CN1780622A - 作为5－羟色胺再摄取抑制剂的4－(2－苯基硫烷基－苯基)－哌啶衍生物 - Google Patents

作为5－羟色胺再摄取抑制剂的4－(2－苯基硫烷基－苯基)－哌啶衍生物 Download PDF

Info

Publication number
CN1780622A
CN1780622A CNA2004800091749A CN200480009174A CN1780622A CN 1780622 A CN1780622 A CN 1780622A CN A2004800091749 A CNA2004800091749 A CN A2004800091749A CN 200480009174 A CN200480009174 A CN 200480009174A CN 1780622 A CN1780622 A CN 1780622A
Authority
CN
China
Prior art keywords
phenyl
base
fluoro
piperidines
alkene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800091749A
Other languages
English (en)
Chinese (zh)
Inventor
B·邦-安德森
A·皮施尔
M·约尔根森
T·鲁兰德
T·布赖恩斯滕博尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36091716&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1780622(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN1780622A publication Critical patent/CN1780622A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2004800091749A 2003-04-04 2004-04-02 作为5－羟色胺再摄取抑制剂的4－(2－苯基硫烷基－苯基)－哌啶衍生物 Pending CN1780622A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300520 2003-04-04
DKPA200300520 2003-04-04

Publications (1)

Publication Number Publication Date
CN1780622A true CN1780622A (zh) 2006-05-31

Family

ID=36091716

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800091749A Pending CN1780622A (zh) 2003-04-04 2004-04-02 作为5－羟色胺再摄取抑制剂的4－(2－苯基硫烷基－苯基)－哌啶衍生物

Country Status (10)

Country Link
KR (1) KR101107536B1 (ko)
CN (1) CN1780622A (ko)
AR (1) AR043965A1 (ko)
BR (1) BRPI0408647A (ko)
CL (1) CL2004000725A1 (ko)
EA (1) EA010869B1 (ko)
IS (1) IS2676B (ko)
NZ (1) NZ541859A (ko)
UA (1) UA81472C2 (ko)
ZA (1) ZA200507181B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101970408A (zh) * 2007-12-14 2011-02-09 H.隆德贝克有限公司 4-[2，3-二氟-6-(2-氟-4-甲基-苯基硫基)-苯基]-哌啶
CN105348204A (zh) * 2015-11-18 2016-02-24 乳源瑶族自治县大众药品贸易有限公司 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4198419A (en) * 1979-01-10 1980-04-15 American Hoechst Corporation Phenylthiophenylpiperidines
PL355289A1 (en) * 1999-10-13 2004-04-05 Pfizer Products Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101970408A (zh) * 2007-12-14 2011-02-09 H.隆德贝克有限公司 4-[2，3-二氟-6-(2-氟-4-甲基-苯基硫基)-苯基]-哌啶
CN105348204A (zh) * 2015-11-18 2016-02-24 乳源瑶族自治县大众药品贸易有限公司 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途
CN105348204B (zh) * 2015-11-18 2018-09-14 乳源瑶族自治县大众药品贸易有限公司 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途

Also Published As

Publication number Publication date
ZA200507181B (en) 2007-03-28
EA200501577A1 (ru) 2006-04-28
IS2676B (is) 2010-09-15
BRPI0408647A (pt) 2006-03-07
AR043965A1 (es) 2005-08-17
UA81472C2 (en) 2008-01-10
CL2004000725A1 (es) 2005-02-18
NZ541859A (en) 2008-10-31
IS7996A (is) 2005-08-22
KR20050119681A (ko) 2005-12-21
KR101107536B1 (ko) 2012-01-31
EA010869B1 (ru) 2008-12-30

Similar Documents

Publication Publication Date Title
CN1038932C (zh) 取代的哌啶类化合物的立体选择性制备方法
CN1210250C (zh) 苯衍生物、其制备方法以及含有它们的药用组合物
CN100351239C (zh) 嘧啶衍生物及其用作cb2调节剂的用途
CN1082040A (zh) 吲哚类
CN1290847C (zh) 氮杂－芳基哌嗪类化合物
CN1196680C (zh) 新的多巴胺神经传递调节剂
CN1741999A (zh) 用作GSK－3β抑制剂的哒嗪酮衍生物
CN1890218A (zh) 微管蛋白抑制剂
CN1668610A (zh) 苯基－[4－(3－苯基－1h－吡唑－4－基)－嘧啶－2－基]－胺衍生物
CN1934091A (zh) 治疗神经变性障碍的咪唑化合物
CN1060841A (zh) 喹唑啉衍生物及其制备方法
CN1268133A (zh) 含有稠合环取代基的作为nos抑制剂的2－氨基吡啶
CN1427825A (zh) 吲哚满－2－酮衍生物、其制备方法及其作为催产素受体配体的应用
CN1934082A (zh) 有机化合物
CN1610664A (zh) 3－氮杂二环[3.1.0]己烷衍生物作为类阿片受体拮抗剂
CN1515554A (zh) 生产2-氨基-6-(2-取代的-4-苯氧基)取代的吡啶类化合物的中间体
CN1839135A (zh) 三环δ阿片样物质调节剂
CN1250542C (zh) 具有抗肿瘤活性的2－(1h－吲哚－3－基)－2－氧代－乙酰胺
CN1809558A (zh) 作为5ht4－拮抗剂的4－(氨甲基)－哌啶苯甲酰胺
CN1906163A (zh) 作为肾素抑制剂的4－苯基哌啶衍生物
CN1926117A (zh) 用于改进感知、注意力、学习效率、和/或记忆力的6－氨基－5－氰基－嘧啶－4－酮类化合物
CN1668589A (zh) 6－位置经取代的吲哚啉衍生物、其制备及用作药剂的用途
CN1183907C (zh) 新的咪唑啉化合物、其制备方法和含有它们的药物组合物
CN1160332C (zh) 用于治疗抑郁症的n-芳氧基乙基胺衍生物
CN1777585A (zh) 作为5－羟色胺再摄取抑制剂的4－(2－苯硫基－苯基)－1,2,3,6－四氢吡啶衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1092060

Country of ref document: HK

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1092060

Country of ref document: HK