CN106955341A - A kind of sorrow is escaped careless health liquor and preparation method thereof - Google Patents

A kind of sorrow is escaped careless health liquor and preparation method thereof Download PDF

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CN106955341A
CN106955341A CN201710193111.2A CN201710193111A CN106955341A CN 106955341 A CN106955341 A CN 106955341A CN 201710193111 A CN201710193111 A CN 201710193111A CN 106955341 A CN106955341 A CN 106955341A
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sorrow
escaped
parts
health liquor
preparation
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CN106955341B (en
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黄茂莘
王炜
蔡杨靖
陈玲
韩鹏定
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Second Affiliated Hospital Of Hainan Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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    • A61K2236/10—Preparation or pretreatment of starting material
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

Escaped careless health liquor and preparation method thereof the invention discloses a kind of sorrow, the health liquor includes the raw material of following parts by weight：Sorrow escape grass 10~20 parts, 10~15 parts of fructus alpiniae oxyphyllae, 5~10 parts of coix seed, 15~20 parts of Radix Glycyrrhizae.The health liquor collection sorrow of the present invention is escaped grass, fructus alpiniae oxyphyllae, coix seed and Radix Glycyrrhizae plurality of raw materials, is mutually cooperateed with, is significantly improved antifatigue effect, have humidification to spleen, thymus gland immune organ, can significantly increase body immunity；There is the tonifying Qi that takes care of health, tonify the liver and kidney, stimulate circulation etc. effect simultaneously, human body is had no side effect, can long-term taking, be easily absorbed by the body.

Description

A kind of sorrow is escaped careless health liquor and preparation method thereof
Technical field
The present invention relates to health liquor technical field, more particularly to a kind of sorrow is escaped careless health liquor and preparation method thereof.
Background technology
With the development of society, people to material requisite more and more higher, work, family, in school work each side pressure all Very big, the busy date is easy to carelessness and taken exercise, and adds stress greatly, is easily caused body and some bad situations occur, Into the state of inferior health, fatiguability, immunity is poor.
Health liquor refers to the wine with specific healthcare function, and with regulation body function, people can be by drinking in right amount Health liquor adjusts physical function.Health liquor is numerous in variety in the market, and formula, nutrition, function are different, but existing There is the unconspicuous shortcoming of health-care effect in health liquor.
The content of the invention
In view of this, escaped careless health liquor and preparation method thereof the invention provides a kind of sorrow, solve above-mentioned technical problem.
The technological means that the present invention is used is as follows：A kind of sorrow is escaped careless health liquor, includes the raw material of following parts by weight：Sorrow is escaped grass 10~20 parts, 10~15 parts of fructus alpiniae oxyphyllae, 5~10 parts of coix seed, 15~20 parts of Radix Glycyrrhizae.
Further, the health liquor includes the raw material of following parts by weight：Sorrow escape grass 15 parts, 12 parts of fructus alpiniae oxyphyllae, coix seed 8 Part, 18 parts of Radix Glycyrrhizae.
A kind of sorrow is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, steam blasting：Sorrow is escaped in grass input steam blasting tank, 2.0~3.0Mpa of burst pressure, the dwell time maintains 90~120s；
S3, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven；
S4, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed；
S5, alcohol extracting：By the sorrow after above-mentioned processing escape grass, fructus alpiniae oxyphyllae and coix seed input alcohol extraction tank in, use volumetric concentration For 60~80% ethanol solution heating and refluxing extraction, filter, concentration obtains medicinal extract；
S6, immersion：In the medicinal extract that step S4 Radix Glycyrrhizae is added to step S5, soaked 1~2 month with rice wine sealing, every Agitation in 15~20 days is once；
S7, filtering：The soak that step S6 is obtained takes out, and filters, packing.
Further, in the step S2, steam blasting pressure is 2.5Mpa, and the dwell time maintains 100s.
Further, in the step S3, the segmentation baking operation is：First in 180~220 DEG C of oven cooking cycles 25~35 Minute, then it is transferred to 280~320 DEG C of oven cooking cycles, 5~10 points of kinds, then be transferred to 180~220 DEG C of oven cooking cycles 15~20 minutes.
Further, in the step S3, first in 200 DEG C of oven cooking cycles 30 minutes, 300 DEG C of oven cooking cycles 8 are then transferred to Point kind, then be transferred to 200 DEG C of oven cooking cycles 20 minutes.
Further, in the step S4, Radix Glycyrrhizae fills gauze bag after crushing, and heat is steamed 15~25 minutes.
Further, in the step S5, refluxing extraction temperature is 70~80 DEG C, is extracted 3~4 hours.
Further, in the step S6, the number of degrees of rice wine are 15~20 degree.
Further, in the step S6, the mass ratio of rice wine and raw material is 2~3：1.
Following basis《Chinese Pharmacopoeia》、《Dictionary of medicinal plant》And《Chinese draft》Introduce the nature and flavor of primary raw material medicine, return Through basic conditions such as, function and applications.
Sorrow is escaped grass：It is sweet, pungent, slight bitter, mild-natured, enter liver and kidney channel.Complete stool is used as medicine, clearing heat and detoxicating, eliminating stasis to subdue swelling, anti-inflammatory solution Wine etc. is acted on, and can improve systemic blood flow state, strengthens cardiac contractility ability, improves blood pressure, containing abundant protein.
Fructus alpiniae oxyphyllae：It is pungent, warm-natured, returns spleen warp, kidney channel.It is warming spleen and stopping diarrha, saliva is taken the photograph, kidney, astringent sperm contracting urine is warmed up.Let out for malaria Rush down, crymodynia in abdomen, many salivas of mouth, enuresis with renal asthenia, frequent urination, gonorrhoea of passing out semen.
Coix seed：It is sweet, light, cold nature.Returns spleen warp, stomach, lung channel.Sharp water medicine；Excreting dampness diuresis.Suitable for oedema, pin Under gas, dribbling urination, damp-warm diseases, diarrhea band, arthralgia pain due to rheumatism, muscle arteries and veins contraction, lung carbuncle, acute appendicitis, flat wart.
Radix Glycyrrhizae：It is mild-natured, sweet, return 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription. For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate medicine poison It is property, strong.
Beneficial effect：The health liquor collection sorrow of the present invention is escaped grass, fructus alpiniae oxyphyllae, coix seed and Radix Glycyrrhizae plurality of raw materials, is mutually cooperateed with, Antifatigue effect is significantly improved, there is humidification to spleen, thymus gland immune organ, body immunity can be significantly increased； There is the tonifying Qi that takes care of health, tonify the liver and kidney, stimulate circulation etc. effect simultaneously, human body is had no side effect, can long-term taking, Yi Beiren Body absorbs.In addition, the present invention is escaped grass by steam blasting sorrow, the dissolution rate of active ingredient can be increased；By being segmented baking benefit Moisture in intelligence benevolence, coix seed, first paragraph elder generation drying material, then second segment steep temperature rise, make its explosion, enhancing fructus alpiniae oxyphyllae, It is active in coix seed, and stablize its active component under the conditions of the 3rd section of relatively lower temp, effectively improve it living in alcohol extracting The recovery rate of property composition；By crushing Radix Glycyrrhizae, increase Radix Glycyrrhizae fully contacts in follow-up immersion with soak, improves immersion and imitates Really.
Embodiment
The principles and features of the present invention are described below, and illustrated embodiment is served only for explaining the present invention, is not intended to Limit the scope of the present invention.
Embodiment 1
A kind of sorrow is escaped careless health liquor, includes the raw material of following parts by weight：Sorrow escape grass 10 parts, 10 parts of fructus alpiniae oxyphyllae, coix seed 5 Part, 15 parts of Radix Glycyrrhizae.
Embodiment 2
A kind of sorrow is escaped careless health liquor, includes the raw material of following parts by weight：Sorrow escape grass 20 parts, 15 parts of fructus alpiniae oxyphyllae, coix seed 10 Part, 20 parts of Radix Glycyrrhizae.
Embodiment 3
A kind of sorrow is escaped careless health liquor, includes the raw material of following parts by weight：Sorrow escape grass 15 parts, 12 parts of fructus alpiniae oxyphyllae, coix seed 8 Part, 18 parts of Radix Glycyrrhizae.
Sorrow described in above-described embodiment 1~3 is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, steam blasting：Sorrow is escaped in grass input steam blasting tank, burst pressure is 2.5Mpa, the dwell time maintains 100s；
S3, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven, first in 200 DEG C of 30 points of oven cooking cycles Clock, is then transferred to 300 DEG C of oven cooking cycles, 8 points of kinds, then is transferred to 200 DEG C of oven cooking cycles 20 minutes；
S4, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed, Radix Glycyrrhizae fills gauze bag after crushing, heat is steamed 20 minutes；
S5, alcohol extracting：By the sorrow after above-mentioned processing escape grass, fructus alpiniae oxyphyllae and coix seed input alcohol extraction tank in, use volumetric concentration For 75% ethanol solution heating and refluxing extraction, refluxing extraction temperature is 75 DEG C, is extracted 3.5 hours；Filtering, concentration, obtains medicinal extract；
S6, immersion：In the medicinal extract that step S4 Radix Glycyrrhizae is added to step S5, immersion 45 days is sealed with 18 degree of rice wine, often Every agitation in 15 days once；The mass ratio of rice wine and raw material is 2：1；
S7, filtering：The soak that step S6 is obtained takes out, and filters, packing.
Embodiment 4
The difference of the present embodiment and embodiment 3 is, the sorrow is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, steam blasting：Sorrow is escaped in grass input steam blasting tank, burst pressure 2.0Mpa, the dwell time maintains 120s；
S3, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven, first in 180 DEG C of 35 points of oven cooking cycles Clock, is then transferred to 280 DEG C of oven cooking cycles, 10 points of kinds, then is transferred to 180 DEG C of oven cooking cycles 20 minutes；
S4, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed, Radix Glycyrrhizae fills gauze bag after crushing, heat is steamed 15 minutes；
S5, alcohol extracting：By the sorrow after above-mentioned processing escape grass, fructus alpiniae oxyphyllae and coix seed input alcohol extraction tank in, use volumetric concentration For 60% ethanol solution heating and refluxing extraction, refluxing extraction temperature is 70 DEG C, is extracted 4 hours；Filtering, concentration, obtains medicinal extract；
S6, immersion：In the medicinal extract that step S4 Radix Glycyrrhizae is added to step S5, immersion 2 months is sealed with 15 degree of rice wine, often Every agitation in 20 days once；The mass ratio of rice wine and raw material is 2：1；
S7, filtering：The soak that step S6 is obtained takes out, and filters, packing.
Embodiment 5
The difference of the present embodiment and embodiment 3 is, the sorrow is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, steam blasting：Sorrow is escaped in grass input steam blasting tank, burst pressure 3.0Mpa, the dwell time maintains 90s；
S3, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven, first in 220 DEG C of 25 points of oven cooking cycles Clock, is then transferred to 320 DEG C of oven cooking cycles, 5 points of kinds, then is transferred to 220 DEG C of oven cooking cycles 15 minutes；
S4, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed, Radix Glycyrrhizae fills gauze bag after crushing, heat is steamed 25 minutes；
S5, alcohol extracting：By the sorrow after above-mentioned processing escape grass, fructus alpiniae oxyphyllae and coix seed input alcohol extraction tank in, use volumetric concentration For 80% ethanol solution heating and refluxing extraction, refluxing extraction temperature is 80 DEG C, is extracted 3 hours；Filtering, concentration, obtains medicinal extract；
S6, immersion：In the medicinal extract that step S4 Radix Glycyrrhizae is added to step S5, immersion 1 month is sealed with 20 degree of rice wine, often Every agitation in 15 days once；The mass ratio of rice wine and raw material is 3：1；
S7, filtering：The soak that step S6 is obtained takes out, and filters, packing.
Comparative example 1
A kind of sorrow is escaped careless health liquor, includes the raw material of following parts by weight：12 parts of fructus alpiniae oxyphyllae, 8 parts of coix seed, 18 parts of Radix Glycyrrhizae.
The sorrow is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven, first in 200 DEG C of 30 points of oven cooking cycles Clock, is then transferred to 300 DEG C of oven cooking cycles, 8 points of kinds, then is transferred to 200 DEG C of oven cooking cycles 20 minutes；
S3, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed, Radix Glycyrrhizae fills gauze bag after crushing, heat is steamed 20 minutes；
S4, alcohol extracting：Fructus alpiniae oxyphyllae after above-mentioned processing and coix seed are put into alcohol extraction tank, are 75% with volumetric concentration Ethanol solution heating and refluxing extraction, refluxing extraction temperature is 75 DEG C, is extracted 3.5 hours；Filtering, concentration, obtains medicinal extract；
S5, immersion：In the medicinal extract that step S3 Radix Glycyrrhizae is added to step S4, immersion 45 days is sealed with 18 degree of rice wine, often Every agitation in 15 days once；The mass ratio of rice wine and raw material is 2：1；
S6, filtering：The soak that step S5 is obtained takes out, and filters, packing.
Comparative example 2
The difference of comparative example 2 and embodiment 3 is, the sorrow is escaped the preparation method of careless health liquor, is comprised the following steps：
S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
S2, immersion：Each raw material is directly added into jar, is soaked 45 days, was stirred every 15 days with 18 degree of rice wine sealing Once；The mass ratio of rice wine and raw material is 2：1；
S3, filtering：The soak that step S2 is obtained takes out, and filters, packing.
Embodiment 1~5 and comparative example 1~2 are done into mouse animal experiment, including power exhausts swimming test and immune organ The test of organ index and mononuclear-macrophage phagocytic function.
Wherein, power exhausts swimming test investigation mouse movement endurance, and its swimming time length can reflect mouse movement fatigue Degree, swimming time is to evaluate that physical fatigue is important, intuitively index.The organ index of immune organ is to weigh body The initial indication of immunologic function.The phagocytic activity of mononuclear macrophage is the important indicator for weighing body non-specific immune function One of, the size of macrophage carbonic clearance index (K) and phagocytic index (α) can reflect the strong of endothelium network phagocytic function It is weak.
Experimental animal, packet and administration：Mouse：250, male and female half and half, 18~21g of body weight, random packet, if embodiment 1~5, comparative example 1~2, blank control (physiological saline, negative control) and positive controls (pure rice wine), give by every group 10 Medicine body product is 0.2mL/10gd, successive administration 30d.Every group or each experiment set 3 Duplicate Samples, are repeated 3 times, display data For the average value of 9 groups of data.Significance difference analysis (P ＜ 0.05) is carried out using SAS 9.2.
1st, power exhausts swimming test
Through stomach perfusion to mouse, one time a day, continuous 30d, and 60min after administration, mouse is placed in swimming trunk, water every time The mouse of the body weight lead counterweight of root of the tail portion load 5% is placed in swimming trunk by deep 50cm, water temperature (25 ± 0.5 DEG C).Record is swum certainly Start the time that can not be emerged to head whole submerged 10s, as the most long swimming time of mouse, compared with control group Its otherness.
Each experimental group of table 1 is on mouse swimming time influence (X ± SD)
Experimental group Number of animals (only) Swimming time (s)
Positive control 10 385.94±43.25
Negative control 10 421.51±34.32
Embodiment 1 10 678.23 ± 36.82 (*, * *)
Embodiment 2 10 674.65 ± 37.23 (*, * *)
Embodiment 3 10 696.32 ± 35.46 (*, * *)
Embodiment 4 10 683.51 ± 35.63 (*, * *)
Embodiment 5 10 682.23 ± 35.35 (*, * *)
Comparative example 1 10 518.28 ± 55.74 (*, * *)
Comparative example 2 10 604.14 ± 45.96 (*, * *)
Note：* compared with negative control (blank control), there is significant difference (P ＜ 0.05)；* is compared with positive control, There is significant difference (P ＜ 0.01).
As shown in Table 1, compared with negative control, the mouse swimming time of embodiment 1~5 is longer (P ＜ 0.05), performance It is more active, while having stronger significant difference (P ＜ 0.01) with positive controls, as a result show, sorrow of the invention escape grass protect Strong wine can significantly extend mouse swimming time, significantly improve mouse anti-reflecting fatigue ability, show that the sorrow of the present invention is escaped careless health care Wine has antifatigue effect.Wherein, compared with embodiment 1~2, the mouse swimming time of embodiment 3 is most long, shows reality It is preferred proportioning to apply the escape component ratio of careless health liquor of the sorrow of example 3；Compared with embodiment 4~5, the mouse power of embodiment 3 exhausts trip The swimming time is also longer, shows that the escape preparation method of careless health liquor of the sorrow of embodiment 3 is more preferably technological parameter.Embodiment 3 with it is right Ratio 1 is compared, and the mouse swimming time of embodiment 3 is longer, and anti-fatigue ability is relatively strong, illustrate sorrow escape grass with formula in Fructus alpiniae oxyphyllae, coix seed, Radix Glycyrrhizae are combined, and collaboration improves its antifatigue ability；Embodiment 3 is compared with comparative example 2, embodiment 3 Mouse swimming time it is also longer, anti-fatigue ability is also relatively strong, illustrate in preparation method of the invention to raw material Processing, can more preferably extract the active ingredient of each component, effectively improve its antifatigue ability.
2nd, to the influence of mouse immune organ organ index
Through stomach perfusion to mouse, one time a day, continuous 30d, puts to death animal, and dissection weighs spleen, thymic weight, calculates internal organs Index.Spleen or spleen or thymus gland milligram number that chest spleen index is 10g body weight.Spleen index=spleen quality (mg)/weight (g) * 10g, Thymus index=thymic factor D injection (mg)/weight (g) * 10g, its otherness is compared with control group.
Influence (± SD) of each experimental group of table 2 to mouse immune organ organ index
Experimental group Number of animals (only) Spleen weight index (mg/10g) Chest gland weight index (mg/10g)
Negative control 10 52.93±9.58 12.53±0.46
Embodiment 1 10 36.35±1.65* 11.34±0.21*
Embodiment 2 10 36.86±1.53* 11.41±0.23*
Embodiment 3 10 35.37±1.26* 11.21±0.20*
Embodiment 4 10 36.19±1.34* 11.46±0.23*
Embodiment 5 10 37.25±1.69* 11.37±0.24*
Comparative example 1 10 43.63±2.34* 11.95±0.41*
Comparative example 2 10 44.54±2.15* 11.83±0.34*
Note：* compared with negative control (blank control), there is significant difference (P ＜ 0.05).
As shown in Table 2, compared with negative control, the spleen/body weight ratio, thymus gland/body weight ratio to mouse have significantly Difference (P ＜ 0.05), spleen weight index, the chest gland weight index of embodiment 1~5 is more excellent, shows that the sorrow of the present invention is escaped careless health liquor Spleen, thymus gland immune organ to mouse have enhancing effect.Wherein, compared with embodiment 1~2, the spleen of embodiment 3 refers to again Number, chest gland weight index are optimal, further demonstrate that the escape component ratio of careless health liquor of the sorrow of embodiment 3 is preferred proportioning；With implementation Example 4~5 is compared, and the spleen of embodiment 3 weight index, chest gland weight index are more excellent, further demonstrates that the sorrow of embodiment 3 is escaped the system of careless health liquor Preparation Method is more preferably technological parameter.Embodiment 3 compared with comparative example 1, the spleen of embodiment 3 weight index, chest gland weight index compared with Excellent, immunologic function enhancing illustrate that sorrow grass of escaping is combined with fructus alpiniae oxyphyllae, coix seed, Radix Glycyrrhizae in formula, collaboration strengthens its and work(is immunized Energy；Embodiment 3 is compared with comparative example 2, and the spleen weight index of embodiment 3, chest gland weight index are also more excellent, and immunologic function also strengthens, and says Processing in bright preparation method of the invention to raw material, effectively strengthens its immunologic function.
3rd, to the influence of mouse monokaryon macrophage phagocytic function
Through stomach perfusion to mouse, one time a day, continuous 30d, every time 1h, the indian ink of mouse tail vein injection 25% after administration Water 20mL/kg, takes the μ L of blood 20 from right angular vein clump respectively in 1min, 5min after injection, is placed in 3mL 0.1%Na2CO3Solution In, OD values are determined on 722 ultraviolet specrophotometers after mixing under 680nm, calculates and cleaned up in the unit interval index (K), with Control group compares its difference condition；Mouse is taken off into cervical vertebra processing afterwards, liver, spleen are taken respectively, is blotted after blood and weighed with filter paper, is calculated Clean up index (K) and phagocytic index (α).Clean up index (K)=(lgOD1-lgOD5)/(t5-t1), phagocytic index (α)=K1/3× K, α value of body weight/(liver weight+spleen weight), statistics medicine group and control group, and carry out the test of t values.
Influence (X ± SD) of each experimental group of table 3 to mouse monokaryon macrophage carbonic clearance
Experimental group Number of animals (only) Clean up index (K) Phagocytic index (α)
Negative control 10 0.018±0.005 4.463±0.832
Embodiment 1 10 0.041±0.005* 6.629±0.383*
Embodiment 2 10 0.042±0.004* 6.732±0.457*
Embodiment 3 10 0.046±0.002* 6.856±0.125*
Embodiment 4 10 0.043±0.004* 6.673±0.462*
Embodiment 5 10 0.045±0.006* 6.782±0.508*
Comparative example 1 10 0.026±0.009* 5.365±0.549*
Comparative example 2 10 0.034±0.007* 6.057±0.634*
Note：* compared with negative control (blank control), there is significant difference (P ＜ 0.05).
From table 3, relative to negative control, embodiment 1~5 cleans up index and phagocytic index be significantly higher than it is negative right According to, and difference has conspicuousness (P ＜ 0.05), show the present invention sorrow escape careless health liquor can significantly improve clearance in mice index and Phagocytic index, with strengthen immunity effect.Wherein, compared with embodiment 1~2, embodiment 3 cleans up index and phagocytic index It is optimal, further show that the escape component ratio of careless health liquor of the sorrow of embodiment 3 is preferred proportioning；Compared with embodiment 4~5, Embodiment 3 clean up index and phagocytic index is more excellent, further show the sorrow of embodiment 3 escape careless health liquor preparation method be compared with It is preferred that technological parameter.Embodiment 3 compared with comparative example 1, embodiment 3 clean up index and phagocytic index is more excellent, furtherly Bright sorrow grass of escaping is combined with fructus alpiniae oxyphyllae, coix seed, Radix Glycyrrhizae in formula, its immunity of collaboration enhancing；Embodiment 3 and comparative example 2 compare, embodiment 3 clean up index and phagocytic index is also more excellent, immunity also strengthens, further illustrate the present invention system To the processing of raw material in Preparation Method, effectively strengthen its immunity.
In actual applications, sorrow of the invention escape careless health liquor have it is antifatigue, improve immunity function, also with support Body tonifying Qi, the effect such as tonify the liver and kidney, stimulate circulation, are easily absorbed by the body, and long-term taking has no side effect to human body.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, all essences in the present invention God is with principle, and any modifications, equivalent substitutions and improvements done etc. should be included within the scope of protection of the invention.

Claims (10)

  1. The careless health liquor 1. a kind of sorrow is escaped, it is characterised in that include the raw material of following parts by weight：Sorrow is escaped careless 10~20 parts, fructus alpiniae oxyphyllae 10~15 parts, 5~10 parts of coix seed, 15~20 parts of Radix Glycyrrhizae.
  2. The careless health liquor 2. sorrow according to claim 1 is escaped, it is characterised in that include the raw material of following parts by weight：Sorrow is escaped grass 15 parts, 12 parts of fructus alpiniae oxyphyllae, 8 parts of coix seed, 18 parts of Radix Glycyrrhizae.
  3. The preparation method of careless health liquor 3. sorrow according to claim 1 is escaped, it is characterised in that comprise the following steps：
    S1, weigh above-mentioned raw materials respectively by weight, remove the removal of impurity, dust；
    S2, steam blasting：Sorrow is escaped in grass input steam blasting tank, 2.0~3.0Mpa of burst pressure, dwell time maintenance 90~ 120s；
    S3, baking：Fructus alpiniae oxyphyllae, coix seed are put into progress segmentation baking in baking oven；
    S4, crushing：The size-reduced machine of Radix Glycyrrhizae is crushed；
    S5, alcohol extracting：By the sorrow after above-mentioned processing escape grass, fructus alpiniae oxyphyllae and coix seed input alcohol extraction tank in, with volumetric concentration be 60 ~80% ethanol solution heating and refluxing extraction, is filtered, and concentration obtains medicinal extract；
    S6, immersion：In the medicinal extract that step S4 Radix Glycyrrhizae is added to step S5, with rice wine sealing immersion 1~2 month, every 15~ Agitation in 20 days is once；
    S7, filtering：The soak that step S6 is obtained takes out, and filters, packing.
  4. The preparation method of careless health liquor 4. sorrow according to claim 3 is escaped, it is characterised in that in the step S2, steam Burst pressure is 2.5Mpa, and the dwell time maintains 100s.
  5. The preparation method of careless health liquor 5. sorrow according to claim 3 is escaped, it is characterised in that described in the step S3 Operation is toasted in segmentation：First in 180~220 DEG C of oven cooking cycles 25~35 minutes, be then transferred to 280~320 DEG C of oven cooking cycles 5~ 10 points of kinds, then it is transferred to 180~220 DEG C of oven cooking cycles 15~20 minutes.
  6. The preparation method of careless health liquor 6. sorrow according to claim 5 is escaped, it is characterised in that described in the step S3 In step S3, first in 200 DEG C of oven cooking cycles 30 minutes, 300 DEG C of oven cooking cycles, 8 points of kinds are then transferred to, then be transferred to 200 DEG C of baking boxs bakings It is roasting 20 minutes.
  7. The preparation method of careless health liquor 7. sorrow according to claim 3 is escaped, it is characterised in that in the step S4, Radix Glycyrrhizae Gauze bag is filled after crushing, heat is steamed 15~25 minutes.
  8. The preparation method of careless health liquor 8. sorrow according to claim 3 is escaped, it is characterised in that in the step S5, backflow Extracting temperature is 70~80 DEG C, is extracted 3~4 hours.
  9. The preparation method of careless health liquor 9. sorrow according to claim 3 is escaped, it is characterised in that in the step S6, rice wine The number of degrees be 15~20 degree.
  10. The preparation method of careless health liquor 10. sorrow according to claim 3 is escaped, it is characterised in that in the step S6, rice wine Mass ratio with raw material is 2~3：1.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108085227A (en) * 2017-12-29 2018-05-29 广东国方医药科技有限公司 Five leaf flower health care wines of a kind of beauty treatment tranquilizing the mind and preparation method thereof
CN110075187A (en) * 2019-05-17 2019-08-02 安徽省博禾功能食品有限公司 A kind of sorrow is escaped careless wine and preparation method
CN110916241A (en) * 2019-11-20 2020-03-27 许达勇 Nicotine aerosol and preparation method thereof

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* Cited by examiner, † Cited by third party
Title
南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 *
张龙等主编: "《绿色化学》", 31 August 2014, 华中科技大学出版社 *
黄丹民: "鳄嘴花特征活性组分对HepA移植瘤小鼠的抗肿瘤机制与安全性评价的研究", 《中国博士学位论文全文数据库》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108085227A (en) * 2017-12-29 2018-05-29 广东国方医药科技有限公司 Five leaf flower health care wines of a kind of beauty treatment tranquilizing the mind and preparation method thereof
CN110075187A (en) * 2019-05-17 2019-08-02 安徽省博禾功能食品有限公司 A kind of sorrow is escaped careless wine and preparation method
CN110916241A (en) * 2019-11-20 2020-03-27 许达勇 Nicotine aerosol and preparation method thereof

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