CN1318042C - Application of barbat skullcap in preparing medication for treating diabetes - Google Patents
Application of barbat skullcap in preparing medication for treating diabetes Download PDFInfo
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- CN1318042C CN1318042C CNB2004100924557A CN200410092455A CN1318042C CN 1318042 C CN1318042 C CN 1318042C CN B2004100924557 A CNB2004100924557 A CN B2004100924557A CN 200410092455 A CN200410092455 A CN 200410092455A CN 1318042 C CN1318042 C CN 1318042C
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Abstract
The present invention provides an application of barbed skullcap herb in preparing a drug for curing diabetes, the drug and a method for preparing the drug. Active ingredients of the drug are barbed skullcap herb powder. The whole barbed skullcap herb is used as raw medicinal materials, impurities are taken out, residual roots are removed, and the barbed skullcap herb is scalded in 85 to 95 DEG C. of hot water for 1 to 3 minutes; after quickly cooled down, the barbed skullcap herb is dried and is ground into fine powder; the raw material medicinal powder is made into a capsule preparation according to the conventional technology, and each capsule contains 0.6 to 0.8 g of the raw drugs. The barbed skullcap herb is used as the drug for curing diabetes, and the effect of the medical application is obvious. The drug for curing diabetes of the present invention can obviously reduce blood sugar, can cure diabetic complications, and can improve the health condition of diabetes patients. The drug for curing diabetes has the advantages of obvious curative effect, no toxic side effect on taking the drug for a long time and low price, and the drug for curing diabetes is a novel drug for treating diabetes.
Description
Technical field
The invention belongs to the new purposes of medicine, be specifically related to the purposes of Herba Portulacae Grandiflorae aspect preparation treatment diabetes medicament.
Background technology
Diabetes reduce mainly due to insulin in the body or lack, and make carbohydrate metabolism get muddled institute extremely, and any age all can fall ill, but in the majority with the middle-aged and elderly people after 40 years old.The oral drugs that are used for the treatment of this class disease at present are a lot, can be divided into two classes substantially, and a class is a chemical synthetic drug, and a class is a compound Chinese medicinal preparation.Chemical synthetic drug or because of its side effect is bigger, late result is not good should not be taken for a long time, particularly requires careful usefulness for some gastroenteropathy patients or hepatic and kidney function obstacle person; Or because of it costs an arm and a leg, the patient burden does not rise.The traditional Chinese medical science is called diabetes " quenching one's thirst ", and what employing at present was more in the compound Chinese medicinal preparation is diabetes pill and ten Six-element diabetes capsule.
The prescription of diabetes pill is: Radix Puerariae, Radix Rehmanniae, the Radix Astragali, Radix Trichosanthis, Stigma Maydis, Fructus Schisandrae Sphenantherae, Rhizoma Dioscoreae, glibenclamide (Western medicine).Diabetes pill is a Chinese and Western medicine mixture, and wherein the Therapeutic Principle of Chinese medicine is nourishing kidney-YIN, supplementing QI for promoting the production of body fluid, is used for type of deficiency of both QI and YIN and quenches one's thirst.Owing to contain glibenclamide, multiple untoward reaction might take place in period in a medicine, requires weakling and old people Ying Shenyong, hepatic and kidney function obstacle person forbidding.
The prescription of ten Six-element diabetes capsule is: the Radix Astragali, Radix Rehmanniae, Radix Ginseng, Radix Glehniae, Fructus Corni, Rhizoma Dioscoreae Gypsum Fibrosum, Rhizoma Coptidis, Radix Trichosanthis, Radix Puerariae, the Rhizoma Anemarrhenae, Poria, Rhizoma Alismatis, Rhizoma Atractylodis, Radix Salviae Miltiorrhizae, Fructus Lycii.Its Therapeutic Principle is benefiting qi and nourishing yin, clearing away heat and promoting production of body fluid, is used for the auxiliary treatment of deficiency of YIN dryness-heat type diabetes.
Also have some Chinese patent medicine preparations, do not exemplify one by one here.
Above compound Chinese medicinal preparation has certain curative effect to the diabetes of different disease types.Because type ii diabetes is commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people, need take medicine throughout one's life for the disease controlling diabetics, compound Chinese medicinal preparation costs an arm and a leg, and this has just brought very big financial burden to the patient.If the medicine of a kind of good effect, low-cost treatment diabetes can be arranged, be numerous diabeticss, one of the rural area diabetics big Gospel particularly.
Summary of the invention
The Chinese herbal medicine Herba Portulacae Grandiflorae is the herb of portulacaceous plant Portulaca grandilora.Portulaca grandilora (Portulacagrandiflora Hook) is annual meat herbaceous plant, and all there is cultivation various places.The Chinese medicine voluminous dictionary is on the books, its nature and flavor: " hardship, cold." function cures mainly: heat clearing away, detoxifcation.Control laryngopharynx swelling and pain, scald traumatic injury, eczema.By retrieval, find no the bibliographical information of pass Chinese herbal medicine Herba Portulacae Grandiflorae aspect the treatment diabetes.
The purpose of this invention is to provide the purposes of a kind of Herba Portulacae Grandiflorae aspect preparation treatment diabetes medicament.
Another object of the present invention provides the preparation method of medicine and this medicine of above-mentioned treatment diabetes.
Traditional Chinese medical science traditional theory is thought, eats sweet plump flavor impairing the spleen and stomach, and transformation failure of spleen leads to interior-heat, pents up dryness-transformation, and rapid digestion of food consumes Tianjin and sends out to quenching one's thirst; Or five will too drastic, strongly fragrant and fire-transformation, the bright body fluid that disappears also can cause and quench one's thirst.In a word, the scorching fire-transformation of the deficiency of YIN that multiple reason causes, it is the main cause of primary disease that Tianjin is dried up hot excessive.Its nature and flavor of Herba Portulacae Grandiflorae " hardship, cold " are got at the present invention this key of hitting, function heat clearing away, detoxifcation, single with simply, the efficacy of a drug is absorbed in, clearly its heat then fire does not pull the devil by the tail from the body fluid that goes out, separate then pure and impure clearly demarcated each smooth its road of its poison, quench one's thirst from controlling it.
Based on above theory of Chinese medical science, inventive point of the present invention is the purposes of Herba Portulacae Grandiflorae aspect preparation treatment diabetes medicament.
According to the purposes of said medicine, the medicine that is used for the treatment of diabetes of the present invention's preparation is made up of active component and pharmaceutically acceptable carrier, and described active component is the Herba Portulacae Grandiflorae powder.
The preparation method that the present invention treats the medicine of diabetes is: get the Herba Portulacae Grandiflorae herb as crude drug, choose clean impurity, remove undesirable root, scalded 1-3 minute in 85-95 ℃ hot water, cooling is milled to pasty state rapidly, and the vacuum concentration after drying becomes powder; Above raw material medicated powder is prepared into capsule preparations according to common process, and every capsules contains medicated powder 0.6-0.8 gram.
Another preparation method that the present invention treats the medicine of diabetes is: get the Herba Portulacae Grandiflorae herb as crude drug, choose clean impurity, remove undesirable root, in 85-95 ℃ hot water, scalded 1-3 minute, wear into fine powder after the oven dry, be prepared into capsule preparations according to common process then, every capsules contains medicated powder 0.6-0.8 gram.
The present invention is with the medicine of Herba Portulacae Grandiflorae as the treatment diabetes, and the purposes effect of medicine is remarkable, takes the medicine of the treatment diabetes of the present invention's preparation, and energy is blood sugar lowering obviously, and can treat the complication of diabetes, improves diabetes patient's health status.Because this medication is imitated obviously, to take for a long time and have no side effect, low price is a kind of medicine of novel treatment diabetes.
The specific embodiment
According to above-mentioned Herba Portulacae Grandiflorae in the purposes aspect the preparation treatment diabetes medicament, the active component that the present invention is used for the production for treating diabetes medicine is the Herba Portulacae Grandiflorae powder, its preparation method is: get free of contamination Herba Portulacae Grandiflorae herb as crude drug, choose clean impurity, remove undesirable root, scalded 2 minutes in 90 ℃ hot water, after the cooling, the oven dry mill is fine powder rapidly; Above raw material medicated powder is prepared into capsule preparations according to common process, and every capsules contains medicated powder 0.6-0.8 gram.
The present invention treats the preparation method of the medicine of diabetes, and wherein the active component of Herba Portulacae Grandiflorae becomes pharmaceutical composition with pharmaceutically acceptable vehicle group, makes powder, tablet, granule, electuary, pill, capsule and oral liquid.
Case 1: Lee * *, the man, 57 years old, the Dong Zhen of Wenxi County united principal, suffered from diabetes through the May 4th one examination in hospital in 1997, blood glucose 13.7, glucose in urine (++ ++), in JIUYUE in the same year hospitalization on the 4th, symptom takes an evident turn for the better.The clothes diabetes pill, is taken at twice at 20 of every days after leaving hospital.But fasting glucose is still more than 7, and two hours after the meal blood glucose is about 10, and fatigue and weak, blood pressure are 140/90.June 2 calendar year 2001, inactive diabetes pill changed clothes Herba Portulacae Grandiflorae capsule, took at twice 8 of every days, took 1 wheat harvesting period, diabetic symptom promptly disappears, and about 5.2-6.1, glucose in urine is (-) to fasting glucose substantially, post-prandial glycemia is about 7, and blood pressure reduces to 120/80, and taking medicine is quite a different person.Take medicine twice every day now, sooner or later taking medicine before meal 3-4 grain.
Case 2: permitted * *, the woman, 53 years old, calendar year 2001 health get fat, the whole body pruritus, arthralgia, waist soreness, myasthenia of limbs, or moving, or have a meal, or sleep all perspires, turbid urine, dry mouth and tougue is had a sleepless night.On January 4th, 2002, through Wenxi County's examination in hospital, blood pressure 140/90, blood glucose 6.9, glucose in urine (+++), urine protein (+) is diagnosed as diabetes.Hypoglycemia occurs after taking diabetes pill, effect is undesirable.So begin to take Herba Portulacae Grandiflorae with in April, 2002, take 1 wheat harvesting period three-many-one-little phenomenon and disappear, on one's body energetically, also superficial, sleep might as well.Chemical examination on May 20th, 2002, blood glucose is 5.4, and glucose in urine and urine protein are (-), and I identify oneself transference cure, and disease is fully recovered, just withdrawal.Nearly 2 months of drug withdrawal, hospital finds her and suffers from hysteroma, has an operation in hospital July 17, and hospital does not know that she is the diabetes patient, checks that chemical examination blood glucose is also very normal.It is very successful to perform the operation, and all are normal in the back of leaving hospital.Spent a period of time again, she feels that xerostomia is thirsty, numb hand and foot, and whole body is scratched where it itches, and insomnia is nervous, and is forgetful, mood agitation, general weakness, frequent micturition.On January 10th, 2003, remove Wenxi County's examination in hospital, fasting glucose is 11, and glucose in urine is (++ ++), and urine protein is (±), and blood pressure is 150/90, whole body is swollen, edema of lower limbs.Begin again to take the Herba Portulacae Grandiflorae capsule, add the diabetes pill capsule, obey drug withdrawal behind 6 bottles of diabetes pilles, only obey Herba Portulacae Grandiflorae every day.In May, 2004, chemical examination blood glucose reduces to 5.4, and glucose in urine and urine protein are (-), have not had a sleepless night, and swelling has also disappeared, spiritedness, blood pressure reduces to 120/80, the ailing elimination.Also hold on now and take the Herba Portulacae Grandiflorae capsule, respectively obey two every day sooner or later ante cibum.
The present invention successively takes the capsular type ii diabetes patient of Herba Portulacae Grandiflorae to 40 aspirations since calendar year 2001, carries out clinical observation, male 22 people wherein, and women 18 people, maximum 70 years old age, minimal ages 47 years old, the shortest 2 years of the course of disease, the course of disease is the longest 15 years.Take the Herba Portulacae Grandiflorae capsule according to the present invention's preparation, every day twice, each 4,60 days is a course of treatment.Therapeutic outcome shows: blood glucose, glucose in urine obviously descend." new drug (Chinese medicine) the treatment diabetes clinical research Therapeutic Principle " that formulate according to health ministry bureau of drug administration judges that produce effects (clinical cure) reaches 80.0%, and effective (improvement) reaches 15%, and total effective rate reaches 95%.And stable disease, relative complication has also had obvious treatment and improvement, does not also have hypoglycemic reaction.Originally taking showing of diabetes pill changes into and take the reflection of the capsular diabetics of Herba Portulacae Grandiflorae: " take the diabetes pill dose and be difficult for grasping, cause blood glucose fluctuated, and be prone to the hypoglycemia phenomenon, the control effect is undesirable." to confirm that the present invention is used for the treatment of diabetes safe and effective, its effect is better than diabetes pill.
The present invention takes Herba Portulacae Grandiflorae capsule curative effect statistical table to the type ii diabetes patient
| Produce effects (healing) | Effectively (improvement) | Invalid | Add up to | Total effective rate | |||
| Number | ％ | Number | ％ | Number | ％ | Number | ％ |
| 32 | 80 | 6 | 15 | 2 | 5 | 40 | 95 |
Illustrate: (1) [curative effect determinate standard] formulated " new drug (Chinese medicine) treatment diabetes clinical research Therapeutic Principle " according to Ministry of Public Health bureau of drug administration and is divided into three grades.A produce effects [clinical cure]: treatment back symptom disappears substantially, and fasting glucose is reduced to 7.2mmol/L and following, and glucose in urine is below (+) reaches.B is (improvements) effectively, and treatment back symptom is obviously improved, and fasting glucose is reduced to 8.3mmol/L and following, and glucose in urine is reduced to below (++) reach.C is invalid: treatment back symptom does not have obvious improvement, and blood glucose, glucose in urine do not reach above-mentioned standard.
Claims (5)
1, the purposes of Herba Portulacae Grandiflorae aspect preparation treatment diabetes medicament.
2, a kind of medicine for the treatment of diabetes, it is made up of active component and pharmaceutically acceptable carrier, it is characterized in that described active component is the Herba Portulacae Grandiflorae powder, this powder is to get the Herba Portulacae Grandiflorae herb as crude drug, scalded 1-3 minute in 85-95 ℃ hot water, cooling is milled to pasty state rapidly, the vacuum concentration after drying becomes powder or scalded 1-3 minute in 85-95 ℃ hot water, wears into fine powder after the oven dry.
3, the preparation method of the medicine of treatment diabetes according to claim 2 is characterized in that getting the Herba Portulacae Grandiflorae herb as crude drug, chooses clean impurity, remove undesirable root, in 85-95 ℃ hot water, scalded 1-3 minute, rapidly cooling, be milled to pasty state, the vacuum concentration after drying becomes powder; Above raw material medicated powder is prepared into capsule preparations according to common process, and every capsules contains medicated powder 0.6-0.8 gram.
4, the preparation method of the medicine of treatment diabetes according to claim 2, it is characterized in that getting the Herba Portulacae Grandiflorae herb as crude drug, choose clean impurity, remove undesirable root, in 85-95 ℃ hot water, scalded 1-3 minute, wear into fine powder after the oven dry, be prepared into capsule preparations according to common process then, every capsules contains medicated powder 0.6-0.8 gram.
5, the preparation method of the medicine of treatment diabetes according to claim 2 is characterized in that the active component of above-mentioned Herba Portulacae Grandiflorae becomes pharmaceutical composition with pharmaceutically acceptable vehicle group, makes powder, tablet, granule, electuary, pill or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100924557A CN1318042C (en) | 2004-12-28 | 2004-12-28 | Application of barbat skullcap in preparing medication for treating diabetes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100924557A CN1318042C (en) | 2004-12-28 | 2004-12-28 | Application of barbat skullcap in preparing medication for treating diabetes |
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| Publication Number | Publication Date |
|---|---|
| CN1660294A CN1660294A (en) | 2005-08-31 |
| CN1318042C true CN1318042C (en) | 2007-05-30 |
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| CNB2004100924557A Expired - Fee Related CN1318042C (en) | 2004-12-28 | 2004-12-28 | Application of barbat skullcap in preparing medication for treating diabetes |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518622B (en) * | 2008-02-27 | 2011-01-12 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetes complicated with urinary infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172705C (en) * | 2002-11-29 | 2004-10-27 | 贵州健兴药业有限公司 | Patent Chinese medicine for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172705C (en) * | 2002-11-29 | 2004-10-27 | 贵州健兴药业有限公司 | Patent Chinese medicine for treating diabetes |
Non-Patent Citations (5)
| Title |
|---|
| 中药半枝莲的研究进展 谭永红，王诗华，梁容梅，西南国防医药，第12卷第2期 2002 * |
| 半支莲 新农业，第8期 2004 * |
| 半支莲 新农业，第8期 2004;半支莲与保健 家庭医学，第9期 2000;鲜马齿见在临床上的应用 时珍国医国药，第12卷第3期 2001;中药半枝莲的研究进展 谭永红，王诗华，梁容梅，西南国防医药，第12卷第2期 2002 * |
| 半支莲与保健 家庭医学，第9期 2000 * |
| 鲜马齿见在临床上的应用 时珍国医国药，第12卷第3期 2001 * |
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| CN1660294A (en) | 2005-08-31 |
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