CN111449998B - Plant extract hair loss preventing hair growth liquid and preparation method thereof - Google Patents
Plant extract hair loss preventing hair growth liquid and preparation method thereof Download PDFInfo
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Abstract
The application discloses a plant extract hair loss prevention hair growth liquid and a preparation method thereof, comprising a tea bran fermentation extract and a plant extract, wherein the mass ratio of the tea bran fermentation extract to the plant extract is 0.8-1.25: 0.7 to 1.25; wherein the tea bran fermentation extract is prepared by decocting tea bran with water and concentrating under reduced pressure after the tea bran is acted by active yeast; the plant extract is a mixed solution of Polygoni Multiflori radix extract, folium Platycladi extract, ecliptae herba extract, radix Angelicae sinensis extract, cortex Mori extract and Glycyrrhrizae radix extract. The application provides a plant extract hair loss preventing and growing liquid, which comprises tea bran, polygonum multiflorum, cacumen biotae, eclipta alba, angelica sinensis, cortex mori radicis, liquorice and active yeast, and can change the blood circulation of the head, activate hair follicles, realize rapid hair loss prevention and repair and achieve the effect of treating both principal and secondary aspect of the disease through the mutual synergistic effect of the components of various plant extracts.
Description
Technical Field
The application belongs to the field of cosmetics, and in particular relates to plant extract hair loss prevention hair growth liquid and a preparation method thereof.
Background
The traditional Chinese medicine considers that hair is blood, kidney stores essence, hair grows in the hair, the hair depends on the enrichment of essence and blood, the dense and bright hair represents health, good images can be given to people, the shapes and states of the hair are different, the impressions of the people are different, and healthy and beautiful hair is more confident in interpersonal interaction. Also various hair diseases such as alopecia, small hair, dandruff, etc. can cause bad psychological effects such as spelt, anxiety, etc., serious persons even affect social activities, and thus care of hair has to be taken in daily life.
Most healthy people have the problems of redness of scalp, pimple, itching of head, dandruff, dryness, hair loss and the like. Because of the complexity of the cause of hair loss, traditional Chinese medicine believes that there are two causes of hair loss: firstly, the blood is hot-air dryness, the blood heat is over-ridden, yin blood is damaged, the blood tiger produces wind, yin blood is more damaged, the yin blood can not go up to the top to nourish hair roots, the hair roots are dry, or the hair roots are deficient and fall off; secondly, the spleen and stomach damp-heat, spleen deficiency and failure in transportation and transformation, and the weak, sweet and thick taste of the spleen and stomach are eaten, so that the damp-heat evaporates the vertex, erodes the hair root, the hair root is corroded gradually, and the hair is sticky and falls off. There are also studies showing that head hair is also affected by androgens, such as testosterone can be metabolized to Dihydrotestosterone (DHT) by 5 a-reductase (5 a-R), which binds to intracellular receptor egg mass and induces the formation of specific proteins, thus impeding hair growth and thus leading to hair loss.
Therefore, inhibition of 5 alpha-reductase activity is crucial, and currently marketed hair-growing medicines are high in cost, not ideal in therapeutic effect, and most of the products are general in effect. Therefore, there is a need in the art for a natural hair loss preventing and hair growing liquid with the effects of removing dandruff, relieving itching, wu Faliang hair, preventing hair loss and growing hair, and achieving better hair growing effect while achieving hair loss prevention.
Disclosure of Invention
This section is intended to outline some aspects of embodiments of the application and to briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section as well as in the description of the application and in the title of the application, which may not be used to limit the scope of the application.
The present application has been made in view of the above and/or problems occurring in the prior art.
Therefore, the application aims to overcome the defects in the prior art and provide the plant extract hair loss prevention hair growth liquid.
In order to solve the technical problems, the application provides the following technical scheme: a plant extract hair loss preventing and growing liquid is characterized in that: the tea bran fermentation extracting solution and the plant extracting solution are mixed according to the mass ratio of 0.8-1.25: 0.7 to 1.25; wherein, the liquid crystal display device comprises a liquid crystal display device,
the tea bran fermentation extract is prepared by decocting tea bran with water and concentrating under reduced pressure after the tea bran is acted by active yeast, the preparation method comprises the steps of adding the crushed tea bran into the active yeast, uniformly stirring, placing into a container, adding equal amount of water, fermenting for 120-144 hours at 36-38 ℃, adding 4-6 times of water into the fermented product, heating to 90-95 ℃ and decocting for 1.5-2 hours, filtering to obtain first decoction liquid medicine, adding 3-4 times of water into the obtained dregs, heating to 85-90 ℃, decocting for 1-1.5 hours, filtering to obtain first decoction liquid medicine, combining the first and second decoction liquid medicines, concentrating under reduced pressure to obtain the tea bran fermentation extract;
the plant extract is a mixed solution of polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, cortex mori radicis extract and liquorice extract, wherein the mixed mass ratio of the polygonum multiflorum extract, the biota orientalis extract, the eclipta alba extract, the angelica sinensis extract, the cortex mori radicis extract and the liquorice extract is 8-12: 8-12: 8-12: 4 to 6:4 to 6:2 to 4.
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the crushed tea bran is taken and added with active yeast, wherein the tea bran is crushed to 40-80 meshes, and the mass ratio of the active yeast to the tea bran is 1-3: 50 to 60.
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the active yeast is Angel yeast with viable count of 1×10 10 CFU/g。
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: combining the first and second decoction liquid medicine, concentrating under reduced pressure, wherein the concentration temperature is 60-80 ℃, and concentrating to the specific gravity of 1.25.
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the preparation method of the biota orientalis extract comprises the steps of cleaning and drying biota orientalis, crushing the biota orientalis to 40-80 meshes, soaking the biota orientalis in 75% alcohol for four times for 3 days each time, carrying out suction filtration, mixing all obtained filtrate, and concentrating the filtrate at 60 ℃ until the relative density is 1.21 to obtain the biota orientalis extract; the preparation method of the polygonum multiflorum extract comprises the steps of weighing polygonum multiflorum, cleaning, drying, adding ethanol aqueous solution with the volume fraction of 60% which is 10-12 times of the weight of the polygonum multiflorum, heating, refluxing and extracting for 2.5-3 h, filtering, and concentrating filtrate at 60 ℃ until the relative density is 1.21, thus obtaining the polygonum multiflorum extract.
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the eclipta extract is prepared by weighing eclipta, cleaning, drying, adding 5-8 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extract, adding 3-5 times of water into the obtained residue, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extract, combining the first extract and the second extract, filtering by a ceramic membrane, concentrating under reduced pressure, concentrating at a concentration temperature of not more than 80 ℃ and at a concentration temperature of 60 ℃ to a specific gravity of 1.25, thus obtaining the eclipta extract;
the preparation method of the Chinese angelica extract comprises the steps of weighing Chinese angelica, cleaning, drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating to a specific gravity of 1.25 at a concentration temperature of not more than 80 ℃ and 60 ℃ to obtain the eclipta extract;
the preparation method of the white mulberry root-bark extract comprises the steps of weighing white mulberry root-bark, cleaning and drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating at a concentration temperature of not more than 80 ℃ and 60 ℃ to a specific gravity of 1.25 to obtain the white mulberry root-bark extract;
the preparation method of the licorice root bark extract comprises the steps of weighing licorice root bark, cleaning, drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating to a specific gravity of 1.25 at a concentration temperature of not more than 80 ℃ at a temperature of 60 ℃ to obtain the licorice root extract.
As a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the mass ratio of the tea bran fermentation extract to the plant extract is 1:0.8, wherein the mixing mass ratio of the polygonum multiflorum extract, the biota orientalis extract, the eclipta alba extract, the angelica sinensis extract, the cortex mori radicis extract and the liquorice extract is 10:8:12:6:4:4.
as a preferable scheme of the plant extraction anti-hair loss hair growth liquid, the application comprises the following steps: the hair-loss preventing and hair-growing liquid also comprises a humectant, a preservative, a thickener and deionized water, wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 0.8-1.25: 0.2 to 0.4:0.2 to 0.6:0.1 to 0.2:10 to 20..
The application also aims to overcome the defects in the prior art and provide a preparation method of the plant extract hair loss prevention hair growth liquid.
In order to solve the technical problems, the application provides the following technical scheme: a preparation method of plant extract hair loss preventing hair growth promoting liquid comprises,
preparing a tea bran fermentation extract: adding crushed tea bran into active yeast, stirring uniformly, placing into a container, adding equal amount of water, fermenting at 36-38 ℃ for 120-144 hours, adding 4-6 times of water, heating to 90-95 ℃ for 1.5-2 hours, filtering to obtain first decoction liquid, adding 3-4 times of water into the obtained dregs, heating to 85-90 ℃ for 1-1.5 hours, filtering to obtain first decoction liquid, combining the first and second decoction liquid, and concentrating under reduced pressure to obtain tea bran fermentation extract;
taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 8-12: 8-12: 8-12: 4 to 6:4 to 6: 2-4, mixing to obtain plant extract;
fermenting the tea bran extract and the plant extract according to the mass ratio of 0.8-1.25: 0.7 to 1.25, uniformly stirring, adding a humectant, a preservative, a thickening agent and a solvent, and uniformly stirring to obtain the plant extract anti-hair loss hair growing liquid; wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 0.8-1.25: 0.2 to 0.4:0.2 to 0.6:0.1 to 0.2:10 to 20.
The application has the beneficial effects that:
(1) The application provides a plant extract hair loss preventing and growing liquid, which comprises tea bran, polygonum multiflorum, cacumen biotae, eclipta alba, angelica sinensis, cortex mori radicis, liquorice and active yeast, and can change the blood circulation of the head, activate hair follicles, realize rapid hair loss prevention and repair and achieve the effect of treating both principal and secondary aspect of the disease through the mutual synergistic effect of the components of various plant extracts. The plant extract hair loss preventing and hair growing liquid has stronger active ingredients and the effects of removing dandruff, relieving itching, wu Faliang hair and preventing hair loss and hair growth by utilizing the action of the tea bran and the active yeast to convert macromolecular nutrient substances into absorbable micromolecular nutrient substances and degrade harmful ingredients, and simultaneously being more beneficial to the action of the active ingredients in the tea bran.
(2) The application provides a plant extract hair loss preventing and growing liquid, which combines active ingredients in polygonum multiflorum, eclipta, angelica sinensis, white mulberry root-bark and liquorice extracts through the action of active ingredients in tea bran extract and cacumen biotae, and the active ingredients of the plant extracts are mutually synergistic, so that the effects of head blood circulation can be changed, hair follicles can be activated and hair restoration can be realized, and meanwhile, the plant extract ingredients are mutually synergistic, so that the plant extract hair loss preventing and growing liquid has a very strong 5 alpha-reductase inhibiting action.
Detailed Description
In order that the above-recited objects, features and advantages of the present application will become more apparent, a more particular description of the application will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application, but the present application may be practiced in other ways other than those described herein, and persons skilled in the art will readily appreciate that the present application is not limited to the specific embodiments disclosed below.
Further, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic can be included in at least one implementation of the application. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
The preparation method of the biota orientalis leaf extract comprises the following steps: cleaning folium Platycladi, drying, pulverizing to 40 mesh, soaking in 75% ethanol for 3 days four times, vacuum filtering, mixing all filtrates, and concentrating at 60deg.C to relative density of 1.21 to obtain folium Platycladi extract.
The preparation method of the polygonum multiflorum extract comprises the following steps: weighing Polygoni Multiflori radix, cleaning, drying, pulverizing to 80 mesh, adding 10 times of 60% ethanol water solution, heating and reflux extracting for 3 hr, filtering, and concentrating the filtrate at 60deg.C to relative density of 1.21 to obtain Polygoni Multiflori radix extract.
The preparation method of the eclipta alba extract comprises the following steps: weighing eclipta alba, cleaning, drying, adding 8 times of water, heating to 100 ℃, decocting for 2 hours, filtering to obtain a first extracting solution, adding 3 times of water into the obtained dregs, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating at 60 ℃ to a specific gravity of 1.25 to obtain the eclipta alba extract.
The preparation method of the angelica sinensis extract comprises the following steps: weighing radix Angelicae sinensis, cleaning, drying, adding 6 times of water, heating to 100deg.C, decocting for 1.5 hr, filtering to obtain first extractive solution, adding 5 times of water, heating to 100deg.C, decocting for 1 hr, filtering to obtain second extractive solution, mixing the first and second extractive solutions, filtering with ceramic membrane, concentrating under reduced pressure, and concentrating at 60deg.C to specific gravity of 1.25 to obtain radix Angelicae sinensis extract.
The preparation method of the mulberry bark extract comprises the following steps: weighing cortex Mori, cleaning, drying, adding 4 times of water, heating to 100deg.C, decocting for 2 hr, filtering to obtain first extractive solution, adding 3 times of water, heating to 100deg.C, decocting for 1 hr, filtering to obtain second extractive solution, mixing the first and second extractive solutions, filtering with ceramic membrane, concentrating under reduced pressure, and concentrating at 60deg.C to specific gravity of 1.25 to obtain cortex Mori extract;
the preparation method of the licorice extract comprises the following steps: weighing Glycyrrhrizae radix bark, cleaning, drying, adding 5 times of water, heating to 100deg.C, decocting for 2 hr, filtering to obtain first extractive solution, adding 3 times of water into the residue, heating to 100deg.C, decocting for 1 hr, filtering to obtain second extractive solution, mixing the first and second extractive solutions, filtering with ceramic membrane, concentrating under reduced pressure, and concentrating at 60deg.C to specific gravity of 1.25 to obtain Glycyrrhrizae radix extract.
Example 1
The embodiment provides a preparation method of a plant extract hair loss prevention hair growth liquid, which comprises the following steps:
(1) Preparing a tea bran fermentation extract: taking crushed tea bran (the tea bran is crushed to 80 meshes), adding active yeast (the mass ratio of the active yeast to the tea bran is 3:50), stirring uniformly, placing into a container, adding equal amount of water, fermenting at 38 ℃ for 120 hours, taking a fermented product, adding 6 times of water, heating to 90 ℃, decocting for 2 hours, filtering to obtain a first decoction liquid, adding 4 times of water into the obtained residue, heating to 85 ℃, decocting for 1 hour, filtering to obtain a first decoction liquid, combining the first and second decoction liquid, concentrating under reduced pressure (the concentration temperature is 60 ℃ and the concentration specific gravity is 1.25), and obtaining a tea bran fermentation extract;
(2) Taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 10:12:8:6:4:4, mixing to obtain a plant extract;
(3) Fermenting the tea bran extract and the plant extract according to a mass ratio of 1.25:1, mixing, stirring uniformly, adding a humectant, a preservative, a thickener and a solvent, and stirring uniformly to obtain the plant extract anti-hair loss hair growing liquid; wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 1.25:0.2:0.4:0.1:10.
example 2
The embodiment provides a preparation method of a plant extract hair loss prevention hair growth liquid, which comprises the following steps:
(1) Preparing a tea bran fermentation extract: taking crushed tea bran (the tea bran is crushed to 80 meshes), adding active yeast (the mass ratio of the active yeast to the tea bran is 1:50), stirring uniformly, placing into a container, adding an equal amount of water, fermenting at 36 ℃ for 144 hours, taking a fermented product, adding 4 times of water, heating to 90 ℃, decocting for 2 hours, filtering to obtain a first decoction liquid, adding 4 times of water into the obtained residue, heating to 85 ℃, decocting for 1 hour, filtering to obtain a first decoction liquid, combining the first and second decoction liquid, concentrating under reduced pressure (the concentration temperature is 60 ℃ and the concentration specific gravity is 1.25), and obtaining a tea bran fermentation extract;
(2) Taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 8:8:12:6:6:4, mixing to obtain a plant extract;
(3) The tea bran fermentation extracting solution and the plant extracting solution are mixed according to the mass ratio of 1:1.25, mixing, stirring uniformly, adding a humectant, a preservative, a thickening agent and a solvent, and stirring uniformly to obtain the plant extract anti-hair loss hair growing liquid; wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 1.25:0.2:0.4:0.1:10.
example 3
The embodiment provides a preparation method of a plant extract hair loss prevention hair growth liquid, which comprises the following steps:
(1) Preparing a tea bran fermentation extract: taking crushed tea bran (the tea bran is crushed to 40 meshes), adding active yeast (the mass ratio of the active yeast to the tea bran is 3:50), stirring uniformly, placing into a container, adding equal amount of water, fermenting at 38 ℃ for 144 hours, taking a fermented product, adding 6 times of water, heating to 90 ℃, decocting for 1.5 hours, filtering to obtain a first decoction liquid, adding 3-4 times of water into the obtained residue, heating to 90 ℃, decocting for 1.5 hours, filtering to obtain a first decoction liquid, merging the first decoction liquid and the second decoction liquid, concentrating under reduced pressure (the concentration temperature is 80 ℃ and the concentration specific gravity is 1.25), and obtaining a tea bran fermentation extract;
(2) Taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 8:12:8:6:6:4, mixing to obtain a plant extract;
(3) Fermenting the tea bran extract and the plant extract according to the mass ratio of 0.8:0.7, mixing, stirring uniformly, adding the humectant, the preservative, the thickener and the solvent, and stirring uniformly to obtain the plant extract anti-hair loss hair growing liquid; wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 1.25:0.4:0.6:0.2:20.
example 4
The embodiment provides a preparation method of a plant extract hair loss prevention hair growth liquid, which comprises the following steps:
(1) Preparing a tea bran fermentation extract: taking crushed tea bran (the tea bran is crushed to 80 meshes), adding 6 times of water, heating to 95 ℃, decocting for 2 hours, filtering to obtain first decoction liquid, adding 4 times of water into the obtained dregs, heating to 90 ℃, decocting for 1.5 hours, filtering to obtain first decoction liquid, combining the first and second decoction liquid, concentrating under reduced pressure (the concentration temperature is 60 ℃, concentrating to the specific gravity of 1.25), and obtaining tea bran fermentation extract;
(2) Taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 10:12:8:6:4:4, mixing to obtain a plant extract;
(3) Fermenting the tea bran extract and the plant extract according to a mass ratio of 1.25:1, mixing, stirring uniformly, adding a humectant, a preservative, a thickener and a solvent, and stirring uniformly to obtain the plant extract anti-hair loss hair growing liquid; wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 1.25:0.2:0.4:0.1:10.
effect evaluation: selecting 150 subjects with scalp easy to get oil, alopecia areata and baldness in the age range of 20-50 years as subjects; wherein 78 men and 72 women; the 150 volunteers are divided into 5 groups, 30 persons are respectively used in the first group, the second group, the third group and the fourth group, the extraction-planting hair-loss-preventing hair-growing liquid prepared in the examples 1, 2, 3 and 4 is used in the fifth group, and the fifth group is a better hair-loss-preventing hair-growing liquid sample (simply referred to as a commercially available sample) sold in the market at present, and the using method is as follows: the hair growth liquid sample is smeared on scalp, and is used for 2 months continuously once a day in the morning and evening.
Efficacy evaluation criteria: 1) The effect is shown: stopping alopecia, and regrowing black hair in the hairless area; 2) The method is effective: the alopecia is obviously improved, and black hair grows again in partial hairless areas; 3) Invalidation: the alopecia is not improved and reduced, and no new hair grows at the hairless place. The results are shown in Table 1.
TABLE 1
Example 5
The extracts of examples 1-4 and 10g of the better anti-hair-loss hair-growing liquid sample sold in the market at present are added with 23.5g of 1, 3-butanediol and 35.5g of distilled water to obtain standby products (1 st group, 2 nd group, 3 rd group, 4 th group and 5 th group respectively) of different test groups.
(1) Test mice weighing 15-20g were collected, and under mild anesthesia with diethyl ether, the back hair of the mice was plucked out with a mixture of rosin and paraffin wax to an area of about 3cm×4cm, and the mice were grouped into test groups (group 1, group 2, group 3, group 4 and group 5, 10 animals per group), normal control group (group 6), and solvent group (group 1, 3-butanediol—group 7).
(2) And uniformly smearing the spare products of each test group on the skin of the back dehairing area of each group of mice on the next day after dehairing, wherein the dosage of each test group is 10ml/kg, the control group is given with the same volume of physiological saline, the solvent group is given with the same volume of 1, 3-butanediol for 1 time/day, the continuous 10 days are carried out, the hair growth condition of each group of mice is observed after the administration for 10 days, and the scoring is carried out according to the hair growth condition of the mice.
Scoring criteria: not grown, the skin of the dehaired area is flesh-colored: 0 minutes; the skin of the dehairing area is grey: 1, dividing; the skin of the dehairing area is black: 2, dividing; the skin of the depilatory area is black and a little hair grows: 3 minutes.
At the end of the experiment, the skin of the back dehairing area of the mouse is taken and fixed by formalin to be used as a pathological section, and the growth condition of hair follicles is observed. The effect on normal mouse hair growth is shown in Table 2.
TABLE 2
| Score after 10 days of administration | Hair follicle number/field of view | |
| Group 1 | 2.7±0.3 | 182.2±6.4 |
| Group 2 | 2.4±0.2 | 162.4±5.2 |
| Group 3 | 2.3±0.1 | 156.5±6.2 |
| Group 4 | 2.0±0.3 | 141.4±5.6 |
| Group 5 | 1.8±0.2 | 138.8±3.2 |
| Group 6 | 1.4±0.1 | 96.7±5.8 |
| Group 7 | 1.2±0.1 | 92.1±5.2 |
Example 6
Effect evaluation test of inhibition of 5α -reductase activity:
group 1: the blank test group is 5 alpha-reductase, dependency reduced coenzyme (NADPH) and Tris buffer solution;
group 2: the blank control group is testosterone, 5 alpha-reductase, dependency reduced coenzyme (NADPH) and Tris buffer solution with serial concentrations;
group 3: the finasteride group is finasteride solution, testosterone with serial concentration, 5α -reductase, dependency reduced coenzyme (NADPH), tris buffer solution;
group 4: the test group was a plant extract composition (the content of each plant extract in the extract composition is the same as that in example 1), testosterone, 5α -reductase, dependent reduced coenzyme (NADPH), tris buffer solution at a series concentration;
in groups 1 to 4, the same reagent was used in the same amount.
The reaction systems of groups 1 to 1 are respectively and continuously incubated at 37 ℃, and a time change curve of the OD value of the characteristic absorption wavelength of NADPH is continuously measured at 340nm by an ultraviolet grating spectrophotometer to calculate the enzyme activity. The average value of the groups in parallel 5 is obtained, and the measurement results are shown in Table 3.
TABLE 3 Table 3
As can be seen from Table 3, the plant extract hair loss preventing hair growth liquid of the present application has an inhibitory effect on the activity of alpha-reductase.
Example 7
(1) Under the preparation process conditions of example 1, other conditions were unchanged, and the influence of the formula of different plant extracts on the hair-loss preventing effect of the hair-loss preventing hair-growing liquid by plant extraction was examined, and the results are shown in Table 3.
TABLE 4 Table 4
| Test 1 | Test 2 | Test 3 | Test 4 | Test 5 | |
| Polygonum multiflorum extract | 0 | 0 | 10 | 10 | 10 |
| Extract of biota orientalis | 0 | 0 | 0 | 12 | 12 |
| Eclipta extract | 8 | 0 | 8 | 8 | 0 |
| Angelica sinensis extract | 6 | 6 | 6 | 0 | 6 |
| Cortex Mori extract | 4 | 4 | 4 | 0 | 0 |
| Licorice root extract | 4 | 4 | 4 | 4 | 0 |
| Total effective rate (%) | 78.24 | 72.13 | 79.12 | 84.2 | 83.2 |
From table 4, it can be seen that the effects of changing the blood circulation of the head, activating hair follicle and realizing hair restoration can be achieved by combining the active ingredients in the extracts of polygonum multiflorum, eclipta, angelica sinensis, cortex mori radicis and liquorice through the interaction of the active ingredients in the tea bran extract and the biota orientalis.
The tea bran, also called tea cake and tea seed cake, has a purplish brown granule, is a residue cake of oil tea seed after oil extraction, and contains saporin as effective component. The quality standard of the tea seed cake is as follows: the tea saponin contains 12-18%, residual oil <2%, protein 12-16%, starch and saccharide 30-50%, fiber 10-12%, water content <12%, and impurity <2%. The tea seed cake contains tea saponin, protein, natural tea oil and the like, has the effects of stopping dandruff, relieving itching, removing oil, sterilizing and repairing damaged hair quality after long-term use, and has obvious hair blackening and generating effects, thus being one of the optimal cleaning agents in nature;
active yeast, active dry yeast is a dry yeast product which maintains strong fermentation ability after being squeezed, dried and dehydrated by specially cultured fresh yeast. Squeezing the squeezed yeast into strips or pellets, continuously drying with low-humidity circulating air by using a fluidized bed to enable the final fermentation water content to reach about 8%, and keeping the fermentation capacity of the yeast. Fermenting with tea bran, and converting into absorbable micromolecular substances to degrade harmful components;
polygonum multiflorum (academic name: fallopia multiflora (thunder.) Harald.) also known as Polygonum multiflorum, ziwuteng, caulis Polygoni Multiflori, etc. Is a perennial entangled vine of Polygonum multiflorum of Polygonaceae, and has thick root tuber, oblong shape and black brown color. The root tuber contains anthraquinone compounds, mainly emodin, chrysophanol, physcion, rhein and chrysophanone. Has effects of blackening and moistening hair after washing hair;
the dried branch tip and leaf of Platycladus orientalis PLatycladus orientalis (L.) Franco belonging to Cupressaceae are dried branch tip and leaf of Platycladus orientalis PLatycladus orientalis (L.) Franco belonging to Cupressaceae, and are cold in nature, bitter in taste and astringent. The main components are volatile oil, flavone, tannin, etc. Has effects of cooling blood, stopping bleeding, promoting hair growth, and blackening hair. Has effects of promoting hair growth and blackening hair after washing hair;
eclipta alba is the dry aerial part of ecliptapromata L. Sweet, sour and cold, contains volatile oil, tannin, saponin, ecliptin, vitamin A, etc. Has good curative effect on dizziness, teeth loosening, waist and back ache, lower limb flaccidity, and various bleeding caused by blood heat caused by liver and kidney yin deficiency. After shampooing, the hair growth is promoted, and the beard and hair become black;
angelica sinensis is dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae, sweet and pungent in taste, and warm in nature. Comprises ligustilide, n-butenolide, ferulic acid, nicotinic acid, sucrose and various amino acids, sesquiterpenoids, etc. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. After shampooing, the shampoo has soft and smooth hair loss preventing effect;
cortex Mori is dry root bark of dicotyledon Moraceae Morus alba removed plug skin, and has sweet and cold taste, mainly benzofurans, stilbenes, flavonoids, phenylpropanoids, triterpenes, alkaloids, etc. Has various modern pharmacological activities such as blood pressure reduction, anti-inflammatory and anticancer. After shampooing, the shampoo has the anti-drop attack effect;
glycyrrhrizae radix is dry root and rhizome of Glycyrrhiza uralensis Glycyrrhiza uralensis Fisch. Glycyrrhiza uralensis Glycyrrhiza inflata bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Sweet taste, mild nature, main ingredients of glycyrrhizin, glycyrrhizic acid, glycyrrhizin flavonoid, rear curtain ratio santalin, formononetin, quercetin, etc. Has the effects of invigorating spleen, replenishing qi, clearing heat, detoxicating, eliminating phlegm, relieving cough, relieving spasm, relieving pain and harmonizing various medicines. According to the application, through the action of the tea bran extract and the active ingredients in the biota orientalis leaves, and the combination of the active ingredients in the polygonum multiflorum, eclipta, angelica sinensis, cortex mori radicis and liquorice extracts, the active ingredients of the extracts of various plants are mutually synergistic, so that the effects of changing the blood circulation of the head, activating hair follicles and realizing hair restoration can be changed, and when the tea bran extract is not in the formula range of the application, the synergistic effect is reduced.
(2) The effect of inhibiting 5. Alpha. -reductase activity of the plant extracts prepared in test 1 and test 2 in this example was evaluated according to the evaluation test method of inhibiting 5. Alpha. -reductase activity in example 6, and the results are shown in Table 5.
Group 5: the test group was a plant extract composition (the content of each plant extract in the extract composition is the same as that in test 1), testosterone, 5α -reductase, dependent reduced coenzyme (NADPH), tris buffer solution at a series concentration;
group 6: the test group was a plant extract composition (the content of each plant extract in the extract composition is the same as that in test 2), testosterone, 5α -reductase, dependent reduced coenzyme (NADPH), tris buffer solution at a series concentration;
in groups 1 to 6, the same reagent was used in the same amount.
TABLE 5
As can be seen from Table 5, the tea bran extract has a synergistic effect with the inhibition of alpha-reductase activity by the active ingredient of biota orientalis, the active ingredient of Polygonum multiflorum and the active ingredient of Ecliptae herba.
The application provides a plant extract hair loss preventing and growing liquid, which combines the active ingredients in the extracts of polygonum multiflorum, eclipta, angelica sinensis, white mulberry root-bark and liquorice through the action of active ingredients in tea bran extract and cacumen biotae, and the active ingredients of the extracts of the plants are mutually synergistic, so that the effects of changing the blood circulation of the head, activating hair follicles and realizing the restoration of hair can be changed, and simultaneously, the mutual synergistic action of the active ingredients of the plant extract has very strong 5 alpha-reductase inhibiting action
The application provides a plant extract hair loss preventing and growing liquid, which comprises tea bran, polygonum multiflorum, cacumen biotae, eclipta alba, angelica sinensis, cortex mori radicis, liquorice and active yeast, and can change the blood circulation of the head, activate hair follicles, realize rapid hair loss prevention and repair and achieve the effect of treating both principal and secondary aspect of the disease through the mutual synergistic effect of the components of various plant extracts. The plant extract hair loss preventing and hair growing liquid has stronger active ingredients and the effects of removing dandruff, relieving itching, wu Faliang hair and preventing hair loss and hair growth by utilizing the action of the tea bran and the active yeast to convert macromolecular nutrient substances into absorbable micromolecular nutrient substances and degrade harmful ingredients, and simultaneously being more beneficial to the action of the active ingredients in the tea bran.
It should be noted that the above embodiments are only for illustrating the technical solution of the present application and not for limiting the same, and although the present application has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present application may be modified or substituted without departing from the spirit and scope of the technical solution of the present application, which is intended to be covered in the scope of the claims of the present application.
Claims (2)
1. A preparation method of plant extract hair loss prevention hair growth liquid is characterized by comprising the following steps: comprising the steps of (a) a step of,
preparing a tea bran fermentation extract: taking tea bran crushed to 80 meshes, adding active yeast, wherein the mass ratio of the active yeast to the tea bran is 3:50, uniformly stirring, placing into a container, adding an equal amount of water, fermenting at 38 ℃ for 120 hours, taking a fermented product, adding 6 times of water, heating to 90 ℃, decocting for 2 hours, filtering to obtain a first decoction liquid medicine, adding 4 times of water into the obtained residue, heating to 85 ℃, decocting for 1 hour, filtering to obtain a first decoction liquid medicine, combining the first and second decoction liquid medicines, concentrating under reduced pressure, concentrating at 60 ℃ until the specific gravity is 1.25, and obtaining a tea bran fermentation extract;
taking polygonum multiflorum extract, biota orientalis extract, eclipta alba extract, angelica sinensis extract, white mulberry root-bark extract and liquorice extract according to the mass ratio of 10:12:8:6:4:4, mixing to obtain a plant extract;
mixing the tea bran fermentation extract and the plant extract according to the mass ratio of 1.25:1, uniformly stirring, adding a humectant, a preservative, a thickener and a solvent, and uniformly stirring to obtain the plant extraction anti-hair loss hair growth liquid;
wherein the thickener is xanthan gum, the humectant is 1-10wt% of 1, 3-butanediol, the preservative is 0.08-0.15wt% of methylparaben, the solvent is deionized water, and the mass ratio of the tea bran fermentation extract to the humectant, the preservative, the thickener and the deionized water is 1.25:0.2:0.4:0.1:10;
the preparation method of the biota orientalis extract comprises the steps of cleaning and drying biota orientalis, crushing the biota orientalis to 40-80 meshes, soaking the biota orientalis in 75% alcohol for four times for 3 days each time, carrying out suction filtration, mixing all obtained filtrate, and concentrating the filtrate at 60 ℃ until the relative density is 1.21 to obtain the biota orientalis extract;
the preparation method of the polygonum multiflorum extract comprises the steps of weighing polygonum multiflorum, cleaning and drying, adding ethanol aqueous solution with the volume fraction of 60% which is 10-12 times of the weight of the polygonum multiflorum, heating and refluxing for 2.5-3 h, filtering, and concentrating filtrate at 60 ℃ until the relative density is 1.21 to obtain the polygonum multiflorum extract;
the eclipta extract is prepared by weighing eclipta, cleaning, drying, adding 5-8 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extract, adding 3-5 times of water into the obtained residue, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extract, combining the first extract and the second extract, filtering by a ceramic membrane, concentrating under reduced pressure, concentrating at a concentration temperature of not more than 80 ℃ and at a concentration temperature of 60 ℃ to a specific gravity of 1.25, thus obtaining the eclipta extract;
the preparation method of the Chinese angelica extract comprises the steps of weighing Chinese angelica, cleaning, drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating to a specific gravity of 1.25 at a concentration temperature of not more than 80 ℃ and 60 ℃ to obtain the eclipta extract;
the preparation method of the white mulberry root-bark extract comprises the steps of weighing white mulberry root-bark, cleaning and drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating at a concentration temperature of not more than 80 ℃ and 60 ℃ to a specific gravity of 1.25 to obtain the white mulberry root-bark extract;
the preparation method of the licorice root bark extract comprises the steps of weighing licorice root bark, cleaning, drying, adding 4-6 times of water, heating to 100 ℃, decocting for 1.5-2 hours, filtering to obtain a first extracting solution, adding 3-5 times of water into the obtained residues, heating to 100 ℃, decocting for 1 hour, filtering to obtain a second extracting solution, combining the first extracting solution and the second extracting solution, filtering by a ceramic membrane, concentrating under reduced pressure, and concentrating to a specific gravity of 1.25 at a concentration temperature of not more than 80 ℃ at a temperature of 60 ℃ to obtain the licorice root extract.
2. The method of manufacturing according to claim 1, wherein: the active yeast is Angel yeast with viable count of 1×10 10 CFU/g。
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