CN115463059A - 一种温和清爽修复组合物及其制备方法 - Google Patents
一种温和清爽修复组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及A61K医药组合物技术领域，更具体地，本发明提供了一种温和清爽修复组合物及其制备方法。本发明以亚麻籽油、桃木油、大豆异黄酮、葡糖基芸香苷、生育酚、岩藻多糖、透明质酸、二丁羟基甲苯、叔丁基对苯二酚、羟乙基尿素、甘油、丙二醇等物质为制备原料，制备得到的修复组合物具有优异的修复效果和稳定储存性，同时安全无刺激，也可适用于婴儿皮肤表面，在实际使用过程中具有广泛的应用范围。
Description
技术领域
本发明涉及A61K医药组合物技术领域，更具体地，本发明提供了一种温和清爽修复组合物及其制备方法。
背景技术
近年来，随着皮肤修复领域的不断更新和飞速发展，各种各样的修复膏、修复霜不断问世。但随着人体皮肤受损的原因不断增多，目前现有技术中修复产品大多为针对某一类疤痕进行修复，市面上的皮肤修复产品渐渐的不能满足消费者日益增长的需求。尤其在针对痘印修复、激光术后皮肤发红、蚊虫叮咬后皮肤受损、烫伤疤痕、婴儿面部湿疹和尿布疹、放疗后皮肤溃烂等方面的皮肤修复，现有技术中的修复产品很难做到同时修复缓解，如何扩大修复产品的修复范围成为了科研工作者们的工作重心之一。
专利公开号为CN10971040A的中国发明专利公开了一种应用于创面的修复组合物、制备方法及其应用，在本公开专利中以黄芪、黄连、地榆为中药基体，向其中加入了冰片、西伯利亚落叶松木提取物等物质，制备得到的修复组合物具有良好的止血效果、生物相容性，可以减少术后疤痕的生成，但其制备得到的修复组合物仅适用于痔疮手术术后修复，应用范围受限，同时其产品的储存稳定性和安全温和性也未得到突出体现。
因此，开发一种安全环保、安全无刺激、修复效果显著、储存稳定性优异，且成人、婴儿均适用的皮肤外伤修复的组合物在皮肤修复领域具有潜在的应用价值。
发明内容
为了解决上述技术问题，本发明第一方面提供了一种温和清爽修复组合物，按重量份计，制备原料包括以下组分：植物类修复剂100-120份，含氮或氧有机类化合物0.1-1份，油溶性稳定调节剂0.05-0.1份，皮肤调节剂6-8份，复合调理剂1-3份。
作为本发明一种优选的技术方案，所述植物类修复剂包括花生油、芝麻油、亚麻籽油、大豆油、菜籽油、桃木油、银耳提取物、忍冬花提取物、金盏花提取物中一种或多种的组合。
作为本发明一种更优选的技术方案，所述植物类修复剂为亚麻籽油、桃木油，亚麻籽油和桃木油的重量比为（1-2）：（0.5-1.5）。
作为本发明一种最优选的技术方案，所述亚麻籽油和桃木油的重量比为1.5：1。
作为本发明一种优选的技术方案，所述含氮或氧有机类化合物包括脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物、多肽类化合物。
作为本发明一种更优选的技术方案，所述含氮或氧有机类化合物为脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物，脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物的重量比为（0.2-0.8）：（0.5-1）：（1-1.5）：（1.2-1.8）。
作为本发明一种最优选的技术方案，所述脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物的重量比为0.6：0.8：1：1.2。
作为本发明一种优选的技术方案，所述脂肪族酮类化合物包括月桂氮卓酮、N-正烷基苯并异噻酮唑酮、四氢胡椒碱中一种或多种的组合。
作为本发明一种优选的技术方案，所述黄酮类化合物包括大豆异黄酮、葡糖基芸香苷、橙皮苷、槲皮素中一种或多种的组合。
作为本发明一种更优选的技术方案，所述黄酮类化合物为大豆异黄酮、葡糖基芸香苷，大豆异黄酮、葡糖基芸香苷的重量比为（0.4-0.8）：（1-1.5）。
作为本发明一种最优选的技术方案，所述大豆异黄酮、葡糖基芸香苷的重量比为0.6：1.4。
作为本发明一种优选的技术方案，所述多酚类化合物包括生育酚、茶多酚中一种或多种的组合。
作为本发明一种优选的技术方案，所述多糖类化合物包括岩藻多糖、肝素、透明质酸、甲壳素中一种或多种的组合。
作为本发明一种更优选的技术方案，所述多糖类化合物为岩藻多糖、透明质酸，岩藻多糖和透明质酸的重量比为（1-2）：（0.2-0.5）。
作为本发明一种最优选的技术方案，所述岩藻多糖和透明质酸的重量比为1.5：0.3。
作为本发明一种优选的技术方案，所述油溶性稳定调节剂包括二丁羟基甲苯、叔丁基对苯二酚、丁基羟基茴香醚、没食子酸内酯中一种或多种的组合。
作为本发明一种更优选的技术方案，所述油溶性稳定调节剂为二丁羟基甲苯、叔丁基对苯二酚，二丁羟基甲苯和叔丁基对苯二酚的重量比为（0.3-0.7）：（0.5-1）。
作为本发明一种最优选的技术方案，所述二丁羟基甲苯和叔丁基对苯二酚的重量比为0.5：0.7。
作为本发明一种优选的技术方案，所述皮肤调节剂包括烟酰胺、神经酰胺、角鲨烷、红没药醇、辛基十二烷醇、脂肪酸中一种或多种的组合。
作为本发明一种更优选的技术方案，所述皮肤调节剂为烟酰胺、角鲨烷、红没药醇，烟酰胺、角鲨烷、红没药醇的重量比为（0.2-0.6）：（0.5-0.7）：（0.3-0.9）。
作为本发明一种最优选的技术方案，所述烟酰胺、角鲨烷、红没药醇的重量比为0.4：0.6：0.5。
作为本发明一种优选的技术方案，所述复合调理剂包括羟乙基尿素、乳酸钠、甘油、丙二醇、辛酸甘油三酯、聚山梨醇酯80中一种或多种的组合。
作为本发明一种更优选的技术方案，所述复合调理剂为羟乙基尿素、甘油、丙二醇，羟乙基尿素、甘油、丙二醇的重量比为（1-2）：（0.5-1）：（0.4-0.6）。
作为本发明一种最优选的技术方案，所述羟乙基尿素、甘油、丙二醇的重量比为1.5：0.7：0.5。
作为本发明一种优选的技术方案，所述温和清爽修复组合物的制备原料还包括多肽类化合物。
作为本发明一种优选的技术方案，所述植物类修复剂、多肽类化合物的重量比为100：（0-0.1）。
本发明的第二方面提供了一种温和清爽修复组合物的制备方法，包括以下步骤：
将植物类修复剂，含氮或氧有机类化合物，油溶性稳定调节剂，皮肤调节剂，复合调理剂、多肽类化合物在60-80℃的条件下进行均质搅拌，即得所述温和清爽修复组合物。
与现有技术相比，本发明具有如下有益效果：
1、本发明制备得到的温和清爽修复组合物，通过采用亚麻籽油和桃木油进行合理复配，尤其当亚麻籽油和桃木油的重量比为1.5：1时，由于其特有的活性成分，使得修复组合物在激光术后、蚊虫叮咬、烫伤等受损皮肤表面具有优异的生物亲和力，在促进了本体系中大豆异黄酮、葡糖基芸香苷等物质的在皮肤受损部位的渗透作用效果，提升了修复组合物在受损皮肤表面的修复效果的同时，还进一步提升了产品的稳定性。
2、本发明制备得到的温和清爽修复组合物，通过向组合物中加入重量比为0.6：0.8：1：1.2的月桂氮卓酮、黄酮类化合物、生育酚、多糖类化合物，尤其当黄酮类化合物为重量比为0.6：1.4的大豆异黄酮、葡糖基芸香苷，多糖类化合物为重量比为1.5：0.3的岩藻多糖、透明质酸时，其在本体系由重量比为1.5：1亚麻籽油和桃木油组成的修复基体中有优异的相容性和稳定性，可以保证其中的有效成分可以在受损皮肤表面具有优异的渗透效果，使得修复组合物中大豆异黄酮、葡糖基芸香苷、生育酚、岩藻多糖、透明质酸更易被受损皮肤表面吸收，对红痘印、激光医美术后修复、烫伤、擦伤等皮肤受损后的发红具有优异的修复效果，同时还促进其受损皮肤处的新城代谢，可以有效激活表皮细胞，加快了受损皮肤的恢复时间。
3、本发明制备得到的温和清爽修复组合物，通过采用合理复配的二丁羟基甲苯、叔丁基对苯二酚，尤其当二丁羟基甲苯和叔丁基对苯二酚的重量比为0.5：0.7时，可以在不影响亚麻籽油和桃木油在受损皮肤表面优异亲和力的同时，还显著提升大豆异黄酮、葡糖基芸香苷、生育酚、岩藻多糖、透明质酸等活性成分的有效作用时间，同时还安全不刺激，使得制备得到的修复产品可以涂覆于婴儿肌肤的表面，尤其对于婴儿的湿疹和尿布疹有优异的修复效果，进一步扩大了修复组合物的实际使用受众。
4、本发明制备得到的温和清爽修复组合物，通过向体系中同时加入重量比为1.5：0.7：0.5的羟乙基尿素、甘油、丙二醇，在提升修复组合物储存稳定性的同时，还在成人或婴儿受损皮肤表面具有良好的渗透力，可以缓解受损皮肤表面的皮肤状态，与本体系中的桂氮卓酮、亚麻籽油和桃木油协同作用，在保证其它活性成分具有优异渗透效果的基材上，实现短时间内的渗透，有效缩短了修复组合物的修复周期，尤其对于放疗后的皮肤溃烂疼痛难忍的受损皮肤表面，涂覆四天就有明显的修复效果，涂覆九天后就可以基本痊愈。
5、本发明制备得到的温和清爽修复组合物，以亚麻籽油和桃木油为主要修复基体，向其中加入了大豆异黄酮、葡糖基芸香苷、生育酚、岩藻多糖、透明质酸、二丁羟基甲苯、叔丁基对苯二酚、羟乙基尿素、甘油、丙二醇，生育酚、月桂氮卓酮，制备得到的修复组合物具有优异的储存稳定性、修复效果，同时在短时间内就具有优异的修复效果，并且修复组合物温和无刺激、安全清爽，可以作用与婴儿皮肤表面，在受损皮肤应用领域具有广泛的应用范围。
附图说明
图1为使用实施例3制备得到的温和清爽修复组合物对放疗溃烂皮肤的修复效果：其中，A为修复前的照片、B为修复4天的照片、C为修复6天的照片、D为修复9天的照片；
图2为使用实施例3制备得到的温和清爽修复组合物对婴儿面部湿疹的修复效果：其中，A为修复前的照片、B为修复5天的照片；
图3为使用实施例3制备得到的温和清爽修复组合物对红痘印的修复效果：其中，A为修复前的照片、B为修复7天的照片；
图4为使用实施例3制备得到的温和清爽修复组合物对激光医美术后泛红肌肤的修复效果：其中，A为修复前的照片、B为修复2天的照片；
图5为使用实施例3制备得到的温和清爽修复组合物对激光医美术后泛红肌肤的修复效果：其中，A为修复前的照片、B为修复16天的照片。
实施例
实施例1
实施例1提供了一种温和清爽修复组合物，按质量百分比计，按重量份计，制备原料包括以下组分：植物类修复剂100份，含氮或氧有机类化合物0.1份，油溶性稳定调节剂0.05份，皮肤调节剂6份，复合调理剂1份，多肽类化合物0.05份。
所述植物类修复剂为亚麻籽油、桃木油，亚麻籽油和桃木油的重量比为1.5：1；所述亚麻籽油购自深圳市诚致生物开发有限公司；桃木油购自吉水县红星天然药用香料油厂；
所述含氮或氧有机类化合物为月桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物，所述月桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物的重量比为0.6：0.8：1：1.2；所述黄酮类化合物为重量比为0.6：1.4的大豆异黄酮、葡糖基芸香苷；所述大豆异黄酮购自上海易恩化学技术有限公司；葡糖基芸香苷购自北京拜尔生物技术有限公司；所述茶多酚购自河北创之源生物科技有限公司；所述多糖类化合物为重量比为1.5：0.3的岩藻多糖和透明质酸；所述岩藻多糖购自陕西新天域生物科技有限公司；透明质酸购自定陶县地元生化制品有限公司；
所述油溶性稳定调节剂为重量比为0.5：0.7的二丁羟基甲苯和叔丁基对苯二酚；所述二丁羟基甲苯的CAS号为128-37-0；叔丁基对苯二酚的CAS号为1945-33-0；
所述皮肤调节剂为重量比为0.4：0.6：0.5为烟酰胺、角鲨烷、红没药醇；所述烟酰胺的CAS号为98-92-0；角鲨烷的CAS号为111-01-3；红没药醇的CAS号为515-69-5；
所述复合调理剂为重量比为1.5：0.7：0.5的羟乙基尿素、甘油、丙二醇；所述羟乙基尿素的CAS号为2078-71-9；甘油的CAS号为56-81-5；丙二醇的CAS号为57-55-6；
所述多肽类化合物为蓝铜胜肽，蓝铜胜肽购自江苏采薇生物科技有限公司；
所述温和清爽修复组合物的制备方法，包括以下步骤：
将植物类修复剂，含氮或氧有机类化合物，油溶性稳定调节剂，皮肤调节剂，复合调理剂、多肽类化合物在75℃的条件下进行均质搅拌，即得所述温和清爽修复组合物。
实施例2
实施例2提供了一种温和清爽修复组合物，按质量百分比计，按重量份计，制备原料包括以下组分：植物类修复剂120份，含氮或氧有机类化合物1份，油溶性稳定调节剂0.1份，皮肤调节剂8份，复合调理剂3份，多肽类化合物0.1份。
所述植物类修复剂为亚麻籽油、桃木油，亚麻籽油和桃木油的重量比为1.5：1；所述亚麻籽油购自深圳市诚致生物开发有限公司；桃木油购自吉水县红星天然药用香料油厂；
所述含氮或氧有机类化合物为桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物，所述桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物的重量比为0.6：0.8：1：1.2；所述黄酮类化合物为重量比为0.6：1.4的大豆异黄酮、葡糖基芸香苷；所述大豆异黄酮购自上海易恩化学技术有限公司；葡糖基芸香苷购自北京拜尔生物技术有限公司；所述茶多酚购自河北创之源生物科技有限公司；所述多糖类化合物为重量比为1.5：0.3的岩藻多糖和透明质酸；所述岩藻多糖购自陕西新天域生物科技有限公司；透明质酸购自定陶县地元生化制品有限公司；
所述油溶性稳定调节剂为重量比为0.5：0.7的二丁羟基甲苯和叔丁基对苯二酚；所述二丁羟基甲苯的CAS号为128-37-0；叔丁基对苯二酚的CAS号为1945-33-0；
所述皮肤调节剂为重量比为0.4：0.6：0.5为烟酰胺、角鲨烷、红没药醇；所述烟酰胺的CAS号为98-92-0；角鲨烷的CAS号为111-01-3；红没药醇的CAS号为515-69-5；
所述复合调理剂为重量比为1.5：0.7：0.5的羟乙基尿素、甘油、丙二醇；所述羟乙基尿素的CAS号为2078-71-9；甘油的CAS号为56-81-5；丙二醇的CAS号为57-55-6；
所述多肽类化合物为蓝铜胜肽，蓝铜胜肽购自江苏采薇生物科技有限公司；
所述温和清爽修复组合物的制备方法同实施例1。
实施例3
实施例3提供了一种温和清爽修复组合物，按质量百分比计，按重量份计，制备原料包括以下组分：植物类修复剂110份，含氮或氧有机类化合物0.2份，油溶性稳定调节剂0.08份，皮肤调节剂7份，复合调理剂2份，多肽类化合物0.02份。
所述植物类修复剂为亚麻籽油、桃木油，亚麻籽油和桃木油的重量比为1.5：1；所述亚麻籽油购自深圳市诚致生物开发有限公司；桃木油购自吉水县红星天然药用香料油厂；
所述含氮或氧有机类化合物为桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物，所述桂氮卓酮、黄酮类化合物、茶多酚、多糖类化合物的重量比为0.6：0.8：1：1.2；所述黄酮类化合物为重量比为0.6：1.4的大豆异黄酮、葡糖基芸香苷；所述大豆异黄酮购自上海易恩化学技术有限公司；葡糖基芸香苷购自北京拜尔生物技术有限公司；所述茶多酚购自河北创之源生物科技有限公司；所述多糖类化合物为重量比为1.5：0.3的岩藻多糖和透明质酸；所述岩藻多糖购自陕西新天域生物科技有限公司；透明质酸购自定陶县地元生化制品有限公司；
所述油溶性稳定调节剂为重量比为0.5：0.7的二丁羟基甲苯和叔丁基对苯二酚；所述二丁羟基甲苯的CAS号为128-37-0；叔丁基对苯二酚的CAS号为1945-33-0；
所述皮肤调节剂为重量比为0.4：0.6：0.5为烟酰胺、角鲨烷、红没药醇；所述烟酰胺的CAS号为98-92-0；角鲨烷的CAS号为111-01-3；红没药醇的CAS号为515-69-5；
所述复合调理剂为重量比为1.5：0.7：0.5的羟乙基尿素、甘油、丙二醇；所述羟乙基尿素的CAS号为2078-71-9；甘油的CAS号为56-81-5；丙二醇的CAS号为57-55-6；
所述多肽类化合物为蓝铜胜肽，蓝铜胜肽购自江苏采薇生物科技有限公司；
所述温和清爽修复组合物的制备方法同实施例1。
其中，所述温和清爽修复组合物的谱图数据为：H NMR (400 MHz, CDCl3) δ:5.43-5.24 (m, 5H), 4.31 (d, J = 4.0 Hz, 5H), 4.28 (d, J = 4.0 Hz, 5H), 2.821(t, J = 8.0 Hz, 17H), 2.31 (t, J = 8.0 Hz, 17H), 2.12-1.99 (m, 27H), 1.61 (s,18H), 1.29 (d, J = 9.0 Hz, 100H)
对比例1
对比例1的具体实施方式同实施例3，不同之处在于，所述植物类修复剂为桃木油。
对比例2
对比例2的具体实施方式同实施例3，不同之处在于，没有加入生育酚和多糖类化合物。
性能评价
（1）储存稳定性能测试
将实施例1-3、对比例1-2制备得到的修复组合物置于温度为35℃，湿度为95%的密闭空间中静置14h，观察修复组合物的情况；
若无变色分层，则为A级；
若出现变色或分层，则为B级，测得数据见表1；
（2）修复效果测试
将实施例3制备得到的修复组合物均匀涂覆于皮肤的修复部分，每天两次，观察皮肤的修复效果，测试结果见图1-5。
表1 修复组合物储存稳定性能测试结果
| 储存稳定性 | |
| 实施例1 | A级 |
| 实施例2 | A级 |
| 实施例3 | A级 |
| 对比例1 | B级 |
| 对比例2 | B级 |
Claims (10)
1.一种温和清爽修复组合物，其特征在于，按重量份计，制备原料包括以下组分：植物类修复剂100-120份，含氮或氧有机类化合物0.1-1份，油溶性稳定调节剂0.05-0.1份，皮肤调节剂6-8份，复合调理剂1-3份。
2.根据权利要求1所述修复组合物，其特征在于，所述植物类修复剂包括花生油、芝麻油、亚麻籽油、大豆油、菜籽油、桃木油、银耳提取物、忍冬花提取物、金盏花提取物中一种或多种的组合。
3.根据权利要求1或2所述修复组合物，其特征在于，所述植物类修复剂为亚麻籽油、桃木油，亚麻籽油和桃木油的重量比为(1-2)：(0.5-1.5)。
4.根据权利要求1所述修复组合物，其特征在于，所述含氮或氧有机类化合物包括脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物、多肽类化合物。
5.根据权利要求1或4所述修复组合物，其特征在于，所述含氮或氧有机类化合物为脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物，脂肪族酮类化合物、黄酮类化合物、多酚类化合物、多糖类化合物的重量比为(0.2-0.8)：(0.5-1)：(1-1.5)：(1.2-1.8)。
6.根据权利要求4所述修复组合物，其特征在于，所述黄酮类化合物包括大豆异黄酮、葡糖基芸香苷、橙皮苷、槲皮素中一种或多种的组合。
7.根据权利要求4或6所述修复组合物，其特征在于，所述黄酮类化合物为大豆异黄酮、葡糖基芸香苷，大豆异黄酮、葡糖基芸香苷的重量比为(0.4-0.8)：(1-1.5)。
8.根据权利要求4所述修复组合物，其特征在于，所述多糖类化合物包括岩藻多糖、肝素、透明质酸、甲壳素中一种或多种的组合。
9.根据权利要求4或8所述修复组合物，其特征在于，所述多糖类化合物为岩藻多糖、透明质酸，岩藻多糖和透明质酸的重量比为(1-2)：(0.2-0.5)。
10.一种如权利要求1-9任一项所述修复组合物的制备方法，其特征在于，包括以下步骤：
将植物类修复剂，含氮或氧有机类化合物，油溶性稳定调节剂，皮肤调节剂，复合调理剂、多肽类化合物在60-80℃的条件下进行均质搅拌，即得所述温和清爽修复组合物。
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| CN110025513A (zh) * | 2019-05-09 | 2019-07-19 | 伊犁弥玥泉生物科技有限公司 | 一种含矿物温泉的无痕修复组合物 |
| CN110279638A (zh) * | 2019-07-11 | 2019-09-27 | 浙江康满家日用品有限公司 | 一种修复肌肤用护肤组合物及其制备方法 |
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