CN112675086A - Passion fruit hand-washing-free gel hand sanitizer and preparation method thereof - Google Patents
Passion fruit hand-washing-free gel hand sanitizer and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a passion fruit washing-free hand-washing-free gel hand sanitizer and a preparation method thereof. The passion fruit no-clean gel hand sanitizer is prepared from the following components in percentage by weight: 0.5-1.0% of passion fruit extract; 30-75% of ethanol; 0.1-0.4% of carbomer; 0.2-1% of a humectant; 0.1-0.4% of triethanolamine; 0.1-0.4% of a bactericide; the balance of water. The essence of passion fruit peel is extracted and added into the hand-free gel, so that the prepared gel product has pleasant fruit fragrance, and the prepared hand-free gel is transparent and colorless and has good hand feeling by optimizing the proportion of the passion fruit essence and other components, and has good bacteriostatic action on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa; the product has good stability, no irritation to skin, and skin moistening and caring effects; solves the problem that the prior hand-washing-free gel product adopts essence to improve the fragrance.
Description
Technical Field
The invention belongs to the technical field of disinfection, cleaning and sanitation, and particularly relates to a passion fruit hand-washing-free gel hand sanitizer and a preparation method thereof.
Background
Along with improvement of living standards of people and convenient use of transportation modes, people can frequently go out for travel, gather meals, shop and other public activities, so that hands of people are easy to contact various pathogenic microorganisms such as bacteria, viruses and the like, if the pathogenic microorganisms cannot be timely and effectively removed, the pathogenic microorganisms can survive for hours at palms, finger joints, fingertips and other positions, and even can continue to grow and propagate, and the pathogenic microorganisms and the viruses can be hidden and propagated places. For example, contaminated hands can scratch the nose and rub the eyes without being cleaned, germs on the hands can enter the hands in a false manner, and easily enter the human body through respiratory tracts, nasal and ocular membranes and the like; the hands can take things to eat without disinfection, and microorganisms such as bacteria, viruses and the like on the hands can be transferred to food, so that people can easily infect various diseases after eating the food; before the towel is used, hands are not cleaned, germs on the hands are transferred to the towel, and when a face is washed, the towel contacts with the eye strength membrane, the nose strength membrane and the like, and the germs can enter a human body by riding the machine.
The hand sanitizer is a cleaning solution for cleaning hands, and some specific components of the hand sanitizer can sterilize and disinfect the hand sanitizer and can be divided into common hand sanitizers, disinfectant hand sanitizers and heavy oil hand sanitizers. The solution type hand sanitizer is hand cleaning liquid widely used at present, and has the defects of splashing, high water consumption in use and short disinfection time. The hand-washing-free gel is a novel hand sanitizer which is currently developed, and overcomes the defects of a solution type disinfection hand sanitizer. At present, most of hand-washing-free gel products researched in the market adopt chemical components to improve fragrance, so that people's favor and use feeling of the products are enhanced, and the chemical components comprise essence, pigment and the like, so that the hand-washing-free gel products have potential threat to human bodies after long-term use. Therefore, the invention is of great importance in the aspect of preparing the antibacterial wash-free gel without any fragrance pigment additive, and the research on the wash-free gel without essence and pigment is less at present; mainly focuses on the antibacterial research of the wash-free gel.
For example, patent publication No. CN109771315A discloses an environment-friendly hand-washing-free disinfection gel and a preparation method thereof, which comprises the following components: the bactericide comprises a bactericide, a thickening agent, polyhydric alcohol with 2-6 carbon atoms, a pH regulator, a loquat extract, water and an auxiliary agent; the adjuvant comprises rosemary extract, lavender extract, olive extract, green tea extract, mint extract, licorice extract, chrysanthemum extract, rose extract, jasmine extract and tea flower extract; the auxiliary agent has the effects of whitening, resisting aging and slowly releasing soft and fresh fragrance, and has lasting fragrance and pure fragrance. The patent proposes that the plant extract is added into the hand-free gel to improve the fragrance, but the hand-free gel has poor fragrance stability and complex fragrance components, the fragrance of the gel is not easy to control in the preparation process, and peculiar smell is easy to appear.
Disclosure of Invention
In order to solve the technical problems in the prior art, the invention provides a passion fruit hand-washing-free gel hand sanitizer and a preparation method thereof, and particularly the passion fruit hand-washing-free gel hand sanitizer is realized by the following technical scheme.
The invention provides a passion fruit washing-free gel hand sanitizer which is prepared from the following components in percentage by weight: 0.5-1.0% of passion fruit extract; 30-75% of ethanol; 0.1-0.4% of carbomer; 0.2-1% of a humectant; 0.1-0.4% of triethanolamine; 0.1-0.4% of a bactericide; the balance of water.
Preferably, the passion fruit no-clean gel hand sanitizer is prepared from the following components in percentage by weight: 0.75% of passion fruit extract; 45% of ethanol; 0.2% of carbomer; 0.25% of humectant; 0.2 percent of triethanolamine; 0.25% of bactericide; the balance of water.
Preferably, the bactericide is one of guanidine salts, quaternary ammonium salts and nonionic compounds; the humectant is one of essential oil, polyalcohol and bionic substances; the carbomer is one of carbomer U20, carbomer 940 and carbomer 2020.
More preferably, the bactericide is triclosan; the humectant is glycerol; the carbomer is carbomer 940.
Preferably, the preparation method of the passion fruit essence liquid comprises the following steps: pulverizing passion fruit peel, adding 10 times of 40-60% ethanol solution, and vacuum soaking to obtain soaked substance; adding a small amount of protective agent into the impregnated material, adding into a differential pressure tank, performing differential pressure extraction at normal temperature, filtering, and recovering ethanol from the filtrate at low temperature under reduced pressure to obtain extractive solution; purifying the extracting solution by AB-8 macroporous resin, eluting by using 30% ethanol solution, and rotationally evaporating to remove ethanol to obtain the passion fruit extract.
The passion fruit extract can be prepared from passion fruit pulp or passion fruit pulp and pericarp.
Preferably, the passion fruit peel is crushed to 60-80 meshes.
Preferably, the vacuum impregnation treatment is: the vacuum degree is-0.07 to-0.01 MPa, and the time is 1 to 2 hours.
Preferably, the protective agent is vitamin C, and the addition amount of the protective agent is 0.1-0.2% of the mass of the passion fruit.
Preferably, the pressure difference value during the high pressure difference extraction is-0.1-30 MPa.
Preferably, the preparation method of the passion fruit no-clean gel hand sanitizer comprises the following steps: mixing carbomer with water, adding the passion fruit extract, and homogenizing to obtain gel; then slowly stirring and adding the triethanolamine, the humectant and the bactericide, and uniformly stirring to obtain the transparent passion fruit wash-free gel.
The invention adopts vacuum impregnation combined with low-temperature high-pressure difference technology to extract the fragrance components in the passion fruit, and the extraction process is carried out at low temperature; solves the problems that in the existing high-temperature extraction technology, such as a steam distillation method, a distillation extraction method and the like, some heat-sensitive components in the passion fruit peel are heated and decomposed, and non-volatile substances are heated and decomposed to generate peculiar smell substances with other raw materials; and the extraction rate of aroma components of the passion fruit peel is high, and the aroma of the extracting solution is relatively thick and pure. To further illustrate the extraction experiments of the extraction method of the present invention, the present inventors conducted the following studies.
1. Screening and researching by a method: screening an extraction mode: in the process of technological research, the invention aims to utilize the active ingredients of the passion fruit peel to the maximum extent; raw material of 60-80 meshes of passion fruit powder; respectively adopting a steam distillation method, a dichloromethane extraction method, an ethanol ultrasonic extraction method and an ethanol microwave extraction method to separate an extraction solvent and water in an extracting solution to obtain extracted absolute oil, and carrying out qualitative analysis on the extracted essential oil by using a GC-MS method, wherein the results show that ester and acid fragrance components in the passion fruit peel are extracted to the maximum extent, the ester content is greater than or equal to 35.46%, and the acid content is greater than or equal to 24.31%; moreover, the fragrance is thick and pure, and no peculiar smell is generated.
2. Research on crushing particle size of passion fruit peel: when the passion fruit peel is subjected to high pressure difference extraction, the crushing or crushing degree of the passion fruit peel has great influence on the dissolution of effective components, and the research finds that the dissolution of volatile components is not facilitated due to the oversize crushing granularity (smaller than 60 meshes) of the passion fruit peel, the extraction of fragrance components is not facilitated due to the fact that passion fruit powder is easy to agglomerate due to the oversize crushing granularity, and the volatile components can be rapidly volatilized in the crushing and sieving process due to the fact that oil glands of the crushed passion fruit peel are damaged. When the fresh fruit peel is crushed to 60-80 meshes, the extraction rate of volatile oil is high. Before the passion fruit peel is subjected to high pressure difference extraction, vacuum impregnation treatment is adopted, so that an extraction solvent can fully permeate into the passion fruit peel powder, the juice in the passion fruit peel powder is fully impregnated, and the extraction rate of volatile oil is higher. When the passion fruit peel is subjected to high pressure difference extraction, the passion fruit peel is treated by vitamin C, the vitamin C has a good stabilizing effect, the reaction loss of volatile components in the extraction process can be reduced, and the obtained extract has high contents of esters and acids.
The invention also considers the bacteriostasis and stability of the obtained gel product:
1.1 test materials
(1) The passion fruit no-clean gel hand sanitizer comprises the following components:
test group 1: 0.5 percent of passion fruit extract; 30% of ethanol; 9400.1% of carbomer; 0.2% of glycerin; 0.1 percent of triethanolamine; 0.1 percent of triclosan; the balance of water.
Test group 2: 0.75% of passion fruit extract; 45% of ethanol; 9400.2% of carbomer; 0.25% of glycerin; 0.2 percent of triethanolamine; 0.25 percent of triclosan; the balance of water.
Test group 3: 1.0% of passion fruit extract; 75% of ethanol; 9400.4% of carbomer; 1% of glycerol; 0.4 percent of triethanolamine; 0.4 percent of triclosan; the balance of water.
Test group 4: 1.0% of passion fruit extract; 30% of ethanol; carbomer U200.4%; 0.2% of glycerin; 0.4 percent of triethanolamine; 0.1 percent of triclosan; the balance of water.
Test group 5: the low proportion of components: 0.3 percent of passion fruit extract; 25% of ethanol; 9400.08% of carbomer; 0.1% of glycerol; 0.05 percent of triethanolamine; 0.05 percent of triclosan; the balance of water.
Experimental group 6: high proportion of components: 1.25% of passion fruit extract; 78% of ethanol; 9400.6% of carbomer; 1.2% of glycerol; 0.7 percent of triethanolamine; 0.5 percent of triclosan; the balance of water.
1.2 bacteriostasis test: the test method comprises the following steps: tests are carried out according to the standard of disinfection technical specification (current, 2002) and the bacteriostasis method in the literature ' observation of bacteriostasis performance of polyhexamethylene biguanide hydrochloride compound wash-free gel ' (China journal of Disinfection science) '; the results of the bacteriostatic performance test are shown in table 1.
TABLE 1 Sterilization effect of Passion fruit no-wash gel liquid soap
1.3 product quality evaluation: taking the passion fruit no-clean gel hand sanitizer products prepared by the test groups 1-4, carrying out sensory evaluation on transparency, color, smell and hand feeling of the passion fruit no-clean gel hand sanitizer products, and detecting dynamic viscosity and volatilizing the passion fruit no-clean gel hand sanitizer products; the method for measuring the drying time comprises the following steps: 10 volunteers were selected, and 1.0g of the gel product was rubbed on the hands at 20 ℃ for 20 seconds, and then spread out with hands to begin timing, and the time spent was recorded until the hands were completely dry. The evaluation results are shown in table 2.
TABLE 2 sensory evaluation of Passion fruit Wash-free gel hand sanitizer products
As can be seen from tables 1 and 2, the gel products prepared in the test groups 1 to 4 have better antibacterial effect and better transparency, color, smell and hand feeling than the gel products prepared in the test groups 5 to 6.
1.4 skin irritation test: taking 5 rabbits female and male rabbits respectively, dividing into 4 groups, and each group comprises 2 rabbits; the test was acclimated in the laboratory for 3 days before shaving the hair 24h earlier. 1-4 groups 0.1mL of gel prepared by test groups 1-4, respectively, was applied to skin in the range of 2.5cm by 2.5cm on one side of the spine, and a blank control was made on the other side. After 6, the gel is removed. The application was repeated for 15 days, 1 time per day, and the results were observed. The result shows that the compound washing-free gel stock solution is not abnormal and does not form erythema after contacting the skin of the rabbit; the integral value of the skin irritation reaction is 0, and the no-wash gel hand sanitizer provided by the invention has no irritation to the skin of rabbits.
1.5 stability test: according to the standard of disinfection technical specification (currently, 2002), passion fruit no-clean gel hand sanitizer products prepared by test groups 1-4 are placed in a constant temperature box at 37 ℃ for storage for 3 months, samples before and after storage are taken, bacteriostasis tests are carried out on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa according to the bacteriostasis test method, the bacteriostasis rate is calculated, and the stability of the passion fruit no-clean gel hand sanitizer products is judged according to the change of the bacteriostasis rate before and after the bacteriostasis test. After the passion fruit no-clean gel hand sanitizer products of test groups 1-4 are stored for 3 months, the transparency, color and smell of the hand sanitizer products are not obviously changed; the antibacterial rate of the product is 100% after 3min when the product is applied to Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa. The passion fruit no-clean gel hand sanitizer products of test groups 1-4 are demonstrated to have good stability.
The invention has the beneficial effects that:
by optimizing the extraction method of the passion fruit peel extract, the ester and acid fragrance components in the passion fruit peel can be extracted to the maximum extent, so that the prepared extract has peculiar smell of grass, pure and strong fragrance and the like.
The essence of passion fruit peel is extracted and added into the hand-free gel, so that the prepared gel product has pleasant fruit fragrance, and the prepared hand-free gel is transparent and colorless and has good hand feeling by optimizing the proportion of the passion fruit essence and other components, and has good bacteriostatic action on escherichia coli staphylococcus aureus, candida albicans and pseudomonas aeruginosa; the product has good stability, no irritation to skin, and skin moistening and caring effects; solves the problem that the prior absorption-free gel product adopts essence to improve the fragrance.
Detailed Description
The technical solution of the present invention is further limited by the following specific embodiments, but the scope of the claims is not limited to the description.
Example 1 preparation of passion fruit extract 1
Crushing 100g of passion fruit peel to 60-80 meshes, adding 10 times of 40% ethanol solution, and carrying out immersion treatment for 2 hours under the vacuum degree of-0.07-0.01 MPa to obtain an immersion substance; adding 0.1% by mass of vitamin C into the impregnated material, adding into a differential pressure tank, extracting at normal temperature under the condition of-0.1-30 MPa differential pressure change, filtering, and recovering ethanol in the filtrate at low temperature under reduced pressure to obtain an extracting solution; purifying the extracting solution by AB-8 macroporous resin, eluting by using 30% ethanol solution, and rotationally evaporating to remove ethanol to obtain the passion fruit extract.
Example 2 passion fruit extract 2
Crushing 100g of passion fruit peel to 60-80 meshes, adding 10 times of 60% ethanol solution, and performing immersion treatment for 1h under the vacuum degree of-0.07-0.01 MPa to obtain an immersion substance; adding 0.2% by mass of vitamin C into the impregnated material, adding into a differential pressure tank, extracting at normal temperature under the condition of-0.1-30 MPa differential pressure change, filtering, and recovering ethanol in the filtrate at low temperature under reduced pressure to obtain an extracting solution; purifying the extracting solution by AB-8 macroporous resin, eluting by using 30% ethanol solution, and rotationally evaporating to remove ethanol to obtain passion fruit extract 2.
Example 3
The components are as follows: 10.5 percent of passion fruit extract; 30% of ethanol; 9400.1% of carbomer; 0.2% of glycerin; 0.1 percent of triethanolamine; 0.1 percent of triclosan; the balance of water.
Preparation: mixing carbomer 940 with water, adding the passion fruit extract, uniformly mixing, and slowly adding triethanolamine to obtain gel; then sequentially adding glycerol and triclosan, and uniformly stirring to obtain the transparent passion fruit wash-free gel.
Example 4
The components are as follows: 10.75 percent of passion fruit extract; 45% of ethanol; 9400.2% of carbomer; 0.25% of glycerin; 0.2 percent of triethanolamine; 0.25 percent of triclosan; the balance of water.
Preparation: mixing carbomer 940 with water, adding the passion fruit extract, uniformly mixing, and slowly adding triethanolamine to obtain gel; then sequentially adding glycerol and triclosan, and uniformly stirring to obtain the transparent passion fruit wash-free gel.
Example 5
The components are as follows: 21.0% of passion fruit extract; 75% of ethanol; 9400.4% of carbomer; 1% of glycerol; 0.4 percent of triethanolamine; 0.4 percent of triclosan; the balance of water.
Preparation: mixing carbomer 940 with water, adding the passion fruit extract, uniformly mixing, and slowly adding triethanolamine to obtain gel; then sequentially adding glycerol and triclosan, and uniformly stirring to obtain the transparent passion fruit wash-free gel.
Example 5
The components are as follows: 21.0% of passion fruit extract; 30% of ethanol; carbomer U200.4%; 0.2% of glycerin; 0.4 percent of triethanolamine; 0.1 percent of triclosan; the balance of water.
Preparation: mixing carbomer U20 with water, adding the passion fruit extract, and slowly adding triethanolamine to obtain gel; then sequentially adding glycerol and triclosan, and uniformly stirring to obtain the transparent passion fruit wash-free gel.
It should be noted that the above examples and test examples are only for further illustration and understanding of the technical solutions of the present invention, and are not to be construed as further limitations of the technical solutions of the present invention, and the invention which does not highlight essential features and significant advances made by those skilled in the art still belongs to the protection scope of the present invention.
Claims (10)
1. The passion fruit washing-free gel hand sanitizer is characterized by being prepared from the following components in percentage by weight: 0.5-1.0% of passion fruit extract; 30-75% of ethanol; 0.1-0.4% of carbomer; 0.2-1% of a humectant; 0.1-0.4% of triethanolamine; 0.1-0.4% of a bactericide; the balance of water.
2. The passion fruit no-clean gel hand sanitizer according to claim 1, which is prepared from the following components in percentage by weight: 0.75% of passion fruit extract; 45% of ethanol; 0.2% of carbomer; 0.25% of humectant; 0.2 percent of triethanolamine; 0.25% of bactericide; the balance of water.
3. The passion fruit no-clean gel hand sanitizer according to claim 1 or 2, wherein the bactericide is one of guanidinium salts, quaternary ammonium salts and nonionic compounds; the humectant is one of essential oil, polyalcohol and bionic substances; the carbomer is one of carbomer U20, carbomer 940 and carbomer 2020.
4. The passion fruit no-clean gel hand sanitizer according to claim 3, wherein the bactericide is triclosan; the humectant is glycerol; the carbomer is carbomer 940.
5. The passion fruit no-clean gel hand sanitizer according to claim 1 or 2, wherein the preparation method of the passion fruit essence sanitizer comprises the following steps: pulverizing passion fruit peel, adding 10 times of 40-60% ethanol solution, and vacuum soaking to obtain soaked substance; adding a small amount of protective agent into the impregnated material, adding into a differential pressure tank, performing differential pressure extraction at normal temperature, filtering, and recovering ethanol from the filtrate at low temperature under reduced pressure to obtain extractive solution; purifying the extracting solution by AB-8 macroporous resin, eluting by using 30% ethanol solution, and rotationally evaporating to remove ethanol to obtain the passion fruit extract.
6. The passion fruit no-clean gel hand sanitizer according to claim 5, wherein the passion fruit peel is crushed to 60-80 meshes.
7. The passion fruit no-clean gel hand sanitizer according to claim 5, wherein the vacuum impregnation treatment is: the vacuum degree is-0.07 to-0.01 MPa, and the time is 1 to 2 hours.
8. The passion fruit no-clean gel hand sanitizer according to claim 5, wherein the protective agent is vitamin C, and the addition amount of the protective agent is 0.1-0.2% of the mass of the passion fruit.
9. The passion fruit no-clean gel hand sanitizer according to claim 5, wherein the pressure difference value during high-pressure-difference extraction is-0.1 to 30 MPa.
10. The method for preparing the passion fruit no-clean gel hand sanitizer according to claim 1 or 2, wherein after the carbomer is mixed with water, the passion fruit essence is added to be uniform, and then the triethanolamine is added slowly with stirring to prepare the gel; and adding the humectant and the bactericide, and uniformly stirring to prepare the transparent passion fruit wash-free gel.
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