CN117412953A - Axl抑制剂 - Google Patents
Axl抑制剂 Download PDFInfo
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- CN117412953A CN117412953A CN202280034595.5A CN202280034595A CN117412953A CN 117412953 A CN117412953 A CN 117412953A CN 202280034595 A CN202280034595 A CN 202280034595A CN 117412953 A CN117412953 A CN 117412953A
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
一类Axl抑制剂。具体的,涉及一种如式(1)、(2)、(3)、(4)所示的新化合物和/或其药学上可接受的盐,以及含有如式(1)、(2)、(3)、(4)所示化合物的组合物和/或其药学上可接受的盐,制备方法和其作为Axl抑制剂在抗肿瘤药物制备中的用途。
Description
本申请要求申请日为2021年5月12日的中国申请CN202110518860.4的优先权。本申请引用上述中国申请的全文。
本发明涉及药物化学领域,更具体而言,涉及具有Axl激酶抑制作用的新化合物及其制备方法和该类化合物在抗肿瘤药物制备中的用途。
受体酪氨酸激酶(RTK)感知细胞外细胞信号,激活细胞质和细胞核内信号转导通路,调节细胞的存活、生长、分化、粘附和迁移。RTK的异常表达或激活参与与癌症细胞转化、肿瘤形成和转移。酪氨酸激酶抑制剂已经在临床上用于***。
Axl是RTK激酶的TAM亚家族的成员。该家族的其他成员包括MER和Tyro-3。TAM家族激酶包含与配体结合的胞外结构域,介导信号传递的跨膜结构域和保守的胞内激酶结构域。Axl和MER在各类白血病和多种实体瘤细胞中过度表达,促进癌症细胞的存活,转移以及耐药。除了癌症细胞以外,AXL在肿瘤微环境中的血管上皮细胞和平滑细胞(Korshunov等,Circ.Res.2006,98,1446),以及包括巨噬细胞,树突细胞,自然杀伤细胞等在内多种免疫细胞中表达,促进血管生成,免疫抑制和肿瘤细胞的免疫逃逸(Sharif等,J.Exp.Med.2006,203,1891;Rothlin等,Cell.2007,131,1124)(Lu等,Nature.1999,398,723;Lu&Lemke,Science.2001,293,306;Prasad等,Mol.Cell Neurosci.2006,3,96;Shankar等,J.Neurosci.2003,23,4208)。由此可见,AXL通过多重机制参与了肿瘤的发生和发展。
除了肿瘤以外,Axl通路的过度激活参与了免疫、血小板功能、血管钙化、凝血酶诱导的血管平滑肌细胞等功能紊乱诱发的血管疾病,和急性和慢性肾小球肾炎、糖尿病性肾病和慢性同种异体移植排斥等病理过程。Axl抑制剂预计将为多种疾病提供治疗效益,包括癌症(包括实体瘤,如癌和肉瘤、白血病和淋巴恶性疾病),血管疾病(包括但不限于血栓形成、动脉粥样硬化和再狭窄)、肾脏疾病(包括但不限于急性和慢性肾小球肾炎、糖尿病性肾病和移植排斥)和紊乱的血管生成诱发的有严重后果的疾病(包括但不限于糖尿病视网膜病变、视网膜病、银屑病、类风湿性关节炎、粥样斑、卡波西肉瘤和血管瘤)。
因此,开发高活性Axl激酶的小分子抑制剂具有重要的临床价值。
WO2015012298A1报道了具有Axl抑制活性的化合物A(WO2015012298A1中实施例5)。该化合物治疗奥希替尼耐药的非小细胞肺癌(Osimertinib-resistant non-small-cell lung cancer)的临床I期实验正在进行中;
发明内容
本发明提供了式(1)-式(4)所示的化合物或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物:
本发明的另一个目的是提供了一种药物组合物,其含有药学上可接受的载体、稀释剂和/或赋形剂,以及本发明所示化合物、或其各异构体、各晶型、药学上可接受的盐、 水合物或溶剂合物作为活性成分。
本发明的再一个目的提供了本发明所示的化合物、或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物或上述药物组合物用于制备治疗、调节或预防与Axl蛋白相关疾病的药物中的应用。
本发明的再一个目的还提供治疗、调节或预防与Axl蛋白相关疾病的方法,包括对受试者给与治疗有效量的本发明所示的化合物、或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物或上述药物组合物。
通过合成和仔细研究了多类涉及具有Axl抑制作用的新化合物,发明人发现在式(1)、(2)、(3)、(4)所示的化合物中,化合物(1)与化合物A相比,具有意想不到的PK性质改善和Axl抑制活性提高。
应理解,本发明的前述一般性描述和以下详细描述都是示例性和说明性的,旨在提供对所要求保护的本发明的进一步说明。
化合物的进一步形式
“药学上可接受”这里指一种物质,如载体或稀释液,不会使化合物的生物活性或性质消失,且相对无毒,如,给予个体某物质,不会引起不想要的生物影响或以有害的方式与任何其含有的组分相互作用。
术语“药学上可接受的盐”指一种化合物的存在形式,该形式不会引起对给药有机体的重要的刺激,且不会使化合物的生物活性和性质消失。在某些具体方面,药学上可接受的盐是通过本发明所示化合物与酸反应获得,如盐酸、氢溴酸、氢氟酸、硫酸、磷酸、硝酸、碳酸等无机酸,甲酸、乙酸、丙酸、草酸、三氟乙酸、丙二酸、琥珀酸、富马酸、马来酸、乳酸、苹果酸、酒石酸、柠檬酸、苦味酸、甲磺酸、苯磺酸、对甲苯磺酸等有机酸以及天冬氨酸、谷氨酸等酸性氨基酸。
应理解药学上可接受的盐的参考包括溶剂添加形式或结晶形式,尤其是溶剂化物或多晶型。溶剂化物含有化学计量或非化学计量的溶剂,且是在与药学上可接受溶剂如水,乙醇等,结晶化过程中选择性形成的。当溶剂是水时形成水合物,或当溶剂是乙醇时形成醇化物。本发明所示化合物的溶剂化物按照本文所述的方法,很方便的制得或形成。举例说明,本发明所示化合物的水合物从水/有机溶剂的混合溶剂中重结晶而方便的制得,使用的有机溶剂包括但不限于,四氢呋喃、丙酮、乙醇或甲醇。此外,在此提到的化合物能够以非溶剂化和溶剂化形式存在。总之,对于在此提供的化合物和方法为目的,溶剂化形式被认为相当于非溶剂化形式。
在其他具体实施例中,本发明所示化合物被制备成不同的形式,包括但不限于,无定形,粉碎形和毫微-粒度形式。此外,本发明所示化合物包括结晶型,也可以作为多晶型。多晶型包括化合物的相同元素组成的不同晶格排列。多晶型通常有不同的X-射线衍射光谱、红外光谱、熔点、密度、硬度、晶型、光和电的性质、稳定性和溶解性。不同的因素如重结晶溶剂,结晶速率和贮存温度可能引起单一晶型为主导。
在另一个方面,本发明所示化合物可能存在手性中心和/或轴手性,并因此以消旋体、外消旋混合物、单一对映体、非对映异构体化合物和单一非对映体的形式、和顺反异构体的形式出现。每个手性中心或轴手性将独立地产生两个旋光异构体,并且所有可能的旋光异构体和非对映体混合物以及纯或部分纯的化合物包括在本发明的范围之内。本发明意味着包括这些化合物的所有这种异构形式。
本发明的化合物可以在一个或多个构成该化合物的原子上包含非天然比例的原子同位素。例如,可用放射性同位素标记化合物,比如氚(
3H)、碘-125(
125I)和C-14(
14C)。又例如,可用重氢取代氢原子形成氘代化合物,氘与碳构成的键比普通氢和碳构成的键更坚固,相比于未氘代药物,通常氘代药物具有降低毒副作用、增加药物稳定性、增强疗效、延长药物体内半衰期等优势。本发明的化合物的所有同位素组成的变换,无论放射性与否,都包含在本发明的范围之内。
术语
如果无另外说明,用于本发明申请,包括说明书和权利要求书中的术语,定义如下。必须注意,在说明书和所附的权利要求书中,如果文中无另外清楚指示,单数形式“一个”包括复数意义。如果无另外说明,使用质谱、核磁、HPLC、蛋白化学、生物化学、重组DNA技术和药理的常规方法。在本申请中,如果无另外说明,使用“或”或“和”指“和/或”。
特定药学及医学术语
术语“可接受的”,如本文所用,指一个处方组分或活性成分对一般治疗目标的健康没有过分的有害影响。
术语“治疗”、“治疗过程”或“疗法”如本文所用,包括缓和、抑制或改善疾病的症状或状况;抑制并发症的产生;改善或预防潜在代谢综合症;抑制疾病或症状的产生,如控制疾病或情况的发展;减轻疾病或症状;使疾病或症状减退;减轻由疾病或症状引起的并发症,或预防或治疗由疾病或症状引起的征兆。如本文所用,某一化合物或药物组合物,给药后,可以使某一疾病、症状或情况得到改善,尤指其严重度得到改善,延迟发病,减 缓病情进展,或减少病情持续时间。无论固定给药或临时给药、持续给药或间歇给药,可以归因于或与给药有关的情况。
“活性成分”指本发明所示化合物,以及本发明所示化合物的药学上可接受的无机或有机盐。本发明的化合物可以含有一个或多个不对称中心(手性中心或轴手性),并因此以消旋体、外消旋混合物、单一对映体、非对映异构体化合物和单一非对映体的形式出现。可以存在的不对称中心,取决于分子上各种取代基的性质。每个这种不对称中心将独立地产生两个旋光异构体,并且所有可能的旋光异构体和非对映体混合物以及纯或部分纯的化合物包括在本发明的范围之内。本发明意味着包括这些化合物的所有这种异构形式。
“化合物(compound)”、“组合物(composition)”、“药剂(agent)”或“医药品(medicine or medicament)”等词在此可交替使用,且都是指当施用于个体(人类或动物)时,能够透过局部和/或全身性作用而诱发所亟求的药学和/或生理反应的一种化合物或组合物。
“施用(administered、administering或、administration)”一词在此是指直接施用所述的化合物或组合物,或施用活性化合物的前驱药(prodrug)、衍生物(derivative)、或类似物(analog)等。
虽然用以界定本发明较广范围的数值范围与参数皆是约略的数值,此处已尽可能精确地呈现具体实施例中的相关数值。然而,任何数值本质上不可避免地含有因个别测试方法所致的标准偏差。在此处,“约”通常是指实际数值在一特定数值或范围的正负10%、5%、1%或0.5%之内。或者是,“约”一词代表实际数值落在平均值的可接受标准误差之内,视本领域技术人员的考虑而定。除了实验例之外,或除非另有明确的说明,当可理解此处所用的所有范围、数量、数值与百分比(例如用以描述材料用量、时间长短、温度、操作条件、数量比例及其它相似者)均经过“约”的修饰。因此,除非另有相反的说明,本说明书与附随权利要求书所揭示的数值参数皆为约略的数值,且可视需求而更动。至少应将这些数值参数理解为所指出的有效位数与采用一般进位法所得到的数值。
除非本说明书另有定义,此处所用的科学与技术词汇的含义与本领域技术人员所理解的惯用的意义相同。此外,在不和上下文冲突的情形下,本说明书所用的单数名词涵盖该名词的复数型;而所用的复数名词时亦涵盖该名词的单数型。
治疗用途
本发明提供了使用本发明所示化合物或药物组合物通常可用于抑制Axl激酶,因此可用于治疗与Axl激酶活性相关的一种或多种病症。因此,在某些实施方式中,本发明提供了用于治疗Axl激酶介导的病症的方法,所述方法包括向有需要的患者施用本发明 化合物、或其药学上可接受的组合物的步骤。
可用本发明化合物治疗的癌症包括但不限于,血液恶性肿瘤(白血病、淋巴瘤、骨髓瘤包括多发性骨髓瘤、骨髓异常增生综合症和骨髓增生姓综合症)和实体瘤(癌例如***、乳腺、肺、结肠、胰腺、肾、卵巢以及软组织癌和骨肉瘤,以及间质瘤)等。
给药途径
本发明的化合物及其药学上可接受的盐可制成各种制剂,其中包含安全、有效量范围内的本发明化合物或其药学上可接受的盐及药理上可以接受的赋形剂或载体。其中“安全、有效量”指的是:化合物的量足以明显改善病情,而不至于产生严重的副作用。化合物的安全、有效量根据治疗对象的年龄、病情、疗程等具体情况来确定。
“药学上可以接受的赋形剂或载体”指的是:一种或多种相容性固体或液体填料或凝胶物质,它们适合于人使用,而且必须有足够的纯度和足够低的毒性。“相容性”在此指的是组合物中各组份能与本发明的化合物以及它们之间相互掺和,而不明显降低化合物的药效。药理上可以接受的赋形剂或载体部分例子有纤维素及其衍生物(如羧甲基纤维素钠、乙基纤维素钠、纤维素乙酸酯等)、明胶、滑石、固体润滑剂(如硬脂酸、硬脂酸镁)、硫酸钙、植物油(如豆油、芝麻油、花生油、橄榄油等)、多元醇(如丙二醇、甘油、甘露醇、山梨醇等)、乳化剂(如
)、润湿剂(如十二烷基硫酸钠)、着色剂、调味剂、稳定剂、抗氧化剂、防腐剂、无热原水等。
施用本发明化合物时,可以口服、直肠、肠胃外(静脉内、肌肉内或皮下)、局部给药。
用于口服给药的固体剂型包括胶囊剂、片剂、丸剂、散剂和颗粒剂。在这些固体剂型中,活性化合物与至少一种常规惰性赋形剂(或载体)混合,如柠檬酸钠或磷酸二钙,或与下述成分混合:(a)填料或增容剂,例如,淀粉、乳糖、蔗糖、葡萄糖、甘露醇和硅酸;(b)粘合剂,例如,羟甲基纤维素、藻酸盐、明胶、聚乙烯基吡咯烷酮、蔗糖和***胶;(c)保湿剂,例如,甘油;(d)崩解剂,例如,琼脂、碳酸钙、马铃薯淀粉或木薯淀粉、藻酸、某些复合硅酸盐、和碳酸钠;(e)缓溶剂,例如石蜡;(f)吸收加速剂,例如,季胺化合物;(g)润湿剂,例如鲸蜡醇和单硬脂酸甘油酯;(h)吸附剂,例如,高岭土;和(i)润滑剂,例如,滑石、硬脂酸钙、硬脂酸镁、固体聚乙二醇、十二烷基硫酸钠,或其混合物。胶囊剂、片剂和丸剂中,剂型也可包含缓冲剂。
固体剂型如片剂、糖丸、胶囊剂、丸剂和颗粒剂可采用包衣和壳材制备,如肠衣和其它本领域公知的材料。它们可包含不透明剂,并且,这种组合物中活性化合物或化合物的释放可以延迟的方式在消化道内的某一部分中释放。可采用的包埋组分的实例是聚合 物质和蜡类物质。必要时,活性化合物也可与上述赋形剂中的一种或多种形成微胶囊形式。
用于口服给药的液体剂型包括药学上可接受的乳液、溶液、悬浮液、糖浆或酊剂。除了活性化合物外,液体剂型可包含本领域中常规采用的惰性稀释剂,如水或其它溶剂,增溶剂和乳化剂,例知,乙醇、异丙醇、碳酸乙酯、乙酸乙酯、丙二醇、1,3-丁二醇、二甲基甲酰胺以及油,特别是棉籽油、花生油、玉米胚油、橄榄油、蓖麻油和芝麻油或这些物质的混合物等。
除了这些惰性稀释剂外,组合物也可包含助剂,如润湿剂、乳化剂和悬浮剂、甜味剂、矫味剂和香料。
除了活性化合物外,悬浮液可包含悬浮剂,例如,乙氧基化异十八烷醇、聚氧乙烯山梨醇和脱水山梨醇酯、微晶纤维素、甲醇铝和琼脂或这些物质的混合物等。
用于肠胃外注射的组合物可包含生理上可接受的无菌含水或无水溶液、分散液、悬浮液或乳液,和用于重新溶解成无菌的可注射溶液或分散液的无菌粉末。适宜的含水和非水载体、稀释剂、溶剂或赋形剂包括水、乙醇、多元醇及其适宜的混合物。
用于局部给药的本发明化合物的剂型包括软膏剂、散剂、贴剂、喷射剂和吸入剂。活性成分在无菌条件下与生理上可接受的载体及任何防腐剂、缓冲剂,或必要时可能需要的推进剂一起混合。
本发明化合物可以单独给药,或者与其他药学上可接受的化合物联合给药。使用药物组合物时,是将安全有效量的本发明化合物适用于需要治疗的哺乳动物(如人),其中施用时剂量为药学上认为的有效给药剂量,对于60kg体重的人而言,日给药剂量通常为1~2000mg,优选50~1000mg。当然,具体剂量还应考虑给药途径、病人健康状况等因素,这些都是熟练医师技能范围之内的。
本发明提到的上述特征,或实施例提到的特征可以任意组合。本案说明书所揭示的所有特征可与任何组合物形式并用,说明书中所揭示的各个特征,可以任何可提供相同、均等或相似目的的替代性特征取代。因此除有特别说明,所揭示的特征仅为均等或相似特征的一般性例子。
在下面的说明中将会详细阐述上述化合物、方法、药物组合物的各个具体方面、特性和优势,使本发明的内容变得十分明了。在此应理解,下述的详细说明及实例描述了 具体的实施例,仅用于参考。在阅读了本发明的说明内容后,本领域的技术人员可对本发明作各种改动或修改,这些等价形势同样落于本申请所限定的范围。
所有实施例中,
1H-NMR用Varian Mercury 400核磁共振仪记录,化学位移以δ(ppm)表示;分离用硅胶未说明均为200-300目,洗脱液的配比均为体积比。
本发明采用下述缩略词:CDCl
3代表氘代氯仿;EtOAc代表乙酸乙酯;Hexane代表正己烷;HPLC代表高效液相色谱;MeCN代表乙腈;DCM代表二氯甲烷;DIPEA代表二异丙基乙基胺;DMF代表N,N-二甲基甲酰胺;DMAP代表4-(二甲氨基)吡啶;DMSO代表二甲亚砜;HATU代表O-(7-氮杂苯并***-1-基)-NNN′N′-四甲基脲六氟磷酸酯;hr代表小时;min代表分钟;K
2CO
3代表碳酸钾;min代表分钟;MeOH代表甲醇;MS代表质谱;NMR代表核磁共振;Pd/C代表钯碳;POCl
3代表三氯氧磷;TEA代表三乙胺;TLC代表薄层色谱。
实施例1 化合物1的合成
步骤1:化合物int_1-2的合成:
100mL单口瓶中加入int_1-1(200mg,0.951mmol),DMF(5mL),无水碳酸钾(5.92g,42.9mmol)和氟碘甲烷(229mg,1.43mmol),混合液氩气置换后室温搅拌反应16小时, LC-MS检测反应完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相用饱和氯化钠溶液(10mL*2)洗涤两次,无水硫酸钠干燥,过滤,浓缩得淡棕色固体产物(211mg,收率:90.5%)。
ESI-MS m/z:242[M+H]
+
步骤2:化合物int_1-3的合成:
50mL单口瓶中加入int_1-2(211mg,0.86mmol),DMF(5mL),DIPEA(1.5mL)和6-硝基吡啶-3-醇(121mg,0.86mmol),混合液氩气置换后升温至100℃搅拌反应72小时,LC-MS检测反应基本完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相依次用饱和碳酸氢钠溶液(10mL),饱和氯化钠溶液(10mL)洗涤,无水硫酸钠干燥,过滤,浓缩得棕色油状物(228mg,收率:76%)。ESI-MS m/z:346[M+H]
+
步骤3:化合物int_1-4的合成:
100mL单口瓶中加入int_1-3(228mg,粗品,0.66mmol),MeOH(10mL),DCM(1mL),10%钯碳(50mg,wet=55%),氢气置换三次后室温常压搅拌氢化。72小时后LC-MS检测反应完全,混合液经硅藻土助滤,滤液浓缩得产物(220mg,收率:100%)。
ESI-MS m/z:316[M+H]
+
步骤4:化合物1的合成:
50mL单口瓶中加入int_1-4(93mg,0.295mmol),DMF(5mL),DIPEA(114mg,0.885mmol),HATU(170mg,0.442mmol)和int_1-5(84mg,0.295mmol),混合液氩气置换后升温至60℃搅拌反应4小时,LC-MS检测反应基本完全后,混合液用制备LC-MS纯化得产物(16mg,收率:9.3%)。
1H NMR(400MHz,Chloroform-d)δ11.94(s,1H),9.33(s,1H),8.55(d,J=5.3Hz,1H),8.50(d,J=9.0Hz,1H),8.21(d,J=2.8Hz,1H),7.92(s,1H),7.66–7.54(m,4H),7.48(s,1H),7.27(d,J=1.7Hz,1H),7.25(s,1H),6.44(d,J=5.3Hz,1H),5.98(s,1H),5.84(s,1H),4.05(s,3H),2.65–2.54(m,4H),2.12(q,J=6.3Hz,2H).
ESI-MS m/z:581[M+H]
+
实施例2 化合物2的合成
步骤1:化合物int_2-2的合成:
100mL单口瓶中加入int_2-1(200mg,0.951mmol),DMF(5mL),无水碳酸钾(5.92g,42.9mmol)和氟碘甲烷(229mg,1.43mmol),混合液氩气置换后室温搅拌反应16小时,LC-MS检测反应完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相用饱和氯化钠溶液(10mL*2)洗涤两次,无水硫酸钠干燥,过滤,浓缩得淡棕色固体产物(208mg,收率:90%)。
ESI-MS m/z:242[M+H]
+
步骤2:化合物int_2-3的合成:
50mL单口瓶中加入int_2-2(208mg,0.86mmol),DMF(5mL),DIPEA(1.5mL)和6-硝基吡啶-3-醇(121mg,0.86mmol),混合液氩气置换后升温至100℃搅拌反应72小时,LC-MS检测反应基本完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相依次用饱和碳酸氢钠溶液(10mL),饱和氯化钠溶液(10mL)洗涤,无水硫酸钠干燥,过滤,浓缩得棕色油状物(220mg,收率:76%)。ESI-MS m/z:346[M+H]
+
步骤3:化合物int_2-4的合成:
100mL单口瓶中加入int_2-3(220mg,粗品,0.66mmol),MeOH(10mL),DCM(1mL),10%钯碳(50mg,wet=55%),氢气置换三次后室温常压搅拌氢化。72小时后LC-MS检测反应完全,混合液经硅藻土助滤,滤液浓缩得产物(220mg,收率:100%)。
ESI-MS m/z:316[M+H]
+
步骤4:化合物2的合成:
50mL单口瓶中加入int_2-4(100mg,0.317mmol),DMF(5mL),DIPEA(114mg,0.885mmol),HATU(170mg,0.442mmol)和int_1-5(84mg,0.295mmol),混合液氩气置换后升温至60℃搅拌反应4小时,LC-MS检测反应基本完全后,混合液用制备LC-MS纯化得产物(19mg,收率:10.3%)。
1H NMR(400MHz,Chloroform-d)δ11.95(s,1H),9.32(s,1H),8.54(d,J=5.3Hz,1H),8.51(d,J=9.0Hz,1H),8.22(d,J=2.8Hz,1H),7.80(s,1H),7.66–7.54(m,5H),7.27(d,J=1.5Hz,1H),6.50(d,J=5.3Hz,1H),6.00(s,1H),5.87(s,1H),4.06(s,3H),2.59(dt,J=13.3,6.3Hz,4H),2.11(q,J=6.3Hz,2H).
ESI-MS m/z:581[M+H]
+.
实施例3 化合物3的合成
步骤1:化合物int_3-2的合成:
100毫升单口瓶中加入40毫升硝酸(64%),冰浴下滴加1-氟-2,3-二甲氧基苯(8g,51.23mmol),冰浴下搅拌15分钟后自然升至室温继续搅拌15分钟。TLC监测反应完毕后,反应液倒入200毫升冷水之中,乙酸乙酯萃取。有机相无水硫酸钠干燥,过滤,滤液减压浓缩,残留物柱层析得目标产物(6g,产率:58%,白色固体)。
1H NMR(400MHz,Chloroform-d)δ7.68(ddd,J=10.7,2.7,0.8Hz,1H),7.61(t,J=2.2Hz,1H),4.07(dd,J=2.2,0.8Hz,3H),3.96(d,J=0.8Hz,3H).
步骤2:化合物int_3-3的合成:
室温下将int_3-2(6g,29.83mmol),10%钯碳(600mg,wet=55%)悬浮于甲醇(150mL)之中。氢气置换三次后室温常压搅拌反应过夜。LC-MS检测有大量产物生成,混合液经硅藻土助滤,滤液浓缩得目标产物(5g,产率97%,灰色固体)。
ESI-MS m/z:172[M+H]
+
步骤3:化合物int_3-5的合成:
室温下将int_3-3(5.11g,29.85mmol)和int_3-4(6.46g,29.85mmol)悬浮于乙醇(150mL)之中。氩气保护下回流搅拌1小时。LC-MS监测反应完毕,冷却至室温后,减压浓缩,残留物柱层析得目标产物(10g,产率98%,棕色液体)。
步骤4:化合物int_3-6的合成:
室温下将int_3-5(10.2g,29.88mmol)悬浮于二苯醚(100mL)之中,升温至250℃回流1小时。LC-MS监测反应完毕,冷却至室温后,过滤收集不溶物,得目标产物(2.6g,产率30%,棕色固体)。粗品直接用于下步反应。
ESI-MS m/z:296[M+H]
+
步骤5:化合物int_3-7的合成:
室温下将int_3-6(3g,10.16mmol)悬浮于乙醇(20mL)中,加入氢氧化钠水溶液(4M,80mL),反应液在90℃搅拌2小时,LC-MS监测反应完毕,冷却至室温后用浓盐酸调pH至1,收集固体,用冷稀盐酸洗涤,干燥得到目标产物(2.6g,产率:95%,灰褐色固体)。ESI-MS m/z:268[M+H]
+
步骤6:化合物int_3-8的合成:
室温下将int_3-6(2.6g,9.73mmol)悬浮于二苯醚(120mL)之中,升温至250℃回流1小时。LC-MS监测反应完毕,冷却至室温后,过滤收集不溶物,得目标产物(2g,产率92%,灰色固体)。
ESI-MS m/z:224[M+H]
+
步骤7:化合物int_3-9的合成:
室温下将int_3-8(1.7g,7.62mmol)溶于三氯氧膦(15mL)中。100℃搅拌1小时,LC-MS监测反应完毕,减压浓缩去除多余的三氯氧膦,残留物加入大量水中搅拌10分钟。DCM萃取,有机相无水硫酸钠干燥,滤液减压浓缩,残留物柱层析得到目标产物(1.3g,产率:61%,灰色固体)。
1H NMR(400MHz,DMSO-d6)δ8.68(d,J=4.8Hz,1H),7.56(d,J=4.8Hz,1H),7.41(d,J =1.9Hz,1H),3.99(s,3H),3.92(s,3H).
ESI-MS m/z:242[M+H]
+
步骤8:化合物int_3-10的合成:
50mL单口瓶中加入int_3-9(300mg,1.24mmol),int_3-10(260.7mg,1.24mmol),氯苯(12mL),DMAP(227mg,1.86mmol),混合液氩气置换后升温至130℃搅拌反应12小时,LC-MS检测反应基本完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相依次用饱和碳酸氢钠溶液(10mL),饱和氯化钠溶液(10mL)洗涤,无水硫酸钠干燥,过滤,浓缩得棕色油状物(68mg,收率:17.5%)。
ESI-MS m/z:316[M+H]
+
步骤9:化合物3的合成:
50mL单口瓶中加入int_3-11(5 7mg,0.17mmol),DMF(5mL),DIPEA(66mg,0.5mmol),HATU(100mg,0.34mmol)和int_1-5(97mg,0.34mmol),混合液氩气置换后升温至60℃搅拌反应4小时,LC-MS检测反应基本完全后,混合液用制备LC-MS纯化得产物(20mg,产率:41.5%,白色固体)。
1H NMR(400MHz,DMSO-d6)δ11.97(s,1H),8.97(s,1H),8.63(d,J=5.5Hz,1H),8.42(d,J=9.1Hz,1H),8.34(d,J=2.9Hz,1H),7.86(dd,J=9.0,2.9Hz,1H),7.69–7.57(m,3H),7.46(dd,J=7.0,1.8Hz,2H),7.37(d,J=1.7Hz,1H),6.69(d,J=5.5Hz,1H),4.00(s,3H),3.91(s,3H),2.53(d,J=5.9Hz,4H),1.98(p,J=6.1Hz,2H).
ESI-MS m/z:581[M+H]
+
实施例4 化合物4的合成
步骤1:化合物int_4-2的合成:
50mL单口瓶中加入int_4-1(210mg,0.86mmol),DMF(5mL),DIPEA(1.5mL)和6-硝基吡啶-3-醇(121mg,0.86mmol),混合液氩气置换后升温至100℃搅拌反应72h,LC-MS检测反应基本完全后,混合液中加入乙酸乙酯(10mL),水(10mL),搅拌,分液,水相再用乙酸乙酯(10mL)萃取,合并有机相依次用饱和碳酸氢钠溶液(10mL),饱和氯化钠溶液(10mL)洗涤,无水硫酸钠干燥,过滤,浓缩得油状物(198mg,收率:68%)。
ESI-MS m/z:346[M+H]
+
步骤2:化合物int_4-3的合成:
100mL单口瓶中加入int_4-2(198mg,0.57mmol),MeOH(10mL),DCM(1mL),10%钯碳(50mg,wet=55%),氢气置换三次后室温常压搅拌氢化。72h后LC-MS检测反应完全,混合液经硅藻土助滤,滤液浓缩得产物(180mg,收率:100%)。
ESI-MS m/z:316[M+H]
+
步骤4:化合物4的合成:
50mL单口瓶中加入int_4-3(100mg,0.317mmol),DMF(5mL),DIPEA(114mg,0.885mmol),HATU(170mg,0.442mmol)和int_1-5(84mg,0.295mmol),混合液氩气置换后升温至60℃搅拌反应4h,LC-MS检测反应基本完全后,混合液用制备LC-MS纯化得产物(29mg,收率:15.8%)。
ESI-MS m/z:581[M+H]
+
实施例5 本发明化合物体外抑制Axl酶活试验
用DMSO梯度稀释的化合物和Axl或c-Met重组蛋白混合,室温放置10分钟后,加入biotin标记的TK底物(TK)和ATP。室温反应40分钟后,加入Sa-XL 665和Crytate标记的TK抗体,室温孵育1小时后检测615和665nm处荧光强度。计算665nm和615 nm荧光强度的比值。与DMSO对照组相比,计算化合物IC
50。结果见下列表1。
表1.本发明化合物对重组蛋白Axl的抑制活性
化合物 | Axl酶活抑制(IC 50,nM) | c-Met酶活抑制(IC 50,nM) |
1 | 0.8 | 5.49 |
2 | +++ | - |
3 | +++ | - |
4 | +++ | - |
化合物A | 1.1 | 13.35 |
+++表示IC
50小于或等于50nM
++表示IC
50为50nM至100nM
+表示IC
50大于100nM。
-表示活性未测
从表1数据可知,本发明化合物对重组蛋白Axl的酶活性有较好的抑制活性。并且与化合物A相比,化合物1对于c-Met酶的抑制活性有意想不到的提高。
实施例6 本发明化合物对BaF3-Axl细胞的体外抗增殖活性
96孔板内种植10000/孔过表达Axl的BaF3(BaF3-Axl)细胞后加入用DMSO梯度稀释的化合物,处理3天后,用CTL-PLUS测量细胞内ATP的水平。与DMSO组对比,计算化合物抑制细胞生长的百分比和IC
50,结果见下列表2。
表2 本发明化合物对BaF3-Axl细胞的抗增殖活性
化合物 | BaF3-Axl细胞抗增殖活性IC 50(nM) |
1 | 0.5 |
2 | 3.5 |
3 | 5 |
4 | >5 |
化合物A | 1.2 |
从表2数据可见本发明化合物对BaF3/Axl细胞都具有较强的抗增殖活性,但化合物2和化合物3对BaF3/Axl细胞的抗增殖活性都弱于化合物1。这一结果表明在化合物1,2,3中,氟原子取代的位置对化合物的活性有意想不到的影响。并且与化合物A相比,化合物1有意想不到的抗BaF3/Axl增殖活性提高。
实施例7 本发明化合物的体内药代动力学实验
选取7至10周龄的CD-1雌性小鼠,静脉和口服给药的剂量分别为2mg/Kg和10mg/Kg。小鼠在给药前禁食至少12小时,给药4小时后恢复供食,整个实验期间自由饮水。实验当天静脉组动物通过尾静脉单次注射给予相应化合物,给药体积为10ml/Kg。口服组动物通过灌胃单次注射给予相应化合物,给药体积为10ml/Kg。在给药前称量动物体重,根据体重计算给药体积。样品采集时间为:0.083(注射组),0.167,0.5,1,2,4,8,24h。每个时间点通过颌下静脉丛采集大约200uL全血用于制备血浆供高效液相色谱-串联质谱(LC-MS/MS)进行浓度测定。所有动物在采集完最后一个时间点的PK样品后进行CO
2麻醉安乐死。采用Phoenix WinNonlin
TM version8.3(Certara)药动学软件的非房室模型处理血浆浓度,使用线性对数梯形法计算药动学参数。体内药代动力学结果见下列表3。
表3 本发明化合物的体内药代动力学评价结果
从表3数据可见,在小鼠药代动力学实验中,相比较化合物A,本发明中化合物1的Vdss升高,体内清除率下降,半衰期延长,AUC提升。与化合物A相比,化合物1有意想不到的药代动力学性质改善。
虽然以上描述了本发明的具体实施方式,但是本领域的技术人员应当理解,这些仅是举例说明,在不背离本发明的原理和实质的前提下,可以对这些实施方式做出多种变更或修改。因此,本发明的保护范围由所附权利要求书限定。
Claims (3)
- 一种如式(1)-式(4)所示的化合物或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物:
- 一种药物组合物,其特征在于,其含有药学上可接受的赋形剂或载体,以及如权利要求1所述的化合物、或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物作为活性成分。
- 一种如权利要求1所述的化合物、或其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物或如权利要求2所述的药物组合物在制备治疗与Axl蛋白相关疾病药物中的应用。
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CN2021105188604 | 2021-05-12 | ||
CN202110518860 | 2021-05-12 | ||
PCT/CN2022/092266 WO2022237843A1 (zh) | 2021-05-12 | 2022-05-11 | Axl抑制剂 |
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US7732613B2 (en) * | 2005-09-14 | 2010-06-08 | Bristol-Myers Squibb Company | Met kinase inhibitors |
WO2008048375A1 (en) * | 2006-05-19 | 2008-04-24 | Bayer Healthcare Ag | Pyridonecarboxamide derivatives useful in treating hyper-proliferative and angiogenesis disorders |
SG10201510307WA (en) * | 2011-11-14 | 2016-01-28 | Cephalon Inc | Uracil derivatives as axl and c-met kinase inhibitors |
TWI649308B (zh) * | 2013-07-24 | 2019-02-01 | 小野藥品工業股份有限公司 | 喹啉衍生物 |
EP3239147B9 (en) * | 2014-12-25 | 2020-01-08 | Ono Pharmaceutical Co., Ltd. | Quinoline derivative |
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