CN103751548A - Chinese medicinal preparation for treating senile depression - Google Patents
Chinese medicinal preparation for treating senile depression Download PDFInfo
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- CN103751548A CN103751548A CN201410033230.8A CN201410033230A CN103751548A CN 103751548 A CN103751548 A CN 103751548A CN 201410033230 A CN201410033230 A CN 201410033230A CN 103751548 A CN103751548 A CN 103751548A
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Abstract
The invention relates to a Chinese medicinal preparation for treating senile depression, which is prepared from the following raw materials: Abelmoschus moschatus, Epipactis yunnanensis, Eriosema himalaicum, Tarenna mollissima, Microsorium buergerianum, Stellariza yunnanensis, Asparagus setaceus, Styrax obassia, Viola japonica, Comanthosphace ingpoensis, Selaginella doederleinii, Herba Inulae Cappae, Gaura lindheimeri, Orchis, Pilea cadierei, Broussonetia kaempfer, Limonium sinense and Broussonetia kazinoki. The Chinese medicinal preparation for treating senile depression provided by the invention has reasonable formulation and definite effect, and can be used for effectively treating senile depression.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of depression in old age.
Background technology
Depression in old age refers to that First episode is after 60 years old, a kind of mental disorder take lasting depressive mood as main clinical manifestation, there is obvious depressed syndrome, how with various Chronic Somatic Diseases, in addition each tract, because Age-related regression declines to the ability of resisting psychic trauma, more easily brings out.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of depression in old age.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of depression in old age, it is to be made by weight by following bulk drugs: Radix seu folium abelmoschi moschati 5-30 part, Radix epipactinis 5-30 part, Eriosema himalaicum Ohashi 5-30 part, Folium seu Fructus Tarennae 5-30 part, flag 10-20 part, Radix Stellariae Yunnanensis 10-20 part, Herba Asparagi Setacei 10-20 part, Fructus Styracis obassiae 10-20 part, Herba Violae japonicae 1-10 part, Herba Elsholtziae Ciliatae 1-10 part, Herba Selaginellae Doederleinii 1-10 part, Herba Inulae cappae 1-10 part, white butterfly flower 1-10 part, Herba Orchidis Latifoliae 1-5 part, pilea cadierei 1-5 part, paddy skin rattan 1-5 part, Herba Limonii Gmelinii 1-5 part and a Folium et Cacumen Broussonetiae Kazinoki 1-5 part.
Preferably, the medicament for the treatment of depression in old age of the present invention is to be made by weight by following bulk drugs: 18 parts of Radix seu folium abelmoschi moschatis, 18 parts of Radix epipactinis, 16 parts of Eriosema himalaicum Ohashis, 11 parts, 15 parts, one flag of Folium seu Fructus Tarennae, 12 parts of Radix Stellariae Yunnanensiss, 12 parts of Herba Asparagi Setaceis, 11 parts of Fructus Styracis obassiaes, 9 parts of Herba Violae japonicaes, 9 parts of Herba Elsholtziae Ciliataes, 8 parts of Herba Selaginellae Doederleiniis, 8 parts of Herba Inulae cappaes, white butterfly are spent 2 parts of 8 parts, 3 parts of Herba Orchidis Latifoliae, 3 parts of pilea cadiereis, 3 parts, paddy skin rattan, 2 parts of Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki.
More preferably, described medicament can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, capsule or decoction.
In compositions of the present invention, Radix seu folium abelmoschi moschati, Radix epipactinis, Eriosema himalaicum Ohashi, Folium seu Fructus Tarennae are monarch drug; Flag, Radix Stellariae Yunnanensis, Herba Asparagi Setacei, a Fructus Styracis obassiae are ministerial drug; Herba Violae japonicae, Herba Elsholtziae Ciliatae, Herba Selaginellae Doederleinii, Herba Inulae cappae, white butterfly flower are adjuvant drug; Herba Orchidis Latifoliae, pilea cadierei, paddy skin rattan, Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki are for making medicine, and various composition performance synergism are to produce optimum efficiency.
In order to understand better the present invention, with reference to < < Chinese medicine voluminous dictionary > > second edition (Shanghai science tech publishing house, 2005) explanation of some crude drug that, use in the present invention sees the following form:
The drug prescription for the treatment of depression in old age of the present invention is reasonable, and effect is clear and definite, can effectively treat depression in old age.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent otherwise in the present invention is percetage by weight.
Embodiment decoction of the present invention
Get 18 grams of Radix seu folium abelmoschi moschatis, 18 grams of Radix epipactinis, 16 grams of Eriosema himalaicum Ohashis, 11 grams, 15 grams, one flag of Folium seu Fructus Tarennae, 12 grams of Radix Stellariae Yunnanensiss, 12 grams of Herba Asparagi Setaceis, 11 grams of Fructus Styracis obassiaes, 9 grams of Herba Violae japonicaes, 9 grams of Herba Elsholtziae Ciliataes, 8 grams of Herba Selaginellae Doederleiniis, 8 grams of Herba Inulae cappaes, white butterfly and spend 2 grams of 8 grams, 3 grams of Herba Orchidis Latifoliae, 3 grams of pilea cadiereis, 3 grams, paddy skin rattan, 2 grams of Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki, add 15000 milliliters, water, in the flask that condenser is housed, at 80 ℃, heat 5 hours, filter, filtrate is decoction of the present invention.
Experimental example
Physical data
Selection meets patient's 60 examples of inclusive criteria, is this Out-patient Department and inpatient, by medical order, is divided into matched group 30 examples, treatment group 30 examples.Treatment group: male 15 examples, female's 15 examples, 63.2 years old mean age, average course of disease 2.3 years; Matched group: male 15 examples, female's 15 examples, 64.1 years old mean age, average course of disease 2.4 years.Above 2 groups of every and Syndrome Types of TCMs, medical situation, Epidemiological Analysis difference not statistically significant (P>0.05), has comparability by statistics.
Inclusive criteria
Western medicine diagnose: all meet < < Chinese Spirit Obstacles classification and diagnostic criteria > > the 3rd edition (CCMD-3) (psychiatric department branch of Chinese Medical Association Chinese Spirit Obstacles classification and diagnostic criteria (CCMD-3) [S]. Jinan: Shandong science tech publishing house, 2001; 4. diagnostic criteria).Tcm diagnosis standard with reference to the differentiation of symptoms and signs for classification of syndrome of the melancholia in < < Chinese Internal Medicine > > (Zhou Zhongying chief editor. Chinese Internal Medicine [M] .7 version. Beijing: China Traditional Chinese Medicine Publishing House, 2003:392-397.).Hamilton depressive scale (HAMD >=17 point).Brink senile depression scale (DGS >=11 point.Male or female, the course of disease is more than 1 year, and the age is more than 60 years old.Inactive various antidepressant before treatment, get rid of apparatus factors and cause depressive state.
The decoction making in the oral embodiment for the treatment of group is treated, and one day 2 times, each oral 200 milliliters, treats continuously 3 months.
The oral deanxit sheet of matched group (Denmark Ling Bei pharmaceutical Co. Ltd), sooner or later respectively take 1 every day, treats continuously 3 months.
Curative effect determinate standard
With reference to < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > (State Administration of Traditional Chinese Medicine. traditional Chinese medical science disease Standardization of diagnosis and curative effect (S) Nanjing: publishing house of Nanjing University, 1994; 20.).Cure: mental state and emotion are normal, and interest increases, resourceful, normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effective: mental state and emotion are clearly better, anxiety reduces, and self evaluation increases, and diet, sleep normal, can adapt to daily life substantially.Invalid: symptom is not improved.
Result
Therapeutic outcome through two groups of treatments sees the following form:
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 21 | 8 | 1 | 96.67 |
| Matched group | 30 | 10 | 15 | 5 | 83.33 |
Untoward reaction
There are 2 routine xerostomia cases in matched group, 1 example headache case, the nauseating case of 1 example.Treatment group has no untoward reaction.
Model case
Zhang, female, 62 years old, retired government functionary.Depressed, impatient, insomnia, everything is lost interest in, and givees free rein to fancy more than 2 years, and thoughts of suicide is strong.Taking antidepressant drug can not tolerate, and subjective symptoms increases the weight of, in Lai Wo institute treatment January 8 in 2013.The decoction making in oral embodiment is treated, and one day 2 times, each oral 200 milliliters, treats continuously 3 months.Symptom disappears substantially, and mental state and emotion are normal, and interest increases, resourceful, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Liu, female, 65 years old, retired secondary school teachers.Depressed, can't be happy, during sad melancholy wish cry, life enthusiasm interest decline, companion impatiently insomnia, fatigue and weak, time have thoughts of suicide more than 2 years.In Lai Wo institute treatment February 15 in 2013.The decoction making in oral embodiment is treated, and one day 2 times, each oral 200 milliliters, treats continuously 3 months.Symptom disappears substantially, and mental state and emotion are normal, and interest increases, resourceful, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Ma, man, 63 years old, peasant.Depressed, like sulkyly, occupied with nothing all day, short-tempered, accompany vexed bitter taste, inappetence, fatigue and weak, accompanies vexed insomnia, and lethargy is depressed, retardation of thinking, sensation Working Life is without any meaning, and companion's thoughts of suicide frequently waits a year and a half to have a surplus.In Lai Wo institute treatment January 29 in 2013.The decoction making in oral embodiment is treated, and one day 2 times, each oral 200 milliliters, treats continuously 3 months.Symptom disappears substantially, and mental state and emotion are normal, and interest increases, resourceful, and normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effect of follow-up visit by telephone has no recurrence half a year.
Claims (3)
1. treat the medicament of depression in old age for one kind, it is characterized in that, it is to be made by weight by following bulk drugs: Radix seu folium abelmoschi moschati 5-30 part, Radix epipactinis 5-30 part, Eriosema himalaicum Ohashi 5-30 part, Folium seu Fructus Tarennae 5-30 part, flag 10-20 part, Radix Stellariae Yunnanensis 10-20 part, Herba Asparagi Setacei 10-20 part, Fructus Styracis obassiae 10-20 part, Herba Violae japonicae 1-10 part, Herba Elsholtziae Ciliatae 1-10 part, Herba Selaginellae Doederleinii 1-10 part, Herba Inulae cappae 1-10 part, white butterfly flower 1-10 part, Herba Orchidis Latifoliae 1-5 part, pilea cadierei 1-5 part, paddy skin rattan 1-5 part, Herba Limonii Gmelinii 1-5 part and a Folium et Cacumen Broussonetiae Kazinoki 1-5 part.
2. the medicament for the treatment of depression in old age according to claim 1, it is characterized in that, it is to be made by weight by following bulk drugs: 18 parts of Radix seu folium abelmoschi moschatis, 18 parts of Radix epipactinis, 16 parts of Eriosema himalaicum Ohashis, 11 parts, 15 parts, one flag of Folium seu Fructus Tarennae, 12 parts of Radix Stellariae Yunnanensiss, 12 parts of Herba Asparagi Setaceis, 11 parts of Fructus Styracis obassiaes, 9 parts of Herba Violae japonicaes, 9 parts of Herba Elsholtziae Ciliataes, 8 parts of Herba Selaginellae Doederleiniis, 8 parts of Herba Inulae cappaes, white butterfly are spent 2 parts of 8 parts, 3 parts of Herba Orchidis Latifoliae, 3 parts of pilea cadiereis, 3 parts, paddy skin rattan, 2 parts of Herba Limonii Gmelinii and Folium et Cacumen Broussonetiae Kazinoki.
3. the medicament for the treatment of depression in old age according to claim 1 and 2, is characterized in that, described medicament can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, capsule or decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410033230.8A CN103751548B (en) | 2014-01-24 | 2014-01-24 | A kind of medicament for the treatment of depression in old age |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410033230.8A CN103751548B (en) | 2014-01-24 | 2014-01-24 | A kind of medicament for the treatment of depression in old age |
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| CN103751548A true CN103751548A (en) | 2014-04-30 |
| CN103751548B CN103751548B (en) | 2015-11-25 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277852A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
| CN1895477A (en) * | 2006-06-14 | 2007-01-17 | 广州汉方现代中药研究开发有限公司 | Antidespressant and its preparation |
| CN101607036A (en) * | 2008-06-20 | 2009-12-23 | 河北以岭医药研究院有限公司 | The application of a kind of Chinese medicine composition in the medicine of preparation treatment depression |
| CN103495044A (en) * | 2006-11-14 | 2014-01-08 | 王选民 | Pure traditional Chinese medicine preparation for treating neurosis |
-
2014
- 2014-01-24 CN CN201410033230.8A patent/CN103751548B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277852A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Pharmaceutical for preventing and treating senile dementia and depression, and its prepn. process |
| CN1895477A (en) * | 2006-06-14 | 2007-01-17 | 广州汉方现代中药研究开发有限公司 | Antidespressant and its preparation |
| CN103495044A (en) * | 2006-11-14 | 2014-01-08 | 王选民 | Pure traditional Chinese medicine preparation for treating neurosis |
| CN101607036A (en) * | 2008-06-20 | 2009-12-23 | 河北以岭医药研究院有限公司 | The application of a kind of Chinese medicine composition in the medicine of preparation treatment depression |
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| Publication number | Publication date |
|---|---|
| CN103751548B (en) | 2015-11-25 |
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