CN103751548B - A kind of medicament for the treatment of depression in old age - Google Patents
A kind of medicament for the treatment of depression in old age Download PDFInfo
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- CN103751548B CN103751548B CN201410033230.8A CN201410033230A CN103751548B CN 103751548 B CN103751548 B CN 103751548B CN 201410033230 A CN201410033230 A CN 201410033230A CN 103751548 B CN103751548 B CN 103751548B
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Abstract
The present invention relates to a kind of medicament for the treatment of depression in old age, it is made up of following bulk drugs: Radix seu folium abelmoschi moschati, Radix epipactinis, Eriosema himalaicum Ohashi, Folium seu Fructus Tarennae, Yi Zhiqi, Radix Stellariae Yunnanensis, Herba Asparagi Setacei, Fructus Styracis obassiae, Herba Violae japonicae, Herba Elsholtziae Ciliatae, Herba Selaginellae Doederleinii, Herba Inulae cappae, Bai Diehua, Herba Orchidis Latifoliae, pilea cadierei, paddy skin rattan, Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki.The drug prescription for the treatment of depression in old age of the present invention is reasonable, and definite effect, effectively can treat depression in old age.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of depression in old age.
Background technology
Depression in old age refers to that First episode is after 60 years old, with a kind of mental disorder that lasting depressive mood is main clinical manifestation, there is obvious depressed syndrome, many with various Chronic Somatic Diseases, in addition each tract declines to the ability resisting psychic trauma due to Age-related regression, more easily brings out.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of depression in old age.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of depression in old age, it is made up by weight of following bulk drugs: Radix seu folium abelmoschi moschati 5-30 part, Radix epipactinis 5-30 part, Eriosema himalaicum Ohashi 5-30 part, Folium seu Fructus Tarennae 5-30 part, flag 10-20 part, Radix Stellariae Yunnanensis 10-20 part, Herba Asparagi Setacei 10-20 part, Fructus Styracis obassiae 10-20 part, Herba Violae japonicae 1-10 part, Herba Elsholtziae Ciliatae 1-10 part, Herba Selaginellae Doederleinii 1-10 part, Herba Inulae cappae 1-10 part, white butterfly flower 1-10 part, Herba Orchidis Latifoliae 1-5 part, pilea cadierei 1-5 part, paddy skin rattan 1-5 part, Herba Limonii Gmelinii 1-5 part and a Folium et Cacumen Broussonetiae Kazinoki 1-5 part.
Preferably, the medicament for the treatment of depression in old age of the present invention is made up by weight of following bulk drugs: Radix seu folium abelmoschi moschati 18 parts, Radix epipactinis 18 parts, Eriosema himalaicum Ohashi 16 parts, Folium seu Fructus Tarennae 15 parts, 11 parts, flag, Radix Stellariae Yunnanensis 12 parts, Herba Asparagi Setacei 12 parts, Fructus Styracis obassiae 11 parts, Herba Violae japonicae 9 parts, Herba Elsholtziae Ciliatae 9 parts, Herba Selaginellae Doederleinii 8 parts, Herba Inulae cappae 8 parts, white butterfly spend 8 parts, Herba Orchidis Latifoliae 3 parts, pilea cadierei 3 parts, 3 parts, paddy skin rattan, Herba Limonii Gmelinii 2 parts and Folium et Cacumen Broussonetiae Kazinoki 2 parts.
More preferably, described medicament can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, capsule or decoction.
In the present compositions, Radix seu folium abelmoschi moschati, Radix epipactinis, Eriosema himalaicum Ohashi, Folium seu Fructus Tarennae are monarch drug; Flag, Radix Stellariae Yunnanensis, Herba Asparagi Setacei, a Fructus Styracis obassiae are ministerial drug; Herba Violae japonicae, Herba Elsholtziae Ciliatae, Herba Selaginellae Doederleinii, Herba Inulae cappae, white butterfly flower are adjuvant drug; Herba Orchidis Latifoliae, pilea cadierei, paddy skin rattan, Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki are for making medicine, and various ingredient exerts synergism is to produce optimum efficiency.
In order to understand the present invention better, with reference to " Chinese medicine voluminous dictionary " second edition (Shanghai science tech publishing house, 2005), the explanation of some crude drug used in the present invention sees the following form:
The drug prescription for the treatment of depression in old age of the present invention is reasonable, and definite effect, effectively can treat depression in old age.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment decoction of the present invention
Get Radix seu folium abelmoschi moschati 18 grams, Radix epipactinis 18 grams, Eriosema himalaicum Ohashi 16 grams, Folium seu Fructus Tarennae 15 grams, 11 grams, flag, Radix Stellariae Yunnanensis 12 grams, Herba Asparagi Setacei 12 grams, Fructus Styracis obassiae 11 grams, Herba Violae japonicae 9 grams, Herba Elsholtziae Ciliatae 9 grams, Herba Selaginellae Doederleinii 8 grams, Herba Inulae cappae 8 grams, white butterfly spend 8 grams, Herba Orchidis Latifoliae 3 grams, pilea cadierei 3 grams, 3 grams, paddy skin rattan, Herba Limonii Gmelinii 2 grams and Folium et Cacumen Broussonetiae Kazinoki 2 grams, add 15000 milliliters, water, heat 5 hours at 80 DEG C in the flask that condenser is housed, filter, filtrate is decoction of the present invention.
Experimental example
Physical data
Select patient 60 example meeting inclusive criteria, be this Out-patient Department and inpatient, be divided into matched group 30 example by medical order, treatment group 30 example.Treatment group: man 15 example, female 15 example, 63.2 years old mean age, average course of disease 2.3 years; Matched group: man 15 example, female 15 example, 64.1 years old mean age, average course of disease 2.4 years.Above 2 groups of every and Syndrome Types of TCM, medical situations, through statistical analysis no significant difference (P>0.05), have comparability.
Inclusive criteria
Western medicine diagnose: all meet " Chinese Spirit Obstacles classification and diagnostic criteria " the 3rd edition (CCMD-3) (psychiatric department branch of Chinese Medical Association Chinese Spirit Obstacles classification and diagnostic criteria (CCMD-3) [S]. Jinan: Shandong science tech publishing house, 2001; 4. diagnostic criteria).Tcm diagnosis standard with reference to the melancholia in " Chinese Internal Medicine " differentiation of symptoms and signs for classification of syndrome (Zhou Zhongying is edited. Chinese Internal Medicine [M] .7 version. Beijing: China Traditional Chinese Medicine Publishing House, 2003:392-397.).Hamilton depressive scale (HAMD >=17 point).Brink Periodontitis in elderly patients (DGS >=11 point.Male or female, the course of disease more than 1 year, the age is more than 60 years old.Inactive various antidepressant before treatment, gets rid of apparatus factors and causes depressive state.
Decoction obtained in the oral embodiment for the treatment of group is treated, one day 2 times, oral 200 milliliters at every turn, continuously treatment 3 months.
The oral deanxit sheet of matched group (Ling Bei pharmaceutical Co. Ltd of Denmark), every day respectively takes 1 sooner or later, continuously treatment 3 months.
Curative effect determinate standard
Reference " Chinese medical disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine. Chinese medical disease Standardization of diagnosis and curative effect (S) Nanjing: publishing house of Nanjing University, 1994; 20.).Cure: normally, interest increases, resourceful for mental state and emotion, normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effective: mental state and emotion are clearly better, anxiety reduces, and self evaluation increases, and diet, sleeps normal, substantially can adapt to daily life.Invalid: symptom is not improved.
Result
Therapeutic outcome through treatment two groups sees the following form:
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 21 | 8 | 1 | 96.67 |
| Matched group | 30 | 10 | 15 | 5 | 83.33 |
Untoward reaction
There are 2 routine xerostomia cases in matched group, 1 example headache case, the nauseating case of 1 example.Treatment group has no untoward reaction.
Model case
Zhang, female, 62 years old, retired government functionary.Depressed, impatiently, insomnia, everything is lost interest in, and give free rein to fancy more than 2 years, thoughts of suicide is strong.Take antidepressant drug can not tolerate, subjective symptoms increases the weight of, and carrys out my institute's treatment on January 8th, 2013.Decoction obtained in oral embodiment is treated, one day 2 times, oral 200 milliliters at every turn, continuously treatment 3 months.Symptom disappears substantially, and normally, interest increases, resourceful for mental state and emotion, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Liu, female, 65 years old, retired secondary school teachers.Depressed, can't be happy, during sad melancholy for cry, life enthusiasm interest decline, companion impatiently have a sleepless night, fatigue and weak, time have thoughts of suicide more than 2 years.My institute's treatment is carried out on February 15th, 2013.Decoction obtained in oral embodiment is treated, one day 2 times, oral 200 milliliters at every turn, continuously treatment 3 months.Symptom disappears substantially, and normally, interest increases, resourceful for mental state and emotion, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Ma, man, 63 years old, peasant.Depressed, like sulky, occupied with nothing all day, short-tempered, accompany vexed bitter taste, inappetence, fatigue and weak, accompany vexed insomnia, lethargy is depressed, retardation of thinking, and sensation Working Life is without any meaning, and companion's thoughts of suicide frequently waits a year and a half to have a surplus.My institute's treatment is carried out on January 29th, 2013.Decoction obtained in oral embodiment is treated, one day 2 times, oral 200 milliliters at every turn, continuously treatment 3 months.Symptom disappears substantially, and normally, interest increases, resourceful for mental state and emotion, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Claims (2)
1. treat the medicament of depression in old age for one kind, it is characterized in that, it is made up by weight of following bulk drugs: Radix seu folium abelmoschi moschati 5-30 part, Radix epipactinis 5-30 part, Eriosema himalaicum Ohashi 5-30 part, Folium seu Fructus Tarennae 5-30 part, flag 10-20 part, Radix Stellariae Yunnanensis 10-20 part, Herba Asparagi Setacei 10-20 part, Fructus Styracis obassiae 10-20 part, Herba Violae japonicae 1-10 part, Herba Elsholtziae Ciliatae 1-10 part, Herba Selaginellae Doederleinii 1-10 part, Herba Inulae cappae 1-10 part, white butterfly flower 1-10 part, Herba Orchidis Latifoliae 1-5 part, pilea cadierei 1-5 part, paddy skin rattan 1-5 part, Herba Limonii Gmelinii 1-5 part and a Folium et Cacumen Broussonetiae Kazinoki 1-5 part.
2. the medicament for the treatment of depression in old age according to claim 1, it is characterized in that, it is made up by weight of following bulk drugs: Radix seu folium abelmoschi moschati 18 parts, Radix epipactinis 18 parts, Eriosema himalaicum Ohashi 16 parts, Folium seu Fructus Tarennae 15 parts, 11 parts, flag, Radix Stellariae Yunnanensis 12 parts, Herba Asparagi Setacei 12 parts, Fructus Styracis obassiae 11 parts, Herba Violae japonicae 9 parts, Herba Elsholtziae Ciliatae 9 parts, Herba Selaginellae Doederleinii 8 parts, Herba Inulae cappae 8 parts, white butterfly spend 8 parts, Herba Orchidis Latifoliae 3 parts, pilea cadierei 3 parts, 3 parts, paddy skin rattan, Herba Limonii Gmelinii 2 parts and Folium et Cacumen Broussonetiae Kazinoki 2 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410033230.8A CN103751548B (en) | 2014-01-24 | 2014-01-24 | A kind of medicament for the treatment of depression in old age |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410033230.8A CN103751548B (en) | 2014-01-24 | 2014-01-24 | A kind of medicament for the treatment of depression in old age |
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| CN103751548B true CN103751548B (en) | 2015-11-25 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277852A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
| CN1895477A (en) * | 2006-06-14 | 2007-01-17 | 广州汉方现代中药研究开发有限公司 | Antidespressant and its preparation |
| CN101607036A (en) * | 2008-06-20 | 2009-12-23 | 河北以岭医药研究院有限公司 | The application of a kind of Chinese medicine composition in the medicine of preparation treatment depression |
| CN103495044A (en) * | 2006-11-14 | 2014-01-08 | 王选民 | Pure traditional Chinese medicine preparation for treating neurosis |
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2014
- 2014-01-24 CN CN201410033230.8A patent/CN103751548B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277852A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
| CN1895477A (en) * | 2006-06-14 | 2007-01-17 | 广州汉方现代中药研究开发有限公司 | Antidespressant and its preparation |
| CN103495044A (en) * | 2006-11-14 | 2014-01-08 | 王选民 | Pure traditional Chinese medicine preparation for treating neurosis |
| CN101607036A (en) * | 2008-06-20 | 2009-12-23 | 河北以岭医药研究院有限公司 | The application of a kind of Chinese medicine composition in the medicine of preparation treatment depression |
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