CN110916241A - Nicotine aerosol and preparation method thereof - Google Patents
Nicotine aerosol and preparation method thereof Download PDFInfo
- Publication number
- CN110916241A CN110916241A CN201911140172.8A CN201911140172A CN110916241A CN 110916241 A CN110916241 A CN 110916241A CN 201911140172 A CN201911140172 A CN 201911140172A CN 110916241 A CN110916241 A CN 110916241A
- Authority
- CN
- China
- Prior art keywords
- nicotine
- aerosol
- prepared
- parts
- essential oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a nicotine aerosol and a preparation method thereof, wherein the nicotine aerosol comprises the following raw materials in parts by weight: 1 part of nicotine, 30-50 parts of aerosol generating agent, 140-160 parts of polishing agent, 0.4-0.6 part of dawangcao essential oil and 0.1-0.3 part of eclipta extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.4-0.8 carbon dioxide and water, wherein the polishing agent is prepared from the following components in percentage by mass: 0.3-0.5 of tetrafluoroethane and heptafluoropropane. The aerosol prepared from carbon dioxide and water, the parabolic agent compounded from tetrafluoroethane and heptafluoropropane, high-purity nicotine and the dawang grass essential oil and the eclipta alba extract are combined, the mixture ratio is scientific, the nicotine aerosol can be well fused, the drug loading effect is good, the synergy is realized, the prepared nicotine aerosol is good in fogging property, and the remarkable anti-fatigue effect is achieved.
Description
Technical Field
The invention relates to the technical field of nicotine processing, in particular to a nicotine aerosol and a preparation method thereof.
Background
Nicotine is a colorless, transparent, oily volatile irritant liquid. Nicotine is a major habitual source for smokers. The nicotine absorbed in cigarette smoke reaches human brain for 7.5s, so that smoker feels a soft and pleasant feeling.
The smoke generated in the burning process of the common cigarette is a gas mixture with particulate matters, the mixture is not only toxic and harmful, but also seriously pollutes the environment, such as tar, carbon dioxide, hydrocyanic acid, acrylic acid, arsenic, lead, mercury and the like, and the smoke has more harm to people than polluted chemical gas and is a main pollution source of the cigarette.
The nicotine aerosol is a clear liquid suspension or emulsion prepared by filling nicotine, an aerosol generating agent and a proper propellant into a pressure-resistant closed container with a special valve system, and the content is sprayed out in a mist shape by the pressure of the propellant when in use. Nicotine aerosols produce "smoke" which is a mixture of gases free of environmental contaminants. Reduce the harm of the cigarette to human body. Therefore, a nicotine aerosol and a preparation method thereof are urgently needed to solve the problems.
Disclosure of Invention
In view of this, the present invention provides a nicotine aerosol and a method for preparing the same.
The technical scheme of the invention is realized as follows:
the invention provides a nicotine aerosol which comprises the following raw materials in parts by weight: 1 part of nicotine, 30-50 parts of aerosol generating agent, 140-160 parts of polishing agent, 0.4-0.6 part of dawangcao essential oil and 0.1-0.3 part of eclipta extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.4-0.8 carbon dioxide and water, wherein the polishing agent is prepared from the following components in percentage by mass: 0.3-0.5 of tetrafluoroethane and heptafluoropropane. The present invention uses nicotine with a purity of 99% or more. Wherein, the Li Wang Cao has the functions of clearing away heat and toxic material, removing blood stasis and detumescence, improving the general blood flow state, enhancing the myocardial contractility, improving the blood pressure, and has rich protein and high nutritive value. The Ecliptae herba has effects of nourishing liver and kidney, improving nonspecific immunity, reducing allergy, and reducing release of bioactive medium.
Preferably, the nicotine aerosol comprises the following raw materials in parts by weight: 1 part of nicotine, 38 parts of aerosol generating agent, 152 parts of parabolic agent, 0.5 part of Litsea coreana essential oil and 0.2 part of eclipta alba extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.5 of carbon dioxide and water, the polishing agent being prepared from a mixture of 1: 0.4 of tetrafluoroethane and heptafluoropropane.
Preferably, the preparation method of the Litsea cubeba essential oil comprises the following steps: taking the dawn grass, cleaning, drying and crushing, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction, extracting at the temperature of 40-50 ℃ and under the extraction pressure of 25-30 MPa for 0.5-1 h, adding 0.8-1L of absolute ethyl alcohol into each kilogram of dawn grass powder, continuing to extract for 1-2 h, and separating to obtain the dawn grass essential oil.
Preferably, the preparation method of the eclipta alba extract comprises the following steps: taking the whole eclipta, cleaning, putting into a steam explosion tank, and maintaining the pressure for 50-80 s under the condition that the pressure is 1.1-1.3 MPa; after steam explosion, performing alcohol extraction, adding 2-4 times of 85-98% (V/V) ethanol solution, performing alcohol extraction at 55-65 ℃ for 1-2 h, repeatedly extracting for 2-4 times, combining extracting solutions, and performing reduced pressure concentration until the relative density is 1.0-1.1 to obtain the eclipta extract.
The invention provides a preparation method of nicotine aerosol, which comprises the following steps: mixing nicotine, dawang grass essential oil, eclipta alba extract and a parabolic agent, and performing oscillation blending at the oscillation speed of 200-230 rpm, the oscillation temperature of 35-48 ℃ and the oscillation time of 1-2 h; and adding an aerosol generating agent, mixing, and packaging to obtain the nicotine aerosol.
Preferably, the oscillation speed is 210rpm, the oscillation temperature is 42-45 ℃, and the oscillation time is 1.5 h.
Compared with the prior art, the invention has the beneficial effects that:
(1) the aerosol prepared from carbon dioxide and water, the parabolic agent compounded from tetrafluoroethane and heptafluoropropane, high-purity nicotine and the dawang grass essential oil and the eclipta alba extract are combined, the mixture ratio is scientific, the nicotine aerosol can be well fused, the drug loading effect is good, the synergy is realized, the prepared nicotine aerosol is good in fogging property, and the obvious anti-fatigue effect is achieved.
(2) The preparation method of the essential oil of the liwangcao and the eclipta extract fully retains the active ingredients and further improves the efficacy.
(3) By adopting the preparation method of the nicotine aerosol, more components are more fully fused, the effects of the Litsea cubeba essential oil and the eclipta alba extract are further improved, and the fogging property is improved.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
A nicotine aerosol comprises the following raw materials in parts by weight: 1 part of nicotine, 30 parts of aerosol generating agent, 160 parts of polishing agent, 0.4 part of Li Wang grass essential oil and 0.3 part of yerbadetajo herb extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.4 of carbon dioxide and water, the polishing agent being prepared from a mixture of 1: 0.3 of tetrafluoroethane and heptafluoropropane.
Example 2
A nicotine aerosol comprises the following raw materials in parts by weight: 1 part of nicotine, 50 parts of aerosol generating agent, 140 parts of polishing agent, 0.6 part of Li Wang grass essential oil and 0.1 part of yerbadetajo herb extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.8 of carbon dioxide and water, the polishing agent being prepared from a mixture of 1: 0.5 tetrafluoroethane and heptafluoropropane.
Example 3
A nicotine aerosol comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 1 part of nicotine, 38 parts of aerosol generating agent, 152 parts of polishing agent, 0.5 part of Li Wang grass essential oil and 0.2 part of yerbadetajo herb extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.5 of carbon dioxide and water, the polishing agent being prepared from a mixture of 1: 0.4 of tetrafluoroethane and heptafluoropropane.
The method of making the nicotine aerosol of examples 1-3 above, comprising the steps of:
(1) the preparation method of the Li Wang Cao essential oil comprises the following steps: cleaning, drying and crushing the dawn grass, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction, extracting at the temperature of 45 ℃ and under the pressure of 28MPa for 0.8h, adding 1L of absolute ethyl alcohol into each kilogram of dawn grass powder, continuing to extract for 1.5h, and separating to obtain the dawn grass essential oil;
(2) the preparation method of the yerbadetajo herb extract comprises the following steps: cleaning whole plant of Ecliptae herba, placing into a steam explosion tank, and maintaining the pressure for 75s under the condition of 1.2 MPa; extracting with ethanol after steam explosion, adding 3 times of 90% (V/V) ethanol solution, extracting with ethanol at 58-62 deg.C for 1.5h, repeating the extraction for 3 times, mixing extractive solutions, and concentrating under reduced pressure to relative density of 1.05 to obtain Ecliptae herba extract;
(3) mixing nicotine, dawang grass essential oil, eclipta alba extract and a parabolic agent, and performing oscillation blending at the oscillation speed of 210rpm, the oscillation temperature of 42-45 ℃ and the oscillation time of 1.5 h; and adding an aerosol generating agent, mixing, and packaging to obtain the nicotine aerosol.
Example 4
This example is consistent with the formulation of example 3, except that the nicotine aerosol formulation was prepared by the method comprising the steps of:
(1) the preparation method of the Li Wang Cao essential oil comprises the following steps: cleaning, drying and crushing the dawn grass, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction, extracting at 40 ℃ under the extraction pressure of 25MPa for 1h, adding 0.8L of absolute ethyl alcohol into each kilogram of dawn grass powder, continuing extracting for 1h, and separating to obtain the dawn grass essential oil;
(2) the preparation method of the yerbadetajo herb extract comprises the following steps: cleaning whole plant of Ecliptae herba, placing into a steam explosion tank, and maintaining the pressure for 80s under the condition of 1.1 MPa; performing alcohol extraction after steam explosion, adding 2 times of 98% (V/V) ethanol solution, performing alcohol extraction at 55-58 ℃ for 2h, repeatedly extracting for 2 times, combining extracting solutions, and concentrating under reduced pressure to relative density of 1.05 to obtain an eclipta extract;
(3) mixing nicotine, dawang grass essential oil, eclipta alba extract and a parabolic agent, and performing oscillation blending at the oscillation rate of 200pm, the oscillation temperature of 35-40 ℃ and the oscillation time of 2 h; and adding an aerosol generating agent, mixing, and packaging to obtain the nicotine aerosol.
Example 5
This example is consistent with the formulation of example 3, except that the nicotine aerosol formulation was prepared by the method comprising the steps of:
(1) the preparation method of the Li Wang Cao essential oil comprises the following steps: cleaning, drying and crushing the dawn grass, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction, extracting at the temperature of 50 ℃ and under the pressure of 30MPa for 0.5h, adding 1L of absolute ethyl alcohol into each kilogram of dawn grass powder, continuing extracting for 2h, and separating to obtain the dawn grass essential oil.
(2) The preparation method of the yerbadetajo herb extract comprises the following steps: cleaning whole plant of Ecliptae herba, placing into a steam explosion tank, and maintaining the pressure for 50s under the condition of 1.3 MPa; extracting with ethanol after steam explosion, adding 4 times of 85% (V/V) ethanol solution, extracting with ethanol at 60-65 deg.C for 1 hr, repeatedly extracting for 4 times, mixing extractive solutions, and concentrating under reduced pressure to relative density of 1.05 to obtain Ecliptae herba extract.
(3) Mixing nicotine, dawang grass essential oil, eclipta alba extract and a parabolic agent, and performing oscillation blending at the oscillation speed of 230rpm, the oscillation temperature of 42-48 ℃ and the oscillation time of 1 h; and adding an aerosol generating agent, mixing, and packaging to obtain the nicotine aerosol.
Comparative example 1
This comparative example differs from example 3 in that the nicotine aerosol comprises the following raw materials in parts by weight: 1 part of nicotine, 50 parts of aerosol generating agent and 200 parts of propellant, wherein the aerosol generating agent is prepared by mixing 1: 1 and water, the polishing agent being prepared from 1: 1 tetrafluoroethane and heptafluoropropane.
Comparative example 2
This comparative example differs from example 3 in that the nicotine aerosol formulation has 0.2 parts of wang grass essential oil and 0.5 parts of yerbadetajo herb extract.
Comparative example 3
The comparative example is different from example 3 in that the preparation method of the riemerella essential oil comprises the following steps: cleaning, drying and crushing the dawn grass, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction at 55 ℃ and under 20MPa for 3h, and separating to obtain the dawn grass essential oil.
Comparative example 4
The comparative example is different from example 3 in that the preparation method of the yerbadetajo herb extract is characterized in that the whole plant of the yerbadetajo herb is directly subjected to alcohol extraction without air explosion to prepare the yerbadetajo herb extract.
Exhaustive swimming test
The exhaustion swimming test investigates the exercise endurance of the mouse, the swimming time can reflect the exercise fatigue degree of the mouse, and the exhaustion swimming time is an important and visual index for evaluating the physical fatigue.
The experimental method comprises the following steps: 220 mice, each half of male and female, weighing 19-21 g, were divided into 11 groups, and nicotine aerosols of examples 1-5 and comparative examples 1-4, a blank control (physiological saline) and a positive control group (normal cigarette) were administered in this order, 20 mice per group, and the dose was 0.1m g/mouse. The nicotine aerosol and the common cigarette generate aerosol, and the aerosol enters the body through the breathing of a mouse, the mouse is placed in a swimming box at the water depth of 50cm and the water temperature (25 +/-0.5 ℃) after administration, and the mouse with the tail root loaded with a 5% weight lead weight is placed in the swimming box. The time from the start of swimming until the head is fully submerged in water and cannot float out of the water surface for 10 seconds is recorded as the maximum swimming time of the mouse. The experimental results are as follows:
| experimental group | Animal number (only) | Swimming time(s) |
| Positive control | 20 | 475.3 |
| Blank control | 20 | 418.5 |
| Examples1 | 20 | 615.4 |
| Example 2 | 20 | 628.3 |
| Example 3 | 20 | 686.1 |
| Example 4 | 20 | 652.8 |
| Example 5 | 20 | 648.4 |
| Comparative example 1 | 20 | 492.9 |
| Comparative example 2 | 20 | 515.3 |
| Comparative example 3 | 20 | 551.7 |
| Comparative example 4 | 20 | 528.4 |
The above table shows that the mice in examples 1 to 5 have long exhaustion swimming time and active performance, and the results show that the nicotine aerosol provided by the invention can significantly prolong the exhaustion swimming time of the mice and significantly improve the anti-fatigue capability of the mice, which indicates that the nicotine aerosol provided by the invention has significant anti-fatigue effect.
Secondly, the nicotine aerosol prepared in the example 1-5 is tested for the spraying rate and the particle size of the fog particles.
(1) The testing steps of the particle size of the fog particles are as follows:
a) taking three samples, and removing air remained in a valve and/or a suction pipe during filling operation according to a required spraying method;
b) placing the sample in a constant-temperature water bath at 25 ℃ to ensure that the water submerges the sprayer and keeping the temperature for 30 min;
c) put on a glove with thick skin, take out the sample and dry it. Shaking the sample six times;
d) preparing for detection by using a laser diffraction particle size analyzer, and measuring a background after the instrument is stabilized for 5 min;
e) and positioning the sample, enabling the central line of the sprayed mist beam to be positioned on the same plane as the laser beam, keeping the central line vertical to the laser beam, spraying at different distances from the laser beam, and checking the shading rate of the sample. When the shading rate value reaches 0.1-0.5 range, positioning the sample;
f) spraying and sampling for 5s again, measuring the result, repeating the test for two times, and taking an average value;
g) and testing the second sample and the third sample by the method, wherein the average value of the three test results is the particle size of the fog particles of the product.
(2) The ejection rate testing step comprises:
a) taking three samples, and removing air remained in a valve and/or a suction pipe during filling operation according to a required spraying method;
b) placing the sample in a constant-temperature water bath at 25 ℃ to ensure that the water submerges the sprayer and keeping the temperature for 30 min;
c) wearing thick gloves, taking out the sample, and wiping to dry;
d) weighing to obtain m1(accurate to 0.01 g);
e) shake the sample six times and press the valve 5 s. Then wiping off the liquid adhered on the surface of the sample, and weighing to obtain m2(accurate to0.01 g); ejection rate (X)1) Calculating according to the formula (3):
in the formula X1The ejection rate is given in grams per second (g/s);
m1the mass of the sample before ejection is given in grams (g);
m2the mass of the sample after ejection is given in grams (g);
t is the actual injection time in seconds(s).
Repeating the steps (b-e) for two times, and taking an average value.
f) The second and third samples were tested in this way and the average of the three test results was the ejection rate of the product.
The detection results are as follows:
| test examples | Particle size of atomized particles (μm) | Ejection rate (g/s) |
| Example 1 | 1.6 | 2.45 |
| Example 2 | 1.7 | 2.50 |
| Example 3 | 1.5 | 2.42 |
| Example 4 | 1.6 | 2.47 |
| Example 5 | 1.5 | 2.43 |
The above results show that the nicotine aerosols of embodiments 1 to 5 of the present invention have fine particle size, good spraying rate, and good fogging property.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. The nicotine aerosol is characterized by comprising the following raw materials in parts by weight: 1 part of nicotine, 30-50 parts of aerosol generating agent, 140-160 parts of polishing agent, 0.4-0.6 part of dawangcao essential oil and 0.1-0.3 part of eclipta extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.4-0.8 carbon dioxide and water, wherein the polishing agent is prepared from the following components in percentage by mass: 0.3-0.5 of tetrafluoroethane and heptafluoropropane.
2. The nicotine aerosol as claimed in claim 1, which comprises the following raw materials in parts by weight: 1 part of nicotine, 38 parts of aerosol generating agent, 152 parts of polishing agent, 0.5 part of Li Wang grass essential oil and 0.2 part of yerbadetajo herb extract, wherein the aerosol generating agent is prepared from the following components in a molar ratio of 1: 0.5 of carbon dioxide and water, the polishing agent being prepared from a mixture of 1: 0.4 of tetrafluoroethane and heptafluoropropane.
3. The nicotine aerosol as claimed in claim 1, wherein the preparation method of the King Poisseria essential oil comprises the following steps: taking the dawn grass, cleaning, drying and crushing, putting the dawn grass powder into an extraction kettle for supercritical carbon dioxide extraction, extracting at the temperature of 40-50 ℃ and under the extraction pressure of 25-30 MPa for 0.5-1 h, adding 0.8-1L of absolute ethyl alcohol into each kilogram of dawn grass powder, continuing to extract for 1-2 h, and separating to obtain the dawn grass essential oil.
4. A nicotine aerosol as claimed in claim 3, wherein the eclipta extract is prepared by: taking the whole eclipta, cleaning, putting into a steam explosion tank, and maintaining the pressure for 50-80 s under the condition that the pressure is 1.1-1.3 MPa; and (3) after steam explosion, performing alcohol extraction for 2-4 times, combining extracting solutions, and concentrating under reduced pressure until the relative density is 1.0-1.1 to obtain the eclipta extract.
5. The method of claim 4, wherein the alcohol extraction is performed by adding 2-4 times of 85-98% (V/V) ethanol solution.
6. The method for preparing a nicotine aerosol as claimed in claim 4, wherein the alcohol extraction temperature is 55-65 ℃ and the time is 1-2 h.
7. A method of producing a nicotine aerosol as claimed in any one of claims 1 to 6, comprising the steps of: mixing nicotine, dawang grass essential oil, eclipta alba extract and a parabolic agent, and performing oscillation blending at the oscillation speed of 200-230 rpm, the oscillation temperature of 35-48 ℃ and the oscillation time of 1-2 h; and adding an aerosol generating agent, mixing, and packaging to obtain the nicotine aerosol.
8. The method of claim 7, wherein the oscillation rate is 210rpm, the oscillation temperature is 42-45 ℃, and the oscillation time is 1.5 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911140172.8A CN110916241A (en) | 2019-11-20 | 2019-11-20 | Nicotine aerosol and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911140172.8A CN110916241A (en) | 2019-11-20 | 2019-11-20 | Nicotine aerosol and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110916241A true CN110916241A (en) | 2020-03-27 |
Family
ID=69850420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911140172.8A Pending CN110916241A (en) | 2019-11-20 | 2019-11-20 | Nicotine aerosol and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110916241A (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099600A (en) * | 2006-07-07 | 2008-01-09 | 王景伟 | Body health benefits environment-friendly type substituted cigarette inhalant and preparation and application |
| CN103371430A (en) * | 2012-04-26 | 2013-10-30 | 北京创业恒基国际贸易有限公司 | Cigarette inhalant and preparation and application thereof |
| CN104644998A (en) * | 2015-03-06 | 2015-05-27 | 云南中烟工业有限责任公司 | Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets |
| CN104957762A (en) * | 2015-06-01 | 2015-10-07 | 湖北中烟工业有限责任公司 | Suspension type gas fog health care cigarette and preparing method thereof |
| CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
| CN105596961A (en) * | 2016-02-01 | 2016-05-25 | 范洲卫 | Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease and preparation method of traditional Chinese medicine preparation |
| CN106955341A (en) * | 2017-03-28 | 2017-07-18 | 海南医学院第二附属医院 | A kind of sorrow is escaped careless health liquor and preparation method thereof |
| FR3047641A1 (en) * | 2016-02-12 | 2017-08-18 | Laboratoires Ceres | FORMULATION COMPRISING AN AEROSOLIZATION MEDIUM AND NICOTINE R |
| CN107375460A (en) * | 2017-07-21 | 2017-11-24 | 成都柏图生物科技有限公司 | It is a kind of that there is improvement sleep, antifatigue, anti-aging pharmaceutical composition and preparation method |
| CN107982305A (en) * | 2016-10-27 | 2018-05-04 | 北京中科百瑞能工程技术有限责任公司 | A kind of method of steam explosion assisted extraction astragaloside and astragalus polyose |
| CN108815318A (en) * | 2018-09-20 | 2018-11-16 | 肖月华 | A kind of composition for immunological enhancement containing the lactobacillus and preparation method thereof and purposes |
-
2019
- 2019-11-20 CN CN201911140172.8A patent/CN110916241A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099600A (en) * | 2006-07-07 | 2008-01-09 | 王景伟 | Body health benefits environment-friendly type substituted cigarette inhalant and preparation and application |
| CN103371430A (en) * | 2012-04-26 | 2013-10-30 | 北京创业恒基国际贸易有限公司 | Cigarette inhalant and preparation and application thereof |
| CN104644998A (en) * | 2015-03-06 | 2015-05-27 | 云南中烟工业有限责任公司 | Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets |
| CN104957762A (en) * | 2015-06-01 | 2015-10-07 | 湖北中烟工业有限责任公司 | Suspension type gas fog health care cigarette and preparing method thereof |
| CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
| CN105596961A (en) * | 2016-02-01 | 2016-05-25 | 范洲卫 | Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease and preparation method of traditional Chinese medicine preparation |
| FR3047641A1 (en) * | 2016-02-12 | 2017-08-18 | Laboratoires Ceres | FORMULATION COMPRISING AN AEROSOLIZATION MEDIUM AND NICOTINE R |
| CN107982305A (en) * | 2016-10-27 | 2018-05-04 | 北京中科百瑞能工程技术有限责任公司 | A kind of method of steam explosion assisted extraction astragaloside and astragalus polyose |
| CN106955341A (en) * | 2017-03-28 | 2017-07-18 | 海南医学院第二附属医院 | A kind of sorrow is escaped careless health liquor and preparation method thereof |
| CN107375460A (en) * | 2017-07-21 | 2017-11-24 | 成都柏图生物科技有限公司 | It is a kind of that there is improvement sleep, antifatigue, anti-aging pharmaceutical composition and preparation method |
| CN108815318A (en) * | 2018-09-20 | 2018-11-16 | 肖月华 | A kind of composition for immunological enhancement containing the lactobacillus and preparation method thereof and purposes |
Non-Patent Citations (1)
| Title |
|---|
| 凌沛学: "《药物制剂技术》", 31 May 2007, 《中国轻工业出版社》, pages: 268 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Way et al. | Inhibition of gastric acid secretion in vitro by prostaglandin E1 | |
| CN107988297B (en) | Preparation method of vinasse small molecular peptide and application of vinasse small molecular peptide in skin care product | |
| CN111019989B (en) | Pea oligopeptide powder and preparation method thereof | |
| CN112043685A (en) | Recombinant human interferon alpha 1b mutant inhalation solution and preparation method thereof | |
| CN110916241A (en) | Nicotine aerosol and preparation method thereof | |
| CN102614099B (en) | Method for preparing rose extract for supercritical CO2 extraction cosmetics | |
| Reichenbach et al. | Structural changes in Stigmatella aurantiaca during myxospore induction | |
| CN107982083A (en) | A kind of spray containing mutual 100,000 layers of hydrosol of leaf and preparation method thereof | |
| CN106236925B (en) | A kind of Chinese medicine inhalation aerosol and the preparation method and application thereof for treating asthma | |
| KruH et al. | In vitro synthesis of ribonucleic acid in reticulocytes | |
| JP2005510490A (en) | Anti-HSV drugs for blocking HSV-1 and HSV-2 replication and methods for producing substances having anti-HSV activity | |
| JPS63130533A (en) | Method of including solid particle component in inhalant aerosol blend of nicotine | |
| CN110141561A (en) | A kind of technology of preparing of aerosolizable protein dry powder inhalant | |
| Roszman et al. | Suppression of lymphocyte function by products derived from cigarette smoke | |
| Groth et al. | Regeneration of virus receptors in mouse lungs after artificial destruction. | |
| EP0197525A2 (en) | Plant culture cell and use thereof | |
| US3148121A (en) | Water-insoluble whole inhalant complex and method of making same | |
| Rowley et al. | Some nutritional factors influencing growth of yeast cells of Histoplasma capsulatum to mycelial colonies | |
| CN107080970B (en) | A kind of subcritical dialysis process of water soluble ingredient | |
| CN113925848A (en) | Aerosol-forming substrate and aerosol-generating system | |
| Lovejoy Jr et al. | Importance of particle size in aerosol therapy. | |
| US4498485A (en) | Interferon and interferon inducers combined with tobacco products | |
| CN111647462A (en) | Preparation method and application of michelia figo extract for cigarettes | |
| Hashimoto et al. | Occurrence of a toxic substance in the skin of a sea bass Pogonoperca punctata | |
| Cooke et al. | An antiviral substance from Penicillium cyaneo-fulvum biourge: I. Production and partial purification |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200327 |
|
| RJ01 | Rejection of invention patent application after publication |