CN1709454A - Chinese medicine formulation for treating arthrolithiasis, and its preparing method - Google Patents
Chinese medicine formulation for treating arthrolithiasis, and its preparing method Download PDFInfo
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- CN1709454A CN1709454A CN 200510081575 CN200510081575A CN1709454A CN 1709454 A CN1709454 A CN 1709454A CN 200510081575 CN200510081575 CN 200510081575 CN 200510081575 A CN200510081575 A CN 200510081575A CN 1709454 A CN1709454 A CN 1709454A
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Abstract
The present invention relates to a Chinese medicine compound preparation for curing severe and migratory arthralgia due to damp-heat static blood obstruction. Said Chinese medicine compound preparation can be made up by using 5 Chinese medicinal materials of rhubarb, plantago seed, alisma tuber, cyathula root and tetrandra root, and can be made into the dosage forms of tablet, capsule, granules and pills. Besides, said invention also provides its preparation method and concrete steps.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of traditional Chinese compound medicine preparation for the treatment of goat, be particularly useful for the goat due to the dampness and heat stasis, it is characterized in that, per 1000 dosage units are made by following Chinese medicine raw materials by weight proportion: 90 parts of Radix Et Rhizoma Rhei, 60 parts of Semen Plantaginiss, 60 parts of Rhizoma Alismatis, 60 parts of Radix Cyathulaes, 30 parts of Radixs Stephaniae Tetrandrae.The present invention also provides the preparation method of the preparation of this compound medicine.
Background technology:
Gout is the disease that a kind of purine metabolic disturbance causes, it mainly is uric acid sodium salt deposition in vivo that its peculiar pathologic changes, it can cause the pathological changes at positions such as articular cartilage, bone marrow, synovial membrane, periarticular soft tissues and kidney, when urate crystal is calm, can cause partial inflammatory reaction: redness, heat, pain and dysfunction.
Used medicine all carries out from reducing uricopoiesis and increasing urate excretion two aspects.But because of there is bigger toxic and side effects in these medicines, the patient often can not adhere to taking medicine for a long time.Existing treatment goat mainly is to adopt steroidal anti-inflammatory drugs, Western medicine such as glucocorticoid, probenecid, allopurinol, colchicine.Though said medicine can stop the acute attack of gout rapidly, alleviate urate deposition in vivo, the outbreak of prevention gouty arthritis and the formation of gouty renal calculus, still, this type of medicine has in various degree detrimental effect to gastrointestinal tract, the unusual of liver, renal function can be caused when serious, after patient takes medicine for a long time, bone marrow depression in various degree can be caused, hepatic necrosis, oligospermia, mongolism, neurotoxicity reaction and gastrointestinal reaction.Therefore, because this type of poisonous side effect of medicine is bigger, should not take for a long time.
Its symptom of goat is based on joint of the lower extremity red and swollen heat pain repeatedly, belongs to damp and hot numbness category so Chinese medical discrimination.Its pathogenesis or because of the natural endowment deficiency, or because of the eating and drinking without temperance day after tomorrow, visceral dysfunction, distinguish not turbid not normal, dried be wet, heat, the stasis of blood, turbid all diseases gives birth to thereupon, therefore " rushing down turbid blood stasis dispelling " becomes a big main idea of Chinese traditional treatment goat.Once had some Chinese patent medicines to be used for the treatment of gout, but effect not being hated ideal, in the Chinese patent medicine, much is medicated wine effectively, and this is not suitable for not that alcoholic patient, anemia of pregnant woman, heart disease, hyperpietic take.
The objective of the invention is to: a kind of pure oral preparation of Chinese traditional medicinal is provided, and is monarch drug with the Radix Et Rhizoma Rhei in the side, but purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation makes body endogenous dampness, heat, the stasis of blood, turbid heresy descending from the discharge of intestinal internal organs, and the meridians of leading to; With Semen Plantaginis, Rhizoma Alismatis is ministerial drug, and the two is the good medicine commonly used of promoting diuresis with drugs of tasteless flavour, and damp is separated from urine.Compatibility Radix Cyathulae again, but eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome, its property is descending, and is identical with Radix Et Rhizoma Rhei, strengthens the effect of monarch drug, and plays the descending effect that reaches with four ends of priming, is guiding drug; The compatibility Radix stephaniae tetrandrae, inducing diuresis to remove edema, wind-expelling pain-stopping strengthens the power of damp eliminating, and both are adjuvant these.Medicine of the present invention is applicable to various goat patients, has the effect of expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, and curative effect is reliable.
Summary of the invention:
The invention provides a kind of Chinese medical discrimination for the treatment of and belong to traditional Chinese compound medicine preparation of the goat due to the dampness and heat stasis and preparation method thereof.
Compound Chinese medicinal preparation of the present invention, per 1000 dosage units, make by the raw material of Chinese medicine of following weight parts:
60 parts of 60 portions of Rhizoma Alismatis of 90 portions of Semen Plantaginiss of Radix Et Rhizoma Rhei
30 parts of 60 parts of Radixs Stephaniae Tetrandrae of Radix Cyathulae
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutical preparation of the present invention is to process through pulverizing or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the pharmaceutical preparation of the present invention, its shared percentage by weight in preparation can be 0.1～99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, in the unit dose, the amount that contains active substance is 5～800mg, preferably 20～500mg.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, oral liquid, syrup, unguentum, sublimed preparation, drop pill, patch, slow releasing preparation, controlled release preparation.
Pharmaceutical preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Pharmaceutical preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or tincture, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
The present invention also provides the preparation method of pharmaceutical preparation of the present invention, and preferred manufacturing procedure can be passed through following steps, according to prescription:
(1) Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae, Radix Stephaniae Tetrandrae are ground into fine powder;
(2) goods that obtain with step (1) are active constituents of medicine, and make preparation after the medicine acceptable carrier mixes.
The preparation that above step makes can be any pharmaceutical dosage form, preferably tablet, capsule, granule or pill.
Medicine of the present invention is used for the clinical treatment of goat, obtained better curative effect, show that the patient takes medicine after course of treatment, main clinic symptoms such as the joint is red, swollen, hot, pain are obviously alleviated, the pain relief rate reaches 84.5%, have patient's redness of 76.3% to disappear, lower limb disorder obviously alleviates, and mobility is improved greatly.Two courses of treatment of medication, the pain relief rate reaches 91.7%, and red and swollen extinction rate reaches 88.4%, clinical cure rate 21.6%, and obvious effective rate 45.7%, effective percentage 26.8%, total effective rate reaches 94.1%.
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of capsule of the present invention:
Take by weighing Radix Et Rhizoma Rhei 90g, Semen Plantaginis 60g, Rhizoma Alismatis 60g, Radix Cyathulae 60g, Radix Stephaniae Tetrandrae 30g is ground into fine powder, and mixing incapsulates, and makes 1000 (every 0.3g).
Embodiment 2:
The preparation method of tablet of the present invention:
Take by weighing Radix Et Rhizoma Rhei 90g, Semen Plantaginis 60g, Rhizoma Alismatis 60g, Radix Cyathulae 60g, Radix Stephaniae Tetrandrae 30g is ground into fine powder, and mixing is granulated, tabletting, coating is made 1000 (every 0.3g).
Embodiment 3:
The preparation method of granule of the present invention:
Take by weighing Radix Et Rhizoma Rhei 90g, Semen Plantaginis 60g, Rhizoma Alismatis 60g, Radix Cyathulae 60g, Radix Stephaniae Tetrandrae 30g is ground into fine powder, and mixing adds cane sugar powder 400g and dextrin 300g, and mixing is granulated, and packing is made 100 bags (every bag of 10g).
Embodiment 4:
The preparation method of pill of the present invention:
Take by weighing Radix Et Rhizoma Rhei 180g, Semen Plantaginis 120g, Rhizoma Alismatis 120g, Radix Cyathulae 120g, Radix Stephaniae Tetrandrae 60g is ground into fine powder, and mixing adds refined honey, and general ball is put in the vacuum drying oven in 70 ℃ of dryings, and 1000g (the heavy 0.65g of per 10 balls) is made in polishing.
Embodiment 5:
It is composed as follows to fill a prescription
Radix Et Rhizoma Rhei 90g Semen Plantaginis 60g Rhizoma Alismatis 60g
Radix Cyathulae 60g Radix Stephaniae Tetrandrae 30g
Preparation method is identical with embodiment 4.
Claims (7)
1. a compound Chinese medicinal preparation for the treatment of chronic nephropathy is characterized in that, per 1000 dosage units are made by the raw material of Chinese medicine of following weight parts:
60 parts of 60 portions of Rhizoma Alismatis of 90 portions of Semen Plantaginiss of Radix Et Rhizoma Rhei
30 parts of 60 parts of Radixs Stephaniae Tetrandrae of Radix Cyathulae
2. the compound Chinese medicinal preparation of claim 2 wherein also comprises the medicine acceptable carrier.
3. the compound Chinese medicinal preparation of claim 2 is tablet, capsule, granule or pill.
4. the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that, through following steps,
(1) Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae, Radix Stephaniae Tetrandrae are ground into fine powder;
(2) goods that obtain with step (1) are active constituents of medicine, add the medicine acceptable carrier, make preparation behind the mix homogeneously.
5. the preparation method of claim 4 is characterized in that, the preparation that step (2) makes is tablet, capsule, granule or pill.
6. the preparation method of claim 4 is characterized in that, step (2) adds the medicine acceptable carrier, is selected from: starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate; Water, starch slurry, kollidon aqueous solution, kollidon alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution, Mel, water-honey liquor; Carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, cross-linking sodium carboxymethyl cellulose; Magnesium stearate, Macrogol 4000, polyethylene glycol 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel; Correctives is selected from aspartame, flavoring orange essence, Herba Menthae essence.
7. the application of the compound Chinese medicinal preparation of claim 1～5 in the medicine of the goat due to the preparation treatment dampness and heat stasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510081575 CN1709454A (en) | 2005-07-04 | 2005-07-04 | Chinese medicine formulation for treating arthrolithiasis, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510081575 CN1709454A (en) | 2005-07-04 | 2005-07-04 | Chinese medicine formulation for treating arthrolithiasis, and its preparing method |
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| CN1709454A true CN1709454A (en) | 2005-12-21 |
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| CN 200510081575 Pending CN1709454A (en) | 2005-07-04 | 2005-07-04 | Chinese medicine formulation for treating arthrolithiasis, and its preparing method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152262B (en) * | 2007-09-25 | 2011-05-25 | 邱日辉 | Anti-gout novel medical preparation |
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
| CN104644911A (en) * | 2013-11-18 | 2015-05-27 | 沈阳绿洲制药有限责任公司 | Compound traditional Chinese medicinal preparation for treating gout |
| CN106214880A (en) * | 2016-10-20 | 2016-12-14 | 广西田林县林子蚂蜂养殖科技有限公司 | A kind of wasp wine treating gout |
| CN108186825A (en) * | 2018-03-07 | 2018-06-22 | 黄振忠 | A kind of drug for treating gout |
| CN113925915A (en) * | 2021-09-23 | 2022-01-14 | 凯乐康医药科技有限公司 | Borneol gel for treating gout |
-
2005
- 2005-07-04 CN CN 200510081575 patent/CN1709454A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152262B (en) * | 2007-09-25 | 2011-05-25 | 邱日辉 | Anti-gout novel medical preparation |
| CN104161912A (en) * | 2013-05-16 | 2014-11-26 | 康普药业股份有限公司 | Tongfengshu capsule and preparation method thereof |
| CN104644911A (en) * | 2013-11-18 | 2015-05-27 | 沈阳绿洲制药有限责任公司 | Compound traditional Chinese medicinal preparation for treating gout |
| CN106214880A (en) * | 2016-10-20 | 2016-12-14 | 广西田林县林子蚂蜂养殖科技有限公司 | A kind of wasp wine treating gout |
| CN108186825A (en) * | 2018-03-07 | 2018-06-22 | 黄振忠 | A kind of drug for treating gout |
| CN113925915A (en) * | 2021-09-23 | 2022-01-14 | 凯乐康医药科技有限公司 | Borneol gel for treating gout |
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