CN1277852A - Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process - Google Patents
Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process Download PDFInfo
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- CN1277852A CN1277852A CN 00109186 CN00109186A CN1277852A CN 1277852 A CN1277852 A CN 1277852A CN 00109186 CN00109186 CN 00109186 CN 00109186 A CN00109186 A CN 00109186A CN 1277852 A CN1277852 A CN 1277852A
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Abstract
The present invention relates to a traditional Chinese medicine for preventing and treating senile dementia and depression, and it is composed of gingko leaf, ginseng, and herba epimedii. It is prepared through market purchasing, weighing, drying pulverizing, dipping, decocting, alcohol extracting, concentrating, and combining. Advantages include abundant raw material, easy to prepare, simple in method, and low in cost.
Description
The present invention relates to a kind of medicine and preparation technology who prevents and treats alzheimer disease and depression, relate to specifically a kind ofly be prepared from by Folium Ginkgo, Radix Ginseng and Herba Epimedii, to preventing and treating senile dementia and depression is evident in efficacy, have another name called medicine and preparation technology for " the clever nanocapsule of silver ginseng ".
At present, along with the progress of society, the raising of living standards of the people, people more and more pay attention to the health of self.From the medical science angle analysis: human free radical is some macromolecules, and it can pass through the Oxidation damaging cells, makes human organ aging, and human body (old people) is easy to make it to produce balance-loss state, i.e. alzheimer disease or depression with advancing age.Yet, existingly can play some side's medicines that defying age is prevented and treated alzheimer disease and depression, " obstinately follow tradition " very much constantly on the medicine selecting, influenced the selected of active drug; In addition, also lack modern medicine theoretically to prescription face progress of research; Moreover its drug effect of medicine of existing treatment alzheimer disease and depression is poor, and it is slow to take effect, even the medicine that has is absolutely void, takes nothing for a long time and very acts on, and cost is high again.So existing medicine can not satisfy people's demand, old friends wish to have a kind of with low cost, cure rate is high, the medicine that can effectively prevent and treat alzheimer disease and depression comes out.
Solution of the present invention is to be monarch with the puckery flat Folium Ginkgo of nature and flavor sweetness and bitterness, gets the effect of its " the beneficial heart is astringed the lung, severe palpitation, " " Chinese medicine voluminous dictionary " " QI invigorating nourishes heart, the kidney tonifying YIN nourishing ".Clinical practice, Folium Ginkgo have the cerebral blood flow increasing amount, blood vessel dilating, and blood viscosity lowering, anti-hypoxia improves memory, anxiety ... Deng effect, so as monarch; Radix Ginseng with little hardship sweet in flavor and warm in property is a minister, gets its strongly invigorating primordial QI, promotes the production of body fluid admittedly take off, nourishing the brain and tranquilizing the mind, the effect of happy Fructus Alpiniae Oxyphyllae is with auxilliary monarch drug Folium Ginkgo, clinical practice finds that Radix Ginseng can not only improve circulation, increases coronary blood flow, the protection heart, and can improve brain tissue metabolism, repair dysmnesia, anti-hypoxia, defying age, resisting fatigue is reconciled immunologic function ... or the like, so as minister; Herba Epimedii with property acrid-sweet flavor temperature is an assistant, goes into Liver and kidney two warps, gets its kidney invigorating and YANG supporting; the benefit essence is good for bone, dispels the effect of rheumatism, " herbal text ": " specially invigorating kidney-YANG "; " Elementary Medicine " " controls the hemiplegia hands and feet caused by paralysis, the extremity numbness of the skin " etc., through clinical observation " Herba Epimedii has the reinforcement myocardial contraction; coronary blood flow increasing, the protection brain cell, antioxidation; defying age; anoxia enduring, so short gonad functions etc. are as assistant.
After the combination of above-mentioned three medicines, but nourishing the liver and kidney, sperm adding and marrow healthing, regulating functional activities of vital QI, YIN and YANG balance regulating is to preventing and treating senile dementia and curative effect of depression is remarkable.
The object of the present invention is to provide a kind ofly to be prepared from by Folium Ginkgo, Radix Ginseng and Herba Epimedii, with low cost, cure rate is high, can effectively prevent and treat the medicine and the preparation technology of alzheimer disease and depression.
The object of the present invention is achieved like this, it is made up of Folium Ginkgo, Radix Ginseng and Herba Epimedii, through being purchased, weighing, drying, pulverizing, immersion, decocting in water, alcohol extraction, concentrating, merge prepared and form, it is characterized in that: it is the medicine of being made by the following weight proportion raw material:
Folium Ginkgo 100-280g
Radix Ginseng 100-280g
Herba Epimedii 150-420g.
Prevent and treat the preparation technology of the medicine of alzheimer disease and depression, it is characterized in that, press following prepared:
(1) preparation of Semen Ginkgo glycoside
1. with the Folium Ginkgo chopping, steeped 1 hour with two times of water loggings, after 1 hour, boiling water boiled 1 hour, leached water cooking liquid, and its medicinal residues add 2 times of water again, and boiling water boils half an hour, leaches water cooking liquid once more, extracted twice liquid is merged,
2. decompression is concentrated into 1/5 of original volume under 60 ℃ of conditions, after the cooling, adds the isopropyl alcohol that concentrates long-pending 2 times of liquid, precipitating proteins and jelly, the sedimentary solution of filtering adds the distilled water of 1/5 volume, boils off isopropyl alcohol again, filtered while hot is put coldly, separates out thick Folium Ginkgo glycoside
3. leaching, drying makes it to be dissolved in the dehydrated alcohol of 10 times of volumes, and filtering insoluble matter, solution add 1/5 suitable quantity of water, boil off ethanol, add 15g silica gel and stir, remove red pigment in the solution, take advantage of the occasion again to filter, after the filtrate cooling, promptly have pure Semen Ginkgo glycoside to separate out, drying gets the Semen Ginkgo glycoside
(2) preparation of icariine
1. get the Herba Epimedii chopping, steeped 1 hour with 2 times of water loggings, decocting in water leached in 1 hour, added 2 times water again, and decocting in water 1 hour filters, merging filtrate,
2. concentrate at once, be concentrated into 1/5 extractum shape of original volume,
3. use 95% alcohol reflux secondary of one times of concentrated solution, alcohol extraction is got liquid and is merged, and reclaims ethanol, gets pure rare extractum,
4. use the long-pending dichloromethane extraction of quite pure rare extractum monoploid 5 times, till the dichloromethane color is shallow,
6. reuse chloroform: methanol=5: 1 one times of water layer volumes, aqueous layer extracted, at last the ethyl acetate of inferior water layer with one times of water layer volume extracted 5 times, merge the ethyl acetate extract, reclaim solvent to 1/5 of original volume and will concentrate placement, separate out yellow powder, with 60% ethyl alcohol recrystallization three times, get yellow acicular crystal, be icariine
(3) be purchased or make by oneself the ginsenoside:
1. get Radix Ginseng and make 20 purpose ginsenoside powder, soak with two times of Radix Ginseng coarse powder volumes methanol, heat to 80 ℃ of extractions, extracting solution is concentrated into original volume 1/5, places, and has Saponin to separate out,
2. in concentrated solution, add the ether of suitable concentrated solution volume 10-15 amount, quicken to settle out, purification,
3. add 95% ether of 1/3 amount, Saponin is separated out, and filters, and it is good to handle three purity,
(4) with the Semen Ginkgo glycoside of above-mentioned (), the icariine of (two), ginsenoside's mix homogeneously of (three), with solid phase enclose method: get it filled thing and cyclodextrin, after molecular proportion dissolving in 1: 1, row solid phase bag and, with capsule subpackage, promptly get the medicine that the present invention prevents and treats alzheimer disease and depression again
The present invention compared with prior art, its raw material sources is wide, preparation easily, method is simple, with low cost, its medicine has that logical god adds that marrow, nourishing the liver nourishing kidney, the beneficial heart are astringed the lung, the effect of blood circulation promoting and blood stasis dispelling, coordinating YIN and YANG, anti-senility, and being a kind ofly has the medicine of special efficacy to preventing and treating alzheimer disease and depression.
Further specify the present invention below in conjunction with embodiment
Embodiment
1. prepare the Semen Ginkgo glycoside
With the chopping of 100g Folium Ginkgo, steeped 1 hour with two times of water loggings, boiling water boiled 1 hour, leach water cooking liquid, medicinal residues add 2 times in water again, and boiling water boils half an hour, extracted twice liquid is merged, and decompression is concentrated into 1/5 of original volume under 60 ℃ of conditions, add the isopropyl alcohol that concentrates long-pending 2 times of liquid after the cooling, precipitating proteins and jelly, the sedimentary solution of filtering, the distilled water that adds 1/5 volume boils off isopropyl alcohol, filtered while hot again, put cold, promptly separate out thick Folium Ginkgo glycoside, leaching, drying, make it to be dissolved in the dehydrated alcohol of 10 times of volumes, filtering insoluble matter, solution add 1/5 suitable quantity of water, boil off ethanol, adding 15g silica gel stirs, to remove red pigment in the solution, take advantage of the occasion again to filter, after the filtrate cooling, promptly there is pure Semen Ginkgo glycoside to separate out, is drying to obtain.In time, leach, and for the second time, adds 2 times in water again, and decocting in water 1 hour filters, twice filtrate is merged, concentrate at once, be concentrated into 1/5 of original volume, be the extractum shape, with 95% alcohol reflux secondary of one times of concentrated solution, after alcohol extract merges, reclaim ethanol, get pure rare extractum.Extractum amasss dichloromethane extraction 5 times with suitable extractum monoploid, till the dichloromethane color is shallow.Reuse chloroform: methanol=5: 1 one times of water layer volumes, aqueous layer extracted.At last with inferior water layer with the ethyl acetate of one times of water layer volume extraction 5 times, merge the ethyl acetate extract, reclaim solvent to 1/5 of original volume concentrated solution placed, separate out yellow powder, with 60% ethyl alcohol recrystallization three times, get yellow acicular crystal, be icariine.
3. prepare the ginsenoside
Radix Ginseng is developed into ginsenoside's powder, gets 300g20 purpose ginsenoside powder, soak with two times of Radix Ginseng coarse powder volumes methanol, be heated to 80 ℃ of extractions, extracting solution is concentrated into 1/5 of original volume after concentrating, place, have Saponin to separate out, in concentrated solution, add the ether of suitable concentrated solution volume 15 amounts, acceleration settles out, and is purification, is dissolved in 95% ethanol, the ether that adds 1/3 amount, Saponin is separated out, and filters, and it is good to handle three purity.
With above-mentioned Semen Ginkgo glycoside, icariine 2., ginsenoside's mix homogeneously 3. 1., with solid phase enclose method: get it filled thing and cyclodextrin, after molecular proportion dissolving in 1: 1, row solid phase bag and, with capsule subpackage, promptly get the medicine that the present invention of 10-28 feed ration prevents and treats alzheimer disease and depression again.Have another name called for silver and join clever nanocapsule.
Claims (2)
1, a kind of medicine of preventing and treating alzheimer disease and depression, it is made up of Folium Ginkgo, Radix Ginseng and Herba Epimedii, through be purchased, weigh, drying, pulverizing, immersion, decocting in water, alcohol extraction, concentrate, prepared such as merging forms, it is characterized in that: it is the medicine of being made by the following weight proportion raw material:
Folium Ginkgo 100-280g
Radix Ginseng 100-280g
Herba Epimedii 150-420g.
2, the preparation technology who prevents and treats the medicine of alzheimer disease and depression according to claim 1 is characterized in that, presses following prepared:
(1) preparation of Semen Ginkgo glycoside
1. with the Folium Ginkgo chopping, steeped 1 hour with two times of water loggings, after 1 hour, boiling water boiled 1 hour, leached water cooking liquid, and its medicinal residues add 2 times of water again, and boiling water boils half an hour, leaches water cooking liquid once more, extracted twice liquid is merged,
2. decompression is concentrated into 1/5 of original volume under 60 ℃ of conditions, after the cooling, adds the isopropyl alcohol that concentrates long-pending 2 times of liquid, precipitating proteins and jelly, the sedimentary solution of filtering adds the distilled water of 1/5 volume, boils off isopropyl alcohol again, filtered while hot is put coldly, separates out thick Folium Ginkgo glycoside
3. leaching, drying makes it to be dissolved in the dehydrated alcohol of 10 times of volumes, and filtering insoluble matter, solution add 1/5 suitable quantity of water, boil off ethanol, add 15g silica gel and stir, remove red pigment in the solution, take advantage of the occasion again to filter, after the filtrate cooling, promptly have pure Semen Ginkgo glycoside to separate out, drying gets the Semen Ginkgo glycoside
(2) preparation of icariine
1. get the Herba Epimedii chopping, steeped 1 hour with 2 times of water loggings, decocting in water leached in 1 hour, added 2 times water again, and decocting in water 1 hour filters, merging filtrate,
2. concentrate at once, be concentrated into 1/5 extractum shape of original volume,
3. use 95% alcohol reflux secondary of one times of concentrated solution, alcohol extraction is got liquid and is merged, and reclaims ethanol, gets pure rare extractum,
4. use the long-pending dichloromethane extraction of quite pure rare extractum monoploid 5 times, till the dichloromethane color is shallow,
6. reuse chloroform: methanol=5: 1 one times of water layer volume aqueous layer extracted, at last the ethyl acetate of this water layer with one times of water layer volume extracted 5 times, merge the ethyl acetate extract, reclaim solvent to 1/5 of original volume and will concentrate placement, separate out yellow powder, with 60% ethyl alcohol recrystallization three times, yellow acicular crystal, be icariine
(3) be purchased or make by oneself the ginsenoside:
1. get Radix Ginseng and make 20 purpose ginsenoside powder, soak with two times of Radix Ginseng coarse powder volumes methanol, heat to 80 ℃ of extractions, extracting solution is concentrated into original volume 1/5, places, and has Saponin to separate out,
2. in concentrated solution, add the ether of suitable concentrated solution volume 10-15 amount, quicken to settle out, purification,
3. add 95% ether of 1/3 amount, Saponin is separated out, and filters, handle three times,
(4) with the Semen Ginkgo glycoside of above-mentioned (), the icariine of (two), ginsenoside's mix homogeneously of (three), with solid phase enclose method: get it filled thing and cyclodextrin, after molecular proportion dissolving in 1: 1, row solid phase bag and, with capsule subpackage, promptly get the medicine that the present invention prevents and treats alzheimer disease and depression again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00109186A CN1090944C (en) | 2000-06-14 | 2000-06-14 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00109186A CN1090944C (en) | 2000-06-14 | 2000-06-14 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
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| Publication Number | Publication Date |
|---|---|
| CN1277852A true CN1277852A (en) | 2000-12-27 |
| CN1090944C CN1090944C (en) | 2002-09-18 |
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| CN00109186A Expired - Fee Related CN1090944C (en) | 2000-06-14 | 2000-06-14 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1862171A1 (en) * | 2006-06-02 | 2007-12-05 | Hebei Yiling Medicine Research Institute Co., Ltd. | A medicine composition for treating muscular atrophy and myasthenia gravis and method of preparing the same |
| CN100375626C (en) * | 2003-09-05 | 2008-03-19 | 清华大学 | Chinese medicine compound preparation for treating depression and its preparation method |
| CN102188471A (en) * | 2011-04-20 | 2011-09-21 | 长春中医药大学 | Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method |
| CN102772456A (en) * | 2012-08-13 | 2012-11-14 | 桂林百里香生物科技有限公司 | Manufacturing method of sarcandra glabra extraction extractum |
| CN103751548A (en) * | 2014-01-24 | 2014-04-30 | 颜淑环 | Chinese medicinal preparation for treating senile depression |
| CN105232972A (en) * | 2015-09-30 | 2016-01-13 | 郑梅 | Preparation for treating senile dementia and preparation method thereof |
| CN105535007A (en) * | 2016-02-05 | 2016-05-04 | 首都医科大学宣武医院 | Application of icariin and derivatives thereof for preventing and treating psychonosema |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079243C (en) * | 1997-09-09 | 2002-02-20 | 北京东方百信生物技术有限公司 | Naoxinkang preparation and its producing technology |
-
2000
- 2000-06-14 CN CN00109186A patent/CN1090944C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100375626C (en) * | 2003-09-05 | 2008-03-19 | 清华大学 | Chinese medicine compound preparation for treating depression and its preparation method |
| EP1862171A1 (en) * | 2006-06-02 | 2007-12-05 | Hebei Yiling Medicine Research Institute Co., Ltd. | A medicine composition for treating muscular atrophy and myasthenia gravis and method of preparing the same |
| CN102188471A (en) * | 2011-04-20 | 2011-09-21 | 长春中医药大学 | Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method |
| CN102772456A (en) * | 2012-08-13 | 2012-11-14 | 桂林百里香生物科技有限公司 | Manufacturing method of sarcandra glabra extraction extractum |
| CN102772456B (en) * | 2012-08-13 | 2014-06-11 | 南宁智阳科技咨询管理有限公司 | Manufacturing method of sarcandra glabra extraction extractum |
| CN103751548A (en) * | 2014-01-24 | 2014-04-30 | 颜淑环 | Chinese medicinal preparation for treating senile depression |
| CN103751548B (en) * | 2014-01-24 | 2015-11-25 | 颜淑环 | A kind of medicament for the treatment of depression in old age |
| CN105232972A (en) * | 2015-09-30 | 2016-01-13 | 郑梅 | Preparation for treating senile dementia and preparation method thereof |
| CN105535007A (en) * | 2016-02-05 | 2016-05-04 | 首都医科大学宣武医院 | Application of icariin and derivatives thereof for preventing and treating psychonosema |
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| Publication number | Publication date |
|---|---|
| CN1090944C (en) | 2002-09-18 |
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