CN115463059A

CN115463059A - Mild and refreshing repairing composition and preparation method thereof

Info

Publication number: CN115463059A
Application number: CN202210019407.3A
Authority: CN
Inventors: 陈启红
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-01-10
Filing date: 2022-01-10
Publication date: 2022-12-13
Anticipated expiration: 2042-01-10
Also published as: CN115463059B

Abstract

The invention relates to the technical field of A61K pharmaceutical compositions, and particularly provides a mild and refreshing repair composition and a preparation method thereof. The preparation method takes linseed oil, peach wood oil, soybean isoflavone, glucosyl rutin, tocopherol, fucoidin, hyaluronic acid, dibutylhydroxytoluene, tert-butylhydroquinone, hydroxyethyl urea, glycerol, propylene glycol and other substances as preparation raw materials, and the prepared repair composition has excellent repair effect and stable storage property, is safe and non-irritant, can be suitable for the surface of the skin of a baby, and has wide application range in the actual use process.

Description

Mild and refreshing repair composition and preparation method thereof

Technical Field

The invention relates to the technical field of A61K pharmaceutical compositions, and particularly provides a mild and refreshing repair composition and a preparation method thereof.

Background

In recent years, with the continuous renewal and rapid development of the field of skin repair, various kinds of repair creams and repair creams have been developed. However, with the increasing causes of the damaged skin of the human body, most of the repair products in the prior art are used for repairing certain scars, and the skin repair products on the market gradually cannot meet the increasing demands of consumers. Particularly, in the aspects of repairing acne marks, redness of skin after laser operation, skin damage after mosquito bites, scald scars, infant facial eczema, diaper rash, skin ulceration after radiotherapy and the like, the repairing products in the prior art are difficult to repair and relieve simultaneously, and how to expand the repairing range of the repairing products becomes one of the work centers of scientific researchers.

The Chinese patent with patent publication No. CN10971040A discloses a repair composition applied to the wound surface, a preparation method and an application thereof, wherein astragalus, coptis and sanguisorba are used as traditional Chinese medicine matrixes in the patent, borneol, siberian larch extract and other substances are added into the traditional Chinese medicine matrixes, and the prepared repair composition has good hemostatic effect and biocompatibility and can reduce the generation of postoperative scars, but the prepared repair composition is only suitable for the postoperative repair of hemorrhoid surgery, the application range is limited, and the storage stability, safety and mildness of the product are not reflected obviously.

Therefore, the composition for repairing the skin trauma, which is safe and environment-friendly, safe and non-irritant, has an obvious repairing effect and excellent storage stability, and is suitable for adults and infants, has potential application value in the field of skin repair.

Disclosure of Invention

In order to solve the technical problems, the invention provides a mild and refreshing repair composition in a first aspect, which comprises the following raw materials in parts by weight: 100-120 parts of plant repairing agent, 0.1-1 part of nitrogen or oxygen containing organic compound, 0.05-0.1 part of oil soluble stability regulator, 6-8 parts of skin regulator and 1-3 parts of composite conditioner.

As a preferred technical solution of the present invention, the plant repairing agent comprises one or more of peanut oil, sesame oil, linseed oil, soybean oil, rapeseed oil, mahogany oil, tremella extract, honeysuckle extract, and calendula extract.

As a more preferable technical scheme of the invention, the plant repairing agent is linseed oil and mahogany oil, and the weight ratio of the linseed oil to the mahogany oil is (1-2): (0.5-1.5).

As a most preferred technical solution of the present invention, the weight ratio of the linseed oil to the mahogany oil is 1.5:1.

as a preferable technical scheme of the invention, the organic compounds containing nitrogen or oxygen comprise aliphatic ketone compounds, flavonoid compounds, polyphenol compounds, polysaccharide compounds and polypeptide compounds.

In a more preferred embodiment of the present invention, the organic nitrogen or oxygen containing compounds are aliphatic ketones, flavonoids, polyphenols, and polysaccharides, and the weight ratio of the aliphatic ketones, flavonoids, polyphenols, and polysaccharides is (0.2-0.8): (0.5-1): (1-1.5): (1.2-1.8).

According to a most preferred technical scheme of the invention, the weight ratio of the aliphatic ketone compound, the flavonoid compound, the polyphenol compound and the polysaccharide compound is 0.6:0.8:1:1.2.

as a preferable technical scheme of the invention, the aliphatic ketone compound comprises one or more of laurocapram, N-N-alkylbenzisothiazolone and tetrahydropiperine.

As a preferable technical scheme, the flavonoid compound comprises one or more of soybean isoflavone, glucosyl rutin, hesperidin and quercetin.

As a more preferable technical scheme of the invention, the flavonoid compound is soybean isoflavone and glucosyl rutin, and the weight ratio of the soybean isoflavone to the glucosyl rutin is (0.4-0.8): (1-1.5).

As a most preferred technical scheme, the weight ratio of the soybean isoflavone to the glucosyl rutin is 0.6:1.4.

as a preferable technical scheme of the invention, the polyphenol compound comprises one or more of tocopherol and tea polyphenol.

As a preferred technical solution of the present invention, the polysaccharide compound comprises one or a combination of fucoidan, heparin, hyaluronic acid and chitin.

In a more preferred embodiment of the present invention, the polysaccharide compound is fucoidin and hyaluronic acid, and the weight ratio of fucoidin to hyaluronic acid is (1-2): (0.2-0.5).

As a most preferred technical scheme of the invention, the weight ratio of the fucoidan to the hyaluronic acid is 1.5:0.3.

in a preferred embodiment of the present invention, the oil-soluble stability regulator comprises one or more of dibutylhydroxytoluene, tert-butylhydroquinone, butylhydroxyanisole, and gallic acid lactone.

As a more preferable technical scheme of the invention, the oil-soluble stability regulator is dibutylhydroxytoluene and tert-butylhydroquinone, and the weight ratio of the dibutylhydroxytoluene to the tert-butylhydroquinone is (0.3-0.7): (0.5-1).

As a most preferred technical solution of the present invention, the weight ratio of dibutylhydroxytoluene to tert-butylhydroquinone is 0.5:0.7.

in a preferred embodiment of the present invention, the skin conditioning agent comprises one or more of niacinamide, ceramide, squalane, bisabolol, octyldodecanol, and fatty acid.

In a more preferred embodiment of the present invention, the skin conditioner is niacinamide, squalane, bisabolol, and the weight ratio of niacinamide, squalane, and bisabolol is (0.2-0.6): (0.5-0.7): (0.3-0.9).

In a most preferred technical scheme of the invention, the weight ratio of the nicotinamide, the squalane and the bisabolol is 0.4:0.6:0.5.

as a preferred technical solution of the present invention, the compound conditioner comprises one or more of hydroxyethyl urea, sodium lactate, glycerin, propylene glycol, caprylic triglyceride, and polysorbate 80.

As a more preferable technical scheme of the invention, the compound conditioner is hydroxyethyl urea, glycerol and propylene glycol, and the weight ratio of the hydroxyethyl urea to the glycerol to the propylene glycol is (1-2): (0.5-1): (0.4-0.6).

In a most preferred embodiment of the present invention, the weight ratio of hydroxyethyl urea, glycerol and propylene glycol is 1.5:0.7:0.5.

as a preferred technical scheme of the invention, the raw materials for preparing the mild and refreshing repair composition further comprise polypeptide compounds.

As a preferable technical scheme of the invention, the weight ratio of the plant repairing agent to the polypeptide compound is 100: (0-0.1).

In a second aspect of the present invention, there is provided a method for preparing a mild refreshing restorative composition, comprising the steps of:

homogenizing and stirring plant repairing agent, nitrogen or oxygen containing organic compound, oil soluble stable regulator, skin regulator, composite conditioner and polypeptide compound at 60-80 deg.C to obtain the mild and refreshing repairing composition.

Compared with the prior art, the invention has the following beneficial effects:

1. the mild and refreshing repair composition prepared by the invention is prepared by reasonably compounding the linseed oil and the peach wood oil, and particularly when the weight ratio of the linseed oil to the peach wood oil is 1.5:1, due to the special active ingredients, the repair composition has excellent bioaffinity on the surface of the damaged skin after laser operation, mosquito bite, scald and the like, promotes the permeation effect of the soybean isoflavone, glucosyl rutin and other substances in the system on the damaged part of the skin, improves the repair effect of the repair composition on the surface of the damaged skin, and further improves the stability of the product.

2. The mild and refreshing repair composition prepared by the invention is prepared by adding the following components in a weight ratio of 0.6:0.8:1:1.2 of laurocapram, flavonoids, tocopherol and polysaccharides, particularly when the weight ratio of the flavonoids is 0.6:1.4 soybean isoflavone, glucosyl rutin, and polysaccharide compound in the weight ratio of 1.5:0.3 of fucoidin and hyaluronic acid, the weight ratio of the system is 1.5: the repairing matrix composed of the linseed oil and the peach wood oil has excellent compatibility and stability, can ensure that effective components in the repairing matrix can have excellent permeation effect on the surface of damaged skin, so that soybean isoflavone, glucosyl rutin, tocopherol, fucoidin and hyaluronic acid in the repairing composition are more easily absorbed by the surface of the damaged skin, and the repairing matrix has excellent repairing effect on redness of the damaged skin such as pimple marks, post-laser and art repairing, scalds and scratches, and simultaneously promotes the metabolism of the newcastle at the damaged skin, can effectively activate epidermal cells, and quickens the recovery time of the damaged skin.

3. According to the mild and refreshing repair composition prepared by the invention, reasonable compound dibutylhydroxytoluene and tert-butylhydroquinone are adopted, and particularly, when the weight ratio of the dibutylhydroxytoluene to the tert-butylhydroquinone is 0.5:0.7, the excellent affinity of linseed oil and peach wood oil on the surface of damaged skin is not influenced, the effective action time of active ingredients such as soybean isoflavone, glucosyl rutin, tocopherol, fucoidin and hyaluronic acid is also obviously prolonged, and the repairing product is safe and non-irritant, so that the prepared repairing product can be coated on the surface of the skin of an infant, particularly has an excellent repairing effect on eczema and diaper rash of the infant, and the actual use audience of the repairing composition is further expanded.

4. The mild and refreshing repair composition prepared by the invention is prepared by simultaneously adding the components in the weight ratio of 1.5:0.7:0.5 of hydroxyethyl urea, glycerol and propylene glycol, has good permeability on the surface of the damaged skin of adults or infants while improving the storage stability of the repairing composition, can relieve the skin state of the surface of the damaged skin, has synergistic effect with the cinnabarinone, linseed oil and peach wood oil in the system, realizes the penetration in a short time on a base material which ensures that other active ingredients have excellent penetration effect, effectively shortens the repairing period of the repairing composition, has obvious repairing effect particularly on the surface of the damaged skin which is difficult to endure the skin ulceration pain after radiotherapy after being coated for four days, and can be basically cured after being coated for nine days.

5. The mild and refreshing repair composition prepared by the invention takes linseed oil and peach wood oil as main repair matrixes, and soybean isoflavone, glucosyl rutin, tocopherol, fucoidin, hyaluronic acid, dibutylhydroxytoluene, tert-butylhydroquinone, hydroxyethyl urea, glycerol, propylene glycol, tocopherol and laurocapram are added into the main repair matrixes.

Drawings

Fig. 1 is a graph showing the healing effect of a mild and refreshing healing composition prepared in example 3 on radiotherapeutic ulcerated skin: wherein, A is a photo before repair, B is a photo for 4 days of repair, C is a photo for 6 days of repair, and D is a photo for 9 days of repair;

fig. 2 is a graph showing the repairing effect of a mild and refreshing repairing composition prepared in example 3 on facial eczema of infants: wherein A is a photo before repair, and B is a photo after 5 days of repair;

fig. 3 is a graph showing the effect of a mild and refreshing restorative composition prepared in example 3 on the restoration of red pox marks: wherein, A is a photo before repair, B is a photo for 7 days of repair;

fig. 4 is a graph of the effect of using the mild and refreshing restorative composition prepared in example 3 on the post-laser-aesthetic reddened skin: wherein, A is a photo before repair, B is a photo for 2 days of repair;

fig. 5 is a graph showing the effect of using the mild and refreshing repair composition prepared in example 3 on the repair of reddened skin after laser medical arts: wherein A is a photograph before repair, and B is a photograph after 16 days of repair.

Examples

Example 1

Example 1 provides a mild and refreshing repair composition, which is prepared from the following raw materials in parts by weight: 100 parts of plant repairing agent, 0.1 part of nitrogen or oxygen-containing organic compound, 0.05 part of oil-soluble stability regulator, 6 parts of skin regulator, 1 part of composite conditioner and 0.05 part of polypeptide compound.

The plant repairing agent comprises linseed oil and peach wood oil, wherein the weight ratio of the linseed oil to the peach wood oil is 1.5:1; the linseed oil is purchased from Shenzhen Chengzheng Biodevelopment Limited; the mahogany oil is purchased from natural medicinal spice oil factories of Hongxing in Jishui county;

the organic compounds containing nitrogen or oxygen are laurocapram, flavonoids, tea polyphenol and polysaccharide compounds, and the weight ratio of the laurocapram, the flavonoids, the tea polyphenol and the polysaccharide compounds is 0.6:0.8:1:1.2; the weight ratio of the flavonoid compound is 0.6:1.4 soybean isoflavones, glucosyl rutin; the soy isoflavones are available from Shanghai Yien chemical technology, inc.; glucosylcrutin was purchased from beijing bayer biotechnology limited; the tea polyphenol is purchased from Biotech limited of Hebei Chuang; the polysaccharide compound is prepared from the following components in a weight ratio of 1.5:0.3 fucoidan and hyaluronic acid; the fucoidin is purchased from Shanxi New Tian territory Biotechnology GmbH; hyaluronic acid was purchased from diyuan biochemical products, ltd, ding ceramic county;

the oil-soluble stability regulator is prepared from the following components in a weight ratio of 0.5:0.7 of dibutylhydroxytoluene and tert-butylhydroquinone; the CAS number of the dibutylhydroxytoluene is 128-37-0; the CAS number of tert-butylhydroquinone is 1945-33-0;

the skin conditioning agent is prepared from the following components in a weight ratio of 0.4:0.6:0.5 is nicotinamide, squalane, bisabolol; the CAS number of the nicotinamide is 98-92-0; the CAS number of squalane is 111-01-3; the CAS number of bisabolol is 515-69-5;

the composite conditioner is prepared from the following components in percentage by weight of 1.5:0.7:0.5 of hydroxyethyl urea, glycerol, propylene glycol; the CAS number of the hydroxyethyl urea is 2078-71-9; glycerol has CAS number 56-81-5; the CAS number for propylene glycol is 57-55-6;

the polypeptide compound is blue copper peptide, and the blue copper peptide is purchased from Jiangsu Caesawei biological science and technology limited company;

the preparation method of the mild and refreshing repair composition comprises the following steps:

homogenizing and stirring plant repairing agent, nitrogen or oxygen containing organic compound, oil soluble stable regulator, skin regulator, composite conditioner and polypeptide compound at 75 deg.C to obtain the mild and refreshing repairing composition.

Example 2

Embodiment 2 provides a mild and refreshing repairing composition, which comprises the following raw materials in parts by weight: 120 parts of plant repairing agent, 1 part of nitrogen or oxygen-containing organic compound, 0.1 part of oil-soluble stability regulator, 8 parts of skin regulator, 3 parts of composite conditioner and 0.1 part of polypeptide compound.

The plant repairing agent is linseed oil and peach wood oil, and the weight ratio of the linseed oil to the peach wood oil is 1.5:1; the linseed oil is purchased from Shenzhen Chengzheng Biodevelopment Limited; the mahogany oil is purchased from natural medicinal spice oil factories of Hongxing in Jishui county;

the organic compounds containing nitrogen or oxygen are cinnabarinone, flavonoids, tea polyphenol and polysaccharides, and the weight ratio of cinnabarinone, flavonoids, tea polyphenol and polysaccharides is 0.6:0.8:1:1.2; the weight ratio of the flavonoid compound is 0.6:1.4 soybean isoflavones, glucosyl rutin; the soy isoflavones are available from Shanghai Yinn chemical technology, inc.; glucosylcrutin was purchased from beijing bayer biotechnology limited; the tea polyphenol is purchased from Biotech limited of Hebei Chuang; the polysaccharide compound is prepared from the following components in a weight ratio of 1.5:0.3 of fucoidan and hyaluronic acid; the fucoidin is purchased from Shanxi New Tian territory Biotechnology GmbH; hyaluronic acid was purchased from geo-biochemical products, ltd, ding, ceramic county;

the oil-soluble stabilizing and regulating agent is prepared from the following components in a weight ratio of 0.5:0.7 of dibutylhydroxytoluene and tert-butylhydroquinone; the CAS number of the dibutylhydroxytoluene is 128-37-0; the CAS number of tert-butylhydroquinone is 1945-33-0;

the mild and refreshing restorative composition was prepared as in example 1.

Example 3

Embodiment 3 provides a mild and refreshing repairing composition, which comprises the following raw materials in parts by weight: 110 parts of plant repairing agent, 0.2 part of nitrogen or oxygen containing organic compound, 0.08 part of oil-soluble stability regulator, 7 parts of skin regulator, 2 parts of composite conditioner and 0.02 part of polypeptide compound.

The plant repairing agent is linseed oil and peach wood oil, and the weight ratio of the linseed oil to the peach wood oil is 1.5:1; the linseed oil is purchased from Shenzhen honest biology development Limited; the mahogany oil is purchased from natural medicinal spice oil factories of Hongxing in Jishui county;

the nitrogen or oxygen-containing organic compounds are cinnabarinone, flavonoids, tea polyphenol and polysaccharide compounds, and the weight ratio of cinnabarinone to flavonoids to tea polyphenol to polysaccharide compound is 0.6:0.8:1:1.2; the weight ratio of the flavonoid compound is 0.6:1.4 soybean isoflavone, glucosyl rutin; the soy isoflavones are available from Shanghai Yinn chemical technology, inc.; glucosylcrutin was purchased from beijing bayer biotechnology limited; the tea polyphenol is purchased from Biotech limited of Hebei Chuang; the polysaccharide compound is prepared from the following components in a weight ratio of 1.5:0.3 of fucoidan and hyaluronic acid; the fucoidin is purchased from Shanxi New Tian territory Biotechnology GmbH; hyaluronic acid was purchased from geo-biochemical products, ltd, ding, ceramic county;

the composite conditioner is prepared from the following components in a weight ratio of 1.5:0.7:0.5 of hydroxyethyl urea, glycerol, propylene glycol; the CAS number of the hydroxyethyl urea is 2078-71-9; glycerol has CAS number 56-81-5; propylene glycol has CAS number 57-55-6;

the mild, refreshing restorative composition was prepared as in example 1.

Wherein the spectrum data of the mild refreshing repair composition is as follows: h NMR (400 MHz, CDCl) ₃ ) δ: 5.43-5.24 (m, 5H), 4.31 (d, J = 4.0 Hz, 5H), 4.28 (d, J = 4.0 Hz, 5H), 2.821 (t, J = 8.0 Hz, 17H), 2.31 (t, J = 8.0 Hz, 17H), 2.12-1.99 (m, 27H), 1.61 (s, 18H), 1.29 (d, J = 9.0 Hz, 100H)

Comparative example 1

The embodiment of comparative example 1 is the same as example 3 except that the phytoremediation agent is mahogany oil.

Comparative example 2

Comparative example 2 was conducted in the same manner as in example 3 except that no tocopherol and polysaccharide compound was added.

Evaluation of Performance

(1) Storage stability Performance test

Placing the repairing compositions prepared in the examples 1-3 and the comparative examples 1-2 in a closed space with the temperature of 35 ℃ and the humidity of 95% for standing for 14h, and observing the condition of the repairing compositions;

if no color change layering exists, the grade is A;

if color change or layering occurs, the grade is B, and the measured data are shown in a table 1;

(2) Testing of repair Effect

The repairing composition prepared in example 3 was uniformly applied to the repaired portion of the skin twice a day, and the repairing effect of the skin was observed, and the test results are shown in fig. 1 to 5.

TABLE 1 repair compositions storage stability test results

	Storage stability
		Example 1	Class A
Example 2	Class A
		Example 3	Class A
Comparative example 1	Class B
		Comparative example 2	Class B

Claims

1. The mild and refreshing repair composition is characterized by comprising the following raw materials in parts by weight: 100-120 parts of plant repairing agent, 0.1-1 part of nitrogen or oxygen-containing organic compound, 0.05-0.1 part of oil-soluble stability regulator, 6-8 parts of skin regulator and 1-3 parts of composite conditioner.

2. The restoration composition according to claim 1, wherein the phyto-restorative comprises a combination of one or more of peanut oil, sesame oil, linseed oil, soybean oil, rapeseed oil, mahogany oil, tremella extract, honeysuckle extract, calendula extract.

3. The repair composition according to claim 1 or 2, wherein the phytoremediation agent is linseed oil, mahogany oil, and the weight ratio of linseed oil to mahogany oil is (1-2): (0.5-1.5).

4. The repair composition of claim 1 wherein the nitrogen or oxygen containing organic based compound comprises an aliphatic ketone, a flavonoid, a polyphenol, a polysaccharide, a polypeptide.

5. The repair composition according to claim 1 or 4, wherein the nitrogen or oxygen containing organic compounds are aliphatic ketones, flavonoids, polyphenols and polysaccharides, and the weight ratio of the aliphatic ketones, the flavonoids, the polyphenols and the polysaccharides is (0.2-0.8): (0.5-1): (1-1.5): (1.2-1.8).

6. The remedial composition of claim 4 wherein said flavonoids include a combination of one or more of soy isoflavones, glucosyl rutin, hesperidin, quercetin.

7. The repair composition of claim 4 or 6 wherein the flavonoid is soy isoflavone and glucosyl rutin, and the weight ratio of soy isoflavone to glucosyl rutin is (0.4-0.8): (1-1.5).

8. The repair composition of claim 4 wherein the polysaccharide compound comprises a combination of one or more of fucoidan, heparin, hyaluronic acid, and chitin.

9. The repair composition of claim 4 or 8, wherein the polysaccharide compound is fucoidan or hyaluronic acid, and the weight ratio of fucoidan to hyaluronic acid is (1-2): (0.2-0.5).

10. A method of preparing a repair composition according to any one of claims 1 to 9 comprising the steps of: