CN1537599A - Danshi Tongli granule for discharging biliary calculus, and its prepn. method - Google Patents
Danshi Tongli granule for discharging biliary calculus, and its prepn. method Download PDFInfo
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- CN1537599A CN1537599A CNA031183247A CN03118324A CN1537599A CN 1537599 A CN1537599 A CN 1537599A CN A031183247 A CNA031183247 A CN A031183247A CN 03118324 A CN03118324 A CN 03118324A CN 1537599 A CN1537599 A CN 1537599A
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Abstract
An improved Chinese medicine 'Danshi Tongli granule' for treating acute or chronic cholecystitis and cholelithiasis and its preparing process are disclosed. Its advantages are high curative effect, low dosage and high safety.
Description
Technical field
This invention relates to the particulate processing technology technical field of Chinese patent medicine, relates in particular to cholelithiasis treating Danshitongli granule and preparation method.
Background technology
Granule is the pharmaceutical formulation of using always, according to the relevant drug act of China, change dosage form as a kind of new drug research, the particulate original dosage form of cholelithiasis treating Danshitongli is the cholelithiasis treating Danshitongli capsule, has listed in national Bureau of Drugs Supervision's country's standard for traditional Chinese medicines compilation (terrestrial reference rises the GB tentative standard).The technology characteristics of former dosage form is: three flavors such as Olibanum break into fine powder in the prescription, and ten flavors such as all the other Herba Lysimachiaes decoct with water, and make thick paste, add above-mentioned fine powder, and drying is pulverized, and granulates, and is encapsulated, promptly.This medicine dose is big, one time 5, dysphagia, especially to old person, and this pharmaceutically dosage form is single, and application forms still has only capsule, far can not satisfy people's medication demand, its quality standard still can further improve simultaneously, and granule compares with it, also has onset advantage rapidly, based on this, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, the control criterion that improves the quality simultaneously guarantees the quality monitoring of product, improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of cholelithiasis treating Danshitongli granule and preparation method, improve the quality of products and curative effect, increase the stability of product, enrich medicine variety, to satisfy and to ensure people's medication demand better.
1, the particulate preparation method of cholelithiasis treating Danshitongli comprises the steps:
1.1 the particulate prescription of cholelithiasis treating Danshitongli is formed
Herba Lysimachiae 560-1700g Herba Artemisiae Scopariae 560-1700g Radix Curcumae 220-680g
Pericarpium Citri Reticulatae 350-1200g Radix Scutellariae 100-340g Olibanum 80-270g
Sal Nitri 200-600g Alumen 80-270g Radix Et Rhizoma Rhei 100-340g
Rhizoma sparganic 100-340g Fructus Gardeniae 100-340g Radix Glycyrrhizae 60-200g
Myrrha 80-270g right amount of auxiliary materials is made 1000 bags altogether.
Optimum formula is:
Herba Lysimachiae 1125g Herba Artemisiae Scopariae 1125g Radix Curcumae 450g Pericarpium Citri Reticulatae 750g Radix Scutellariae 225g
Olibanum 175g Sal Nitri 400g Alumen 175g Radix Et Rhizoma Rhei 225g rhizoma sparganic 225g
Fructus Gardeniae 225g Radix Glycyrrhizae 125g Myrrha 175g right amount of auxiliary materials is made 1000 bags altogether.
1.2 the particulate preparation technology of cholelithiasis treating Danshitongli
Technology one, will write out a prescription in 13 the flavor medicines be up to the standards standby respectively; Olibanum, Myrrha is ground into fine powder, and it is standby that Alumen is ground into fine powder; Ten flavors such as all the other Herba Lysimachiaes are ground into coarse powder/decoction pieces, decoct with water 2-3 time, decoct 1-3 hour at every turn, and collecting decoction filters, filtrate is condensed into thick paste, adds above-mentioned fine powder, mixes thoroughly, and vacuum drying is ground into fine powder, with the appropriate amount of auxiliary materials mixing, make granule, drying, granulate, packing, promptly.
Technology two, will write out a prescription in 13 the flavor medicines be up to the standards standby respectively; Olibanum, Myrrha is ground into fine powder, and it is standby that Alumen is ground into fine powder; Ten flavors such as all the other Herba Lysimachiaes are ground into coarse powder/decoction pieces, decoct with water 2-3 time, and each 1-3 hour, collecting decoction filtered, and the filtrate concentrate drying is made dried cream powder, adds above-mentioned fine powder and appropriate amount of auxiliary materials mixing, makes granule, drying, and granulate, packing, promptly.
1.3 by the technology gained is granule
The added adjuvant of cholelithiasis treating Danshitongli granule can be: 30 POVIDONE K 30 BP/USP
30, any or multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
Be ground into fine powder in the technology and be generally 80-160 purpose fine powder, the best is broken into 200-300 purpose fine powder for superfine powder.
Being ground into coarse powder/decoction pieces in the technology was 5-30 purpose coarse powder/decoction pieces, was preferably to be ground into 10 purpose coarse powder.
The condition that decocting boils in the technology is: amount of water is that 6-15 doubly measures for the first time, and second and third time doubly measured for 4-10, decocts each 1-3 hour 2-3 time.Best amount of water is 10 times of amounts for the first time in order to decoct three times, and second and third time is 8 times of amounts, 2 hours for the first time, and 1.5 hours for the second time, 1 hour for the third time.
The relative density that is condensed into thick paste in the technology is 1.15-1.45 (60 ℃), and best relative density is 1.36 (60 ℃).
Drying can adopt vacuum drying or adopt spray drying in the technology, and the vacuum drying temperature is controlled at 50-80 ℃, is preferably 60 ℃.Spray drying is for to be concentrated to the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.10 (60 ℃), and inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.
2, the particulate quality control standard of cholelithiasis treating Danshitongli further improves on the capsular basis of original cholelithiasis treating Danshitongli among the present invention, on differentiating former dosage form have Fructus Gardeniae, Pericarpium Citri Reticulatae, thin layer differentiate, now kept, and increased the thin layer of Radix Et Rhizoma Rhei, Radix Scutellariae, Herba Lysimachiae is differentiated; Former dosage form has carried out quantitatively now being kept to Pericarpium Citri Reticulatae on the assay, and increased to Radix Et Rhizoma Rhei quantitatively.
This invention is dosage form technological innovation on existing capsular basis, and quality standard has new raising again, to improving the quality of products significant meaning is arranged, and has enriched medicine variety, satisfies and ensured people's medication demand.
The specific embodiment
The optimum implementation of this invention is to be up to the standards 13 flavor medicines in the prescription standby respectively; Olibanum, Myrrha is ground into fine powder, and it is standby that Alumen is ground into fine powder; Ten flavors such as all the other Herba Lysimachiaes are ground into coarse powder, decoct with water 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filters, and filtrate is condensed into the concentrated solution that relative density is 1.08-1.10 (60 ℃), spray drying is collected dried cream powder, with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, make granule, drying, granulate, packing, promptly.
Claims (7)
1, a kind of cholelithiasis treating Danshitongli granule and preparation method is characterized in that:
(1) will write out a prescription in 13 the flavor medicines be up to the standards respectively standby, Olibanum, Myrrha is ground into fine powder, it is standby that Alumen is ground into fine powder, all the other Herba Lysimachiaes, Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae, Radix Scutellariae, Sal Nitri, Radix Et Rhizoma Rhei, rhizoma sparganic, Fructus Gardeniae, Radix Glycyrrhizae ten flavors are ground into coarse powder/decoction pieces, decoct with water 2-3 time, decoct collecting decoction 1-3 hour at every turn, filter, filtrate is condensed into thick paste, adds above-mentioned fine powder, mix thoroughly, vacuum drying is ground into fine powder, with the appropriate amount of auxiliary materials mixing, make granule, drying, granulate, packing, promptly.
(2) will write out a prescription in 13 the flavor medicines be up to the standards respectively standby, Olibanum, Myrrha is ground into fine powder, it is standby that Alumen is ground into fine powder, and all the other Herba Lysimachiaes, Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae, Radix Scutellariae, Sal Nitri, Radix Et Rhizoma Rhei, rhizoma sparganic, Fructus Gardeniae, Radix Glycyrrhizae ten flavors are ground into coarse powder/decoction pieces, decoct with water 2-3 time, each 1-3 hour, collecting decoction filtered, the filtrate concentrate drying is made dried cream powder, adds above-mentioned fine powder and appropriate amount of auxiliary materials mixing, makes granule, dry, granulate, packing, promptly.
2, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method, it is characterized in that: be ground into fine powder in the technology and be generally 80-160 purpose fine powder, the best is broken into 200-300 purpose fine powder for superfine powder, being ground into coarse powder/decoction pieces in the technology was 5-30 purpose coarse powder/decoction pieces, was preferably to be ground into 10 purpose coarse powder.
3, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method, it is characterized in that: the condition that decocting boils in the technology is: amount of water is that 6-15 doubly measures for the first time, second and third time doubly measured for 4-10, decocts each 1-3 hour 2-3 time, best for decocting three times, amount of water is 10 times of amounts for the first time, and second and third time is 8 times of amounts, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time.
4, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method is characterized in that: the relative density that is condensed into thick paste in the technology is 1.15-1.45 (60 ℃), and best relative density is 1.36 (60 ℃).
5, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method, it is characterized in that: drying can adopt vacuum drying/employing spray drying in the technology, the vacuum drying temperature is controlled at 50-80 ℃, be preferably 60 ℃, spray drying is for to be concentrated to the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, spray drying, inlet temperature is 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.10 (60 ℃), inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.
6, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method is characterized in that: the added adjuvant of cholelithiasis treating Danshitongli granule can be: 30 POVIDONE K 30 BP/USP
30, any/multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
7, cholelithiasis treating Danshitongli granule according to claim 1 and preparation method is characterized in that: have the thin layer of Radix Et Rhizoma Rhei, Radix Scutellariae, Herba Lysimachiae to differentiate that the quantitative assay of Radix Et Rhizoma Rhei is arranged on quality inspection standard.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031183247A CN1537599A (en) | 2003-04-20 | 2003-04-20 | Danshi Tongli granule for discharging biliary calculus, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031183247A CN1537599A (en) | 2003-04-20 | 2003-04-20 | Danshi Tongli granule for discharging biliary calculus, and its prepn. method |
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| Publication Number | Publication Date |
|---|---|
| CN1537599A true CN1537599A (en) | 2004-10-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031183247A Pending CN1537599A (en) | 2003-04-20 | 2003-04-20 | Danshi Tongli granule for discharging biliary calculus, and its prepn. method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323712C (en) * | 2005-08-25 | 2007-07-04 | 咸阳步长医药科技发展有限公司 | Medicine composition for treating cholelithiasis |
| CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN110638865A (en) * | 2019-08-20 | 2020-01-03 | 广西万寿堂药业有限公司 | Traditional Chinese medicine composition containing oldenlandia and preparation method thereof |
-
2003
- 2003-04-20 CN CNA031183247A patent/CN1537599A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323712C (en) * | 2005-08-25 | 2007-07-04 | 咸阳步长医药科技发展有限公司 | Medicine composition for treating cholelithiasis |
| CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN102357215B (en) * | 2011-11-16 | 2013-01-02 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN110638865A (en) * | 2019-08-20 | 2020-01-03 | 广西万寿堂药业有限公司 | Traditional Chinese medicine composition containing oldenlandia and preparation method thereof |
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