CN114949078A - 一种具有胃肠道粘膜保护作用的组合物及其制备方法 - Google Patents
一种具有胃肠道粘膜保护作用的组合物及其制备方法 Download PDFInfo
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- CN114949078A CN114949078A CN202210683963.0A CN202210683963A CN114949078A CN 114949078 A CN114949078 A CN 114949078A CN 202210683963 A CN202210683963 A CN 202210683963A CN 114949078 A CN114949078 A CN 114949078A
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- potassium sorbate
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Abstract
本发明公开了一种具有胃肠道粘膜保护作用的组合物及其制备方法,属于中药组合物技术领域,具体包括以下重量份数的原料:桑葚1‑9份、枸杞子1‑9份、葛根1‑5份、枳椇子1‑5份、菊花1‑3份、甘草0.1‑2份、蜂蜜0.5‑2.5份、白砂糖0.5‑2.5份和山梨酸钾0.005‑0.015份。同时本发明公开了利用水为溶剂对原料中有效成分进行提取,然后浓缩离心得到能够直接引用的具有胃肠道粘膜保护作用组合物的制备方法。本发明提供的产品可直接饮用,方便消费者携带与使用。本发明中的制备方法简单易操作,便于工业化推广。
Description
本申请是申请日为2021年06月01日、申请号为202110610343.X、发明名称为《一种解酒护肝组合物及其制备方法》的分案申请。
技术领域
本发明涉及中药组合物技术领域,更具体的说是涉及一种具有胃肠道粘膜保护作用的组合物及其制备方法。
背景技术
酒精饮料系指供人们饮用的且乙醇含量在0.5%(vol)以上的饮料,包括各种发酵酒、蒸馏酒、配制酒及预调酒,我国是世界酒精饮料的生产和消费大国,酒精饮料在我国生产历史悠久,工艺传承久远,在漫长的发展历史中,产生了丰富的品种。
目前,普遍关注的是酒精对肝脏造成的损伤,解酒产品多数基于保护肝脏,预防化学性肝损伤这一机理来开发。实际上,酒精摄入过量不仅对肝脏造成损害,而且对胃肠道也有直接和间接的影响。近年来,我国因酒精摄入过量引起胃肠道出血以及胃炎的发病率呈现逐年上升趋势。酒精可以溶于脂质从而进入胃壁内,胃液中氢离子回渗入粘膜上皮细胞,导致组胺、5-羟色胺和肝素释放,引起粘膜下动脉短路,毛细血管压力升高与通透性增加,出现粘膜充血、红细胞渗出、胃粘膜糜烂出血等胃粘膜损伤。酒精对小肠的影响主要是引起十二指肠和空肠绒毛肿胀,表面皱襞消失,粘膜上皮细胞的微绒毛密度降低,并且随着酒精浓度增加,相关病理性变化也会出现加重。
现有技术中的多数解酒产品存在适应症较多,治疗范围广,疗效不明确,针对性不强等缺点。
因此,如何提供一种解酒效果好,且能够保护肠胃及肝脏的组合物是本领域技术人员亟需解决的问题。
发明内容
有鉴于此,本发明提供了一种护肝解酒,具有保护肠胃粘膜作用的中药组合物,同时提供了该组合物的制备方法。实施例结果表明:本发明的具有胃肠道粘膜保护作用的组合物胃肠道黏膜保护效果优于***,可见,本发明的组合物对胃肠道粘膜保护作用显著。
为了实现上述目的,本发明采用如下技术方案:
本发明提供了一种具有胃肠道粘膜保护作用的组合物,包括以下重量份数的原料:桑葚1-9份、枸杞子1-9份、葛根1-5份、枳椇子1-5份、菊花1-3份、甘草0.1-2份、蜂蜜0.5-2.5份、白砂糖0.5-2.5份和山梨酸钾0.005-0.015份。
优选的,包括以下重量份数的原料:桑葚3-7份、枸杞子3-7份、葛根2-4份、枳椇子2-4份、菊花1.5-2.5份、甘草0.7-1.3份、蜂蜜1-2份、白砂糖1-2份和山梨酸钾0.005-0.015份。
优选的,包括以下重量份数的原料:桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1份、蜂蜜1.5份、白砂糖1.5份和山梨酸钾0.01份;
或者桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1.0份、蜂蜜1.5份、白砂糖2.5份和山梨酸钾0.005份。
本发明还提供了一种解酒护肝组合物,包括以下重量份数的原料:桑葚1-9份、枸杞子1-9份、葛根1-5份、枳椇子1-5份、菊花1-3份、甘草0.1-2份、蜂蜜0.5-2.5份、白砂糖0.5-2.5份和山梨酸钾0.005-0.015份。
优选的,包括以下重量份数的原料:桑葚3-7份、枸杞子3-7份、葛根2-4份、枳椇子2-4份、菊花1.5-2.5份、甘草0.7-1.3份、蜂蜜1-2份、白砂糖1-2份和山梨酸钾0.005-0.015份。
优选的,包括以下重量份数的原料:桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1份、蜂蜜1.5份、白砂糖1.5份和山梨酸钾0.01份;
或者桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1.0份、蜂蜜1.5份、白砂糖2.5份和山梨酸钾0.005份。
有益效果:桑葚:性寒,味甘、酸。归心、肝、肾经。始载于《神农本草经》,言能“明目、轻身、通神。”,《本草纲目》曰:“利五脏关节,通血气。久服不饥,安魂镇神,令人聪明,变白不老。……捣汁饮,解中酒毒”。
枸杞子:味甘、性平、归肝、肾经,具有滋补肝肾、益精明目、润肺止咳、延缓衰老等功效。具有增强免疫力、抗肿瘤、防衰老、降血糖、降血脂、护肝等方面的药理作用。药理研究表明,枸杞子具有增强免疫力、抗肿瘤、防衰老、降血糖、降血脂、护肝等方面的药理作用。
葛根:性平,味甘、辛,归脾、胃、肺经。具有解肌退热、生津止渴、透疹、升阳止泻、通经活络、解酒毒的功效。总黄酮具有降低乙醛毒性,降低酒精对大脑的抑制功能;能抑制肠胃对酒精的吸收,促进血液中酒精的代谢和***,减少酒精对器官损害等作用。
枳椇子:性平,味甘、酸。归心、脾经。具有清热利尿,止咳除烦,解酒毒的功效。枳椇子能够缩短醉酒时间及因醉酒而引发的睡眠时间,激活酒精代谢过程中相关的酶类,如乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)、谷胱甘肽过氧化氢酶(GSH-PX)等。可有效地减缓和阻碍乙醇进入人体的速度和浓度,从而减少乙醇对肝脏等脏器的损害。
菊花:味甘苦,性微寒,有散风清热、清肝明目和解毒消炎等作用。对口干、火旺、目涩等疾病有一定的疗效。主治感冒风热、头痛病、疮疗毒等,对眩晕、头痛、耳鸣有防治作用。
甘草:味甘性平,归脾、胃、心、肺经。研究通过构建酒精导致肝脂肪变性大鼠模型,研究异甘草素对酒精性脂肪变性的影响,结果发现异甘草素能有效地增加SIRT1和AMPK的磷酸化,从而减少酒精性脂肪变性中甘油三酯(TG)的积累。从而达到保肝目的。
蜂蜜:味甘性平,自古就被作为药食同源的食品,其具有保护肝脏、胃肠道、心血管***以及抗菌消炎、润肺祛痰、保护创面、抗肿瘤等作用。有文献报道,蜂蜜能促进酒精分解代谢,减轻饮酒原因造成的头痛症状,其所含的果糖是主要功效成分。研究还发现,蜂蜜能够通过降低线粒体膜脂质过氧化程度的方式起到保护肝脏作用。
本发明还提供了一种具有胃肠道粘膜保护作用的组合物或一种解酒护肝组合物的制备方法,包括以下步骤:
(1)原料预处理:将葛根、甘草一同加水浸泡1h;将桑椹、枸杞子分别装袋,与枳椇子、菊花一同加水浸泡15min;浸泡结束后将原料用水清洗1-2遍;
(2)提取:将预处理后的原料混合,再在85~94℃下用水提取2h后200目过筛,重复提取后合并滤液;
(3)浓缩:将所述滤液减压浓缩后,置于4℃条件下静置6-8h,然后离心保留上清液,得到离心上清液;
(4)配制:将白砂糖、山梨酸钾和蜂蜜与所述离心上清液搅拌均匀后过滤、定容,再次搅拌均匀,得具有胃肠道粘膜保护作用、解酒护肝组合物;
其中,为使得白砂糖、山梨酸钾和蜂蜜能够更容易溶解于离心上清液中,可以先将白砂糖、山梨酸钾与蜂蜜先溶解于少量水中形成混合溶液,然后再将混合溶液与离心上清液混合均匀。
有益效果:本发明根据物料的特性,分批采用不同的处理方法,能够保存原料的有效成分。且最后制成的产品,可直接饮用,方便消费者携带及使用。
优选的,步骤(2)所述预处理后的原料与水的质量比为1:8。
有益效果:上述料液比能够提高对原料中有效物质的提取率。
优选的,步骤(3)所述减压浓缩过程中压力为-0.08~-0.1MPa,温度为60-70℃,且所述滤液浓缩后在室温下相对密度为1.03±0.005g/mL。
有益效果:上述减压浓缩条件能够在不破坏提取液中有效成分的前提下提高产品中有效物质含量。
优选的,步骤(3)所述离心过程中离心机转速为17000r/min。
有益效果:离心使得浓缩滤液固液分离,保留提取液。
优选的,步骤(4)所述过滤滤芯为10μm。
有益效果:过滤后能够使得产品中的固体含量降低,提高产品口感。
本发明还提供了上述技术方案所述的具有胃肠道粘膜保护作用的组合物或上述技术方案制备得到的具有胃肠道粘膜保护作用的组合物在制备具有胃肠道黏膜保护作用药物中的应用。
本发明还提供了上述技术方案所述的具有胃肠道粘膜保护作用的组合物或上述技术方案制备得到的具有胃肠道粘膜保护作用的组合物在制备具有具有解酒护肝作用药物中的应用。
经由上述的技术方案可知,与现有技术相比,本发明公开提供了一种解酒护肝组合物及其制备方法,本发明充分利用植物原料本身解酒功效,同时各原料协同增效,既能有效缓解醉酒症状,缩短醒酒时间,又能保护胃肠道和肝脏等。经醉酒动物模型评价结果表明在保护胃肠道、解酒醒酒、保护肝脏等功能方面具有显著作用。本发明最终得到的产品可直接饮用,方便消费者使用,并且,本发明提供的制备方法简单易操作,能够保存原料的有效成分。
具体实施方式
下面将结合本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种解酒护肝组合物,包括以下原料:
桑葚9份、枸杞子1份、葛根1份、枳椇子5份、菊花1.0份、甘草2.0份、蜂蜜2.5份、白砂糖1.5份和山梨酸钾0.01份。
一种解酒护肝组合物的制备方法,包括以下步骤:
(1)提取
将葛根、甘草、桑椹、枸杞子、枳椇子、菊花依配方量混合,加入8倍水在90℃下提取2次,每次2h,过200目筛网,合并滤液。
(2)浓缩
将上述滤液,减压(-0.08~-0.1MPa,60-70℃)浓缩至相对密度1.03±0.005g/mL(25℃测),4℃静置6-8h。
(3)离心
将静置后的液体用管试离心机17000r/min,进液速度200L/h,保留上清液。
(4)配制
将白砂糖、蜂蜜和山梨酸钾溶解于少量水中,再与离心上清液混合,搅拌10min,过10μm滤芯,定容,搅拌10min,得配制液,密度为1.032g/mL(12℃测),固含物10%。
实施例2
一种解酒护肝组合物,包括以下原料:
桑葚7份、枸杞子2份、葛根2份、枳椇子4份、菊花1.5份、甘草1.5份、蜂蜜2.0份、白砂糖2.5份和山梨酸钾0.015份。
一种解酒护肝组合物的制备方法,包括以下步骤:
(1)提取
将葛根、甘草、桑椹、枸杞子、枳椇子、菊花依配方量混合,加入8倍水在94℃下提取2次,每次2h,过200目筛网,合并滤液。
(2)浓缩
将上述滤液,减压(-0.08~-0.1MPa,60-70℃)浓缩至相对密度1.03±0.005g/mL(25℃测),4℃静置6-8h。
(3)离心
将静置后的液体用管试离心机17000r/min,进液速度200L/h,保留上清液。
(4)配制
将白砂糖、蜂蜜和山梨酸钾溶解于少量水中,再与离心上清液混合,搅拌10min,过10μm滤芯,定容,搅拌10min,得配制液,密度为1.032g/mL(12℃测),固含物10%。
实施例3
一种解酒护肝组合物,包括以下原料:
桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2.0份、甘草1.0份、蜂蜜1.5份、白砂糖2.5份和山梨酸钾0.005份。
一种解酒护肝组合物及其制备方法,包括以下步骤:
(1)提取
将葛根、甘草、桑椹、枸杞子、枳椇子、菊花依配方量混合,加入8倍水在85℃下提取2次,每次2h,过200目筛网,合并滤液。
(2)浓缩
将上述滤液,减压(-0.08~-0.1MPa,60-70℃)浓缩至相对密度1.03±0.005g/mL(25℃测),4℃静置6-8h。
(3)离心
将静置后的液体用管试离心机17000r/min,进液速度200L/h,保留上清液。
(4)配制
将白砂糖、蜂蜜和山梨酸钾溶解于少量水中,再与离心上清液混合,搅拌10min,过10μm滤芯,定容,搅拌10min,得配制液,密度为1.032g/mL(12℃测),固含物10%。
实施例4
一种解酒护肝组合物,包括以下原料:
桑葚3份、枸杞子6份、葛根4份、枳椇子2份、菊花2.5份、甘草0.5份、蜂蜜1.0份、白砂糖2.0份和山梨酸钾0.07份。
一种解酒护肝组合物的制备方法,包括以下步骤:
(1)提取
将葛根、甘草、桑椹、枸杞子、枳椇子、菊花依配方量混合,加入8倍水在88℃下提取2次,每次2h,过200目筛网,合并滤液。
(2)浓缩
将上述滤液,减压(-0.08~-0.1MPa,60-70℃)浓缩至相对密度1.03±0.005g/mL(25℃测),4℃静置6-8h。
(3)离心
将静置后的液体用管试离心机17000r/min,进液速度200L/h,保留上清液。
(4)配制
将白砂糖、蜂蜜和山梨酸钾溶解于少量水中,再与离心上清液混合,搅拌10min,过10μm滤芯,定容,搅拌10min,得配制液,密度为1.032g/mL(12℃测),固含物10%。
实施例5
一种解酒护肝组合物,包括以下原料:
桑葚1份、枸杞子9份、葛根5份、枳椇子1份、菊花3.0份、甘草0.1份、蜂蜜0.5份、白砂糖1份和山梨酸钾0.015份。
一种解酒护肝组合物的制备方法,包括以下步骤:
(1)提取
将葛根、甘草、桑椹、枸杞子、枳椇子、菊花依配方量混合,加入8倍水在92℃下提取2次,每次2h,过200目筛网,合并滤液。
(2)浓缩
将上述滤液,减压(-0.08~-0.1MPa,60-70℃)浓缩至相对密度1.03±0.005g/mL(25℃测),4℃静置6-8h。
(3)离心
将静置后的液体用管试离心机17000r/min,进液速度200L/h,保留上清液。
(4)配制
将白砂糖、蜂蜜和山梨酸钾溶解于少量水中,再与离心上清液混合,搅拌10min,过10μm滤芯,定容,搅拌10min,得配制液,密度为1.032g/mL(12℃测),固含物10%。
技术效果:
胃肠保护试验:
随机选取360尾3dpf转基因中性粒细胞绿色荧光斑马鱼于六孔板中,每孔(实验组)均处理30尾斑马鱼。除正常对照组外,其余各实验组均水溶给予TNBS建立斑马鱼胃肠粘膜损伤模型。28℃处理2天后,移除TNBS,分别水溶给予实施例3得到的产品3.91、7.81、15.6、31.3、62.5、125、250、500和1000μL/mL浓度,阳性对照组***15.0μg/mL浓度,同时设置模型对照组和正常对照组(养鱼用水处理),每孔容量为3mL。
表1.实施例3处理后斑马鱼肠腔面积(n=10)
与模型对照组比较,***p<0.001
由上表可知,本发明实施例3得到的产品对斑马鱼胃肠道粘膜保护作用显著。
解酒试验
随机选取360尾5dpf野生型AB品系斑马鱼于六孔板中,每孔(实验组)均处理30尾斑马鱼,水溶给予无水乙醇建立斑马鱼兴奋期醉酒模型。分别水溶给予实施例3得到的产品3.91、7.81、15.6、31.3、62.5、125、250、500和1000μL/mL浓度,阳性对照组“RU21”100μg/mL浓度,同时设置模型对照组和正常对照组(养鱼用水处理斑马鱼),每孔容量为3mL。
表2.实施例3处理后斑马鱼总运动距离(n=12)
与模型对照组比较,**p<0.01,***p<0.001
经由本发明与对照组对比可知,本发明实施例3得到的产品解酒作用显著。
护肝试验
随机选取360尾3dpf野生型AB品系斑马鱼于六孔板中,每孔(实验组)均处理30尾斑马鱼。分别水溶给予实施例3得到的产品3.91、7.81、15.6、31.3、62.5、125、250、500和1000μL/mL浓度,阳性对照组美他多辛149μg/mL浓度,同时设置模型对照组和正常对照组(养鱼用水处理斑马鱼),每孔容量为3mL。除正常对照组外,其余各实验组均水溶给予无水乙醇建立斑马鱼酒精性肝损伤模型。
表3.实施例3处理后斑马鱼体内ALT活力(n=3)
与模型对照组比较,*p<0.5,**p<0.01,***p<0.001
在本实验条件下,经本发明实施例3得到的产品处理后,斑马鱼体内ALT活力降低作用显著。
结果显示,本发明提供的产品对胃肠道粘膜保护作用、解酒作用和ALT活力降低作用。
本说明书中各个实施例采用递进的方式描述,每个实施例重点说明的都是与其他实施例的不同之处,各个实施例之间相同相似部分互相参见即可。
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (10)
1.一种具有胃肠道粘膜保护作用的组合物,其特征在于,包括以下重量份数的原料:桑葚1-9份、枸杞子1-9份、葛根1-5份、枳椇子1-5份、菊花1-3份、甘草0.1-2份、蜂蜜0.5-2.5份、白砂糖0.5-2.5份和山梨酸钾0.005-0.015份。
2.根据权利要求1所述的组合物,其特征在于,包括以下重量份数的原料:桑葚3-7份、枸杞子3-7份、葛根2-4份、枳椇子2-4份、菊花1.5-2.5份、甘草0.7-1.3份、蜂蜜1-2份、白砂糖1-2份和山梨酸钾0.005-0.015份。
3.根据权利要求1所述的组合物,其特征在于,包括以下重量份数的原料:桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1份、蜂蜜1.5份、白砂糖1.5份和山梨酸钾0.01份;
或者桑葚5份、枸杞子4份、葛根3份、枳椇子3份、菊花2份、甘草1份、蜂蜜1.5份、白砂糖2.5份和山梨酸钾0.005份。
4.权利要求1~3任一项所述的组合物的制备方法,其特征在于,包括以下步骤:
(1)原料预处理:将葛根、甘草一同加水浸泡1h;将桑椹、枸杞子、枳椇子、菊花一同加水浸泡15min;浸泡结束后将原料用水清洗1-2遍;
(2)提取:将预处理后的原料混合,再在85~94℃下用水提取2h后200目过筛,重复提取后合并滤液;
(3)浓缩:将所述滤液减压浓缩后,置于4℃条件下静置6-8h,然后离心保留上清液,得到离心上清液;
(4)配制:将白砂糖、山梨酸钾和蜂蜜与所述离心上清液搅拌均匀后过滤、定容,再次搅拌均匀,得具有胃肠道粘膜保护作用的组合物。
5.根据权利要求4所述的制备方法,其特征在于,步骤(2)所述预处理后的原料与水的质量比为1:8。
6.根据权利要求4所述的制备方法,其特征在于,步骤(3)所述减压浓缩过程中压力为-0.08~-0.1MPa,温度为60-70℃,且所述滤液浓缩后在室温下相对密度为1.03±0.005g/mL。
7.根据权利要求4所述的制备方法,其特征在于,步骤(3)所述离心过程中离心机转速为17000r/min。
8.根据权利要求4所述的制备方法,其特征在于,步骤(4)中所述过滤滤芯为10μm。
9.权利要求1~3任一项所述的组合物或权利要求4~8任一项所述制备方法得到的组合物在制备具有胃肠道粘膜保护作用药物中的应用。
10.权利要求1~3任一项所述的组合物或权利要求4~8任一项所述制备方法得到的组合物在制备具有解酒护肝作用药物中的应用。
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