CN1935798A - 一种穿心莲内酯的制备方法 - Google Patents
一种穿心莲内酯的制备方法 Download PDFInfo
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- CN1935798A CN1935798A CN 200510105514 CN200510105514A CN1935798A CN 1935798 A CN1935798 A CN 1935798A CN 200510105514 CN200510105514 CN 200510105514 CN 200510105514 A CN200510105514 A CN 200510105514A CN 1935798 A CN1935798 A CN 1935798A
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- macroporous resin
- alcohol
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- washing
- ethanol
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 26
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- 206010016825 Flushing Diseases 0.000 claims description 4
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- 238000011010 flushing procedure Methods 0.000 claims description 4
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- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 abstract description 3
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 abstract description 3
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- 239000003814 drug Substances 0.000 description 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
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- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 229940040145 liniment Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
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- 238000001179 sorption measurement Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
批次 | 1 | 2 | 3 |
穿心莲内酯纯度(%) | 98.6 | 99.3 | 100.2 |
批次 | 1 | 2 | 3 |
穿心莲内酯纯度(%) | 98.6 | 99.3 | 100.2 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005101055144A CN1935798B (zh) | 2005-09-23 | 2005-09-23 | 一种穿心莲内酯的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005101055144A CN1935798B (zh) | 2005-09-23 | 2005-09-23 | 一种穿心莲内酯的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1935798A true CN1935798A (zh) | 2007-03-28 |
CN1935798B CN1935798B (zh) | 2010-09-08 |
Family
ID=37953564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005101055144A Expired - Fee Related CN1935798B (zh) | 2005-09-23 | 2005-09-23 | 一种穿心莲内酯的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN1935798B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101040883B (zh) * | 2007-04-20 | 2010-11-17 | 广州中医药大学 | 一种穿心莲根提取物及其制备方法和在制备抗血栓药物中的应用 |
CN102382083A (zh) * | 2010-09-01 | 2012-03-21 | 天津天士力现代中药资源有限公司 | 一种穿心莲内酯的制备方法 |
CN101559088B (zh) * | 2009-05-21 | 2012-07-25 | 雷允上药业有限公司 | 穿心莲总内酯与新穿心莲内酯、脱水穿心莲内酯、去氧穿心莲内酯的生产工艺 |
CN103145661A (zh) * | 2013-03-25 | 2013-06-12 | 成都天台山制药有限公司 | 穿心莲内酯的新晶型 |
CN103265509A (zh) * | 2013-05-28 | 2013-08-28 | 江西中医学院 | 一种真空度调控辅助提取穿心莲活性成分的方法 |
CN104557818A (zh) * | 2014-12-16 | 2015-04-29 | 浙江维康药业有限公司 | 一种穿心莲内酯化合物及含有该化合物的滴丸和软胶囊 |
CN104557820A (zh) * | 2014-12-19 | 2015-04-29 | 浙江大学 | 一种纯化穿心莲内酯的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1301988C (zh) * | 2003-03-11 | 2007-02-28 | 随州三江源药业有限公司 | 一种从银杏叶中提取萜类内酯的方法及其得到的产品 |
-
2005
- 2005-09-23 CN CN2005101055144A patent/CN1935798B/zh not_active Expired - Fee Related
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101040883B (zh) * | 2007-04-20 | 2010-11-17 | 广州中医药大学 | 一种穿心莲根提取物及其制备方法和在制备抗血栓药物中的应用 |
CN101559088B (zh) * | 2009-05-21 | 2012-07-25 | 雷允上药业有限公司 | 穿心莲总内酯与新穿心莲内酯、脱水穿心莲内酯、去氧穿心莲内酯的生产工艺 |
CN102382083A (zh) * | 2010-09-01 | 2012-03-21 | 天津天士力现代中药资源有限公司 | 一种穿心莲内酯的制备方法 |
CN102382083B (zh) * | 2010-09-01 | 2015-07-15 | 天津天士力现代中药资源有限公司 | 一种穿心莲内酯的制备方法 |
CN103145661A (zh) * | 2013-03-25 | 2013-06-12 | 成都天台山制药有限公司 | 穿心莲内酯的新晶型 |
CN103145661B (zh) * | 2013-03-25 | 2014-06-18 | 成都天台山制药有限公司 | 穿心莲内酯的新晶型 |
CN103265509A (zh) * | 2013-05-28 | 2013-08-28 | 江西中医学院 | 一种真空度调控辅助提取穿心莲活性成分的方法 |
CN103265509B (zh) * | 2013-05-28 | 2016-01-20 | 江西中医学院 | 一种真空度调控辅助提取穿心莲活性成分的方法 |
CN104557818A (zh) * | 2014-12-16 | 2015-04-29 | 浙江维康药业有限公司 | 一种穿心莲内酯化合物及含有该化合物的滴丸和软胶囊 |
CN104557820A (zh) * | 2014-12-19 | 2015-04-29 | 浙江大学 | 一种纯化穿心莲内酯的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1935798B (zh) | 2010-09-08 |
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Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARM. CO., LTD. |
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Address after: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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Address after: 300410 Tianjin city Beichen District Huaihe road and road intersection Dingjiang tianzhijiao Park forensic Center for Intellectual Property Department Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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Granted publication date: 20100908 Termination date: 20190923 |
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