CN110903194B - 连续制备伏立康唑中间体2-氟-3-氧戊酸乙酯的方法 - Google Patents
连续制备伏立康唑中间体2-氟-3-氧戊酸乙酯的方法 Download PDFInfo
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- CN110903194B CN110903194B CN201911263105.5A CN201911263105A CN110903194B CN 110903194 B CN110903194 B CN 110903194B CN 201911263105 A CN201911263105 A CN 201911263105A CN 110903194 B CN110903194 B CN 110903194B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
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CN110903194B true CN110903194B (zh) | 2022-02-25 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013066629A1 (en) * | 2011-10-19 | 2013-05-10 | Bioformix, Llc | Methylene beta-ketoester monomers, methods for making methylene beta-ketoester monomers, polymerizable compositions and products formed therefrom |
CN105085522A (zh) * | 2015-10-12 | 2015-11-25 | 山东罗欣药业集团股份有限公司 | 一种高纯度盐酸莫西沙星的制备方法 |
CN105859764A (zh) * | 2016-05-04 | 2016-08-17 | 江苏苏南药业实业有限公司 | 一种莫西沙星重要中间体的制备方法 |
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- 2019-12-11 CN CN201911263105.5A patent/CN110903194B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013066629A1 (en) * | 2011-10-19 | 2013-05-10 | Bioformix, Llc | Methylene beta-ketoester monomers, methods for making methylene beta-ketoester monomers, polymerizable compositions and products formed therefrom |
CN105085522A (zh) * | 2015-10-12 | 2015-11-25 | 山东罗欣药业集团股份有限公司 | 一种高纯度盐酸莫西沙星的制备方法 |
CN105859764A (zh) * | 2016-05-04 | 2016-08-17 | 江苏苏南药业实业有限公司 | 一种莫西沙星重要中间体的制备方法 |
Non-Patent Citations (1)
Title |
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相转移法制备2-氟丙酰乙酸乙酯;吕微巍 等;《中国医药工业杂志》;20061231;第37卷(第2期);第83页 * |
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