CN109497093A - A kind of thimerosal - Google Patents
A kind of thimerosal Download PDFInfo
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- CN109497093A CN109497093A CN201811417021.8A CN201811417021A CN109497093A CN 109497093 A CN109497093 A CN 109497093A CN 201811417021 A CN201811417021 A CN 201811417021A CN 109497093 A CN109497093 A CN 109497093A
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
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Abstract
The present invention relates to a kind of thimerosals, and in particular to a kind of multifunctional general thimerosal belongs to external medical product technical field.Thimerosal of the present invention includes the component of following parts by weight: hexamethylene: 4-6 parts, 2-4 parts of enzyme, 1-3 parts of plant extracts, 1-2 parts of food-grade Citric Acid Mono, 5-8 parts of aid antibacteria agent, 900-1200 parts of purified water.The present invention is with hexamethylene+enzyme+plant extracts complex method, basic from sterilizing is changed in form, formula i.e. of the invention is physical sterilization principle, it does not stimulate mildly, it is different from the chemical sterilization principle of the traditional disinfections liquid such as Iodophor, alcohol, sterilization while can generate stimulation.
Description
Invention field
The present invention relates to a kind of thimerosals, and in particular to a kind of multifunctional general thimerosal belongs to external medical articles
Technical field.
Background technique
Illness finds its way in by the mouth in common saying road, and the most germs of entrance are by often to be used in hand and clothing and home life
Object is brought into, moreover, wound be easier infected by germ, gently then occur inflammation hair purulence, it is heavy then may cause pustule sore, pneumonia,
Kidney failure, bacteremia etc., threat to life.It is therefore regular and thoroughly opponent, clothing and household supplies, apparatus carry out disinfection,
Program particularly important in daily life is just correctly become to wound disinfection in time, especially wound disinfection processing is extremely crucial,
If the thimerosal of choosing is not mild enough, instead wound can be stimulated, wound burden is increased while disinfection, is easy to stay scar, in addition one
A little enough high thimerosals of safety, and bacteriostasis can only be played, sterilization levels are not achieved, wound is also possible that inflammation sense
Scar probability is stayed in dye, increase.Presently commercially available traditional disinfection liquid contains the raw materials such as iodine, chlorine, aldehyde, alcohol mostly, not environmentally friendly enough.It is highly-safe
Disinfection Effect it is not good enough, and Disinfection Effect is good, and safety is again not high enough, can stimulate skin, more unsuitable pregnant and lying-in women and baby
Child uses, so, lacking one kind not only can guarantee safe enough but also can reach the thimerosal of efficient sterilizing, be applied to common object
It may replace the thimerosals such as class containing chlorine, ethyl alcohol when product, may replace iodine class, quaternary ammonium disinfectant when being applied to daily wound,
And Disinfection Effect can be kept for a long time.
Summary of the invention
In view of the above-mentioned problems existing in the prior art, the purpose of the present invention is to provide it is a kind of it is highly-safe, validity is good
Thimerosal, thimerosal of the invention is primarily adapted for use in the disinfection of daily wound, it can also be used to the disinfection of vessel, article.
The purpose of the present invention realizes that a kind of thimerosal, the thimerosal includes following weight by following technical solution
The component of number: hexamethylene: 4-6 parts, 2-4 parts of enzyme, 1-3 parts of plant extracts, one water lemon of food-grade
It is 1-2 parts sour, 5-8 parts of aid antibacteria agent, 900-1200 parts of purified water.
The present invention starts with from safety and validity, mainly with hexamethylene+enzyme+plant extracts
Complex method, basic from sterilizing are changed in form, i.e., formula of the invention is physical sterilization principle, do not pierce mildly
Swash, be different from the chemical sterilization principle of the traditional disinfections liquid such as Iodophor, alcohol, sterilization while can generate stimulation.And the present invention
Formula be suitable for pregnant woman, children, it is safe, quick, nontoxic (entrance, pleasing to the eye equal nonhazardous).
In thimerosal of the present invention, body material is hexamethylene, hexamethylene
It is antibacterial for a long time for environment-friendly type macromolecule polymer；It is colourless odorless, it is without any side effects；In electropositive, easily absorption is in negative
All kinds of harmful bacterias of electrical property, virus, due to special bactericidal mechanism, various bacteriums will not generate resistance and patience to it, can
It is used for a long time.Since the guanidine radicals in Polyhaxemethylenguanidine Hydrochloride has very high activity, makes polymer at electropositive, therefore be easy to
It is usually adsorbed in electronegative all kinds of bacteriums, virus, to inhibit the splitting function of bacterium, virus, makes bacterium, virus
Lose fecundity；In addition the film that polymer is formed plugs the respiration channel of microorganism, make microorganism suffocate rapidly and
Extremely；Simultaneously as Polyhaxemethylenguanidine Hydrochloride is polymer architecture, the effective active of guanidine radicals can be made to be improved, so hydrochloric acid
The fungicidal effectiveness of polyhexamethylene guanide is much higher than other guanidine compounds.
In a kind of above-mentioned thimerosal, the enzyme includes the component of following parts by weight: 0.5-1 parts of staphylococcus lysozyme,
1-2 parts of bromelain, 0.5-1 parts of ptyalin.Enzyme is in the nature protein, is divided into plant enzyme, animal ferment, microorganism
Enzyme, nontoxic, enzyme treatment technique is the Green Manufacturing Technology for being acknowledged as meeting environmental requirement at present.The present invention is sub- poly- six
Enzyme is added in methyl biguanide hydrochloride, the bacteriostasis of hexamethylene can be promoted to strong bactericidal effect, reached
To high-effective disinfecting rank, while wound healing can be promoted again, shorten healing time.
Staphylococcus lysozyme is added in the present invention on the basis of hexamethylene, and staphylococcus lysozyme is one
Metalloproteinases of the kind containing zinc, the cell wall that single-minded can degrade has the microorganism of glycine peptide bond structure, by cracking its cell
Wall achievees the purpose that sterilization.When for wound, since it contains zinc ion, zinc ion can be reduced surface of a wound calcium ion concentration, to subtract
Few surface of a wound exudation and mitigation edge of wound oedema, are finally conducive to Wound healing, shorten healing time.And bromelain is planted from pineapple
The general name of a kind of proteolytic enzyme extracted in strain, is primarily present in pineapple stem and fruit, according to the difference of extract part, divides
For stem bromelain and seed-timber stand.Bromelain has immunostimulation, and in vivo and in vitro shows, by right
The stimulation of auxiliary cell and to T cell directly inhibit react, can be enhanced and inhibit the immune response of T cell.Pineapple
Protease can effectively treat oedema and inflammation in various tissues.And ptyalin mainly acts as in formula processing technology
With capableing of the mixing of steady other compositions, and facilitation effect plays.
In a kind of above-mentioned thimerosal, the plant extracts is purslane extract.Purslane
It (PortulacaoleraceaL.) is Portulacaceae annual herb plant, it is edible to be used as medicine, it is a kind of integration of drinking and medicinal herbs
Plant.Flavones has the function of that inhibiting bacteria and diminishing inflammation, triterpenes have the effects that anticancer, anti-inflammatory, anti-bacteria and anti-virus in its extract.It is right
In common food-borne pathogens, such as Escherichia coli, shigella dysenteriae, staphylococcus aureus, bacillus subtilis and typhoid fever bar
Bacterium etc. has apparent bacteriostatic activity, meanwhile, to some fungies, also there is certain inhibiting effect.
In a kind of above-mentioned thimerosal, the aid antibacteria agent is bis- (N1- rubigan-N5- biguanides base) hexanes of 1,6-
Digluconate.1,6- bis- (N1- rubigan-N5- biguanides base) hexane digluconates include belonging to cationic
Object is closed, has apparent affinity to bacterium, bacterial cell membrane can be destroyed, inhibits bacterial metabolism enzyme, to generate killing to bacterium
Effect.
A kind of preparation method of thimerosal, the preparation method specifically comprise the following steps: to weigh the original for preparing thimerosal
Material, heating purified water are added hexamethylene and aid antibacteria agent, are stirring evenly and then adding into enzyme after heat preservation, after
It is continuous to be stirring evenly and then adding into plant extracts and stand, it is obtained after food-grade Citric Acid Mono, then agitated standing then is added
Thimerosal.
In a kind of above-mentioned preparation method of thimerosal, the heating temperature of the purified water is 75-80 DEG C, and soaking time is
4-8min。
In a kind of above-mentioned preparation method of thimerosal, the temperature that the enzyme is added is 35-40 DEG C.It is suitable more than or less than most
Temperature can all reduce enzymatic activity.It is mainly manifested in two aspects: 1. changing the electriferous state of substrate molecule and enzyme molecule, thus
Influence the combination of enzyme and substrate；2. too high or too low temperature can all influence the stability of enzyme, and then make enzyme by irreversible broken
It is bad.
In a kind of above-mentioned preparation method of thimerosal, time of repose is 1.5-2.5h after plant extracts is added, and is added
Time of repose is 0.5-1h after food-grade Citric Acid Mono.
A kind of thimerosal of the present invention, is not limited to spraying and dropping liquid.
A kind of thimerosal of the present invention, can be used on the person, such as site of injury, the place for needing to sterilize can also make
With the place on article, sterilized such as needs.
Compared with prior art, the present invention has the advantage that
1, pleasing to the eye entrance is nontoxic: safety is sufficiently high, allows more the trusting of consumer；Colorless and odorless: be not pungent taste,
There is no ugly color, uses more comfortable；It is non-stimulated: not stimulate wound, severely injured mouth burden is not added, than disappearing for stimulation wound
Venom can more promote wound healing, be not easy to stay scar；
2, not allergy: the delicate skin quality such as women, baby child, the sensitive parts such as face, eye can it is safe to use (Iodophor,
The easy allergy of alcohol)；For a wider population, pregnant and lying-in women and baby Tong Keyong: safe enough, pregnant and lying-in women and baby child can be safe to use
(Iodophor is not useable for pregnant and lying-in women and baby is virgin)；
3, promote wound healing: on the basis of not stimulating wound, biological enzyme component can more promote wound healing, keep wound good
It is fast, reduction stay scar probability；Validity is high: for infecting more serious wound, the present invention can timely and effectively control infection, promote
Into healing, effect is obvious (Iodophor acts on this kind of wound unobvious)
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
Table 1: embodiment 1-5 thimerosal composition
Embodiment 1
It is killed according to addition hexamethylene after the heating purified water heat preservation of the composition of 1 embodiment 1 of table and auxiliary
Microbial inoculum cools down after mixing evenly and enzyme is added, be stirring evenly and then adding into plant extracts and stands, and one water of food-grade is then added
Thimerosal is obtained after citric acid, then agitated standing.Wherein, the heating temperature of purified water is 75 DEG C, soaking time 4min, enzyme
It is 35 DEG C that temperature, which is added, and time of repose is 1.5h after plant extracts is added, and time of repose after food-grade Citric Acid Mono is added
For 0.5h.
Embodiment 2
It is killed according to addition hexamethylene after the heating purified water heat preservation of the composition of 1 embodiment 2 of table and auxiliary
Microbial inoculum cools down after mixing evenly and enzyme is added, be stirring evenly and then adding into plant extracts and stands, and one water of food-grade is then added
Thimerosal is obtained after citric acid, then agitated standing.Wherein, the heating temperature of purified water is 76 DEG C, soaking time 5min, enzyme
It is 36 DEG C that temperature, which is added, and time of repose is 1.7h after plant extracts is added, and time of repose after food-grade Citric Acid Mono is added
For 0.6h.
Embodiment 3
It is killed according to addition hexamethylene after the heating purified water heat preservation of the composition of 1 embodiment 3 of table and auxiliary
Microbial inoculum cools down after mixing evenly and enzyme is added, be stirring evenly and then adding into plant extracts and stands, and one water of food-grade is then added
Thimerosal is obtained after citric acid, then agitated standing.Wherein, the heating temperature of purified water is 77 DEG C, soaking time 6min, enzyme
It is 38 DEG C that temperature, which is added, and time of repose is 2h after plant extracts is added, and time of repose is after food-grade Citric Acid Mono is added
0.8h。
Embodiment 4
It is killed according to addition hexamethylene after the heating purified water heat preservation of the composition of 1 embodiment 4 of table and auxiliary
Microbial inoculum cools down after mixing evenly and enzyme is added, be stirring evenly and then adding into plant extracts and stands, and one water of food-grade is then added
Thimerosal is obtained after citric acid, then agitated standing.Wherein, the heating temperature of purified water is 79 DEG C, soaking time 4-8min,
It is 39 DEG C that temperature, which is added, in enzyme, and time of repose is 2.2h after plant extracts is added, when standing after addition food-grade Citric Acid Mono
Between be 0.9h.
Embodiment 5
It is killed according to addition hexamethylene after the heating purified water heat preservation of the composition of 1 embodiment 5 of table and auxiliary
Microbial inoculum cools down after mixing evenly and enzyme is added, be stirring evenly and then adding into plant extracts and stands, and one water of food-grade is then added
Thimerosal is obtained after citric acid, then agitated standing.Wherein, the heating temperature of purified water is 80 DEG C, soaking time 8min, enzyme
It is 40 DEG C that temperature, which is added, and time of repose is 2.5h after plant extracts is added, and time of repose after food-grade Citric Acid Mono is added
For 1h.
Embodiment 6
Difference with embodiment 3 is only that the enzyme in the composition of the embodiment thimerosal does not include staphylococcus lysozyme,
He is same as Example 3, and details are not described herein again.
Embodiment 7
Difference with embodiment 3 is only that the enzyme in the composition of the embodiment thimerosal does not include protease, other and reality
Apply that example 3 is identical, and details are not described herein again.
Embodiment 8
Difference with embodiment 3 is only that the enzyme in the composition of the embodiment thimerosal does not include ptyalin, other
Same as Example 3, details are not described herein again.
Embodiment 9
Difference with embodiment 3 is only that the plant extracts in the composition of the embodiment thimerosal mentions for other plant
Object is taken, other are same as Example 3, and details are not described herein again.
Embodiment 10
Difference with embodiment 3 is only that the aid antibacteria agent in the composition of the embodiment thimerosal is commonly common kills
Microbial inoculum, other are same as Example 3, and details are not described herein again.
Embodiment 11
Difference with embodiment 3 is only that the temperature that enzyme is added in the preparation process of the embodiment thimerosal is 33 DEG C,
He is same as Example 3, and details are not described herein again.
Embodiment 12
Difference with embodiment 3 is only that the temperature that enzyme is added in the preparation process of the embodiment thimerosal is 41 DEG C,
He is same as Example 3, and details are not described herein again.
Comparative example 1
Difference with embodiment 3 is only that, hexamethylene is not contained in the comparative example thimerosal, other
Same as Example 3, details are not described herein again.
Comparative example 2
Difference with embodiment 3 is only that, enzyme is not contained in the comparative example thimerosal, other are same as Example 3, herein
It repeats no more.
Comparative example 3
Difference with embodiment 3 is only that, plant extracts is not contained in the comparative example thimerosal, other and embodiment 3
Identical, details are not described herein again.
Comparative example 4
Difference with embodiment 3 is only that, food-grade Citric Acid Mono is not contained in the comparative example thimerosal, other and reality
Apply that example 3 is identical, and details are not described herein again.
Comparative example 5
Difference with embodiment 3 is only that, aid antibacteria agent is not contained in the comparative example thimerosal, other and embodiment 3
Identical, details are not described herein again.
Comparative example 6
Difference with embodiment 3 is only that the comparative example thimerosal is commercially available iodophor solution, other are same as Example 3,
Details are not described herein again.
Comparative example 7
Difference with embodiment 3 is only that the comparative example thimerosal is commercially available 75% ethyl alcohol, other are same as Example 3,
Details are not described herein again.
By thimerosal made from above-described embodiment 1-12 and comparative example 1-7 carry out interim trial, it is subsequent to patient carry out with
Track, the results are shown in Table 2:
Wherein, application method includes the following steps: to be aligned at the surface of a wound, and keeps suitable distance, pressing thimerosal to sprinkling
Uniformly.
Non-clinical wound test, the processing comparison of 900 daily wounds.
Wound type: acute wound, this test select wound epidermis diameter to be lower than 2.5cm, the daily wound that can voluntarily handle
Mouthful, such as incised wound, scuffing, the daily broken skin wound of tumble injury.
Wound sum: 900.Test group totally 900, the age is 2-60 years old, and average age is 35 years old.According to age, property
Not, wound size averagely assigns to each group.
Table 2
Illustrate: 1. in embodiment 31 red and swollen situation be finger at wound, encountered water, polluted wound infection
Mild redness is caused, continuing to use to relax later is, red and swollen fading after 4 hours
75% ethanol disinfection liquid is chiefly used in intact skin disinfection and surface disinfection, is not used in cut skin degerming,
Comparative example 7 is mainly used for sterilisation of objects Contrast on effect, therefore without this result in skin wounds disinfection data.
Result judgement standard:
Red and swollen: there is the rubescent swelling phenomenon of a part or whole part being visually observed in wound location；
Stimulation: user experiences slight shouting pain or obvious shouting pain in wound location, and general pain continues at 2 seconds or more；
Suppurate: there is macroscopic apparent white or faint yellow secretion in wound, and experiences with red and swollen heat pain；
Scab forming time: occurs the time in macroscopic scab face to wound face from injured；
The decrustation time: to the time that wound incrustation face all falls off from injured.
Referring to " disinfection technology standard " (2002 editions), surface disinfection field test is done.Sterilization objects are wooden paint
Surface is wiped one time with thimerosal stoste, after effect five minutes, is sampled with cotton swab semar technique, is detected surface natural bacteria sterilizing rate.
Test result is as shown in table 3:
Table 3: the test result of embodiment 1-12 and comparative example 1-7 thimerosal to wooden painted surface.
Remarks: iodophor solution is chiefly used in skin and wound disinfection, is not used in sterilisation of objects, comparative example 6 is mainly used for above-mentioned
The comparison of skin wounds Disinfection Effect, therefore no data in sterilisation of objects test.
It kills logarithm=- log (1- killing rate, 10).
Logarithm > 4 are killed, indicate sterilizing rate > 99.99%；
Logarithm > 3 are killed, indicate sterilizing rate > 99.9%；
Logarithm < 1 is killed, indicates sterilizing rate < 90%；
Example: sterilizing rate 80%, then killing logarithm is 0.699.
It can be seen from the results above that thimerosal produced by the present invention has efficient sterilizing ability, it can be right in the short time
Body surface reaches Disinfection Effect.
Specific embodiment described herein is only an example for the spirit of the invention.The neck of technology belonging to the present invention
The technical staff in domain can do various modifications or supplement or is substituted in a similar manner to described specific embodiment, but simultaneously
Spirit or beyond the scope defined by the appended claims of the invention is not deviated by.
It is skilled to this field although present invention has been described in detail and some specific embodiments have been cited
For technical staff, as long as it is obvious for can making various changes or correct without departing from the spirit and scope of the present invention.
Claims (8)
1. a kind of thimerosal, which is characterized in that the thimerosal includes the component of following parts by weight: cosmocil stearate
Hydrochlorate: 4-6 parts, 2-4 parts of enzyme, 1-3 parts of plant extracts, 1-2 parts of food-grade Citric Acid Mono, 5-8 parts of aid antibacteria agent, purifying
900-1200 parts of water.
2. a kind of thimerosal according to claim 1, which is characterized in that the enzyme includes the component of following parts by weight:
0.5-1 parts of staphylococcus lysozyme, 1-2 parts of bromelain, 0.5-1 parts of ptyalin.
3. a kind of thimerosal according to claim 1, which is characterized in that the plant extracts is purslane extract.
4. a kind of thimerosal according to claim 1, which is characterized in that the aid antibacteria agent is that bis- (N1- is to chlorine by 1,6-
Phenyl-N5- biguanides base) hexane digluconate.
5. a kind of preparation method of thimerosal as described in claim 1, which is characterized in that the preparation method includes following step
It is rapid:
The raw material for preparing thimerosal is weighed, hexamethylene and assisting sterilisation is added in heating purified water after heat preservation
Agent is stirring evenly and then adding into enzyme, continues to be stirring evenly and then adding into plant extracts and stand, and one water lemon of food-grade is then added
Thimerosal is obtained after acid, then agitated standing.
6. a kind of preparation method of thimerosal according to claim 5, which is characterized in that the heating temperature of the purified water
It is 75-80 DEG C, soaking time 4-8min.
7. a kind of preparation method of thimerosal according to claim 5, which is characterized in that the temperature that enzyme is added is 35-40
℃。
8. a kind of preparation method of thimerosal according to claim 5, which is characterized in that stood after plant extracts is added
Time is 1.5-2.5h, and time of repose is 0.5-1h after food-grade Citric Acid Mono is added.
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| CN114032226A (en) * | 2021-10-19 | 2022-02-11 | 广州城市职业学院 | Preparation method and application of papain |
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