CN115023428A - 嘧啶并吡咯类化合物 - Google Patents
嘧啶并吡咯类化合物 Download PDFInfo
- Publication number
- CN115023428A CN115023428A CN202180010090.0A CN202180010090A CN115023428A CN 115023428 A CN115023428 A CN 115023428A CN 202180010090 A CN202180010090 A CN 202180010090A CN 115023428 A CN115023428 A CN 115023428A
- Authority
- CN
- China
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- acceptable salt
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
本申请提供了式(Ib)所示的嘧啶并五元环类化合物或其药学可接受的盐、药物组合物及其制备方法，以及作为JAK3和/或BTK抑制剂的用途。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010071941X | 2020-01-21 | ||
| CN202010071941 | 2020-01-21 | ||
| CN2020110039412 | 2020-09-22 | ||
| CN202011003941 | 2020-09-22 | ||
| PCT/CN2021/073081 WO2021147952A1 (zh) | 2020-01-21 | 2021-01-21 | 嘧啶并吡咯类化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115023428A true CN115023428A (zh) | 2022-09-06 |
Family
ID=76993282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180010090.0A Pending CN115023428A (zh) | 2020-01-21 | 2021-01-21 | 嘧啶并吡咯类化合物 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115023428A (zh) |
| WO (1) | WO2021147952A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315838A (zh) * | 2020-09-30 | 2022-04-12 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202214643A (zh) * | 2020-09-22 | 2022-04-16 | 大陸商江蘇先聲藥業有限公司 | 嘧啶并吡咯類化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9908884B2 (en) * | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
| AU2012311184A1 (en) * | 2011-09-22 | 2014-03-06 | Pfizer Inc. | Pyrrolopyrimidine and purine derivatives |
| KR102181365B1 (ko) * | 2012-08-06 | 2020-11-23 | 에이시아 바이오사이언시스 인코포레이티드. | 단백질 키나아제 억제제로서 새로운 피롤로피리미딘 화합물 |
| SG11201811470PA (en) * | 2016-06-30 | 2019-01-30 | Daewoong Pharmaceutical Co Ltd | Pyrazolopyrimidine derivatives as kinase inhibitor |
| JP2020516682A (ja) * | 2017-04-07 | 2020-06-11 | エイシア セラピューティクス， インコーポレイテッド | ピロロピリミジンキナーゼの薬学的な塩、物理的形態および組成物、ならびにその作製方法 |
| KR102577242B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
| MX2020006799A (es) * | 2017-12-28 | 2020-09-03 | Daewoong Pharmaceutical Co Ltd | Derivados de oxi-fluoropiperidina como inhibidor de cinasa. |
| KR102577241B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
-
2021
- 2021-01-21 CN CN202180010090.0A patent/CN115023428A/zh active Pending
- 2021-01-21 WO PCT/CN2021/073081 patent/WO2021147952A1/zh active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315838A (zh) * | 2020-09-30 | 2022-04-12 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021147952A1 (zh) | 2021-07-29 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination |