CN115670997A - Emulsifying system for skin, preparation method thereof and cosmetic containing same - Google Patents
Emulsifying system for skin, preparation method thereof and cosmetic containing same Download PDFInfo
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- CN115670997A CN115670997A CN202211441024.1A CN202211441024A CN115670997A CN 115670997 A CN115670997 A CN 115670997A CN 202211441024 A CN202211441024 A CN 202211441024A CN 115670997 A CN115670997 A CN 115670997A
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- skin
- emulsifying system
- extract
- content
- cream
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Abstract
The invention provides an emulsifying system for skin, a preparation method thereof and a cosmetic containing the emulsifying system for skin. The skin emulsion system comprises the following components by taking the total mass of the skin emulsion system as 100 percent: and (3) extracting scutellaria baicalensis: 0.11 to 3.9 percent; ceramide: 0.01 to 0.3 percent; a first emulsifier: 21 to 35 percent; solvent: 1 to 4.9 percent; squalane: 50 to 77.88 percent. The skin emulsifying system achieves the effect of promoting absorption by forming a small particle size package of the functional substances, and can lighten the red blood filaments by a method of relieving stimulation and enhancing the skin barrier. The preparation method of the emulsifying system for skin is simple and easy to implement, the raw materials are easy to obtain, and the emulsifying system for skin is suitable for mass production.
Description
Technical Field
The invention relates to an emulsifying system for skin, a preparation method thereof and a cosmetic containing the emulsifying system for skin, in particular to an emulsifying system for skin for improving facial flushing and fading red blood streaks, a preparation method thereof and a cosmetic containing the emulsifying system for skin, and belongs to the field of cosmetics.
Background
In recent years, the skin problems caused by sensitive muscles are gradually the hot spots of research in the cosmetic industry and the medical industry, wherein the red blood filaments caused by the dilation of facial capillaries become the new hot spots of research. The main phenomena of the facial red blood filaments are that the elasticity of the capillary wall is reduced, the brittleness is increased, the blood vessels are continuously and unevenly expanded and even broken, the facial skin is reddened, and the expanded capillary vessels can be seen by naked eyes. Such symptoms can be classified as both primary and secondary. The causes of the secondary telangiectasia comprise five conditions of high altitude climate, hormone-dependent telangiectasia, physical factor stimulation, chemical factor stimulation and complications of local or systemic diseases. Aiming at the secondary telangiectasis population, the laser is commonly used for improving the red blood streak in medical science and America, but the price is high, and the laser is not suitable for most of the population. Lightening red blood filaments in cosmetics can be generally performed by three means, increasing skin barrier, repairing capillaries, and enhancing collagen and elastin viability.
Cited document 1 proposes a composition for repairing facial flushing, telangiectasia, which comprises sophora flower extract, ophicalcite, azelaic acid, propylene glycol, glycerin, etc. The formula can maintain normal resistance of capillary by improving the functional components of capillary, thereby achieving the effects of relieving paroxysmal flushing and persistent flushing of face, and relieving true telangiectasia. However, the compositions of this method have limited effectiveness.
Citation 2 discloses a composition effective for alleviating skin allergy redness. The composition comprises Gentiana lutea root extract, butyrospermum parkii seed cake extract, adianthus communis fruit extract, coffea minor seed extract, dunaliella salina extract, pseudoalteromonas ferment extract, ginseng radix extract, polygonum cuspidatum root extract, malva sylvestris flower extract, fomes officinalis extract, glycyrrhiza glabra root extract, polygonum sibiricum rhizome/root extract, angelica tenuifolia root extract, fucus vesiculosus extract, etc. The formula is suitable for allergic skin red blood streak symptoms, improves the capillary function and enhances the protein activity, and improves the skin redness by relieving the skin sensitivity. However, this method uses a very large amount of raw extract materials, is costly, and is not suitable for large-scale populations.
Cited documents:
cited document 1: CN114159366A
Cited document 2: CN113797153A
Disclosure of Invention
In view of the technical problems in the prior art, for example: the invention firstly provides an emulsifying system for skin, which achieves the effect of promoting absorption by forming a small-particle-size coating of an effect substance and desalts red blood filaments by a method of relieving irritation and enhancing skin barrier.
Furthermore, the invention also provides a preparation method of the emulsifying system for the skin, which is simple and feasible, has easily obtained raw materials and is suitable for mass production.
Further, the present invention provides a facial cream comprising a skin-friendly emulsifying system which can be used to ease irritation and enhance the skin barrier, thereby improving facial flushing and reducing redness.
Means for solving the problems
The invention provides an emulsifying system for skin, which comprises the following components in percentage by mass based on 100% of the total mass of the emulsifying system for skin:
and (3) extracting scutellaria baicalensis: 0.11-3.9%, preferably 1-3%;
ceramide: 0.01 to 0.3%, preferably 0.01 to 0.2%;
a first emulsifier: 21-35%, preferably 25-30%;
solvent: 1-4.9%, preferably 2-4%;
squalane: 50 to 77.88%, preferably 57.99 to 71.9%.
The emulsifying system for the skin is characterized in that the mass ratio of the scutellaria baicalensis extract to the solvent is 1 (0.5-15).
The emulsifying system for skin of the present invention, wherein the first emulsifier comprises polyglyceryl-3 diisostearate and tween-20; preferably, the mass ratio of the polyglycerol-3 diisostearate to the tween-20 is 1 (0.5-2).
The invention also provides a preparation method of the skin emulsifying system, which comprises the step of mixing the components of the skin emulsifying system.
The invention also provides a skin care product which comprises the emulsifying system for skin, wherein the content of the emulsifying system for skin is 10-25%, preferably 15-20% based on 100% of the total mass of the skin care product.
The invention also provides a skin-care cream which comprises the skin emulsifying system, wherein the content of the skin emulsifying system is 10-25% of the total mass of the skin-care cream as 100%.
The skin-care cream further comprises one or a combination of more than two of a second emulsifier, a humectant, a skin conditioner, skin moistening grease, a thickener and a preservative; preferably, the content of the second emulsifier is 3-5%, the content of the humectant is 1-20%, the content of the skin conditioner is 2-4%, the content of the emollient oil is 1-10%, the content of the thickener is 0.5-3%, and the content of the preservative is 0.7-1.0%, based on 100% of the total mass of the skin care cream.
The skin care cream comprises a second emulsifier, wherein the second emulsifier comprises one or a combination of more than two of hydrogenated lecithin, sucrose stearate, sucrose polystearate, PEG-100 stearate, PEG-8 stearate and glycerol stearate.
The skin-care cream provided by the invention is characterized in that the skin conditioner comprises one or more of batyl alcohol, D-panthenol and plant extracts; preferably, the plant extract comprises one or more of a cactus extract, a ophiopogon root extract, an astragalus membranaceus extract, a saposhnikovia divaricata root extract, a calendula extract, an albizia julibrissin flower extract and a gastrodia elata root extract.
The skin care cream comprises one or more of hydrogenated polyisobutene, ethylhexyl palmitate, polydimethylsiloxane, lanolin, shea butter, diisostearyl malate and phytosterol canola oil glyceride.
ADVANTAGEOUS EFFECTS OF INVENTION
The skin emulsifying system achieves the effect of promoting absorption by forming a small particle size package of the functional substances, and can lighten the red blood filaments by a method of relieving stimulation and enhancing the skin barrier.
The preparation method of the emulsifying system for skin is simple and easy to implement, the raw materials are easy to obtain, and the emulsifying system for skin is suitable for mass production.
The cream of the present invention comprises a skin-friendly emulsifying system that can be used to soothe irritation and enhance the skin barrier, thereby improving facial flushing and reducing redness.
Detailed Description
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.
In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, the numerical range represented by "a value a to B value" means a range including the endpoint value A, B.
In the present specification, when "normal temperature" or "room temperature" is used, the temperature may be 10 to 40 ℃.
<First aspect>
The first aspect of the present invention provides an emulsifying system for skin, comprising the following composition, based on 100% of the total mass of the emulsifying system for skin:
and (3) extracting scutellaria baicalensis: 0.11-3.9%, preferably 1-3%;
ceramide (b): 0.01-0.3%, preferably 0.01-0.2%;
a first emulsifier: 21-35%, preferably 25-30%;
solvent: 1-4.9%, preferably 2-4%;
squalane: 50 to 77.88%, preferably 57.99 to 71.9%.
The skin emulsifying system can achieve the effect of promoting absorption by forming the coating of the functional substances with small particle size, and can lighten the red blood filaments by a method of relieving stimulation and enhancing the skin barrier.
Scutellaria baicalensis Georgi extract
Scutellaria baicalensis Georgi (TESB) includes baicalin (baicalin), wogonin (wogonoside), baicalein (baicalein), wogonin (wogonin), and the like. It mainly has the following functions:
(1) has effects in inhibiting various skin pathogenic fungi, resisting inflammation, and resisting allergy. Scutellaria baicalensis Georgi has inhibitory effect on various gram-positive bacteria, gram-negative bacteria and pathogenic dermatophytes, and baicalein has stronger effect than glycoside in anti-allergic reaction.
(2) Absorb ultraviolet rays, have an antiallergic effect, and have a certain repairing effect on the sunburned skin: the scutellaria baicalensis is a good skin scavenger, and in the aspect of sun protection, the baicalin can absorb ultraviolet rays, clear oxygen free radicals, inhibit the generation of melanin and enable the skin to be clean and smooth. Research shows that the sun protection factor of the radix scutellariae content reaches SPF35 4 baicalin, which can inhibit Propionibacterium acnes, when the radix scutellariae content reaches 0.8 g/ml: in vitro experiments show that the effect of baicalin on inhibiting propionibacterium acnes under the same concentration is 2 times that of metronidazole and 115 times that of erythromycin.
(3) Has the following antioxidant effect: the present research shows that the free radical scavenging activity of flavone is closely related to the number and structure of phenolic hydroxyl contained in the flavone, and the baicalin zinc and the baicalin copper have obvious scavenging effect on superoxide radical and protect skin cells from over oxidation of the superoxide radical.
(4) Based on the skin care pharmacology of the scutellaria baicalensis extract, the scutellaria baicalensis extract is often added into medical skin care products to be used as a mask, has the skin whitening, freckle removing and acne removing treatment effects, or is added into whitening cosmetics, acne treatment products, anti-allergy products and sunscreen products according to a certain proportion, and shows that the extract has the effects of increasing the metabolism of the skin, increasing the elasticity of the skin and resisting wrinkles by combining the effects of scavenging free radicals, so that the scutellaria baicalensis extract can be used as an anti-aging cosmetic; in addition, scutellariae radix extract can be used as antiinflammatory agent, sebum secretion inhibitor and humectant.
Specifically, in the present invention, the content of the scutellaria baicalensis extract is 0.11 to 3.9%, preferably 1 to 3%, based on 100% by mass of the total mass of the emulsifying system for skin, for example: 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, etc. When the content of the scutellaria baicalensis extract is 0.11-3.9%, the efficacy of an emulsification system can be ensured, and simultaneously, the stability and the cost performance can be considered.
In the present invention, the scutellaria baicalensis extract can be obtained either by preparation or by purchase.
In some specific embodiments, the mass ratio of the scutellaria baicalensis extract to the solvent is 1 (0.5-15), such as: 1. When the mass ratio of the scutellaria baicalensis extract to the solvent is 1 (0.5-15), the emulsifying system is more favorable to be formed. As the solvent, the present invention is not particularly limited, and may be a solvent commonly used in the art, for example: water, and the like.
Ceramide
Ceramide is a main component of skin stratum corneum lipid, and can help repair skin barrier and make skin soft and glossy. Ceramide not only can resist external stimulation, but also can thicken the horny layer, improve the tolerance of the whole skin, avoid sensitivity and repair red blood filaments, and is an excellent barrier repair component.
The ceramide content is 0.01-0.3%, preferably 0.01-0.2%, for example: 0.03%, 0.05%, 0.08%, 0.12%, 0.15%, 0.18%, 0.2%, 0.22%, 0.25%, 0.28%, etc. When the content of the ceramide is 0.01-0.3%, the efficacy of an emulsification system is ensured, and simultaneously, the stability and the cost performance are both considered.
First emulsifier
According to the invention, the first emulsifier is used, so that the effect of promoting absorption is achieved in a manner that an emulsion system forms functional substances wrapped by small particle sizes.
The content of the first emulsifier is 21-35%, preferably 25-30%, based on 100% of the total mass of the emulsifying system for skin, for example: 22%, 24%, 28%, 32%, 34%, etc.; in the present invention, if the content of the first emulsifier is too low, the inclusion is unstable; if the content of the first emulsifier is too high, the irritativeness is large.
In some specific embodiments, the first emulsifier comprises polyglycerol-3 diisostearate and tween-20, and the polyglycerol-3 diisostearate and tween-20 are used in combination to achieve a synergistic effect, so that a suitable hydrophilic-lipophilic balance value can be achieved.
Further, the mass ratio of the polyglycerol-3 diisostearate to the tween-20 is 1 (0.5 to 2), for example: 1. When the mass ratio of the polyglycerol-3 diisostearate to the tween-20 is 1 (0.5-2), the effects of the polyglycerol-3 diisostearate and the tween-20 can be exerted most effectively.
Squalane
In the present invention, squalane is used as an oil phase component to form an emulsifying system for skin. Squalane is a good emollient oil and also helps to solubilize ceramides. In some particular embodiments, squalane is added in an amount of 50 to 77.88%, preferably 57.99 to 71.9%, for example: 52%, 55.7%, 58%, 62.8%, 65%, 70%, 75%, etc., and a proper amount of squalane is a necessary condition for forming and stabilizing an emulsion system. When the amount of squalane added is 50 to 77.88%, an emulsified system can be formed and the stability of the emulsified system is excellent.
Solvent(s)
Some solvents are also added to form an emulsion system for skin. The solvent is not particularly limited in the present invention, and may be a solvent commonly used in the art, for example, water or the like.
Specifically, in the present invention, the solvent is added in an amount of 1 to 4.9%, preferably 2 to 4%, for example: 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. The invention helps to dissolve active substances and stabilize the system by adding a proper amount of solvent.
Method for preparing emulsifying system for skin
The first aspect of the present invention also provides a method for preparing an emulsifying system for skin, which comprises the step of mixing the components of the emulsifying system for skin of the present invention.
Specifically, the preparation method comprises the following steps:
dissolving ceramide, squalane and a first emulsifier at high temperature to obtain a premix;
mixing the scutellaria baicalensis extract with a solvent to obtain a scutellaria baicalensis extract solution;
mixing the premix and the Scutellariae radix extract solution, and cooling to obtain skin emulsion system.
Further, the preparation method comprises the following steps:
dissolving ceramide, squalane and a first emulsifier at 75-90 ℃ to obtain a premix;
mixing the scutellaria baicalensis extract with a solvent to obtain a scutellaria baicalensis extract solution;
cooling the premix to 55-65 deg.C, stirring to form a deep vortex, adding Scutellariae radix extract solution into the system, and stirring to form a transparent uniform liquid.
And then cooling the transparent and uniform liquid to room temperature to obtain the skin emulsifying system.
When the emulsifying system prepared by the invention is used, the effect of directly using higher active substances can be achieved with less active substance dosage, so that the dosage of the active substances and the formula cost can be greatly reduced when the formula is applied, and the emulsifying system has a good application prospect.
<Second aspect of the invention>
A second aspect of the invention provides a skin care product comprising an emulsifying system for skin according to the invention, wherein the emulsifying system for skin is present in an amount of 10 to 25%, preferably 15 to 20%, based on 100% of the total mass of the skin care product, for example: 12%, 14%, 16%, 18%, 20%, 22%, 24%, etc. When the content of the skin emulsifying system is 10-25%, the penetration of the coated active substance can be promoted.
Further, a second aspect of the present invention provides a skin care cream comprising the emulsifying system for skin according to the present invention, wherein the content of the emulsifying system for skin is 10 to 25% based on 100% of the total mass of the skin care cream, for example: 12%, 14%, 16%, 18%, 20%, 22%, 24%, etc. The cream of the present invention comprises a skin-friendly emulsifying system that can be used to soothe irritation and enhance the skin barrier, thereby improving facial flushing and reducing redness.
In some specific embodiments, the skin cream further comprises one or a combination of two or more of a second emulsifier, a humectant, a skin conditioner, an emollient oil, a thickener, and a preservative; the formula of the skin-care cream is mild, and the efficacy of the scutellaria baicalensis extract can be fully exerted.
Based on the total mass of the skin-care cream being 100%, the content of the second emulsifier is 3% -5%, the content of the humectant is 1% -20%, the content of the skin conditioner is 2% -4%, the content of the emollient oil is 1% -10%, the content of the thickening agent is 0.5% -3%, and the content of the preservative is 0.7% -1.0%.
In the invention, the adding amount of the second emulsifier is 3-5% of the total mass of the skin care cream, such as: may be 3.5-4.5%, may be 3-4%, etc. When the dosage of the second emulsifier is less than 3%, the emulsification is insufficient, so that the system is unstable; when the dosage of the emulsifier is more than 5%, certain influence on the stability of the product can be caused.
Specifically, in the invention, the second emulsifier comprises one or more of hydrogenated lecithin, sucrose stearate, sucrose polystearate, PEG-100 stearate, PEG-8 stearate and glycerol stearate.
The addition amount of the humectant is 1-20% by the total mass of the skin-care cream, and the humectant can play a role in moisturizing. In order to further exert the efficacy of the humectant, the humectant can be added in an amount of 1-18%, 2-16%, 3-14%, 4-15%, 5-14%, 6-13%, or 7-12%. When the content of the humectant is less than 1%, the moisturizing effect is not obvious; when the content of the moisturizer is more than 20%, the skin care cream has a sticky feeling.
In the invention, the humectant comprises one or a combination of more than two of glycerin, dipropylene glycol, glyceryl polyether-26, sodium hyaluronate, PEG/PPG-17/6 copolymer, butanediol, pentanediol, xylitol, betaine, hexanediol, glycerin polyacrylate, propylene glycol, mannose, trehalose and beta-glucan. The combination of multiple humectants is used, so that the skin cream disclosed by the invention has more excellent moisturizing and hydrating effects.
In order to further improve the efficacy of the skin cream of the present application, the skin cream of the present invention further comprises the skin conditioner. The skin conditioner is added to calm the skin, so that the facial skin injury red swelling is relieved, and fine wrinkles are reduced.
The addition amount of the skin conditioner is 2-4% of the total mass of the skin-care cream. Preferably, the skin conditioning agent may be added in an amount of 2.2 to 3.8%, may be 2.5 to 3.5%, may be 2.8 to 3.2%, and the like. When the addition amount of the skin conditioner is less than 2%, it is difficult to achieve the corresponding effect.
Specifically, in the present invention, the skin conditioner comprises one or a combination of two or more of batyl alcohol, D-panthenol and plant extracts; preferably, the plant extract comprises one or more of a cactus extract, a ophiopogon root extract, an astragalus membranaceus extract, a saposhnikovia divaricata root extract, a calendula extract, an albizia julibrissin flower extract and a gastrodia elata root extract.
In the invention, the addition amount of the emollient oil is 1-10% of the total mass of the skin-care cream. For example, it may be 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 8%, 9%, etc. The skin care cream is added with the skin moistening grease, so that the evaporation of water on the surface of the skin can be reduced, and the skin is prevented from being dried and cracked. In addition, by adding emollient oils and fats, a hydrophobic film can be formed on the skin surface to prevent the invasion of harmful substances from the outside. When the content of emollient oil is less than 1%, evaporation of water on the surface of the skin cannot be reduced, and invasion of harmful substances cannot be effectively prevented; when the content of the skin moistening grease is more than 10%, the skin care cream is too greasy, and the use feeling is reduced.
Specifically, in the present invention, the emollient oil comprises one or a combination of two or more of hydrogenated polyisobutene, ethylhexyl palmitate, polydimethylsiloxane, lanolin, shea butter, diisostearyl malate, and phytosterol canola oil glyceride. The thickener can be added in an amount of 0.5-3% based on the total mass of the skin cream, for example, the thickener can be added in an amount of 0.8, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, etc. When the addition amount of the thickener is between 0.5 and 3 percent, the low-viscosity feeling and excellent use feeling are realized, the dispersibility is good, and the absorption is fast. When the addition amount of the thickening agent is less than 0.5%, the skin care cream is thin in texture and does not have any sticky feeling; when the thickener is added in an amount of more than 3%, the skin care cream is too thick and heavy, which may increase the burden on the skin.
The thickening agent comprises one or the combination of more than two of carbomer, xanthan gum, sclerotium rolfsii, behenyl alcohol, acryloyl dimethyl taurate/VP copolymer, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer and a compound of isohexadecane and polysorbate-60.
In addition, the skin cream of the invention also contains a preservative. The addition amount of the preservative in the skin-care cream is 0.7-1% of the total mass of the skin-care cream. The preservative can comprise one or more of phenoxyethanol, methyl hydroxybenzoate, propyl hydroxybenzoate, p-hydroxyacetophenone, ethylhexyl glycerol, benzoic acid and its salt.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are commercially available, and are not indicated by manufacturers.
And (3) extracting scutellaria baicalensis: purchased from tesman (china) ltd.
Examples 1 to 9
The skin emulsion systems of examples 1-9 were prepared according to the following preparation method according to the formulation of table 1 below.
1) Ceramide, squalane, tween-20 and polyglycerol-3 diisostearate are accurately weighed according to table 1, placed in a beaker, heated to 80-85 ℃, and continuously stirred until completely dissolved.
2) Weighing Scutellariae radix extract and water according to Table 1, and mixing well to obtain Scutellariae radix extract water solution.
3) Cooling the system to 60 ℃, stirring at high speed until a deep vortex is formed in a beaker, and dropwise adding the scutellaria baicalensis extract aqueous solution into the system until the scutellaria baicalensis extract aqueous solution becomes transparent and uniform liquid.
4) Cooling, and continuously stirring to room temperature to obtain the emulsion.
Table 1 examples 1-9 raw material components of the skin emulsion system (unit is% by weight)
Performance testing
Stability test
The samples prepared in examples 1 to 9 were left at room temperature for one week, and the appearance state thereof was observed, and the results are shown in Table 2.
And (3) testing the particle size distribution ratio:
the stable samples prepared in examples 1 to 9 were measured for droplet size using a particle size distribution measuring instrument, and the ratio of the droplets having a particle size of 1.5 μm or less was counted, and the results are shown in Table 2.
TABLE 2
| Appearance of the sample | Particle size ratio (d < 1.5 μm)/%) | |
| Example 1 | Semi-permeable | —— |
| Example 2 | Transparent and uniform | 39.29 |
| Example 3 | Transparent and uniform | 43.72 |
| Example 4 | Transparent and uniform | 47.85 |
| Example 5 | Layering | —— |
| Example 6 | Transparent and uniform | 35.94 |
| Example 7 | Transparent and uniform | 37.36 |
| Example 8 | Semi-permeable | —— |
| Example 9 | Semi-permeable | —— |
As can be seen from table 2, the samples prepared in example 1, example 5, example 8 and example 9 were not stable. The first emulsifier used in example 1 was used in a relatively low amount and did not coat the active ingredient, scutellaria baicalensis extract, well; example 5 shows that when the content of the scutellaria baicalensis extract is too low, the stability of inclusion is affected; example 8 shows that when the content of the scutellaria baicalensis extract is too high, the stability of inclusion is affected; example 9 shows that the solvent content is too high, because the entrapped internal phase is relatively large, and stable inclusions cannot be formed.
The samples prepared in example 2, example 3, example 4, example 6 and example 7 were stable.
Generally, the more small particle size droplets that a sample is prepared, the more stable the sample. Of the 5 stable samples, the sample droplet prepared in example 2 accounted for about 40% of the particles with a diameter less than 1.5 μm, and the sample droplets prepared in examples 3 and 4 accounted for more than 40% of the particles with a diameter less than 1.5 μm, indicating that the preparation effect is relatively good.
Comfort test
The emulsified system prepared in example 2 (scutellaria baicalensis extract content 3%) was used as a test sample, and an aqueous solution of scutellaria baicalensis extract (scutellaria baicalensis extract content 6%) was used as a control sample to conduct a relaxation test.
Marking two testing areas with the size of 2cm multiplied by 2cm at the arm of a single hand of a subject, wherein the distance between the two testing areas is more than 3cm, respectively smearing 0.04g of 50% lactic acid solution on the testing areas, quickly smearing 0.05g of testing sample and control sample when red and stabbing pain phenomena occur, uniformly massaging until absorption, and observing the phenomena. The degree of red and pain is counted by 10 points, 0 represents no red and no pain, 10 represents no change, and the lower the point, the better the relieving effect. The results of the relaxation test are shown in table 3 below.
TABLE 3
| Test sample scoring | Control sample scoring | |
| Before smearing | 10 | 10 |
| 30s after smearing | 6 | 8 |
| 2 minutes after application | 4 | 6 |
According to the experimental result, the coated scutellaria baicalensis extract emulsion has faster and better relieving effect compared with the aqueous solution of the scutellaria baicalensis extract.
Application examples 1 to 4
The emulsion system prepared in example 3 was used for the relevant experiments. Skin care creams of application examples 1 to 4 were prepared according to the following preparation method according to the formulation of table 4 below.
1) A, B two phases were accurately weighed.
2) Mixing A, B phase uniformly, heating to 80-85 deg.C, adding phase B into phase A, homogenizing, and cooling.
3) And (3) adding the pre-dissolved C phase when the whole system is continuously stirred and cooled to 60 ℃, and uniformly stirring and homogenizing.
4) And (4) adding the phase D when the temperature of the whole system is reduced to below 45 ℃ by continuous stirring, and discharging after uniform stirring.
5) The skin-care cream is prepared according to the method according to the mass percentage shown in the following table.
Table 4 use of the raw material components of examples 1 to 4 (unit is% by weight)
Application of comparative examples 1 to 4
Skin care creams using comparative examples 1 to 4 were prepared according to the following preparation method according to the formulation of table 5 below.
1) A, B two phases were accurately weighed.
2) Mixing A, B phase uniformly, heating to 80-85 deg.C, adding phase B into phase A, homogenizing, and cooling.
3) And (3) adding the pre-dissolved C phase when the whole system is continuously stirred and cooled to 60 ℃, and uniformly stirring and homogenizing.
4) And (4) adding the phase D when the temperature of the whole system is reduced to below 45 ℃ by continuous stirring, uniformly stirring and discharging.
Table 5 use of the raw material components in comparative examples 1 to 4 (unit is% by weight)
Test of cream repair Effect
Test samples:
application examples 1 to 4 and face cream prepared by application comparative examples 1 to 4
The test method comprises the following steps:
80 women suffering from facial flushing with red blood streak were selected as subjects, randomly divided into 8 groups of 10 persons each, and 10 scores (10 scores means significant improvement, 0 score means no change) were used to score the subjects for their facial flushing and regression of red blood streak. After the subjects received the samples, the samples were applied to the face twice in the morning and evening, 28 days in succession, using coin-sized portions after each cleansing, and recorded and scored at 0, 7, 14, and 28 days by the assigned test person, the initial condition of the subjects' faces being recorded at 0 days, and the scores being uniformly marked as 0.
And (3) testing results:
the number of subjects in each group was 10, and the data results were averaged as shown in table 6.
TABLE 6 evaluation of the effects of improvement of flushing and regression of red blood streaks on the face
As can be seen from the application examples 1-4 in Table 6, the effect of improving the facial flushing and reducing the red blood streak of the subject is enhanced along with the increase of the dosage of the emulsified body for skin prepared in the examples, when the dosage of the emulsified system for skin reaches 25%, the score of improving the facial flushing of the subject reaches 8.9 points, and the score of reducing the red blood streak reaches 6.8 points, which shows that the cream added into the emulsified system prepared in the examples can well relieve the facial irritation of the subject, and effectively improve the facial flushing and reduce the red blood streak.
As can be seen from the test data of application example 3 and application comparative example 1 in Table 6, when the active substance is added in the same amount, the effect of the cream with the encapsulated active substance on improving facial flushing and red blood streaks is much better than that of the cream with the unencapsulated active substance, which shows that the emulsifying system for skin prepared by the invention can effectively enhance the effect of the active substance on the skin.
It should be noted that, although the technical solutions of the present invention are described by specific examples, those skilled in the art can understand that the present invention should not be limited thereto.
While embodiments of the present invention have been described above, the above description is illustrative, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (10)
1. An emulsifying system for skin, characterized by comprising, based on 100% of the total mass of the emulsifying system for skin, the following components:
and (3) extracting scutellaria baicalensis: 0.11-3.9%, preferably 1-3%;
ceramide: 0.01 to 0.3%, preferably 0.01 to 0.2%;
a first emulsifier: 21-35%, preferably 25-30%;
solvent: 1-4.9%, preferably 2-4%;
squalane: 50 to 77.88%, preferably 57.99 to 71.9%.
2. The emulsifying system for skin according to claim 1, wherein the mass ratio of the scutellaria baicalensis extract to the solvent is 1 (0.5-15).
3. The emulsifying system for skin according to claim 1 or 2, wherein the first emulsifier comprises polyglyceryl-3 diisostearate and tween-20; preferably, the mass ratio of the polyglycerol-3 diisostearate to the tween-20 is 1 (0.5-2).
4. A method of preparing a dermal emulsion system comprising the step of mixing the components of the dermal emulsion system of any of claims 1-3.
5. A skin care product comprising the emulsifying system for skin according to any one of claims 1 to 3, wherein the content of the emulsifying system for skin is 10 to 25%, preferably 15 to 20%, based on 100% by mass of the total skin care product.
6. A skin cream comprising the emulsifying system for skin according to any one of claims 1 to 3, wherein the emulsifying system for skin is contained in an amount of 10 to 25% based on 100% by mass of the total skin cream.
7. The skin cream of claim 6, further comprising a second emulsifier, a humectant, a skin conditioner, an emollient oil, a thickener, a preservative, or a combination of two or more thereof; preferably, the content of the second emulsifier is 3-5%, the content of the humectant is 1-20%, the content of the skin conditioner is 2-4%, the content of the emollient oil is 1-10%, the content of the thickener is 0.5-3%, and the content of the preservative is 0.7-1.0%, based on 100% of the total mass of the skin care cream.
8. The skin cream of claim 7, wherein the second emulsifier comprises one or a combination of two or more of hydrogenated lecithin, sucrose stearate, sucrose polystearate, PEG-100 stearate, PEG-8 stearate, and glyceryl stearate.
9. The skin cream of claim 7 or 8, wherein the skin conditioning agent comprises one or a combination of more than two of batyl alcohol, D-panthenol and plant extracts; preferably, the plant extract comprises one or more of a cactus extract, a ophiopogon root extract, an astragalus membranaceus extract, a saposhnikovia divaricata root extract, a calendula extract, an albizia julibrissin flower extract and a gastrodia elata root extract.
10. The skin cream of any one of claims 7-9, wherein the emollient oil comprises one or a combination of two or more of hydrogenated polyisobutene, ethylhexyl palmitate, dimethicone, lanolin, shea butter, diisostearyl malate, phytosterol canola oil glycerides.
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| CN113230172A (en) * | 2021-05-24 | 2021-08-10 | 泉州达浔生物科技有限公司 | Cosmetic or dermatological composition, preparation method and application thereof |
| CN114796000A (en) * | 2022-05-27 | 2022-07-29 | 泉州达浔生物科技有限公司 | Micro-emulsified composition of oleanolic acid and preparation method and application thereof |
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| US20080241084A1 (en) * | 2007-03-29 | 2008-10-02 | Shaklee Corporation | Compositions and methods for inhibiting melanogenesis |
| KR101829553B1 (en) * | 2016-10-31 | 2018-02-19 | 에스케이바이오랜드 주식회사 | Cosmetic composition comprising mixture extract of Pisum sativum, Scutellaria baicalensis, Ulmus davidiana, Hippophae rhamnoides fruit for improvement of skin damage or skin-protection |
| CN107007492A (en) * | 2016-12-26 | 2017-08-04 | 广州市花安堂生物科技有限公司 | A kind of makeup remover and preparation method thereof |
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