CN104306397A - Antibacterial external use ointment and manufacturing method thereof - Google Patents
Antibacterial external use ointment and manufacturing method thereof Download PDFInfo
- Publication number
- CN104306397A CN104306397A CN201410623590.3A CN201410623590A CN104306397A CN 104306397 A CN104306397 A CN 104306397A CN 201410623590 A CN201410623590 A CN 201410623590A CN 104306397 A CN104306397 A CN 104306397A
- Authority
- CN
- China
- Prior art keywords
- parts
- external used
- ointment
- used ointment
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses antibacterial external use ointment and a manufacturing method thereof. Sucrose sulphate silver is contained in the antibacterial external use ointment, and the antibacterial external use ointment comprises the following components in parts by weight: 0.3-1.0 part of sucrose sulphate silver, 7.5-8.0 parts of octadecanol, 3.0-3.5 parts of glycerin monostearate, 5.0-5.5 parts of albolene, 10.0-10.5 parts of liquid paraffin, 7.5-8.0 parts of glycerin, 1.0-1.5 parts of sodium dodecyl sulfate, 0.08-0.1 part of nipagin and 62-65.6 parts of distilled water. The component of sucrose sulphate silver is contained in the antibacterial external use ointment, high bacterial ability of silver ions and recovery effect of sucrose ester for skin injury of people are fully utilized, and through synergistic effect of the silver ions and the sucrose ester, the antibacterial external use ointment with high bactericidal ability and good recovery effect for the skin injury is prepared.
Description
Technical field
The present invention relates to field of pharmaceutical technology, particularly relate to a kind of antibiotic external used ointment and preparation method thereof.
Background technology
The antibacterial sterilization agent of silver ion is used to the existing history for a long time that sterilizes, and has particularly been widely used in water treatment both domestic and external as ionizing aqueous disinfectant.Current silver ion technology has become the effective ways that the mankind resist virus, pathogenic bacteria.Silver-ion antibiotic disinfectant has become one of new highlight of current biotech industry research.
Sucrose is a kind of green, nontoxic, Renewable resource, is formed by the glucose of a part and the fructose dehydrating condensation of a part, is a kind of natural, biodegradable material.Sucrose ester is a kind of green edible surfactant, sucrose ester is nontoxic, and in human body, be decomposed into sucrose and fatty acid and utilized by body, safety is high, to skin and mucosa nonirritant, there is the functions such as good emulsifying, solubilising, moistening, starch aging resistance, antibacterial, viscosity adjustment.Thus the fields such as food, medicine, cosmetics, preserving fruit and vegetable utilizing are widely used in.The alkaline aluminium salt that sucrose octasulfate and metallic aluminium are formed has been widely used in treating on gastroenteritic ulcer clinically, and it dissociates into aluminium hydroxide and sulphuric acid sucrose complex under one's belt.The former has antiacid effect, and the latter and focus surface band positive charge protein bound form protecting film at coat of the stomach, adhere to epithelial cell and ulcer basilar part securely, prevent the erosion of gastric acid and digestive enzyme.
As medical antibacterial externally-applied ointment, product on sale in the market mainly contains Antibiotics and sulfonamides.The long-term antibiotics of use in large area antibacterials, can produce the toxic and side effects of general; Also can bring out the appearance of Resistant strain on the other hand, cause and use antibacterium medicine invalid in the future.Sulfonamides belongs to broad spectrum antibiotic, but has drug resistance to such medicine due to current many common clinical pathogenic bacteria, therefore only for the infection caused by sensitive bacterial and other responsive pathogenic microorganisms.
Application number is with silver nitrate and the sucrose sodium sulfovinate sucrose sulfuric ester that has been Material synthesis silver in the patent of EP02785233A.
Summary of the invention
The invention provides a kind of antibiotic external used ointment and preparation method thereof.The present invention with the addition of sucrose sulfuric ester silver composition in antibiotic external used ointment, make full use of the strong sterilizing ability of silver ion and sucrose ester to the repair of human body skin damnification, by cooperative effect between the two, obtain the antibiotic external used ointment that there is strong sterilizing ability and skin injury is had to fine repair.
Technical scheme provided by the invention is:
A kind of antibiotic external used ointment, containing sucrose sulfuric ester silver in described antibiotic external used ointment.
Preferably, in described antibiotic external used ointment, described antibiotic external used ointment comprises the component of following parts by weight:
Sucrose sulfuric ester silver 0.3-1.0 part, octadecanol 7.5-8.0 part, glyceryl monostearate 3.0-3.5 part, white vaseline 5.0-5.5 part, paraffin hydrocarbons 10.0-10.5 part, glycerol 7.5-8.0 part, sodium lauryl sulphate 1.0-1.5 part, nipalgin 0.08-0.1 part and distilled water 62-65.6 part.
Preferably, in described antibiotic external used ointment, be made up of the component of following parts by weight:
Sucrose sulfuric ester silver 0.6 part, octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts, paraffin hydrocarbons 10.2 parts, glycerol 7.7 parts, sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and distilled water 64 parts.
A manufacture method for antibiotic external used ointment, comprises the following steps:
Step one: get octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts and liquid Paraffin 10.2 parts mixing, stir 5-8min completely transparent to mixed liquor, obtain oil solution, described oil solution is incubated placement at 85-90 DEG C at 90 DEG C, for subsequent use;
Step 2: get sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and glycerol 7.7 parts, add in the distilled water of 51 parts, stir 3-6min and dissolve completely to mixed liquor, obtain aqueous solution at 90 DEG C, described aqueous solution is incubated placement at 85-90 DEG C, for subsequent use;
Step 3: at 85-90 DEG C, adds described oil solution in described aqueous solution, and constantly stirs 1-2min in the same direction, obtain emulsifiable paste matrix;
Step 4: after sucrose sulfuric ester silver 0.6 part is added 13 parts of distilled water, grinding evenly, adds in described emulsifiable paste matrix, and stir 5-8min to the complete emulsifying of mixed liquor in room temperature with constant, room temperature cools, and obtains ointment finished product.
Preferably, in described antibiotic external used ointment, the application of described antibiotic external used ointment in the medicine of preparation wound, burn and other trauma infection contaminations.
The invention provides a kind of antibiotic external used ointment and preparation method thereof.The present invention with the addition of sucrose sulfuric ester silver composition in antibiotic external used ointment, argentiferous preparation as disinfectant, antibacterial and anti-biotic material while antiviral, sterilization, silver ion requires no cells in vivo metabolic process, to human non-toxic's side effect, and action effect can not weaken because of the metabolism of human body, can not produce mutational variety.Sucrose ester is decomposed into sucrose and fatty acid and is utilized by body in human body, and safety is high, to skin and mucosa nonirritant, has the effects such as good emulsifying, solubilising, moistening, starch aging resistance, antibacterial, viscosity adjustment.The present invention with the addition of sucrose sulfuric ester silver composition in antibiotic external used ointment, by the synergism between sucrose ester and silver ion, obtain the antibiotic external used ointment that there is strong sterilizing ability and skin injury is had to fine repair, it has unique advantage with compared with antibiotic medicine, namely, while antiviral, sterilization, silver-ion formulations can not develop immunity to drugs and bring out Resistant strain.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Embodiment 1:
A kind of antibiotic external used ointment, containing sucrose sulfuric ester silver in described antibiotic external used ointment.
In described antibiotic external used ointment, described antibiotic external used ointment comprises the component of following parts by weight:
Sucrose sulfuric ester silver 0.3 part, octadecanol 7.5 parts, glyceryl monostearate 3.0 parts, white vaseline 5.0 parts, paraffin hydrocarbons 10.0 parts, glycerol 7.5 parts, sodium lauryl sulphate 1.0 parts, nipalgin 0.08 part and distilled water 62 parts.
A manufacture method for antibiotic external used ointment, comprises the following steps:
Step one: get octadecanol 7.5 parts, glyceryl monostearate 3.0 parts, white vaseline 5.0 parts and liquid Paraffin 10.0 parts mixing, stir 5min completely transparent to mixed liquor, obtain oil solution, described oil solution is incubated placement at 85 DEG C at 90 DEG C, for subsequent use;
Step 2: get sodium lauryl sulphate 1.0 parts, nipalgin 0.08 part and glycerol 7.5 parts, add in the distilled water of 50 parts, stir 3min and dissolve completely to mixed liquor, obtain aqueous solution at 90 DEG C, described aqueous solution is incubated placement at 85 DEG C, for subsequent use;
Step 3: at 85 DEG C, adds described oil solution in described aqueous solution, and constantly stirs 1-2min in the same direction, obtain emulsifiable paste matrix;
Step 4: after sucrose sulfuric ester silver 0.6 part is added 12 parts of distilled water, grinding evenly, adds in described emulsifiable paste matrix, and stir 5min to the complete emulsifying of mixed liquor in room temperature with constant, room temperature cools, and obtains ointment finished product.
In described antibiotic external used ointment, the application of described antibiotic external used ointment in the medicine of preparation wound, burn and other trauma infection contaminations.
Embodiment 2:
A kind of antibiotic external used ointment, containing sucrose sulfuric ester silver in described antibiotic external used ointment.
In described antibiotic external used ointment, described antibiotic external used ointment comprises the component of following parts by weight:
Sucrose sulfuric ester silver 1.0 parts, octadecanol 8.0 parts, glyceryl monostearate 3.5 parts, white vaseline 5.5 parts, paraffin hydrocarbons 10.5 parts, glycerol 8.0 parts, sodium lauryl sulphate 1.5 parts, nipalgin 0.1 part and distilled water 65 parts.
A manufacture method for antibiotic external used ointment, comprises the following steps:
Step one: get octadecanol 8.0 parts, glyceryl monostearate 3.5 parts, white vaseline 5.5 parts and liquid Paraffin 10.5 parts mixing, stir 8min completely transparent to mixed liquor, obtain oil solution, described oil solution is incubated placement at 90 DEG C at 90 DEG C, for subsequent use;
Step 2: get sodium lauryl sulphate 1.5 parts, nipalgin 0.1 part and glycerol 8.0 parts, add in the distilled water of 52 parts, stir 6min and dissolve completely to mixed liquor, obtain aqueous solution at 90 DEG C, described aqueous solution is incubated placement at 90 DEG C, for subsequent use;
Step 3: at 90 DEG C, adds described oil solution in described aqueous solution, and constantly stirs 1-2min in the same direction, obtain emulsifiable paste matrix;
Step 4: after sucrose sulfuric ester silver 0.6 part is added 13 parts of distilled water, grinding evenly, adds in described emulsifiable paste matrix, and stir 8min to the complete emulsifying of mixed liquor in room temperature with constant, room temperature cools, and obtains ointment finished product.
In described antibiotic external used ointment, the application of described antibiotic external used ointment in the medicine of preparation wound, burn and other trauma infection contaminations.
Embodiment 3:
A kind of antibiotic external used ointment, containing sucrose sulfuric ester silver in described antibiotic external used ointment.
In described antibiotic external used ointment, described antibiotic external used ointment comprises the component of following parts by weight:
Sucrose sulfuric ester silver 0.6 part, octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts, paraffin hydrocarbons 10.2 parts, glycerol 7.7 parts, sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and distilled water 64 parts.
A manufacture method for antibiotic external used ointment, comprises the following steps:
Step one: get octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts and liquid Paraffin 10.2 parts mixing, stir 6min completely transparent to mixed liquor, obtain oil solution, described oil solution is incubated placement at 87 DEG C at 90 DEG C, for subsequent use;
Step 2: get sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and glycerol 7.7 parts, add in the distilled water of 51 parts, stir 3-6min and dissolve completely to mixed liquor, obtain aqueous solution at 90 DEG C, described aqueous solution is incubated placement at 85-90 DEG C, for subsequent use;
Step 3: at 85-90 DEG C, adds described oil solution in described aqueous solution, and constantly stirs 1-2min in the same direction, obtain emulsifiable paste matrix;
Step 4: after sucrose sulfuric ester silver 0.6 part is added 13 parts of distilled water, grinding evenly, adds in described emulsifiable paste matrix, and stir 6min to the complete emulsifying of mixed liquor in room temperature with constant, room temperature cools, and obtains ointment finished product.
In described antibiotic external used ointment, the application of described antibiotic external used ointment in the medicine of preparation wound, burn and other trauma infection contaminations.
Its pharmaceutically active is further illustrated below by pharmaceutical test.
Experiment one: anti-inflammation active testing
Step (one): the foundation of animal skin trauma model
40 SD rat adaptabilities are raised two days later, the urethane 1mL being 25% in lumbar injection mass fraction anaesthetizes, back electric clipper hair, be the sodium sulfide depilation of 10% afterwards with mass fraction, skin, after iodine disinfection, cuts along mark line the circular skin histology that radius is 1cm at spinal column skin of back place shears, under wound surface reaches fascia deeply, SD rat wound is exposed, and all single cage of all SD rats is fed afterwards, sufficient feedwater.
Step (two): animal grouping and administration
SD rat is divided into 4 groups, is respectively blank group, positive controls, solvent group and example pharmaceuticals group.Within second day after grouping, first carry out labelling with transparent membrane along wound surface edge, and cut along labelling, with the thin film in electronic analytical balance accurate weighing label range, and replace area as original area using film quality, often group is averaged, and then starts coating medicine-feeding.
It is the physiological saline solution of 0.85% that blank forms face painting mass fraction; Positive controls wound surface is coated with Sulfadiazine Silver Cream, it comprises the component of following parts by weight: the former medicine of silver sulfadiazine 0.6 part, octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts, paraffin hydrocarbons 10.2 parts, glycerol 7.7 parts, sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and distilled water 64 parts; Solvent is formed face and is coated with corresponding solvent, and it comprises the component of following parts by weight: octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts, paraffin hydrocarbons 10.2 parts, glycerol 7.7 parts, sodium lauryl sulphate 1.2 parts, nipalgin 0.09%, and distilled water 64 parts; Example pharmaceuticals is formed face and is coated with the obtained antibiotic external used ointment of embodiment in the present invention 3, often group every only be coated with medicine and be 0.5g, uniform fold wound surface, be administered once every day until wound healing.
Step (three): anti-inflammation determination of activity
Observe 4 groups of SD rats after wound and administration, wound surface redness, infection, edge of wound contraction of skin, incrustation situation, from after administration 3 days, make marks along wound surface edge with transparent membrane for every 3 days, and cut along labelling, with the thin film in electronic analytical balance accurate weighing label range, and replace area as existing wound surface area using film quality, often group is averaged, with original Area comparison, calculate Wound healing rate, evaluate wound healing degree with this, result is as shown in table 1.Wound healing rate computing formula is as follows:
Healing rate (%)=(original area-existing wound surface area)/original area × 100%
Table 1 four groups of medicines are on the impact of SD Skin Wound Healing In Rats rate
As known from Table 1, in the present invention by the obtained antibiotic external used ointment of embodiment 3 compared with positive controls, blank group and solvent group, in same time, Wound healing rate is high, in short time, wound healing is fast, and the activity by the antibiotic external used ointment that embodiment 3 is obtained with better anti-inflammation and promotion wound healing is described.The present invention is that the new antibiotic external used ointment of research and development provides new thinking.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (5)
1. an antibiotic external used ointment, is characterized in that, containing sucrose sulfuric ester silver in described antibiotic external used ointment.
2. antibiotic external used ointment as claimed in claim 1, is characterized in that, described antibiotic external used ointment comprises the component of following parts by weight:
Sucrose sulfuric ester silver 0.3-1.0 part, octadecanol 7.5-8.0 part, glyceryl monostearate 3.0-3.5 part, white vaseline 5.0-5.5 part, paraffin hydrocarbons 10.0-10.5 part, glycerol 7.5-8.0 part, sodium lauryl sulphate 1.0-1.5 part, nipalgin 0.08-0.1 part and distilled water 62-65.6 part.
3. antibiotic external used ointment as claimed in claim 2, is characterized in that, is made up of the component of following parts by weight:
Sucrose sulfuric ester silver 0.6 part, octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts, paraffin hydrocarbons 10.2 parts, glycerol 7.7 parts, sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and distilled water 64 parts.
4. a manufacture method for antibiotic external used ointment, is characterized in that, comprises the following steps:
Step one: get octadecanol 7.7 parts, glyceryl monostearate 3.2 parts, white vaseline 5.2 parts and liquid Paraffin 10.2 parts mixing, stir 5-8min completely transparent to mixed liquor, obtain oil solution, described oil solution is incubated placement at 85-90 DEG C at 90 DEG C, for subsequent use;
Step 2: get sodium lauryl sulphate 1.2 parts, nipalgin 0.09 part and glycerol 7.7 parts, add in the distilled water of 51 parts, stir 3-6min and dissolve completely to mixed liquor, obtain aqueous solution at 90 DEG C, described aqueous solution is incubated placement at 85-90 DEG C, for subsequent use;
Step 3: at 85-90 DEG C, adds described oil solution in described aqueous solution, and constantly stirs 1-2min in the same direction, obtain emulsifiable paste matrix;
Step 4: after sucrose sulfuric ester silver 0.6 part is added 13 parts of distilled water, grinding evenly, adds in described emulsifiable paste matrix, and stir 5-8min to the complete emulsifying of mixed liquor in room temperature with constant, room temperature cools, and obtains ointment finished product.
5. antibiotic external used ointment as claimed in claim 1, is characterized in that, the application of described antibiotic external used ointment in the medicine of preparation wound, burn and other trauma infection contaminations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410623590.3A CN104306397A (en) | 2014-11-06 | 2014-11-06 | Antibacterial external use ointment and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410623590.3A CN104306397A (en) | 2014-11-06 | 2014-11-06 | Antibacterial external use ointment and manufacturing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104306397A true CN104306397A (en) | 2015-01-28 |
Family
ID=52361806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410623590.3A Pending CN104306397A (en) | 2014-11-06 | 2014-11-06 | Antibacterial external use ointment and manufacturing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104306397A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104926889A (en) * | 2015-05-24 | 2015-09-23 | 广西师范学院 | Sucrose sulfate copper and silver compound as well as preparation method and application thereof |
| CN109394679A (en) * | 2018-12-07 | 2019-03-01 | 中国农业科学院饲料研究所 | A kind of Rifaximin ointment for animal hoof disease |
| CN114159376A (en) * | 2020-09-10 | 2022-03-11 | 九江学院 | Liquiritigenin emulsifying ointment and preparation method and application thereof |
-
2014
- 2014-11-06 CN CN201410623590.3A patent/CN104306397A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104926889A (en) * | 2015-05-24 | 2015-09-23 | 广西师范学院 | Sucrose sulfate copper and silver compound as well as preparation method and application thereof |
| CN109394679A (en) * | 2018-12-07 | 2019-03-01 | 中国农业科学院饲料研究所 | A kind of Rifaximin ointment for animal hoof disease |
| CN109394679B (en) * | 2018-12-07 | 2020-06-09 | 中国农业科学院饲料研究所 | Rifaximin ointment for animal hoof diseases |
| CN114159376A (en) * | 2020-09-10 | 2022-03-11 | 九江学院 | Liquiritigenin emulsifying ointment and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107184427A (en) | A kind of cooperative compositions and application containing polyglutamic acid and hyaluronic acid | |
| CN1969801A (en) | Application of water soluble chitosan in toothpaste and mouthwash | |
| CN106109264B (en) | A kind of facial treatment mask and preparation method thereof with anti-bacteria wet keeping function | |
| CN108354880A (en) | A kind of baby child's skin care compositions and methods | |
| CN106389139A (en) | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof | |
| CN105853260A (en) | Cream for treating diaper dermatitis and preparation method thereof | |
| CN104306397A (en) | Antibacterial external use ointment and manufacturing method thereof | |
| CN110709059A (en) | Dandruff-removing and itching-relieving shampoo composition containing multi-element zinc | |
| CN111514093A (en) | Silver ion ethanol disinfectant and preparation method thereof | |
| CN107982277A (en) | A kind of composite antibacterial aerosol and its preparation method and application | |
| CN103120642B (en) | Gel used for skin diseases and preparation method thereof | |
| CN109758394A (en) | A kind of multiple-effect milky lotion and preparation method thereof containing camellia seed oil | |
| CN1969802A (en) | Application of water soluble chitosan as skin care product | |
| CN109432201B (en) | Gynecological antibacterial gel and preparation method thereof | |
| CN109674875A (en) | Oral ulcer nursing essence | |
| CN102000108A (en) | Gynaecological medicine composition as well as external-use capsule and application thereof | |
| CN110193017B (en) | Film spraying agent for promoting hair growth and preparation method thereof | |
| KR101454874B1 (en) | Composition of anti-bacterial cosmetics containing msm | |
| CN106362141A (en) | Safe and multi-effect freckle removing agent and preparation method thereof | |
| CN103446399B (en) | A kind of external application Chinese medicine pack preparation of Acne treatment and manufacturing process thereof | |
| CN106420399A (en) | Laser cosmetology nursing agent, preparation and use method thereof | |
| CN114533809B (en) | Vitamin E antibacterial cream and preparation method thereof | |
| CN101204470B (en) | Application of grape fermented product on skin sterilization and health protection products filed | |
| CN107789277A (en) | A kind of hyaluronic acid lip composition and preparation method with multi-efficiency | |
| CN108309824A (en) | A kind of hyaluronic acid lip composition and preparation method with multi-efficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150128 |
|
| RJ01 | Rejection of invention patent application after publication |