiation reaction detection groove 133 is excited with specific wavelength, label probe produces fluorescence, receives specific
Optical signal is changed into digital letter by the fluorescence of wavelength, the concentration of fluorescence intensity and determinand into correlation by photovoltaic converter
Number, and bring into the standard curve being loaded into before, calculate the content of determinand.
（8）After detection terminates, centrifuge the electric pushrod 6.2 inside reaction tray and exit used chip detection card 13, collect
Middle processing.
Above example is only the tool to describe the purpose of this utility model in detail, technical scheme and beneficial effect are chosen
Body example, but should in no way limit the scope of protection of the utility model, it is all without prejudice to before the spirit and principles of the utility model
Put, various modifications, equivalent substitution and the improvement made, all should fall within the protection domain of utility model.
Claims (10)
1. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system, including shell and mainframe, it is characterised in that mainframe
Top is provided with chip card storage dish and sample pipe dish, and centrifugation reaction tray is provided between chip card storage dish and sample pipe dish,
Loading system and purging system are provided between centrifugation reaction tray and sample pipe dish；Set on mainframe corresponding to centrifugation reaction tray
There is Systems for optical inspection, mainframe is internally provided with control system and motor, and the motor drive ic card storage dish, centrifugation is instead
It should coil, sample pipe dish, the rotation of loading system.
2. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Chip card storage dish, centrifuges reaction tray, sample pipe dish, and loading system is connected by rotary shaft with motor respectively；The core
Piece card storage dish is internally provided with electric pushrod, and one or more chip card the storage box can be placed by being provided with chip card storage dish
Neck；The outside of each chip card the storage box is provided with bar code information, and each chip card the storage box bottom is provided with chip inspection
Survey card outlet；There are one or more chip necks in the centrifugation reaction tray, size and the chip of chip neck detect card phase
Match somebody with somebody；The chip card the storage box is directly installed in chip card storage dish.
3. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 2, it is characterised in that described
The neck of chip card the storage box is arranged in half journal axle of chip card storage dish, the angle between the neck of each two chip card the storage box
Spend equal, multiple chips detection card can be placed inside chip card the storage box up and down.
4. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 2, it is characterised in that described
Chip detection card carries the micro-fluidic chip of bar code information for a strip, and loading slot, glimmering is arranged in sequence with chip detection card
Light probe groove, reaction detection groove and waste liquid tank, and connect the micro- of loading slot, fluorescence probe groove, reaction detection groove and waste liquid tank
Passage；The fluorescence probe groove solidifies fluorescence probe microballoon antibody or antigen in advance, and reaction detection groove solidifies capture magnetic bead in advance
Microballoon antibody or antigen；The micro-fluidic chip only has loading slot to be communicated by well with the external world, and remaining groove is closing；
When the chip detection card is placed, waste liquid tank one end is close to the center of chip card storage dish.
5. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Centrifugation reaction tray is internally provided with electric pushrod, centrifuges and one or more chip necks, chip are set in half journal axle of reaction tray
Neck is provided with the interface for the chip detection card launched for the outlet at bottom of receiving chip card the storage box；The chip detection card is put
When putting, loading slot one end is close to the center of centrifugation reaction tray；The centrifugation reaction tray bottom is fixed with annular magnet coil, annular
The position of magnet coil is corresponding with the position of the upper reaction detection groove of chip detection card, and loop coil produces magnetic field when being powered, and uses
To adsorb micro- magnetic bead in chip detection card reaction detection groove.
6. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Sample pipe dish is motor-driven rotatable disc structure specimen holder, can place multiple detection sample cells simultaneously.
7. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Loading system includes sample needle, sample-adding needle rack, sample needle service sink, and sample needle is connected by being loaded needle rack with mainframe
Connect, sample-adding needle rack is provided with rotating device, and rotating device drives sample needle clear in sample pipe dish, centrifugation reaction tray and sample needle
Move back and forth between wash pool；The sample needle service sink is embedded in mainframe surface.
8. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Systems for optical inspection includes optical transmitting set, optical receiver, optical filter, optical-electrical converter and corresponding fixing device.
9. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that described
Purging system includes cleaning needle, cleaning needle rack, cleaning fluid bottle, cleaning fluid volume induction installation and fluid path conduit, cleaning needle and passed through
Fluid path conduit is connected with cleaning fluid bottle, and the cleaning fluid bottle is placed in outside mainframe.
10. a kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system according to claim 1, it is characterised in that this is exempted from
Epidemic disease detecting system also includes barcode scanner, and described barcode scanner is one-dimension code or two-dimensional code scanning device, for scanning
Chip card the storage box is outer and the bar code information on chip detection card surface, the bar code information include name of product, lot number, standard song
Line.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107102131A (en) * | 2017-07-03 | 2017-08-29 | 沈阳微流控生物科技有限公司 | A kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system and its detection method |
| CN109946460A (en) * | 2019-04-18 | 2019-06-28 | 天津诺迈科技有限公司 | Chemiluminescence immunoassay detection device and application method based on micro-fluidic chip |
| WO2020010913A1 (en) | 2018-07-12 | 2020-01-16 | 上海速创诊断产品有限公司 | Microfluidic detection chip and manufacturing method therefor, fixing device, and centrifugal detection device |
| CN110726849A (en) * | 2019-10-08 | 2020-01-24 | 广州市赛特检测有限公司 | Automatic replacement detection device for biological detection chip |
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2017
- 2017-07-03 CN CN201720793410.5U patent/CN207036852U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107102131A (en) * | 2017-07-03 | 2017-08-29 | 沈阳微流控生物科技有限公司 | A kind of full-automatic micro-fluidic chip fluorescence immunoassay detecting system and its detection method |
| WO2020010913A1 (en) | 2018-07-12 | 2020-01-16 | 上海速创诊断产品有限公司 | Microfluidic detection chip and manufacturing method therefor, fixing device, and centrifugal detection device |
| US11123731B2 (en) | 2018-07-12 | 2021-09-21 | Shanghai Igenetec Diagnostics Co., Ltd. | Microfluidic detection chip, preparation method thereof, fixing device and centrifugal detection device |
| CN109946460A (en) * | 2019-04-18 | 2019-06-28 | 天津诺迈科技有限公司 | Chemiluminescence immunoassay detection device and application method based on micro-fluidic chip |
| CN109946460B (en) * | 2019-04-18 | 2023-09-22 | 天津诺迈科技有限公司 | Chemiluminescence immune detection device based on micro-fluidic chip and using method |
| CN110726849A (en) * | 2019-10-08 | 2020-01-24 | 广州市赛特检测有限公司 | Automatic replacement detection device for biological detection chip |
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Effective date of registration: 20190321 Address after: Room 2207-2213, No. 18-1 Nanping East Road Comprehensive Workshop, Hunnan New District, Shenyang City, Liaoning Province, 110000 Patentee after: Shenyang suprane Biological Technology Co. Ltd. Address before: 110000 Shenyang Free Trade Pilot Area, Shenyang, Liaoning Province, No. 109-1 Quanyun Road Patentee before: Shenyang microfluidics biological science and Technology Co Ltd |
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