CN118161417A - Preparation method of washing-free disinfection gel and washing-free disinfection gel - Google Patents
Preparation method of washing-free disinfection gel and washing-free disinfection gel Download PDFInfo
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- CN118161417A CN118161417A CN202410414154.9A CN202410414154A CN118161417A CN 118161417 A CN118161417 A CN 118161417A CN 202410414154 A CN202410414154 A CN 202410414154A CN 118161417 A CN118161417 A CN 118161417A
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- gel
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000011550 stock solution Substances 0.000 claims abstract description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
- ILRCGYURZSFMEG-UHFFFAOYSA-N Salidroside Natural products OC1C(O)C(O)C(CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-UHFFFAOYSA-N 0.000 claims abstract description 19
- ILRCGYURZSFMEG-RQICVUQASA-N salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RQICVUQASA-N 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 230000000249 desinfective effect Effects 0.000 claims abstract description 9
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000005303 weighing Methods 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 6
- 239000002562 thickening agent Substances 0.000 claims abstract description 5
- 230000001105 regulatory effect Effects 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 6
- 229940043234 carbomer-940 Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 239000000645 desinfectant Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 6
- 239000003906 humectant Substances 0.000 abstract description 6
- 230000003712 anti-aging effect Effects 0.000 abstract description 4
- 230000003078 antioxidant effect Effects 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 241001165494 Rhodiola Species 0.000 abstract description 3
- 239000002260 anti-inflammatory agent Substances 0.000 abstract description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract description 3
- 230000001766 physiological effect Effects 0.000 abstract description 3
- 239000013589 supplement Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010065390 Inflammatory pain Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000037147 athletic performance Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000010485 coping Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of disinfection, in particular to a preparation method of a no-clean disinfection gel and the no-clean disinfection gel, which comprises the following steps: s1: weighing preparation raw materials, including: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5-1.5 parts of thickener; s2: solvent preparation: adding the raw materials into 40 parts of water, uniformly stirring, and carrying out water bath for 15 to 25 minutes at the temperature of 45 to 55 ℃; s3: regulating the pH value: when the solvent swells, adding triethanolamine, adjusting the pH value to 6-7, and obtaining a stock solution after gel is formed; s4: adding alcohol into the stock solution, mixing, and stirring at 200r/min to obtain the gel. The disinfecting gel is prepared by adding salidroside and glycerol into a formula. Rhodiola root contains high-content phenolic components, shows strong and broad-spectrum oxidation resistance, can be used as an antioxidant, and has anti-aging effect; can be used as anti-inflammatory agent and humectant. Meanwhile, glycerol is the earliest to use in cosmetics, and the humectant glycerol which is widely applied is widely used in various cosmetics to supplement moisture to skin horny layer, regulate skin physiological effect, keep skin healthy and improve use feeling.
Description
Technical Field
The invention relates to the technical field of antibacterial sterilization, in particular to a preparation method of a washing-free sterilization gel and the washing-free sterilization gel.
Background
The gel is free of washing, so that people can clean hands quickly at any time and any place without water, perfumed soap or towels, after the gel is extruded, hands are directly rubbed, the hands are cleaned, and the gel can be volatilized without wiping. The common no-clean gel mainly comprises a chemical reagent compatible no-clean gel and a traditional Chinese medicine component no-clean gel, wherein the traditional Chinese medicine no-clean gel is favored by consumers because the traditional Chinese medicine no-clean gel is used as a pure natural source substance and has few toxic and side effects.
Rhodiola root contains high-content phenolic components, shows strong and broad-spectrum oxidation resistance, can be used as an antioxidant, and has anti-aging effect; can be used as anti-inflammatory agent and humectant. Meanwhile, glycerol is the earliest to use in cosmetics, and the humectant glycerol which is widely applied is widely used in various cosmetics to supplement moisture to skin horny layer, regulate skin physiological effect, keep skin healthy and improve use feeling.
Disclosure of Invention
The invention aims to provide a washing-free disinfection gel containing traditional Chinese medicine components, which has simple synthesis and disinfection effects and provides a certain skin care and moisture preservation effect.
The invention adopts the following technical scheme:
in one aspect, the present invention provides a method of preparing a leave-on disinfecting gel comprising the steps of:
S1: weighing preparation raw materials, including: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5-1.5 parts of thickener;
S2: solvent preparation: adding the raw materials into 40 parts of water, uniformly stirring, and carrying out water bath for 15 to 25 minutes at the temperature of 45 to 55 ℃;
S3: regulating the pH value: when the solvent swells, adding triethanolamine, adjusting the pH value to 6-7, and obtaining a stock solution after gel is formed;
S4: adding alcohol into the stock solution, mixing, and stirring at 200r/min to obtain the gel.
Preferably, the thickener in S1 is carbomer 940.
Preferably, the alcohol concentration in the S2 is 60 parts and the alcohol concentration is 75-95%.
On the other hand, the invention also provides a no-clean disinfecting gel, which is prepared by the preparation method of the no-clean disinfecting gel.
The invention has the beneficial effects that:
(1) The disinfecting gel is prepared by adding salidroside and glycerol into a formula. Rhodiola root contains high-content phenolic components, shows strong and broad-spectrum oxidation resistance, can be used as an antioxidant, and has anti-aging effect; can be used as anti-inflammatory agent and humectant. Meanwhile, glycerol is the earliest to use in cosmetics, and the humectant glycerol which is widely applied is widely used in various cosmetics to supplement moisture to skin horny layer, regulate skin physiological effect, keep skin healthy and improve use feeling.
(2) The added alcohol ensures that the gel has good disinfection effect while conveniently and quickly cleaning hands, and the salidroside and the glycerol also provide certain moisturizing and skin care capabilities.
Drawings
FIG. 1 is a schematic representation of a no-clean disinfecting gel prepared in example 1 of the present invention
FIG. 2 is a diagram showing the disposable sterilizing gel prepared in example 1 of the present invention after bottling
Detailed Description
The invention will be further explained with reference to examples and figures. The following examples are only illustrative of the present invention and are not intended to limit the scope of the invention.
Example 1
(1) Preparation of gel collagen liquid
Step 1, weighing a stock solution, wherein the stock solution comprises the following raw materials in parts by weight: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5 part of carbomer 940, adding 40 parts of water, uniformly stirring, carrying out water bath at 55 ℃ for 25min, swelling, adding triethanolamine, adjusting the pH value to 6-7, and forming gel to obtain a stock solution.
In the embodiment, salidroside is added, and the salidroside has the following main effects:
Antioxidant effect: the salidroside contains rich phenolic compounds, has strong oxidation resistance, can remove free radicals in a body, and reduces oxidative stress, thereby protecting cells from damage.
Anti-fatigue effect: the salidroside can enhance physical endurance and fatigue resistance, improve athletic performance, and promote physical and mental recovery.
Anti-stress effect: salidroside is helpful for regulating nervous system, improving emotion, relieving anxiety and depression, and improving stress coping ability.
Anti-aging effect: salidroside can promote cell metabolism, delay cell aging, and maintain skin elasticity and luster.
Immunomodulatory effects: salidroside can enhance immunity, improve resistance, and resist diseases.
Anti-inflammatory action: salidroside has antiinflammatory effect, and can relieve inflammatory reaction and pain.
(2) Remixing to obtain gel
60 Parts of 99% alcohol is added into the stock solution, and the mixture is stirred uniformly at the rotating speed of 200 r/min.
Example 2
(1) Preparation of gel collagen liquid
Step 1, weighing a stock solution, wherein the stock solution comprises the following raw materials in parts by weight: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5 part of carbomer 940, adding 40 parts of water, uniformly stirring, carrying out water bath at 55 ℃ for 25min, swelling, adding triethanolamine, adjusting the pH value to 6-7, and forming gel to obtain a stock solution.
(2) Remixing to obtain gel
60 Parts of 75% alcohol is added into the stock solution, and the mixture is stirred uniformly at the rotating speed of 200 r/min.
Example 3
(1) Preparation of gel collagen liquid
Step 1, weighing a stock solution, wherein the stock solution comprises the following raw materials in parts by weight: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 940 parts of carbomer, adding 40 parts of water, uniformly stirring, carrying out water bath at 55 ℃ for 25min, swelling, adding triethanolamine, adjusting the pH value to 6-7, and forming gel to obtain a stock solution.
(2) Remixing to obtain gel
60 Parts of 99% alcohol is added into the stock solution, and the mixture is stirred uniformly at the rotating speed of 200 r/min.
Example 4
(1) Preparation of gel collagen liquid
Step 1, weighing a stock solution, wherein the stock solution comprises the following raw materials in parts by weight: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 1.5 parts of carbomer 940, adding 40 parts of water, uniformly stirring, carrying out water bath at 55 ℃ for 25min, swelling, adding triethanolamine, adjusting the pH value to 6-7, and forming gel to obtain a stock solution.
(2) Remixing to obtain gel
60 Parts of 99% alcohol is added into the stock solution, and the mixture is stirred uniformly at the rotating speed of 200 r/min.
Example 5
| Group of | Sterilization rate (%) |
(1) Preparation of gel collagen liquid
Step 1, weighing a stock solution, wherein the stock solution comprises the following raw materials in parts by weight: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5 part of carbomer 940, adding 60 parts of water, uniformly stirring, carrying out water bath at 55 ℃ for 25min, swelling, adding triethanolamine, adjusting the pH value to 6-7, and forming gel to obtain a stock solution.
(2) Remixing to obtain gel
40 Parts of 99% alcohol is added into the stock solution, and the mixture is stirred uniformly at the rotating speed of 200 r/min.
The non-wash disinfection gel prepared in examples 1 to 5 (wherein examples 2 to 5 are comparative examples) and 75% alcohol were used for an antibacterial parallel experiment, each group was used in an amount of 0.1ml, and E.coli, staphylococcus aureus, candida albicans and Pseudomonas aeruginosa were used as the bacteria, and each group was calculated as 100% in terms of the sterilizing ability of 75% alcohol [ (number of colonies in blank group-number of colonies in each group)/(number of colonies in blank group-number of colonies in 75% alcohol group) ].
The foregoing embodiments have been described in detail for the purpose of illustrating the invention, it being understood that the foregoing embodiments are only illustrative of the invention and are not to be construed as limiting the invention, and that: it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof, and such changes and modifications should also be deemed to be within the scope of the invention.
Claims (4)
1. The preparation method of the no-clean disinfection gel is characterized by comprising the following steps:
S1: weighing preparation raw materials, including: 0.1 part of salidroside, 1 part of glycerol, 1 part of propylene glycol and 0.5-1.5 parts of thickener;
S2: solvent preparation: adding the raw materials into 40 parts of water, uniformly stirring, and carrying out water bath for 15 to 25 minutes at the temperature of 45 to 55 ℃;
S3: regulating the pH value: when the solvent swells, adding triethanolamine, adjusting the pH value to 6-7, and obtaining a stock solution after gel is formed;
S4: adding alcohol into the stock solution, mixing, and stirring at 200r/min to obtain the gel.
2. The method for preparing a leave-in disinfectant gel containing traditional Chinese medicine according to claim 1, wherein the thickener in S1 is carbomer 940.
3. The method for preparing a wash-free disinfecting gel containing traditional Chinese medicine according to claim 1, wherein the alcohol concentration in the S2 is 60 parts and the alcohol concentration is 75-95%.
4. A no-wash disinfecting gel, characterized in that: the method for preparing the no-clean disinfecting gel according to any one of claims 1 to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410414154.9A CN118161417A (en) | 2024-04-08 | 2024-04-08 | Preparation method of washing-free disinfection gel and washing-free disinfection gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410414154.9A CN118161417A (en) | 2024-04-08 | 2024-04-08 | Preparation method of washing-free disinfection gel and washing-free disinfection gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118161417A true CN118161417A (en) | 2024-06-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410414154.9A Pending CN118161417A (en) | 2024-04-08 | 2024-04-08 | Preparation method of washing-free disinfection gel and washing-free disinfection gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118161417A (en) |
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2024
- 2024-04-08 CN CN202410414154.9A patent/CN118161417A/en active Pending
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