CN104161912A - Tongfengshu capsule and preparation method thereof - Google Patents
Tongfengshu capsule and preparation method thereof Download PDFInfo
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- CN104161912A CN104161912A CN201310181576.8A CN201310181576A CN104161912A CN 104161912 A CN104161912 A CN 104161912A CN 201310181576 A CN201310181576 A CN 201310181576A CN 104161912 A CN104161912 A CN 104161912A
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Abstract
The invention relates to a Tongfengshu capsule and a preparation method thereof. The Tongfengshu capsule is a Chinese medicinal preparation for treating gout, and is mainly composed of rhubarb, plantain seed, rhizoma alismatis, cyathula root and Radix Stephaniae Tetrandrae. The preparation method includes: in terms of weight percentage, taking 15-50% of rhubarb, 10-40% of plantain seed, 10-40% of rhizoma alismatis, 10-40% of cyathula root and 5-20% of Radix Stephaniae Tetrandrae, conducting superfine grinding on the medicinal materials to obtain fine powder, adding a proper amount of auxiliary materials, then carrying out mixing, granulating and drying, adding an appropriate lubricant, and filling a capsule, thus obtaining the Tongfengshu capsule. The Tongfengshu capsule produced by the method provided by the invention has the advantages of convenient taking, small dosage, convenient oral administration, and simple production equipment, thus being adaptive to industrial popularization.
Description
Technical field
The invention belongs to field of medicine preparations, specifically a kind of Chinese patent medicine preparation for the treatment of goat and preparation method thereof, particularly a kind of gout relieving capsule and preparation method thereof.
Background technology
Gout is a kind of because of purine metabolism obstacle, claim again " hyperuricemia ", belong to arthritic a kind of, claim again metabolic arthritis, be one group of disease that long-term purine metabolism obstacle, hyperuricemia cause tissue injury, in China's medical history, be referred to as " arthromyodynia ".Gout is generally divided into primary gout and secondary gout, primary gout is generally by due to inherited genetic factors, and the ribose phosphate pyrophosphoramide transferring enzyme that main manifestations is human body increases, and glutaminase active reduces, hypoxanthine oxidase increases, and glutathion reductase increases.Secondary gout main manifestations is that human body increases with purine is synthetic, and ribonucleic acid conversion increases, and kidney clearance rate declines.The Western medicine of existing treatment gout mainly adopts steroidal anti-inflammatory drugs, glucocorticoid, probenecid, allopurinol, colchicine, gout Radix Clematidis etc., though these medicines can be treated rapidly the acute attack of gout, but medicine itself has infringement in various degree to the intestines and stomach of human body, pharmacology toxic and side effects is large.
At present, the medicine of domestic institute production for treating gout is varied, for also carrying out in full preparation of the research and development of Chinese patent medicine.CN102000305 B discloses a kind of Chinese medicine preparation for the treatment of gout, and this invention preparation compositions crude drug is comprised of Rhizoma Smilacis Glabrae, Rhizoma Curcumae, Radix Angelicae Pubescentis, Radix Clematidis, Radix Dipsaci, Radix Cyathulae, Semen Plantaginis, Herba Spirodelae, Radix Solani indici, Fructus Chaenomelis, the Cortex Eucommiae, Olibanum, Myrrha, Rhizoma Sparganii.Said composition complicated component, on the one hand, Pharmacology needs to be investigated, and on the other hand, the method that this invention adopts filter and remove residue to make pill or directly take, reduces greatly for the curative effect of medical material and patient's medicine compliance.CN101167902 A discloses a kind of preparation method for the treatment of the Chinese medicine preparation of goat, and this invention is had children outside the state plan Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae and Radix Stephaniae Tetrandrae five kinds of Chinese medicine under certain condition after extraction or micronizing, adopts fluidized-bed spray granulation.This invented technology is advanced, and prescription is simple, but high for equipment requirements, and production cost is high relatively.
The medicine that Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae, Radix Stephaniae Tetrandrae are prepared as primary raw material is take in the present invention, has heat clearing away, dampness removing, detoxicating functions, for dampness and heat stasis goat extremely, therapeutic effect is good, has no side effect.The present invention makes capsule after directly pulverizing with 5 taste Chinese crude drugs, effectively preserved the curative effect of medical material, simultaneously capsule formulation has been covered unpleasant odour and the disintegrate more rapidly in patient body of Radix Et Rhizoma Rhei, Radix Cyathulae, is conducive to improve patient's compliance and the interior bioavailability of body.
Summary of the invention
The present invention aims to provide that a kind of prescription is simple, CN medical material is easy to get, good effect, disintegrate is fast, bioavailability is high, patient's medicine compliance is good Chinese medicine capsule preparation.
A kind of gout relieving capsule of the present invention and preparation method thereof; select capsule formulation; not only splendid to the preservation of medical material curative effect; and the unpleasant odour of having covered Radix Et Rhizoma Rhei, Radix Cyathulae improved patient's compliance, medicine disintegrate in human body is rapid, and bioavailability is greatly high; this invention preparation method is simple; save production cost, be applicable to enterprise scale and produce, had the prospect of marketing.
A kind of gout relieving capsule of the present invention and preparation method thereof, its technical scheme addressing the above problem is:
A kind of gout relieving capsule of the present invention and preparation method thereof, it is characterized in that, described prescription component is counted with umber: Radix Et Rhizoma Rhei 6-9 part, Semen Plantaginis 4-6 part, Rhizoma Alismatis 4-6 part, Radix Cyathulae 4-6 part, Radix Stephaniae Tetrandrae 2-3 part, hydroxypropyl methylcellulose 0.18-0.23 part, polyvidone 0.03-0.04 part, magnesium stearate 0.02-0.04 part, described preparation method, it is characterized in that, the method comprises pulverizing, mixing granulation, is dried, always mixes four large steps.
A kind of gout relieving capsule of the present invention and preparation method thereof, is characterized in that, described prescription main component percentage by weight is:
Radix Et Rhizoma Rhei 15-50%, Semen Plantaginis, Rhizoma Alismatis, each 10-40% of Radix Cyathulae, Radix Stephaniae Tetrandrae 5-20%, pharmaceutic adjuvant 0.1-2%.
A kind of gout relieving capsule of the present invention and preparation method thereof, is characterized in that, the preparation concrete steps of described gout relieving capsule are:
(1) Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae, Radix Stephaniae Tetrandrae 5 taste micronizing obtain fineness 100 order-200 object crude drug fine powders, mix with hydroxypropyl methylcellulose, add ethanol and polyvidone to be mixed with binding agent and granulate, and make particle drying, and the granulate that sieves is standby.
(2) granule of (1) step is added in mixer, then added the magnesium stearate of 80 mesh sieves, abundant mix homogeneously, filled capsules, gets product.
A kind of gout relieving capsule of the present invention and preparation method thereof, is characterized in that, the described ethanol of step (1) is the ethanol of 78-85% concentration.
A kind of gout relieving capsule of the present invention and preparation method thereof, is characterized in that, the binder concn of the described ethanol of step (1) and polyvidone preparation is 1.5-2.5%.
The simple introduction of each medicine and pharmacology in Chinese medicine formula of the present invention:
Radix Et Rhizoma Rhei: another name: general, Huang Liang, fire ginseng, skin are as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, raw army, Radix Et Rhizoma Rhei.Nature and flavor: hardship, cold.Gui Jing: stomach warp; Large intestine channel; Liver Channel; Spleen channel.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.
Semen Plantaginis: another name: Herba Plantaginis reality, Rana limnocharis clothing, pig ear tassel, phoenix eyes Semen Plantaginis.Nature and flavor: sweet; Light; Cold nature.Gui Jing: return lung meridian; Liver Channel; Kidney channel; Urinary bladder channel.Function: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.
Rhizoma Alismatis: another name: watery diarrhea, Rhizoma Alismatis, swan rush down, Semen Nelumbinis and rush down, Saxidomus purpuratus, day bald, grandson Yu.Nature and flavor: sweet; Light; Cold in nature.Gui Jing: return kidney channel; Urinary bladder channel.Function: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.
Radix Cyathulae: another name: Radix Achyranthis Bidentatae, day full Radix Achyranthis Bidentatae, all Radix Achyranthis Bidentatae, rice heart Radix Achyranthis Bidentatae, family's Radix Achyranthis Bidentatae, beef cattle knee joint, large Radix Achyranthis Bidentatae, turn Radix Achyranthis Bidentatae, RADIX CYATHULAE, sweet Radix Cyathulae, imperial Radix Achyranthis Bidentatae.Nature and flavor: sweet; Micro-hardship; Property is put down.Gui Jing: liver; Kidney channel.Function: blood circulation promoting and blood stasis dispelling; Expelling wind and removing dampness.
Radix Stephaniae Tetrandrae: nature and flavor: hardship, pungent, cold.Gui Jing: return urinary bladder channel, kidney channel, spleen channel.Function: wind-damp dispelling, pain relieving, diuretic.
Above data is taken from > > of Chinese Medicine publishing house version < < Pharmacopoeia of People's Republic of China in 2010.
The present invention has the following advantages:
1, medical material of the present invention is common is easy to get, and source is wide, and preparation method is simple, easy and simple to handle, and production cost is low.
2, preparation of the present invention has good drug efficacy, short treating period, instant effect, and bioavailability is high, has no side effect.
3, the invention provides capsule preparations, be applicable to crowd wide, medicine is easy to carry, is convenient to preserve.
The specific embodiment
Enforcement is below only for more detailed description the present invention, but do not limit in any form the present invention.
Embodiment 1
According to prescription, get Radix Et Rhizoma Rhei 6-9 part, Semen Plantaginis 4-6 part, Rhizoma Alismatis 4-6 part, Radix Cyathulae 4-6 part, Radix Stephaniae Tetrandrae 2-3 part, by 5 taste medical materials through selection, washing, dry after micronizing, obtain fineness 100 order-200 object crude drug fine powders, even through applicable mechanical agitation with 0.18-0.23 part hydroxypropyl methylcellulose, add 78-85% ethanol and 0.03-0.04 part polyvidone to be mixed with the binding agent granulation that concentration is 0.8-1.5%, make particle drying, granulate sieves, the magnesium stearate that adds 0.02-0.04 part, mix homogeneously, filled capsules, obtains.
Embodiment 2
According to prescription, get Radix Et Rhizoma Rhei 6-9 part, Semen Plantaginis 4-6 part, Rhizoma Alismatis 4-6 part, Radix Cyathulae 4-6 part, Radix Stephaniae Tetrandrae 2-3 part, by 5 taste medical materials through selection, washing, dry after micronizing, obtain fineness 100 order-200 object crude drug fine powders, even through applicable mechanical agitation with 0.18-0.23 part hydroxypropyl methylcellulose, add 78-85% ethanol and 0.03-0.04 part hydroxypropyl cellulose to be mixed with the binding agent granulation that concentration is 1.5-2.5%, make particle drying, granulate sieves, the magnesium stearate that adds 0.02-0.04 part, mix homogeneously, filled capsules, obtains.
Embodiment 3
According to prescription, get Radix Et Rhizoma Rhei 6-9 part, Semen Plantaginis 4-6 part, Rhizoma Alismatis 4-6 part, Radix Cyathulae 4-6 part, Radix Stephaniae Tetrandrae 2-3 part, by 5 taste medical materials through selection, washing, dry after micronizing, obtain fineness 100 order-200 object crude drug fine powders, even through applicable mechanical agitation with 0.18-0.23 part hydroxypropyl methylcellulose, add 78-85% ethanol and 0.03-0.04 part hydroxypropyl cellulose to be mixed with the binding agent granulation that concentration is 1.5-2.5%, make particle drying, granulate sieves, the silicon dioxide that adds 0.02-0.04 part, mix homogeneously, filled capsules, obtains.
Embodiment 4
According to prescription, get Radix Et Rhizoma Rhei 6-9 part, Semen Plantaginis 4-6 part, Rhizoma Alismatis 4-6 part, Radix Cyathulae 4-6 part, Radix Stephaniae Tetrandrae 2-3 part, by 5 taste medical materials through selection, washing, dry after micronizing, obtain fineness 100 order-200 object crude drug fine powders, even through applicable mechanical agitation with 0.18-0.23 part hydroxypropyl cellulose, add 78-85% ethanol and 0.03-0.04 part polyvidone to be mixed with the binding agent granulation that concentration is 0.8-1.5%, make particle drying, granulate sieves, the silicon dioxide that adds 0.02-0.04 part, mix homogeneously, filled capsules, obtains.
Claims (4)
1. gout relieving capsule and preparation method thereof, it is characterized in that, described prescription main component percentage by weight is: Radix Et Rhizoma Rhei 15-50%, Semen Plantaginis, Rhizoma Alismatis, each 10-40% of Radix Cyathulae, Radix Stephaniae Tetrandrae 5-20%, pharmaceutic adjuvant 0.1-2%, described preparation method, it is characterized in that, the method comprises pulverizing, mixing granulation, is dried, always mixes four large steps.
2. a kind of gout relieving capsule and preparation method thereof according to claim 1, is characterized in that, the preparation concrete steps of described gout relieving capsule are:
(1) Radix Et Rhizoma Rhei, Semen Plantaginis, Rhizoma Alismatis, Radix Cyathulae, Radix Stephaniae Tetrandrae 5 taste micronizing obtain fineness 100 order-200 object crude drug fine powders, mix with hydroxypropyl methylcellulose, add ethanol and polyvidone to be mixed with binding agent and granulate, and make particle drying, and the granulate that sieves is standby;
(2) granule of (1) step is added in mixer, then added the magnesium stearate of 80 mesh sieves, abundant mix homogeneously, filled capsules, gets product.
3. a kind of gout relieving capsule and preparation method thereof according to claim 2, is characterized in that, the described ethanol of step (1) is the ethanol of 50-90% concentration.
4. a kind of gout relieving capsule and preparation method thereof according to claim 2, is characterized in that, the binder concn of the described ethanol of step (1) and polyvidone preparation is 2-10%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310181576.8A CN104161912A (en) | 2013-05-16 | 2013-05-16 | Tongfengshu capsule and preparation method thereof |
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| CN201310181576.8A CN104161912A (en) | 2013-05-16 | 2013-05-16 | Tongfengshu capsule and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412270A (en) * | 2014-09-22 | 2016-03-23 | 天津巨兴科技发展有限公司 | Chinese herbal medicine compound preparation for treating gout |
| CN108420903A (en) * | 2018-05-02 | 2018-08-21 | 傅洪波 | Arhat gout dissipate and the preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709454A (en) * | 2005-07-04 | 2005-12-21 | 北京润德康医药科技有限公司 | Chinese medicine formulation for treating arthrolithiasis, and its preparing method |
| CN101264205A (en) * | 2008-04-25 | 2008-09-17 | 北京中泰天和科技有限公司 | Chinese medicinal composition for treating gout and preparation thereof |
| CN102670744A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Traditional Chinese composition for treating gout and preparation method of same |
| CN103028002A (en) * | 2011-09-29 | 2013-04-10 | 张金荣 | Pharmaceutical preparation for treating gout and preparation method thereof |
-
2013
- 2013-05-16 CN CN201310181576.8A patent/CN104161912A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709454A (en) * | 2005-07-04 | 2005-12-21 | 北京润德康医药科技有限公司 | Chinese medicine formulation for treating arthrolithiasis, and its preparing method |
| CN101264205A (en) * | 2008-04-25 | 2008-09-17 | 北京中泰天和科技有限公司 | Chinese medicinal composition for treating gout and preparation thereof |
| CN102670744A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Traditional Chinese composition for treating gout and preparation method of same |
| CN103028002A (en) * | 2011-09-29 | 2013-04-10 | 张金荣 | Pharmaceutical preparation for treating gout and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412270A (en) * | 2014-09-22 | 2016-03-23 | 天津巨兴科技发展有限公司 | Chinese herbal medicine compound preparation for treating gout |
| CN108420903A (en) * | 2018-05-02 | 2018-08-21 | 傅洪波 | Arhat gout dissipate and the preparation method and application thereof |
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Application publication date: 20141126 |