CN1111510A - 稳定双吡苯丙酸的方法和稳定的双吡苯丙酸液体制剂 - Google Patents
稳定双吡苯丙酸的方法和稳定的双吡苯丙酸液体制剂 Download PDFInfo
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- CN1111510A CN1111510A CN95114803A CN95114803A CN1111510A CN 1111510 A CN1111510 A CN 1111510A CN 95114803 A CN95114803 A CN 95114803A CN 95114803 A CN95114803 A CN 95114803A CN 1111510 A CN1111510 A CN 1111510A
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- pranoprofen
- stable
- antioxidant
- aqueous solution
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- 229960003101 pranoprofen Drugs 0.000 title claims abstract description 128
- 238000000034 method Methods 0.000 title claims abstract description 39
- 239000007788 liquid Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 230000000087 stabilizing effect Effects 0.000 title abstract description 3
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- 239000003963 antioxidant agent Substances 0.000 claims abstract description 40
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- 239000010642 eucalyptus oil Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003504 terephthalic acids Chemical class 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (25)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP44184/94 | 1994-03-15 | ||
JP4418494 | 1994-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1111510A true CN1111510A (zh) | 1995-11-15 |
CN1091597C CN1091597C (zh) | 2002-10-02 |
Family
ID=12684495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95114803A Expired - Fee Related CN1091597C (zh) | 1994-03-15 | 1995-03-14 | 稳定双吡苯丙酸的方法和稳定的双吡苯丙酸液体制剂 |
Country Status (19)
Country | Link |
---|---|
US (2) | US5856345A (zh) |
EP (2) | EP0672414B1 (zh) |
KR (1) | KR100338851B1 (zh) |
CN (1) | CN1091597C (zh) |
AT (1) | ATE297206T1 (zh) |
AU (1) | AU707119B2 (zh) |
BR (1) | BR9501081A (zh) |
CA (1) | CA2144591A1 (zh) |
DE (1) | DE69534258T2 (zh) |
EE (1) | EE9500015A (zh) |
ES (1) | ES2240966T3 (zh) |
FI (1) | FI951190A (zh) |
HU (1) | HUT71245A (zh) |
LT (1) | LT3969B (zh) |
LV (1) | LV10922B (zh) |
NO (1) | NO950970L (zh) |
PL (1) | PL179534B1 (zh) |
RU (1) | RU2148402C1 (zh) |
TW (1) | TW358812B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104010661A (zh) * | 2011-12-27 | 2014-08-27 | 千寿制药株式会社 | 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法 |
CN105283186A (zh) * | 2013-05-30 | 2016-01-27 | 千寿制药株式会社 | 氯苯那敏或其盐的稳定化方法 |
CN106068122A (zh) * | 2014-03-10 | 2016-11-02 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
CN106068123A (zh) * | 2014-03-10 | 2016-11-02 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
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US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
CA2359605A1 (en) * | 1998-12-02 | 2000-06-08 | Gt Merchandising & Licensing Corp. | Gradual hair relaxation composition |
CA2493980A1 (en) * | 2002-07-31 | 2004-02-05 | Pharmacia Corporation | Gelatin capsule exhibiting reduced cross-linking |
WO2004011001A1 (ja) | 2002-07-31 | 2004-02-05 | Senju Pharmaceutical Co., Ltd. | 水性液剤および光安定化された水性液剤 |
US8877168B1 (en) | 2002-07-31 | 2014-11-04 | Senju Pharmaceuticals Co., Ltd. | Aqueous liquid preparations and light-stabilized aqueous liquid preparations |
DE122011100019I1 (de) | 2003-01-21 | 2011-11-03 | Senju Pharma Co | Wassrige flussige zubereitung mit 2-amino-3-(4-bromobenzoyl) phenylessigsaure. |
AU2003100262B4 (en) * | 2003-04-07 | 2003-09-18 | Jurox Pty Ltd | Stable carprofen composition |
US7125497B1 (en) * | 2003-05-22 | 2006-10-24 | Sandia Corporation | Reactive formulations for a neutralization of toxic industrial chemicals |
US20060188557A1 (en) * | 2003-05-23 | 2006-08-24 | Hisamitsu Pharmaceutical Co., Inc. | Prepartaion for external percutaneous administration containing non-steroidal anti-inflammatory drug and interleukin-1 alpha production inhibitor |
US20060073172A1 (en) * | 2004-10-01 | 2006-04-06 | Schneider L W | Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure |
ES2363964B1 (es) | 2009-11-20 | 2012-08-22 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados. |
WO2013129318A1 (ja) * | 2012-02-27 | 2013-09-06 | ロート製薬株式会社 | 眼科用組成物キット |
WO2014129466A1 (ja) * | 2013-02-19 | 2014-08-28 | ロート製薬株式会社 | 網膜疾患の予防、改善、又は治療用粘膜適用剤 |
JP5340498B1 (ja) * | 2013-03-11 | 2013-11-13 | 千寿製薬株式会社 | ソフトコンタクトレンズ用眼科用組成物 |
AR102172A1 (es) | 2015-10-05 | 2017-02-08 | Química Luar S R L | Una composición farmacéutica bactericida y virucida |
KR102478553B1 (ko) | 2018-02-28 | 2022-12-16 | 한림제약(주) | 벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제 |
CN115677733A (zh) * | 2022-12-20 | 2023-02-03 | 济南宣正药业有限公司 | 一种用于普拉洛芬质量研究的化合物及其制备方法和应用 |
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US3931295A (en) | 1974-07-23 | 1976-01-06 | Universal Oil Products Company | Hydroxylation of aromatic compounds |
JPS6056684B2 (ja) * | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
US4565851A (en) * | 1983-04-25 | 1986-01-21 | Eastman Kodak Company | Containers having improved gas barrier properties |
US4525348A (en) * | 1983-12-19 | 1985-06-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Pranoprofen gelled ointment |
JPS60184013A (ja) * | 1984-03-01 | 1985-09-19 | Yoshitomi Pharmaceut Ind Ltd | 点眼剤 |
JPS61130222A (ja) * | 1984-11-30 | 1986-06-18 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
US4940728A (en) * | 1985-05-17 | 1990-07-10 | Postley John E | Treatment for sino-nasal congestion |
US5110492A (en) * | 1985-05-24 | 1992-05-05 | Irene Casey | Cleaner and disinfectant with dye |
US5032392A (en) * | 1986-09-04 | 1991-07-16 | Vision Pharmaceuticals | Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes |
US5414011A (en) * | 1987-09-11 | 1995-05-09 | Syntex (U.S.A.) Inc. | Preservative system for ophthalmic formulations |
US5110493A (en) * | 1987-09-11 | 1992-05-05 | Syntex (U.S.A.) Inc. | Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant |
WO1991012821A1 (en) * | 1990-03-02 | 1991-09-05 | Shiseido Company, Ltd. | Oil-in-water emulsion composition containing nonsteroidal antiphlogistic analgesic |
TW206918B (zh) * | 1991-05-11 | 1993-06-01 | Kuko Seiyaku Kk | |
JPH05124092A (ja) * | 1991-11-06 | 1993-05-21 | Chisso Corp | ポリオレフイン系樹脂製中空容器 |
CA2153553A1 (en) * | 1994-07-13 | 1996-01-14 | Hidekazu Suzuki | Stable lipid emulsion |
-
1995
- 1995-03-14 PL PL95307671A patent/PL179534B1/pl unknown
- 1995-03-14 FI FI951190A patent/FI951190A/fi unknown
- 1995-03-14 RU RU95103893A patent/RU2148402C1/ru active
- 1995-03-14 AT AT95103625T patent/ATE297206T1/de not_active IP Right Cessation
- 1995-03-14 CA CA002144591A patent/CA2144591A1/en not_active Abandoned
- 1995-03-14 DE DE69534258T patent/DE69534258T2/de not_active Expired - Lifetime
- 1995-03-14 ES ES95103625T patent/ES2240966T3/es not_active Expired - Lifetime
- 1995-03-14 NO NO950970A patent/NO950970L/no unknown
- 1995-03-14 CN CN95114803A patent/CN1091597C/zh not_active Expired - Fee Related
- 1995-03-14 KR KR1019950005273A patent/KR100338851B1/ko not_active IP Right Cessation
- 1995-03-14 EP EP95103625A patent/EP0672414B1/en not_active Expired - Lifetime
- 1995-03-14 HU HU9500772A patent/HUT71245A/hu unknown
- 1995-03-14 EP EP01120068A patent/EP1163906A3/en not_active Withdrawn
- 1995-03-14 LT LT95-028A patent/LT3969B/lt not_active IP Right Cessation
- 1995-03-14 TW TW084102389A patent/TW358812B/zh active
- 1995-03-14 LV LVP-95-50A patent/LV10922B/en unknown
- 1995-03-15 EE EE9500015A patent/EE9500015A/xx unknown
- 1995-03-15 BR BR9501081A patent/BR9501081A/pt not_active Application Discontinuation
- 1995-03-15 AU AU14852/95A patent/AU707119B2/en not_active Ceased
-
1997
- 1997-01-07 US US08/779,604 patent/US5856345A/en not_active Expired - Fee Related
- 1997-06-12 US US08/873,924 patent/US5889030A/en not_active Expired - Fee Related
Cited By (9)
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CN104010661A (zh) * | 2011-12-27 | 2014-08-27 | 千寿制药株式会社 | 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法 |
CN104010661B (zh) * | 2011-12-27 | 2017-06-06 | 千寿制药株式会社 | 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法 |
CN105283186A (zh) * | 2013-05-30 | 2016-01-27 | 千寿制药株式会社 | 氯苯那敏或其盐的稳定化方法 |
TWI608837B (zh) * | 2013-05-30 | 2017-12-21 | Senju Pharmaceutical Co Ltd | Method for stabilizing Chlorpheniramine or its salt |
CN105283186B (zh) * | 2013-05-30 | 2018-05-18 | 千寿制药株式会社 | 氯苯那敏或其盐的稳定化方法 |
CN106068122A (zh) * | 2014-03-10 | 2016-11-02 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
CN106068123A (zh) * | 2014-03-10 | 2016-11-02 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
CN106068122B (zh) * | 2014-03-10 | 2019-04-19 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
CN106068123B (zh) * | 2014-03-10 | 2019-09-03 | 千寿制药株式会社 | 二丁基羟基甲苯的稳定化方法 |
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LT3969B (en) | 1996-05-27 |
KR950032201A (ko) | 1995-12-20 |
ES2240966T3 (es) | 2005-10-16 |
DE69534258D1 (de) | 2005-07-14 |
HU9500772D0 (en) | 1995-04-28 |
AU1485295A (en) | 1995-09-21 |
CN1091597C (zh) | 2002-10-02 |
KR100338851B1 (ko) | 2002-10-12 |
EP0672414A2 (en) | 1995-09-20 |
EP0672414B1 (en) | 2005-06-08 |
LV10922B (en) | 1996-08-20 |
NO950970D0 (no) | 1995-03-14 |
LT95028A (en) | 1995-10-25 |
US5889030A (en) | 1999-03-30 |
FI951190A (fi) | 1995-09-16 |
ATE297206T1 (de) | 2005-06-15 |
EP0672414A3 (en) | 1995-12-13 |
EP1163906A3 (en) | 2003-05-21 |
PL179534B1 (pl) | 2000-09-29 |
EE9500015A (et) | 1995-12-15 |
EP1163906A2 (en) | 2001-12-19 |
LV10922A (lv) | 1995-12-20 |
NO950970L (no) | 1995-09-18 |
PL307671A1 (en) | 1995-09-18 |
HUT71245A (en) | 1995-11-28 |
FI951190A0 (fi) | 1995-03-14 |
BR9501081A (pt) | 1996-06-04 |
AU707119B2 (en) | 1999-07-01 |
DE69534258T2 (de) | 2006-05-04 |
TW358812B (en) | 1999-05-21 |
RU2148402C1 (ru) | 2000-05-10 |
CA2144591A1 (en) | 1995-09-16 |
US5856345A (en) | 1999-01-05 |
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