CN1247251C

CN1247251C - Hyperlipemia treating medicine

Info

Publication number: CN1247251C
Application number: CN 200310106475
Authority: CN
Inventors: 臧贤框
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-12-01
Filing date: 2003-12-01
Publication date: 2006-03-29
Anticipated expiration: 2023-12-01
Also published as: CN1546080A

Abstract

The present invention relates to a medicine (blood fat reducing powder) for treating hyperlipemia. The present invention has the function of evidently lowering the concentration of hypertriglyceridemia and can lower transaminase and high blood pressure. The present invention is a Chinese patent medicine which is formed by preparing Chinese herbal medicine raw material according to weight mixture ratios as follows: 20% to 30% of oriental wormwood, 10% to 15% of stringy stonecrop herbs, 12% to 15% of Chinese magnoliavine fruits, 12% to 15% of forsythia fruits, 12% to 15% of plantain herbs, 10% to 15% of glabrous greenbrier rhizomes, 8% to 12% of red dates, 10% to 15% of white atractylodes rhizomes, 12% to 15% of sauted spina date seeds, 12% to 15% of raw hawthorn fruits, 12% to 20% of danshen roots, 12% to 25% of white peony roots, 6% to 10% of tangerine peel, 12% to 20% of solomonseal rhizomes and 12% to 15% of raw cattail pollen.

Description

A kind of medicine for the treatment of hyperlipidemia

Technical field

A kind of medicine for the treatment of hyperlipidemia of the present invention relates to is a kind of medicine (blood fat reducing is loose) for the treatment of various hyperlipidemias, and the concentration that reduces hypertriglyceridemia can be arranged apparently, but also transaminase lowering and hypertension simultaneously.

Background technology

At present, the treatment of hyperlipidemia mainly is to adopt medicines such as zhibituo, XUEZHIKANG JIAONANG, Ipolipid, though these medicines energy relief of symptoms can not effect a radical cure.And most of patients have after taking medicine side effect as: feel sick, side effect such as vomiting, stomach discomfort, stool are undesired, paddy third, glutamic oxaloacetic transaminase, GOT rising, bounce-back is then arranged after the drug withdrawal, its curative effect is not quite desirable, and the relapse rate height is too big to old people's health effect.Hyperlipidemia has become the fatal problem of this class patient at present, has also become a great problem of pendulum in face of the clinician.

Hyperlipidemia is not because eating and drinking without temperance, expectorant are turbidly changed, stagnation of blood stasis, dysfunction of the spleen in transportation, kidney qi are gathered the cause of disease such as weak, that suffocating of liver and gall is unfavorable and formed, Syndrome in TCM can be divided into types such as essential resistance of turbid phlegm, qi depression to blood stasis, insufficiency of the spleen leading to overabundance of dampness, the hepatic and renal YIN deficiency, deficiency of spleen-YANG and kidneyYANG, its harm is very wide, but diseases such as secondary thyroid flesh can go down, diabetes, the nephrotic syndrome, hepatic disease, obesity, fatty liver, cholelithiasis, jeopardize human health, endanger very wide.

Summary of the invention

The present invention is directed to the existing weak point of above-mentioned treatment hyperlipidemia medicine a kind of medicine of treatment hyperlipidemia of novelty is provided, with the Chinese herbal medicine is that preparation of raw material forms, solved the painful life of consequently saving them of hyperlipemic patients, reach the purpose of curing the sickness to save the patient, realize simultaneously producing effects fast, expense is little, no pain, the purpose that do not rebound, have no side effect.

A kind of medicine for the treatment of hyperlipidemia takes following scheme to realize: technical scheme of the present invention is the innovation treatment with the Chinese medicine hyperlipidemia, execute comprehensive general character disease on the basis of controlling at card, extensively consider the hyperlipidemia common sympton, developed a kind of medicine (blood fat reducing is loose) for the treatment of hyperlipidemia of special-purpose medicine of common extensive adaptation treatment hyperlipidemia disease.

A kind of medicine for the treatment of hyperlipidemia of the present invention is the Chinese formulated products of being made by the herbal raw material of following (part) by weight proportioning:

Herba Artemisiae Scopariae 20～30 Herba Sedis 10～15 Fructus Schisandrae Chinensis 12～15 Fructus Forsythiaes 12～15

Herba Plantaginis 12～15 Rhizoma Smilacis Glabraes 10～15 Fructus Jujubaes 8～12 Rhizoma Atractylodis Macrocephalaes 10～15

Semen Ziziphi Spinosae (parched) 12～15 Fructus Crataegi 12～15 Radix Salviae Miltiorrhizaes 12～20 Radix Paeoniae Albas 12～25

Pericarpium Citri Reticulatae 6～10 Rhizoma Polygonatis 12～20 Pollen Tyjphae 12～15.

A kind of each herbal raw material preferred weight (part) proportioning for the treatment of the medicine of hyperlipidemia of preparation the present invention is:

Herba Artemisiae Scopariae 20～25 Herba Sedis 10～12 Fructus Schisandrae Chinensis 10～12 Fructus Forsythiaes 10～12

Herba Plantaginis 10～12 Rhizoma Smilacis Glabraes 10～12 Fructus Jujubaes 10～12 Rhizoma Atractylodis Macrocephalaes 10～12

Semen Ziziphi Spinosae (parched) 10～12 Fructus Crataegi 10～12 Radix Salviae Miltiorrhizaes 12～15 Radix Paeoniae Albas 15～20

Pericarpium Citri Reticulatae 6～8 Rhizoma Polygonatis 12～15 Pollen Tyjphae 10～12.

A kind of each herbal raw material optimum weight (part) proportioning for the treatment of the medicine of hyperlipidemia of preparation the present invention is:

Herba Artemisiae Scopariae 25 Herba Sedis 10 Fructus Schisandrae Chinensis 10 Fructus Forsythiaes 10 Herba Plantaginiss 10

Rhizoma Smilacis Glabrae 10 Fructus Jujubaes 12 Rhizoma Atractylodis Macrocephalaes 10 Semen Ziziphi Spinosae (parched)s 10 Fructus Crataegi 10

Radix Salviae Miltiorrhizae 12 Radix Paeoniae Albas 12 Pericarpium Citri Reticulataes 6 Rhizoma Polygonatis 12 Pollen Tyjphae 10.

The medicine that the present invention is a kind of to treat hyperlipidemia can have nothing in common with each other to the demand of the dosage form of taking medicine according to the patient and make said dosage form on any pharmaceutics, and pharmaceutically dosage form can be serial Chinese patent medicines such as powder (water decoction), pill, tablet, electuary, capsule.

A kind of preparation method for the treatment of the medicine of hyperlipidemia of the present invention: Herba Artemisiae Scopariae, Herba Sedi, Fructus Schisandrae Chinensis, Fructus Forsythiae, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae by said ratio weighing, drying, are powder (water decoction) behind the pulverizer crushing screening.With the above-mentioned general pill that is processed as of Chinese herb medicine water through pulverizing.Above-mentioned Chinese herb medicine through pulverizing is stirred other grain tabletting, oven dry, promptly make tablet.Herba Artemisiae Scopariae, Herba Sedi, Fructus Schisandrae Chinensis, Fructus Forsythiae, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae are pressed the said ratio weighing, pulverized through pulverizer, decoct with water, be condensed into extractum, oven dry, pulverizing, promptly make electuary, capsule is advanced in its fill promptly make capsule.

The present invention combines the clinical common sympton of hyperlipidemia, break present conventional treatments, based on Chinese medical theory, the research of clinical observation is for many years constantly studied improvement to prescription, revise and replenish, grasp eliminating evil positive now principle conscientiously, according to its pathogeny (pathogenesis), taked the rule of treatment of eliminating pathogenic factor for supporting vital QI, Rhizoma Polygonati, the nourishing the liver of Radix Paeoniae Alba kidney tonifying, The liver and the kidney have a common source, the essence and blood alternate, Semen Ziziphi Spinosae (parched) is calmed the nerves and is nourished heart, Fructus Schisandrae Chinensis benefit heart kidney, Fructus Jujubae invigorating the spleen and replenishing QI, the benefit blood and tranquilizing mind, relax the property of medicine, the Herba Artemisiae Scopariae depressed liver-energy dispersing and function of gallbladder promoting, Fructus Forsythiae, the Rhizoma Smilacis Glabrae heat-clearing and toxic substances removing, Herba Sedi, Semen Plantaginis diuresis toxin expelling, Fructus Crataegi strengthening the spleen to promote digestion eliminate indigestion, promoting blood circulation to remove blood stasis, circulation of qi promoting disappears stagnant, be hypertension, coronary heart disease, the key medicine of hyperlipidemia, Radix Salviae Miltiorrhizae, the Pollen Tyjphae promoting blood circulation and breaking stagnation, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae damp eliminating invigorating the spleen for dissipating phlegm.

A kind of characteristics for the treatment of the medicine of hyperlipidemia of the present invention are promptly treated disease feature explanations such as hyperlipemia:

1, obvious curative effects is arranged, have vertical rod to see the effect of shadow to hyperlipemia especially, have no side effect, can be widely used in clinically, satisfy the needs of hyperlipemic patients, the patient took medicine 5～10 days, and self-induction improves significantly and alleviates.

2, took medicine 7～15 days, through chemical examination, triglyceride (blood fat) is reduced to 1.5～2.3mmol/L, and normal value becomes.

3, to reducing hypertension obvious effect is arranged.

4, medicine processing technology of the present invention is simple, cost is low.

5,, the back no pain of taking medicine, do not rebound because medicine of the present invention adopts Chinese herb medicine to make.

Model case one

The king * * self-induction general weakness when the woman went to a doctor to the court in 37 years old, uncomfortable in chest, dizzy, through hospital inspection, be reported as: glutamate pyruvate transaminase 57u/L, glutamic oxaloacetic transaminase, GOT 41u/L, total protein 96.5g/L, triglyceride 10.73mmol/L, ApoA 11.85g/L, apolipoprotein B 2.31g/L, through the here out-patient treatment, took medicine of the present invention 30 days, check once more, be reported as: glutamate pyruvate transaminase 53u/L, glutamic oxaloacetic transaminase, GOT 39u/L, total protein 71g/L, triglyceride 1.41mmol/L, ApoA 11.23g/L, apolipoprotein B 0.87g/L, the above several indexs of result are normal synchronously, follow up a case by regular visits to and do not have bounce-back, original symptom all disappear (curing).

Case two

Wu * * when the man went to a doctor to the court in 39 years old, private prosecution dizziness headache, vexed uneasiness, dark tongue quality, carefully puckery, chemically examine through hospital, the r-glutamy changes phthalein enzyme 57u/L as a result, triglyceride 3.09mmol/L, low density lipoprotein, LDL 3.20g/L, apolipoprotein B 157mg/L, through taking medicine of the present invention 5 days, it is normal that result of laboratory test r-glutamy changes the phthalein enzyme, triglyceride 1.61mmol/L, low density lipoprotein, LDL 3.17g/L, apolipoprotein B 106mg/L, report shows normal.

Case three

Wu * * male 45 years old, when going to a doctor to the court, body is thin partially, waist soreness, xerostomia, red tongue with a little fluid, thready and rapid pulse, through chemical examination, glutamate pyruvate transaminase 106u/L as a result, Aspartic Acid transferring enzyme 51.8u/L, uric acid 484.4umol/L, triglyceride 3.27mmol/L, through taking medicine of the present invention 5 days, through chemical examination, glutamate pyruvate transaminase 34.2u/L as a result, Aspartic Acid transferring enzyme 24.5u/L, uric acid 460.7umol/L, triglyceride 1.66mmol/L, the laboratory report list shows normal.

Case four

Xiao * * when the woman went to a doctor to the court in 33 years old, uncomfortable in chest, dizzy, fat, thick fur is greasy, stringy and rolling pulse, original hepatitis history, channel syndrome is with removing dampness and eliminating phlegm, invigorating the spleen and regulating the stomach, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, give medicine of the present invention 10 days, the clothes conscious improvement in back, through hospital's chemical examination, glutamate pyruvate transaminase was 208u/L originally as a result, existing 101u/L, glutamic oxaloacetic transaminase, GOT was 122u/L originally, existing 61u/L, the former 6.87mmol/L of T-CHOL, existing 6.65mmol/L, the former 5.47mmol/L of triglyceride, existing 1.70mmol/L, the former 3.13g/L of low density lipoprotein, LDL, existing 4.62g/L, the former 1.22mg/L of high density lipoprotein, existing 1.25mg/L, report shows normal.

Clinical observation 200 routine patients use a kind of Drug therapy situation for the treatment of hyperlipidemia of the present invention and add up as follows:

Outpatient service is followed up a case by regular visits to	Number	10 days course of treatment	Two 20 days courses of treatment	Three 30 days courses of treatment	Three more than the course of treatment	Total effective rate %
	Number	10 days course of treatment	Two 20 days courses of treatment	Three 30 days courses of treatment	Three more than the course of treatment	Total effective rate %	Add up to	200	147	35	13	5	98.5
Take a turn for the better	12	12				6	Add up to	200	147	35	13	5	98.5
Take a turn for the better	12	12				6	Produce effects	15	7	6	2		7.5
Cure	170	125	29	11	5	85	Produce effects	15	7	6	2		7.5
Cure	170	125	29	11	5	85	Invalid	3	3				1.5

Annotate: 1, take a turn for the better: the state of an illness is controlled, alleviates blood examination index descend to some extent (not raising) to some extent.

2, produce effects: the disease feelings are clearly better, and the blood examination index obviously descends, and appetite takes a turn for the better to some extent, and appetite increases, and is energetic.

3, cure: the disease feelings all disappear, and the blood examination index is all normal, and diet, the food of receiving are good, and spirit is healthy and vigorous, and (blood examination triglyceride normal index is: reference value 1.5～2.3mmol/L).

4, invalid: through treatment, because (complication), go to other places to cure the disease, therapy discontinued, or because financial difficulties can not be adhered to treatment and abandoned continuing diagnosis and treatment.

The specific embodiment

Embodiment 1, to take by weighing herbal raw material (kilogram) by following weight proportion standby:

Herba Artemisiae Scopariae 20 Herba Sedis 10 Fructus Schisandrae Chinensis 12 Fructus Forsythiaes 12 Herba Plantaginiss 12 Rhizoma Smilacis Glabraes 15 Fructus Jujubaes 8 Rhizoma Atractylodis Macrocephalaes 10 Semen Ziziphi Spinosae (parched)s 15 Fructus Crataegi 15 Radix Salviae Miltiorrhizaes 15 Radix Paeoniae Albas 10 Pericarpium Citri Reticulataes 8 Rhizoma Polygonatis 15 Pollen Tyjphae 15.

Concrete preparation method is as follows: with above-mentioned dry respectively by the load weighted Herba Artemisiae Scopariae of proportioning, Herba Sedi, Fructus Schisandrae Chinensis, Fructus Forsythiae, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae, after putting into the pulverizer crushing screening respectively after the drying, the Chinese herb medicine that these are crushed is fully mixed again, promptly makes a kind of drug powder (water decoction) for the treatment of hyperlipidemia.Also can put into pulverizer together by the load weighted herbal raw material of proportioning and pulverize, promptly make a kind of drug powder (water decoction) for the treatment of hyperlipidemia through sieving above-mentioned.Be processed into a kind of bolus of drug for the treatment of hyperlipidemia with the Chinese herb medicine water after the above-mentioned pulverizing is general.Above-mentioned Chinese herb medicine is after crushed stirred pelletizing press sheet, oven dry, promptly make a kind of medicinal tablet for the treatment of hyperlipidemia.Above-mentioned Herba Artemisiae Scopariae, Herba Sedi, Fructus Schisandrae Chinensis, Fructus Forsythiae, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae are pressed the said ratio weighing, putting into pulverizer pulverizes, putting into container again decocts with water, be condensed into extractum, oven dry, pulverizing, promptly make a kind of medicine instant for the treatment of hyperlipidemia, capsule is advanced in this electuary fill promptly make a kind of medicament capsule for the treatment of hyperlipidemia.

Embodiment 2, to take by weighing herbal raw material (kilogram) by following weight proportion standby:

Herba Artemisiae Scopariae 30 Herba Sedis 15 Fructus Schisandrae Chinensis 15 Fructus Forsythiaes 15 Herba Plantaginiss 15 Rhizoma Smilacis Glabraes 12 Fructus Jujubaes 10 Rhizoma Atractylodis Macrocephalaes 15 Semen Ziziphi Spinosae (parched)s 12 Fructus Crataegi 12 Radix Salviae Miltiorrhizaes 20 Radix Paeoniae Albas 15 Pericarpium Citri Reticulataes 10 Rhizoma Polygonatis 20 Pollen Tyjphae 12.

Concrete preparation method is as follows: with above-mentioned dry respectively by the load weighted Herba Artemisiae Scopariae of proportioning, Herba Sedi, Fructus Schisandrae Chinensis, company, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae, after putting into the pulverizer crushing screening respectively after the drying, the Chinese herb medicine that these are crushed is fully mixed again, promptly makes a kind of drug powder (water decoction) for the treatment of hyperlipidemia.Also can put into pulverizer together by the load weighted herbal raw material of proportioning and pulverize, promptly make a kind of drug powder (water decoction) for the treatment of hyperlipidemia through sieving above-mentioned.Be processed into a kind of bolus of drug for the treatment of hyperlipidemia with the Chinese herb medicine water after the above-mentioned pulverizing is general.Above-mentioned Chinese herb medicine is after crushed stirred pelletizing press sheet, oven dry, promptly make a kind of medicinal tablet for the treatment of hyperlipidemia.Above-mentioned Herba Artemisiae Scopariae, Herba Sedi, Fructus Schisandrae Chinensis, Fructus Forsythiae, Herba Plantaginis, Rhizoma Smilacis Glabrae, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae (parched), Fructus Crataegi, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Polygonati, Pollen Tyjphae are pressed the said ratio weighing, putting into pulverizer pulverizes, putting into container again decocts with water, be condensed into extractum, oven dry, pulverizing, promptly make a kind of medicine instant for the treatment of hyperlipidemia, capsule is advanced in this electuary fill promptly make a kind of medicament capsule for the treatment of hyperlipidemia.

Embodiment 3, to take by weighing herbal raw material (kilogram) by following weight proportion standby:

Herba Artemisiae Scopariae .25 Herba Sedi 12 Fructus Schisandrae Chinensis 10 Fructus Forsythiaes 10 Herba Plantaginiss 10 Rhizoma Smilacis Glabraes 10 Fructus Jujubaes 12 Rhizoma Atractylodis Macrocephalaes 12 Semen Ziziphi Spinosae (parched)s 10 Fructus Crataegi 10 Radix Salviae Miltiorrhizaes 12 Radix Paeoniae Albas 12 Pericarpium Citri Reticulataes 6 Rhizoma Polygonatis 12 Pollen Tyjphae 10.

Claims

1, a kind of medicine for the treatment of hyperlipidemia is characterized in that it is the Chinese formulated products of being made by following herbal raw material by weight ratio:

2, a kind of medicine for the treatment of hyperlipidemia according to claim 1 is characterized in that said medicament is powder, pill, tablet, electuary, capsule.