CN1108940A - 乳酸软膏 - Google Patents
乳酸软膏 Download PDFInfo
- Publication number
- CN1108940A CN1108940A CN94111688A CN94111688A CN1108940A CN 1108940 A CN1108940 A CN 1108940A CN 94111688 A CN94111688 A CN 94111688A CN 94111688 A CN94111688 A CN 94111688A CN 1108940 A CN1108940 A CN 1108940A
- Authority
- CN
- China
- Prior art keywords
- lactic acid
- ointment
- xeroderma
- carbamide
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 239000004310 lactic acid Substances 0.000 title claims abstract description 19
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 18
- 239000002674 ointment Substances 0.000 title claims abstract description 13
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 25
- 206010021198 ichthyosis Diseases 0.000 claims abstract description 14
- 239000004202 carbamide Substances 0.000 claims abstract description 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 12
- 206010048218 Xeroderma Diseases 0.000 claims abstract description 10
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 4
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 3
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 3
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 3
- 239000003381 stabilizer Substances 0.000 claims abstract description 3
- 235000013877 carbamide Nutrition 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003883 ointment base Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- OIALAIQRYISUEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]e Polymers CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO OIALAIQRYISUEV-UHFFFAOYSA-N 0.000 claims description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 3
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 3
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 3
- 239000003871 white petrolatum Substances 0.000 claims description 3
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000036228 toxication Effects 0.000 abstract 1
- 239000006210 lotion Substances 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 231100000438 skin toxicity Toxicity 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 229930182843 D-Lactic acid Natural products 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007682 dermal toxicity Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- SXQFCVDSOLSHOQ-UHFFFAOYSA-N lactamide Chemical compound CC(O)C(N)=O SXQFCVDSOLSHOQ-UHFFFAOYSA-N 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明提供一种疗效确切持久，安全无刺激，使
用方便舒适，易为患者皆接受的治疗鱼鳞病等皮肤干
燥症的外用乳酸软膏。本软膏以乳酸为主药，加适量
氨水使成盐、尿素为助渗剂，胆固醇等为乳化剂、稳定
剂，掺以抗氧剂及其他辅料组成一个稳定的油包水型
软膏基质。本发明处方设计合理，制剂工艺成熟，拟
定的质量标准能控制产品质量，临床使用效果极佳，
对皮肤无毒性、刺激性和致敏反应，是一种治疗皮肤
干燥症安全有效的制剂，有极好的社会效益和经济效
益。
Description
本发明属皮肤干燥症外用治疗药，具体的说是一种乳酸盐脂。
皮肤干燥症是临床常见的皮肤病的一组症状，可由鱼鳞病，异位性皮炎，皮肤浅部真菌感染及某些工农职业性皮肤病等多种原因引起，中老年人多发。其症状为皮肤干燥，严重者引起皲裂，出血和继发感染。本症疗法较多，但疗效不尽如意。国外文献：“12%乳酸盐洗剂治疗皮肤干燥症-一种双盲临床评价”和“12%乳酸胺洗剂与5%乳酸洗剂治疗中度，重度皮肤干燥的疗效比较”的报道。处方中以乳酸盐为主药，制成洗剂，但洗剂疗效不如软膏持久，用药易流失，造成浪费，并且影响治疗效果。国内对皮肤干燥症的治疗研究多以尿素为主药的霜剂，为水包油型，缺点是尿素不稳定，也有用尿素加凡士林混合，虽解决了尿素不稳定的问题，但油腻性太重，污染衣物，尚未见乳酸制剂的研制报道。
本发明的目的在于提供一种疗效确切持久，安全无刺激，使用方便舒适，易被患者接受的治疗鱼鳞病等皮肤干燥症的优良制剂-乳酸软膏。
乳酸软膏是以乳酸为主药，加适量氨水中和部分乳酸使成盐。尿素为助渗剂，能降低皮肤阻力，使角质层肿胀，因而增加了皮肤的穿透性，增强乳酸疗效，同时尿素可增加角质层含水量，两者配合，临床疗效更佳，而尿素易分解，故选用一些辅料组成油包水型软膏基质，有易洗除，对皮肤表面分泌物有亲和力，不妨碍皮肤功能，润滑作用好，久用无干燥感等特点。选用胆固醇等作乳化剂，稳定剂，二丁基羟基甲苯为抗氧剂，掺以其他辅料组成一个稳定的油包水型的软膏基质。
该乳酸软膏配方是：（重量配比）
乳酸 5-15%， 浓氨水 适量（达到PH4.5-5.5），
尿素 8-12%， 胆固醇 3-5%，
单硬脂酸甘油酯 10-15%， 白凡士林 30-40%，
甘油 8-12%， 油酸 2-4%，
对羟基苯甲酸乙酯 0.01-0.05%，
聚氧乙烯（40）单硬脂酸酯 0.6-1.0%，
二丁基羟基甲苯 0.005-0.05%，
蒸馏水 加至100%。
工艺流程见附图。
本发明的主要优点：本药品处方设计合理，制剂工艺成熟，拟定的质量标准能控制产品质量，经留样观察24个月产品稳定，经动物皮肤毒性试验，刺激性试验及过敏性试验，未见皮肤毒性，刺激性及致敏反应。成品PH值4.5-5.5。临床采用随机双盲研究195例中度和重度皮肤干燥症患者治疗两周，疗效肯定。其中治疗组100例，有效率93%，软膏基质组（对照组1）50例，有效率36%；10%尿素霜组（对照组2）46例，有效率71%。检验具有显著性差异，特别是冬季皮肤、手、足干燥皲裂有特效。故本品是一种治疗皮肤干燥症安全有效的制剂。预期可望有较好的社会效益和经济效益。
附图1 乳酸软膏工艺流程。
实施例：乳酸 100克
浓氨水 适量（达到PH值为4.5）
尿素 100克
胆固醇 30克
单硬脂酸甘油酯 70克
白凡士林 320克
油酸 20克
聚氧乙烯（40）单硬脂酸酯 8克
甘油 100克
对羟基苯甲酸乙酯 1克
蒸馏水 加至1000克
Claims (2)
1、一种治疗鱼鳞病及皮肤干燥症的外用药，乳酸软膏其特征是：以乳酸为主药，加适量氨水使成盐，尿素为助渗剂，胆固醇为乳化剂，稳定剂，二丁基羟基甲苯为抗氧剂，掺以其他辅料组成一个稳定的油包水型软膏基质复方制剂。
2、按权利要求1所说的乳酸软膏其特征是：所述制剂中含乳酸5-15%，浓氨水（调节PH值为4.5-5.5），尿素8-12%，胆固醇3-5%，单硬脂酸甘油酯10-15%，白凡士林30-40%，聚氧乙烯（40）单硬脂酸酯0.6-1.0%，甘油8-12%，对羟基苯甲酸乙酯0.05-0.2%，二丁基羟基甲苯0.005-0.05%，蒸馏水加至100%。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94111688A CN1063631C (zh) | 1994-03-23 | 1994-03-23 | 乳酸软膏 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94111688A CN1063631C (zh) | 1994-03-23 | 1994-03-23 | 乳酸软膏 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1108940A true CN1108940A (zh) | 1995-09-27 |
| CN1063631C CN1063631C (zh) | 2001-03-28 |
Family
ID=5035527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94111688A Expired - Fee Related CN1063631C (zh) | 1994-03-23 | 1994-03-23 | 乳酸软膏 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063631C (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058866C (zh) * | 1996-09-23 | 2000-11-29 | 牛德英 | 一种治疗鳞屑、角化型手足癣、甲癣的药物组合物 |
| CN102657601A (zh) * | 2012-05-18 | 2012-09-12 | 乔风敏 | 一种主治鱼鳞病和皮肤干燥症的外用药配方和工艺 |
| CN105832657A (zh) * | 2016-05-27 | 2016-08-10 | 湖北丽益医药科技有限公司 | 一种复方乳酸乳膏、制备方法及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063820A (zh) * | 1991-01-30 | 1992-08-26 | 樊芝芹 | 灰指甲溶解膏的制造方法 |
| CN1069651A (zh) * | 1991-12-09 | 1993-03-10 | 贺建龙 | 速效伤口愈的生产方法 |
-
1994
- 1994-03-23 CN CN94111688A patent/CN1063631C/zh not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058866C (zh) * | 1996-09-23 | 2000-11-29 | 牛德英 | 一种治疗鳞屑、角化型手足癣、甲癣的药物组合物 |
| CN102657601A (zh) * | 2012-05-18 | 2012-09-12 | 乔风敏 | 一种主治鱼鳞病和皮肤干燥症的外用药配方和工艺 |
| CN105832657A (zh) * | 2016-05-27 | 2016-08-10 | 湖北丽益医药科技有限公司 | 一种复方乳酸乳膏、制备方法及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1063631C (zh) | 2001-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69115909T2 (de) | Verwendung von Phospholipiden zur Herstellung eines topischen Arzneimittels zur Beinflussung des Serumcholesterinspiegels | |
| DE69923987T2 (de) | Synergistische antimikrobielle, dermatologische und ophtahalmologische zubereitung, die ein chlorit und wasserstoffperoxid enthalten | |
| DE60130466T2 (de) | Antipruritische zusammensetzungen und die wundheilung fördernde zusammensetzungen | |
| US5874094A (en) | Cream formulation for topical application | |
| US6022565A (en) | Rhus dermatitis treatment composition and method | |
| DE3032481A1 (de) | Praeparat zur therapeutischen und/oder kosmetischen anwendung an lebewesen | |
| DE60028152T2 (de) | Fester, stabiler und konzentrierter biologisch verdaulicher Komplex von Orthokieselsäure und Prozess zur dessen Herstellung | |
| DE60012230T2 (de) | Verwendung einer oligosaccharide enthaltenden dermatologischen zubereitung zur behandlung von hauterkrankungen | |
| DE60112431T2 (de) | Verwendung von biguanidederivaten zur herstellung eines vernarbungsfördernden medikaments | |
| DE3244321C2 (de) | Zusammensetzung für die weibliche Intimhygiene | |
| JPS6227A (ja) | 皮膚科ならびに眼科用の外傷、潰瘍治療用クリーム剤 | |
| DE602004005455T2 (de) | Verfahren zur behandlung oder prävention von chronischen wunden und komplette nahrungszusammensetzung mit glycin und/oder leucin zur verwendung darin | |
| US4840798A (en) | Astringent gel composition and method for use | |
| CN1063631C (zh) | 乳酸软膏 | |
| EP0476113B1 (de) | Arzneimittel zur behandlung von hyperlipidämie und/oder atherosklerose | |
| GB2210789A (en) | Topical application for skin care | |
| EP0366888B1 (de) | Pharmazeutische Zubereitung zur Behandlung entzündeter Nasenschleimhäute | |
| CN115282101B (zh) | 一种降低猫应激反应的宠物沐浴露及其制备方法 | |
| DE3443242A1 (de) | Glycyrrhizin und einen wirkstoff enthaltendes arzneimittel | |
| DE60124516T2 (de) | Kombination des lezithins mit ascorbinsäure | |
| DE1917283C3 (de) | Herstellung antimikrobieller Präparate | |
| CN115105443A (zh) | 一种具有舒缓、修护作用的组合物及其制备方法、应用 | |
| DE102009052808A1 (de) | Eine Heilsalbe mit mindestens einem homöopathisch verdünnten Mineralsalz | |
| JP2766594B2 (ja) | 皮膚乾燥症、アトピー皮膚症、アレルギー皮膚症、皮膚カビ症緩和剤 | |
| CN1029456C (zh) | 用于外阴的***润滑剂的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HUAXI HOSPITAL ATTACHED TO SICHUAN UNIV. Free format text: FORMER NAME OR ADDRESS: HUAXI MEDICAL UNIVERSITY FIRST AFFILIATED HOSPITAL |
|
| CP03 | Change of name, title or address |
Address after: Capital building, 10 South Telecom street, Chengdu, Sichuan Patentee after: West China Hospital of Sichuan University Address before: No. 37, Guoxue Road, South East of Sichuan, Chengdu Patentee before: The First Affiliated Hospital of West China University of Medical Sciences |
|
| ASS | Succession or assignment of patent right |
Owner name: FUJIAN PACIFIC PHARMACY CO.,LTD. Free format text: FORMER OWNER: HUAXI HOSPITAL ATTACHED TO SICHUAN UNIV. Effective date: 20030919 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20030919 Address after: 362211 Fujian Province, Jinjiang City Industrial Zone, Chendai in culvert Patentee after: Fujian Pacific Pharmaceutical Co.,Ltd. Address before: 610041, high building, 10 South Telecom Street South, Sichuan, Chengdu Patentee before: WEST CHINA HOSPITAL OF SICHUAN University |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CI01 | Publication of corrected invention patent application |
Correction item: Termination of patent right Correct: Patent right False: Termination of patent right Number: 21 Volume: 21 |
|
| ERR | Gazette correction |
Free format text: CORRECT: CESSATION OF PATENT RIGHT; FROM: CESSATION OF PATENT RIGHT TO: EFFECTIVE PATENT |