CN111544520A - 微生物发酵的温补肾阳压片糖果的制备方法 - Google Patents
微生物发酵的温补肾阳压片糖果的制备方法 Download PDFInfo
- Publication number
- CN111544520A CN111544520A CN202010483109.0A CN202010483109A CN111544520A CN 111544520 A CN111544520 A CN 111544520A CN 202010483109 A CN202010483109 A CN 202010483109A CN 111544520 A CN111544520 A CN 111544520A
- Authority
- CN
- China
- Prior art keywords
- parts
- freeze
- candy
- dried
- warming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000009508 confectionery Nutrition 0.000 title claims abstract description 43
- 238000000855 fermentation Methods 0.000 title claims abstract description 42
- 230000004151 fermentation Effects 0.000 title claims abstract description 34
- 210000003734 kidney Anatomy 0.000 title claims abstract description 29
- 238000010792 warming Methods 0.000 title claims abstract description 22
- 230000000813 microbial effect Effects 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 39
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000002994 raw material Substances 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 13
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 13
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 13
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 13
- 235000007215 black sesame Nutrition 0.000 claims abstract description 13
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 12
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 12
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 12
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 12
- 235000007716 Citrus aurantium Nutrition 0.000 claims abstract description 12
- 235000005976 Citrus sinensis Nutrition 0.000 claims abstract description 12
- 235000004347 Perilla Nutrition 0.000 claims abstract description 12
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 12
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 12
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000020224 almond Nutrition 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 12
- 229960002675 xylitol Drugs 0.000 claims abstract description 12
- 235000010447 xylitol Nutrition 0.000 claims abstract description 12
- 239000000811 xylitol Substances 0.000 claims abstract description 12
- 244000124853 Perilla frutescens Species 0.000 claims abstract 3
- 238000003756 stirring Methods 0.000 claims description 24
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 14
- 241000894006 Bacteria Species 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 12
- 229920002472 Starch Polymers 0.000 claims description 11
- 239000008107 starch Substances 0.000 claims description 11
- 235000019698 starch Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 241001633680 Polygonatum odoratum Species 0.000 claims description 7
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 239000003456 ion exchange resin Substances 0.000 claims description 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 13
- 241000411851 herbal medicine Species 0.000 abstract description 11
- 241000186660 Lactobacillus Species 0.000 abstract description 5
- 241000756042 Polygonatum Species 0.000 abstract description 5
- 229940039696 lactobacillus Drugs 0.000 abstract description 5
- 239000011573 trace mineral Substances 0.000 abstract description 5
- 235000013619 trace mineral Nutrition 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 150000001413 amino acids Chemical class 0.000 abstract description 4
- 230000007812 deficiency Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 3
- 239000011777 magnesium Substances 0.000 abstract description 3
- 229910052749 magnesium Inorganic materials 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 239000006041 probiotic Substances 0.000 abstract description 3
- 235000018291 probiotics Nutrition 0.000 abstract description 3
- 239000011669 selenium Substances 0.000 abstract description 3
- 229910052711 selenium Inorganic materials 0.000 abstract description 3
- 230000009466 transformation Effects 0.000 abstract description 3
- 239000011701 zinc Substances 0.000 abstract description 3
- 229910052725 zinc Inorganic materials 0.000 abstract description 3
- 235000008737 Polygonatum biflorum Nutrition 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 206010063659 Aversion Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000003414 extremity Anatomy 0.000 abstract 1
- 210000003127 knee Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 description 20
- 241000229722 Perilla <angiosperm> Species 0.000 description 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 9
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 230000009102 absorption Effects 0.000 description 3
- 208000017169 kidney disease Diseases 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000002397 Kinins Human genes 0.000 description 1
- 108010093008 Kinins Proteins 0.000 description 1
- 102100028255 Renin Human genes 0.000 description 1
- 108090000783 Renin Proteins 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 235000005523 excessive nutrition Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明公开了一种微生物发酵的温补肾阳压片糖果的制备方法，涉及压片糖果制备技术领域，主要原料为：葛根、玉竹、杏仁、黄精、紫苏籽、枸杞、代代花、黑芝麻、木糖醇、柠檬酸、冻干型乳酸菌粉、冻干型双歧杆菌粉、冻干型酵母菌粉。该微生物发酵的温补肾阳压片糖果的制备方法利用益生菌将中草药粉恒温发酵，通过发酵清除中草药中的有害成分，解决了现有压片糖果导致患者过多摄入有害成分，长期服用副作用大，对药物的吸收较差，疗效差的问题，并且增加了中草药的营养成分及硒、锌、镁、氨基酸等微量元素，温补肾阳，阴阳两虚，化气行水。用于肾虚水肿、腰膝酸软、小便不利、畏寒肢冷等症状，增强免疫力。
Description
技术领域
本发明涉及压片糖果制备技术领域，具体为一种微生物发酵的温补肾阳压片糖果的制备方法。
背景技术
肾脏是人体的重要器官，它的基本功能是生成尿液，借以清除体内代谢产物及某些废物、毒物，同时经重吸收功能保留水份及其他有用物质，如葡萄糖、蛋白质、氨基酸、钠离子、钾离子、碳酸氢钠等，以调节水、电解质平衡及维护酸碱平衡。肾脏同时还有内分泌功能，生成肾素、***、活性维生素D3、***素、激肽等，又为机体部分内分泌激素的降解场所和肾外激素的靶器官。肾脏的这些功能，保证了机体内环境的稳定，使新陈代谢得以正常进行。
近些年由于生活质量的提高，人们在饮食以及生活习惯方面的不健康现象日渐增多，摄入了过多的营养和热量，而且作息不规律，这给肾脏带来了很大的负担，而且长期得不到休息，这就导致现代人得肾病的几率大大上升。
鉴于此，微生物发酵的温补肾阳压片糖果通过黄精、葛根、枸杞、黑芝麻等起到补气、养阴、益肾，提高机体免疫力的作用。并且由于采用微生物发酵工序，制得的压片糖果清除了中草药中的有害成分，减少了长期服用的副作用，对药物的吸收更好，疗效更佳。
发明内容
(一)解决的技术问题
针对现有技术的不足，本发明提供了一种微生物发酵的温补肾阳压片糖果的制备方法，具备清除中草药中的有害成分，起到补气、养阴、益肾，提高机体免疫力的作用等优点，解决了现有压片糖果无法清除中草药的有害成分、疗效较差的问题。
(二)技术方案
为实现上述清除中草药中的有害成分，起到补气、养阴、益肾，提高机体免疫力的作用的目的，本发明提供如下技术方案：一种微生物发酵的温补肾阳压片糖果的制备方法，该微生物发酵的温补肾阳压片糖果有以下重量份数的原料制成：葛根15～25份、玉竹10～14份、杏仁6～10份、黄精10～20份、紫苏籽6～12份、枸杞8～12份、代代花6～10份、黑芝麻5～9份、木糖醇0.05～0.15份、柠檬酸0.03～0.07份、冻干型乳酸菌粉0.2～0.3份、冻干型双歧杆菌粉0.1～0.3份、冻干型酵母菌粉0.3～0.5份、淀粉8～12份，包括以下步骤：
S1、按重量份数比称取葛根15～25份、玉竹10～14份、杏仁6～10份、黄精10～20份、紫苏籽6～12份、枸杞8～12份、代代花6～10份、黑芝麻5～9份，放入粉碎机内进行粉碎、均质，粉碎至80目过筛取出放入搅拌池内；
S2、按重量份数比称取木糖醇0.05～0.15份、柠檬酸0.03～0.07份、冻干型乳酸菌粉0.2～0.3份、冻干型双歧杆菌粉0.1～0.3份、冻干型酵母菌粉0.3～0.5份、淀粉8～12份，放入搅拌池内；
S3、向搅拌池内加入水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行恒温厌氧发酵；
S4、发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；
S5、将烘干后的原料放入制粒机中制粒、压片、包衣，得到压片糖果；
S6、对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
优选的，所述S3步骤中恒温厌氧发酵的时间为14～16天，温度为37～39℃。
优选的，所述S1步骤中的均质压力为15-25Mpa。
优选的，所述S5步骤中采用的压片机为多冲旋转式压片机。
优选的，所述S3步骤中的水为去离子水，即通过离子交换树脂除去水中的离子态杂质而得到的近于纯净的水。
(三)有益效果
与现有技术相比，本发明提供了一种微生物发酵的温补肾阳压片糖果的制备方法，具备以下有益效果：
本发明利用韩氏五行生物菌叠加发酵技术将中药粉与益生菌进行恒温发酵，清除中草药中的有害成分，增加中草药的营养成分及硒、锌、镁、氨基酸等微量元素，达到温补肾阳，阴阳两虚，化气行水的效果。
并且由于清除中草药中的有害成分，增加中草药的营养成分及微量元素，减小了患者摄入的有害成分，副作用小，对药物的吸收更好，疗效更佳。
具体实施方式
下面将结合本发明的实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例一：
一种微生物发酵的温补肾阳压片糖果的制备方法，该微生物发酵的温补肾阳压片糖果有以下重量份数的原料制成：葛根15份、玉竹10份、杏仁6份、黄精10份、紫苏籽6份、枸杞8份、代代花6份、黑芝麻5份、木糖醇0.05份、柠檬酸0.03份、冻干型乳酸菌粉0.2份、冻干型双歧杆菌粉0.1份、冻干型酵母菌粉0.3份、淀粉8份，包括以下步骤：
S1、按重量份数比称取葛根15份、玉竹10份、杏仁6份、黄精10份、紫苏籽6份、枸杞8份、代代花6份、黑芝麻5份，放入粉碎机内进行粉碎、均质，均质压力为15Mpa，粉碎至80目过筛取出放入搅拌池内；
S2、按重量份数比称取木糖醇0.05份、柠檬酸0.03份、冻干型乳酸菌粉0.2份、冻干型双歧杆菌粉0.1份、冻干型酵母菌粉0.3份、淀粉8份，放入搅拌池内；
S3、向搅拌池内加入去离子水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行14天的37℃的恒温厌氧发酵；
S4、发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；
S5、将烘干后的原料放入制粒机中制粒，并采用多冲旋转式压片机进行压片，之后进行包衣，得到压片糖果；
S6、对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
实施例二：
一种微生物发酵的温补肾阳压片糖果的制备方法，该微生物发酵的温补肾阳压片糖果有以下重量份数的原料制成：葛根20份、玉竹12份、杏仁8份、黄精15份、紫苏籽9份、枸杞10份、代代花8份、黑芝麻7份、木糖醇0.1份、柠檬酸0.05份、冻干型乳酸菌粉0.25份、冻干型双歧杆菌粉0.2份、冻干型酵母菌粉0.4份、淀粉10份，包括以下步骤：
S1、按重量份数比称取葛根20份、玉竹12份、杏仁8份、黄精15份、紫苏籽9份、枸杞10份、代代花8份、黑芝麻7份，放入粉碎机内进行粉碎、均质，均质压力为20Mpa，粉碎至80目过筛取出放入搅拌池内；
S2、按重量份数比称取木糖醇0.1份、柠檬酸0.05份、冻干型乳酸菌粉0.25份、冻干型双歧杆菌粉0.2份、冻干型酵母菌粉0.4份、淀粉10份，放入搅拌池内；
S3、向搅拌池内加入去离子水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行15天的温度为38℃恒温厌氧发酵；
S4、发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；
S5、将烘干后的原料放入制粒机中制粒，并采用多冲旋转式压片机进行压片，之后进行包衣，得到压片糖果；
S6、对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
实施例三：
一种微生物发酵的温补肾阳压片糖果的制备方法，该微生物发酵的温补肾阳压片糖果有以下重量份数的原料制成：葛根25份、玉竹14份、杏仁10份、黄精20份、紫苏籽12份、枸杞12份、代代花10份、黑芝麻9份、木糖醇0.15份、柠檬酸0.07份、冻干型乳酸菌粉0.3份、冻干型双歧杆菌粉0.3份、冻干型酵母菌粉0.5份、淀粉12份，包括以下步骤：
S1、按重量份数比称取葛根25份、玉竹14份、杏仁10份、黄精20份、紫苏籽12份、枸杞12份、代代花10份、黑芝麻9份，放入粉碎机内进行粉碎、均质，均质压力为25Mpa，粉碎至80目过筛取出放入搅拌池内；
S2、按重量份数比称取木糖醇0.15份、柠檬酸0.07份、冻干型乳酸菌粉0.3份、冻干型双歧杆菌粉0.3份、冻干型酵母菌粉0.5份、淀粉12份，放入搅拌池内；
S3、向搅拌池内加入去离子水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行16天的39℃的恒温厌氧发酵；
S4、发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；
S5、将烘干后的原料放入制粒机中制粒，并采用多冲旋转式压片机进行压片，之后进行包衣，得到压片糖果；
S6、对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
实验例：
对实施例1-3提供的微生物发酵的温补肾阳压片糖果的制备方法，观察效果，如下表所示：
判断标准：本发明利用韩氏五行生物菌叠加发酵技术将中药粉与益生菌进行恒温发酵，清除中草药中的有害成分，增加中草药的营养成分及硒、锌、镁、氨基酸等微量元素，达到温补肾阳，阴阳两虚，化气行水的效果。
并且由于清除中草药中的有害成分，增加中草药的营养成分及微量元素，减小了患者摄入的有害成分，副作用小，对药物的吸收更好，疗效更佳
实验方法：
按重量份数比称取葛根20份、玉竹12份、杏仁8份、黄精15份、紫苏籽9份、枸杞10份、代代花8份、黑芝麻7份，放入粉碎机内进行粉碎、均质，均质压力为20Mpa，粉碎至80目过筛取出放入搅拌池内；按重量份数比称取木糖醇0.1份、柠檬酸0.05份、冻干型乳酸菌粉0.25份、冻干型双歧杆菌粉0.2份、冻干型酵母菌粉0.4份、淀粉10份，放入搅拌池内；向搅拌池内加入水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行15天的温度为38℃恒温厌氧发酵；发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；将烘干后的原料放入制粒机中制粒，并采用多冲旋转式压片机进行压片，之后进行包衣，得到压片糖果；对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
临床效果：
1.观察肾病病例60例，年龄25～44岁，分为试验组30例，对照组30例。两组年龄、病情等资料无显著性差异，具有可比性。
2.进一步地将试验组平均分为试验A组、试验B组和试验C组，每组30例。三组年龄、病情等资料无显著性差异，具有可比性。
3.对试验A组、试验B组和试验C组三组病例给予本发明三个实施例中的三种不同配比的压片糖果，使用量均为每次2粒，每日3次，温水口服。对照组病例给予治疗肾病的某验方治疗。7天1疗程，5疗程结束后统计。
统计后得出实施例2中的制备方法制备出的微生物发酵的温补肾阳压片糖果，对患者的疗效最好，患者的病情有明显好转。此外，试验组的患者病例的病情在临床试验后好于对照组。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (5)
1.一种微生物发酵的温补肾阳压片糖果的制备方法，该微生物发酵的温补肾阳压片糖果有以下重量份数的原料制成：葛根15～25份、玉竹10～14份、杏仁6～10份、黄精10～20份、紫苏籽6～12份、枸杞8～12份、代代花6～10份、黑芝麻5～9份、木糖醇0.05～0.15份、柠檬酸0.03～0.07份、冻干型乳酸菌粉0.2～0.3份、冻干型双歧杆菌粉0.1～0.3份、冻干型酵母菌粉0.3～0.5份、淀粉8～12份，其特征在于，包括以下步骤：
S1、按重量份数比称取葛根15～25份、玉竹10～14份、杏仁6～10份、黄精10～20份、紫苏籽6～12份、枸杞8～12份、代代花6～10份、黑芝麻5～9份，放入粉碎机内进行粉碎、均质，粉碎至80目过筛取出放入搅拌池内；
S2、按重量份数比称取木糖醇0.05～0.15份、柠檬酸0.03～0.07份、冻干型乳酸菌粉0.2～0.3份、冻干型双歧杆菌粉0.1～0.3份、冻干型酵母菌粉0.3～0.5份、淀粉8～12份，放入搅拌池内；
S3、向搅拌池内加入水，并搅拌均匀进行混合后取出，将混合后的原料放入发酵罐中进行恒温厌氧发酵；
S4、发酵结束，将原料取出放入烘干机烘干，烘干温度维持在60℃以下；
S5、将烘干后的原料放入制粒机中制粒、压片、包衣，得到压片糖果；
S6、对压片糖果进行质量检测，合格后进行装瓶，每瓶30粒。
2.根据权利要求1所述的微生物发酵的温补肾阳压片糖果的制备方法，其特征在于，所述S3步骤中恒温厌氧发酵的时间为14～16天，温度为37～39℃。
3.根据权利要求1所述的微生物发酵的温补肾阳压片糖果的制备方法，其特征在于，所述S1步骤中的均质压力为15-25Mpa。
4.根据权利要求1所述的微生物发酵的温补肾阳压片糖果的制备方法，其特征在于，所述S5步骤中采用的压片机为多冲旋转式压片机。
5.根据权利要求1所述的微生物发酵的温补肾阳压片糖果的制备方法，其特征在于，所述S3步骤中的水为去离子水，即通过离子交换树脂除去水中的离子态杂质而得到的近于纯净的水。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010483109.0A CN111544520A (zh) | 2020-06-01 | 2020-06-01 | 微生物发酵的温补肾阳压片糖果的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010483109.0A CN111544520A (zh) | 2020-06-01 | 2020-06-01 | 微生物发酵的温补肾阳压片糖果的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111544520A true CN111544520A (zh) | 2020-08-18 |
Family
ID=71999087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010483109.0A Pending CN111544520A (zh) | 2020-06-01 | 2020-06-01 | 微生物发酵的温补肾阳压片糖果的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111544520A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104304627A (zh) * | 2014-11-10 | 2015-01-28 | 长沙市乐道生物科技有限公司 | 黄精枸杞压片糖果及其制备方法 |
| CN106720829A (zh) * | 2016-11-30 | 2017-05-31 | 高振达 | 一种黄精玉竹糖片及其制备方法 |
| CN111110773A (zh) * | 2020-01-19 | 2020-05-08 | 韩褆 | 微生物发酵的提高免疫力中药颗粒散剂及制备方法 |
-
2020
- 2020-06-01 CN CN202010483109.0A patent/CN111544520A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104304627A (zh) * | 2014-11-10 | 2015-01-28 | 长沙市乐道生物科技有限公司 | 黄精枸杞压片糖果及其制备方法 |
| CN106720829A (zh) * | 2016-11-30 | 2017-05-31 | 高振达 | 一种黄精玉竹糖片及其制备方法 |
| CN111110773A (zh) * | 2020-01-19 | 2020-05-08 | 韩褆 | 微生物发酵的提高免疫力中药颗粒散剂及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100374140C (zh) | 一种用于糖尿病的保健品 | |
| CN102846674A (zh) | 一种中药微生态组合物及其制备方法 | |
| CN112494577B (zh) | 一种用于治疗仔猪腹泻的中药微生态制剂及其制备方法 | |
| CN106072578A (zh) | 具有增强人体免疫功能的酵素组合物、泡腾片及制法 | |
| CN104783290B (zh) | 一种具有解酒功能的黑醋酵素的制备方法 | |
| CN105708970B (zh) | 一种具有降血糖功能的保健食品 | |
| CN106912449B (zh) | 一种富硒肉鸡的饲养方法 | |
| CN109589361A (zh) | 一种用于提高母猪产仔率的中药组合物、中药制剂及其制备方法 | |
| CN101347543A (zh) | 一种中药组合物及其制备方法 | |
| CN115005436B (zh) | 一种白芸豆发酵提取物及其制备方法和降糖降压的用途 | |
| CN111544520A (zh) | 微生物发酵的温补肾阳压片糖果的制备方法 | |
| CN114748602A (zh) | 一种能够补肾固元的蛹虫草双参片 | |
| CN101732698A (zh) | 一种具有降血糖功效的中药制剂及其制备方法与应用 | |
| CN114272319A (zh) | 一种促进母畜较短时间发情的中药组合制剂及其制备方法 | |
| CN103719542B (zh) | 一种复合微生物活性添加剂及其应用 | |
| CN101297856B (zh) | 治疗奶牛酒精阳性乳的中药制剂及其制备方法 | |
| CN100364450C (zh) | 解酒保肝保健食品 | |
| CN112741869A (zh) | 一种用于畜禽扶正祛邪的发酵中药制剂及其制备方法 | |
| CN110613793A (zh) | 一种抗肿瘤组合物及其制备方法和用途 | |
| CN114053390B (zh) | 一种耐缺氧的中药组合物及其制备方法和应用 | |
| CN101215505A (zh) | 一种修复基因与活化***细胞的全营养酒及其制备方法 | |
| CN107625863B (zh) | 治疗风湿骨病的复方中药软胶囊及其制备方法 | |
| CN107115379B (zh) | 基于发酵技术治疗皮肤炎症及粘膜修复的中药组合物及其制备方法 | |
| CN116210820A (zh) | 一种防治仔猪腹泻的中药发酵饲料及制备方法 | |
| CN113144127A (zh) | 具有抗炎和/或抗痴呆功能的益智酵素及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |