CN110604295A - 一种复合骨肽及其制备方法 - Google Patents
一种复合骨肽及其制备方法 Download PDFInfo
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- CN110604295A CN110604295A CN201910961260.8A CN201910961260A CN110604295A CN 110604295 A CN110604295 A CN 110604295A CN 201910961260 A CN201910961260 A CN 201910961260A CN 110604295 A CN110604295 A CN 110604295A
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Abstract
本发明提供一种复合骨肽及其制备方法，它包括以下重量份的原料：骨肽浸膏60～70份，大豆蛋白肽5～8份，酪蛋白肽酸钠5～8份，玉竹、黄精和枸杞提取物共10～11份，矿物质元素3～4份，原花青素、叶黄素和白藜芦醇共5～6份，维生素2～3份；它采用具有特定活性功能的牛骨蛋白肽类为主，配以生物活性的植物蛋白肽类及多种微量元素、维生素和特殊植物营养素，通过微生物合成转化与仿胃肠消化酶解提取分离制得，有利于保障产品的自身功效及药疗效果，达到调理人体五脏六腑，提高人体免疫力，整体工艺简便，成本低廉；它广泛适用于骨肽提炼配套使用。
Description
技术领域
本发明涉及一种复合骨肽及其制备方法。
背景技术
随着人们生活质量的逐渐提高，消费观念和健康意识的日益增强，尤其是在现代社会中，由于环境的变化、工作的压力、饮食习惯、缺少锻炼等，导致人们的身体免疫力下降，易疲劳、抗病能力差、人体成亚健康状态；而养生保健的方式很多，包括好的饮食行为习惯，服用保健品以增强体质、提高免疫力等等；因此，除了保持好的饮食行为习惯外，合理服用一定的保健药物，是对于养生保健的一种有益补充。
蛋白质是人的生命基础，人体蛋白质完全来源于食物，而食物中的蛋白质又不能直接被人体吸收利用，必须通过人体胃肠道消化分解成氨基酸或肽才能被小肠道吸收，吸收后的氨基酸或肽通过血液循环***运送到机体各组织器官及组织细胞中合成人体需要的蛋白质包括激素或酶，多余的或未被利用的氨基酸和肽又通过循环***排出到体外；氨基酸或肽在人体中合成蛋白质包括酶与激素须有金属元素和维生素的参与，而蛋白质包括激素或酶的合成能力、活性及原料供应与人体的脏腑机能有密切关系，尤其是脾胃的消化功能更为重要。
发明内容
针对上述情况，本发明的目的在于提供一种复合骨肽及其制备方法，它采用动物骨蛋白肽类为主，配以生物活性的植物蛋白肽类及多种微量元素、维生素和特殊植物营养素，通过微生物合成转化与仿胃肠消化酶解提取分离制得一款具有养身保健的药物，从而达到调理防治亚健康人群身体的目的，配方简单，成本低廉，市场前景广阔，便于推广使用。
为了实现上述目的，一种复合骨肽，它包括以下重量份的原料：骨肽浸膏60～70份，大豆蛋白肽5～8份，酪蛋白肽酸钠5～8份，玉竹、黄精和枸杞提取物共10～11份，矿物质元素3～4份，原花青素、叶黄素和白藜芦醇共5～6份，维生素2～3份。
为了实现方法、效果优化，其进一步的措施是：所述骨肽浸膏包括以下重量份的原料：牛骨40～50份，牛肝和牛肺20～30份，牛血5～10份，山药5～20份，茯苓5～20份。
所述玉竹、黄精和枸杞提取物的重量比为1:1:1。
所述矿物质元素包括硫酸锌、硫酸锰、硫酸镁、有机锗、钼酸钾、酵母硒。
所述维生素包括维生素A、B、C、E、K及叶酸。
本发明还提供一种复合骨肽的制备方法，它包括以下步骤：
①制作骨肽浸膏：将牛骨高温高压脱脂后粉碎，以及分别粉碎牛肝、牛肺、山药和茯苓，按原料重量配比混合、搅拌均匀，接着按重量1:5加入清洁水和1～2％的醋酸和乳酸，在温度120℃、压力0.2Pa的容器内煎煮2-3小时，随后进行粗滤和离心分离，将所得滤液浓缩至稀浸膏，并冷却密封备用；
②制作复合骨肽：将骨肽浸膏，大豆蛋白肽，酪蛋白肽酸钠，玉竹、黄精和枸杞提取物，矿物质元素，原花青素、叶黄素和白藜芦醇，维生素原料按重量配比粉碎后混合，加入原料总重30～50％的清洁水并搅拌均均，加热至100℃保持30～60分钟；随后密闭冷却至35～45℃，植入重量份3～5％的复合菌种(黑曲霉菌、乳酸杆菌、酵母菌)，恒温发酵24～48小时，再加入1倍量纯净水，加热至100℃煎煮1～2小时，随过滤去渣，将所得液体调整PH值至6～7，待冷却至温度为38℃时加入重量份1～2％的胃蛋白酶(活性1:400)，1～2％的胰蛋白酶(活性1:1200)，1～2％木瓜酶，恒温消化12～24小时，再次升温至100℃保持30～60分钟，经滤膜分离，将所得液体分装成每瓶10～50ml的液态复合骨肽，或喷雾干燥分装成每包5g～500g的固态复合骨肽。
本发明相比现有技术所产生的有益效果：
(Ⅰ)本发明利用牛骨的朴骨壮骨之功效；牛肝、牛肺、牛血具有补肝补血养血之功效；山药具有补脾养肺、固肾益精之功效；茯苓具有利水消肺、降血压之功效；黄精具有补气养阴、健脾润肺、益肾之功效；玉竹具有滋养、镇静、強心、降血脂、降血糖的功效；而维生素是维持和调节人体正常代谢的重要物质，矿物质元素是人体骨骼生长、血液必不可缺的微量元素，原花青素、叶黄素和白藜芦醇可改善血液循环；通过各成分的结合达到调理人体五脏六腑，提高人体免疫力，增强体质等功效；
(Ⅱ)本发明采用具有特定活性功能的牛骨蛋白肽类为主，配以生物活性的植物蛋白肽类及多种微量元素、维生素和特殊植物营养素，通过微生物合成转化与仿胃肠消化酶解提取分离制得，有利于保障产品的自身功效及药疗效果，整体工艺简便，成本低廉，具有显著的经济效益和社会效益。
下面结合实施例对本发明作进一步详细说明。
具体实施方式
实施例一：一种复合骨肽，它包括以下重量份的原料：骨肽浸膏70份，大豆蛋白肽5份，酪蛋白肽酸钠5份，玉竹、黄精和枸杞提取物共10份，矿物质元素3份，原花青素、叶黄素和白藜芦醇共5份，维生素2份；所述骨肽浸膏包括以下重量份的原料：牛骨40～50份，牛肝和牛肺20～30份，牛血5～10份，山药5～20份，茯苓5～20份；所述玉竹、黄精和枸杞提取物的重量比为1:1:1；所述矿物质元素包括硫酸锌、硫酸锰、硫酸镁、有机锗、钼酸钾、酵母硒；所述维生素包括维生素A、B、C、E、K及叶酸。
实施例二：一种复合骨肽，它包括以下重量份的原料：骨肽浸膏60份，大豆蛋白肽8份，酪蛋白肽酸钠8份，玉竹、黄精和枸杞提取物共11份，矿物质元素4份，原花青素、叶黄素和白藜芦醇共6份，维生素3份；所述骨肽浸膏包括以下重量份的原料：牛骨40～50份，牛肝和牛肺20～30份，牛血5～10份，山药5～20份，茯苓5～20份；所述玉竹、黄精和枸杞提取物的重量比为1:1:1；所述矿物质元素包括硫酸锌、硫酸锰、硫酸镁、有机锗、钼酸钾、酵母硒；所述维生素包括维生素A、B、C、E、K及叶酸。
实施例三：一种复合骨肽，它包括以下重量份的原料：骨肽浸膏65份，大豆蛋白肽7份，酪蛋白肽酸钠6份，玉竹、黄精和枸杞提取物共10份，矿物质元素4份，原花青素、叶黄素和白藜芦醇共5份，维生素3份；所述骨肽浸膏包括以下重量份的原料：牛骨40～50份，牛肝和牛肺20～30份，牛血5～10份，山药5～20份，茯苓5～20份；所述玉竹、黄精和枸杞提取物的重量比为1:1:1；所述矿物质元素包括硫酸锌、硫酸锰、硫酸镁、有机锗、钼酸钾、酵母硒；所述维生素包括维生素A、B、C、E、K及叶酸。
本发明中复合骨肽的制备方法，它包括以下步骤：
①制作骨肽浸膏：将牛骨高温高压脱脂后粉碎，以及分别粉碎牛肝、牛肺、山药和茯苓，按原料重量配比混合、搅拌均匀，接着按重量1:5加入清洁水和1～2％的醋酸和乳酸，在温度120℃、压力0.2Pa的容器内煎煮2-3小时，随后进行粗滤和离心分离，将所得滤液浓缩至稀浸膏，并冷却密封备用；
②制作复合骨肽：将骨肽浸膏，大豆蛋白肽，酪蛋白肽酸钠，玉竹、黄精和枸杞提取物，矿物质元素，原花青素、叶黄素和白藜芦醇，维生素原料按重量配比粉碎后混合，加入原料总重30～50％的清洁水并搅拌均均，加热至100℃保持30～60分钟；随后密闭冷却至35～45℃，植入重量份3～5％的复合菌种(黑曲霉菌、乳酸杆菌、酵母菌)，恒温发酵24～48小时，再加入1倍量纯净水，加热至100℃煎煮1～2小时，随过滤去渣，将所得液体调整PH值至6～7，待冷却至温度为38℃时加入重量份1～2％的胃蛋白酶(活性1:400)，1～2％的胰蛋白酶(活性1:1200)，1～2％木瓜酶，恒温消化12～24小时，再次升温至100℃保持30～60分钟，经滤膜分离，将所得液体分装成每瓶10～50ml的液态复合骨肽，或喷雾干燥分装成每包5g～500g的固态复合骨肽。
本发明复合骨肽的核心功能成分是：金属硫蛋白复合肽包括钙、铁、锌、硒等，经亚健康状态人群连续食用四周后，发现用户五脏六腑的抵抗力明显提高，身体免疫力显著提高，达到轻身益气，延年益寿的目的，因此本发明产品适合融于日常饮食中。
本发明实施例中产品技术指标检测结果如下：
| 序号 | 技术指标 | 液态复合骨肽 | 固态复合骨肽 |
| 1 | 复合肽 | 2-5％ | 45-65％ |
| 2 | 多糖 | 1-1.5％ | 25-30％ |
| 3 | 原花青素 | 1-1.5‰ | 2.5-3％ |
| 4 | 叶黄素 | 1-1.5‰ | 2.5-3％ |
| 5 | 钙 | 10-30mg/10m | 50-80mg/g |
| 6 | 锌 | 2-5mg/10m | 10-25mg/g |
| 7 | 硒 | 1-2mg/100m | 8-12ug/g |
| 8 | 铁 | 2-5mg/10m | 10-25mg/g |
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，并根据本发明的技术方案及其构思加以等同替换或改变，均应包含在本发明的保护范围之内。
Claims (6)
1.一种复合骨肽，其特征在于包括以下重量份的原料：骨肽浸膏60～70份，大豆蛋白肽5～8份，酪蛋白肽酸钠5～8份，玉竹、黄精和枸杞提取物共10～11份，矿物质元素3～4份，原花青素、叶黄素和白藜芦醇共5～6份，维生素2～3份。
2.根据权利要求1所述复合骨肽，其特征在于所述骨肽浸膏包括以下重量份的原料：牛骨40～50份，牛肝和牛肺20～30份，牛血5～10份，山药5～20份，茯苓5～20份。
3.根据权利要求1所述复合骨肽，其特征在于所述玉竹、黄精和枸杞提取物的重量比为1:1:1。
4.根据权利要求1所述复合骨肽，其特征在于所述矿物质元素包括硫酸锌、硫酸锰、硫酸镁、有机锗、钼酸钾、酵母硒。
5.根据权利要求1所述复合骨肽，其特征在于所述维生素包括维生素A、B、C、E、K及叶酸。
6.一种权利要求1所述复合骨肽的制备方法，其特征在于包括以下步骤：
①制作骨肽浸膏：将牛骨高温高压脱脂后粉碎，以及分别粉碎牛肝、牛肺、山药和茯苓，按原料重量配比混合、搅拌均匀，接着按重量1:5加入清洁水和1～2%的醋酸和乳酸，在温度120℃、压力0.2Pa的容器内煎煮2-3小时，随后进行粗滤和离心分离，将所得滤液浓缩至稀浸膏，并冷却密封备用；
②制作复合骨肽：将骨肽浸膏，大豆蛋白肽，酪蛋白肽酸钠，玉竹、黄精和枸杞提取物，矿物质元素，原花青素、叶黄素和白藜芦醇，维生素原料按重量配比粉碎后混合，加入原料总重30～50%的清洁水并搅拌均均，加热至100℃保持30～60分钟；随后密闭冷却至35～45℃，植入重量份3～5%的复合菌种(黑曲霉菌、乳酸杆菌、酵母菌)，恒温发酵24～48小时，再加入1倍量纯净水，加热至100℃煎煮1～2小时，随过滤去渣，将所得液体调整PH值至6～7，待冷却至温度为38℃时加入重量份1～2%的胃蛋白酶(活性1:400)，1～2%的胰蛋白酶(活性1:1200)，1～2%木瓜酶，恒温消化12～24小时，再次升温至100℃保持30～60分钟，经滤膜分离，将所得液体分装成每瓶10～50ml的液态复合骨肽，或喷雾干燥分装成每包5g～500g的固态复合骨肽。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387393A (zh) * | 2020-05-07 | 2020-07-10 | 北京维泰力特生物医药有限公司 | 一种含有小分子肽、白藜芦醇和花青素的饮料及其制备方法 |
| CN114081188A (zh) * | 2021-12-02 | 2022-02-25 | 丛志甲 | 一种骨肽复合食品的组方及制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0416165A (ja) * | 1990-05-08 | 1992-01-21 | Snow Brand Milk Prod Co Ltd | 骨強化食品、飼料または骨関節疾患予防治療薬 |
| CN105767828A (zh) * | 2016-04-14 | 2016-07-20 | 王中华 | 一种骨肽饮品配方及其制备方法 |
| CN108967800A (zh) * | 2018-08-13 | 2018-12-11 | 蔡艳霞 | 一种功能性固体饮料及其制备方法 |
| CN109744543A (zh) * | 2019-01-09 | 2019-05-14 | 长沙市惠瑞生物科技有限公司 | 一种骨胶原蛋白肽复合粉及其制备方法 |
-
2019
- 2019-10-11 CN CN201910961260.8A patent/CN110604295A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0416165A (ja) * | 1990-05-08 | 1992-01-21 | Snow Brand Milk Prod Co Ltd | 骨強化食品、飼料または骨関節疾患予防治療薬 |
| CN105767828A (zh) * | 2016-04-14 | 2016-07-20 | 王中华 | 一种骨肽饮品配方及其制备方法 |
| CN108967800A (zh) * | 2018-08-13 | 2018-12-11 | 蔡艳霞 | 一种功能性固体饮料及其制备方法 |
| CN109744543A (zh) * | 2019-01-09 | 2019-05-14 | 长沙市惠瑞生物科技有限公司 | 一种骨胶原蛋白肽复合粉及其制备方法 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387393A (zh) * | 2020-05-07 | 2020-07-10 | 北京维泰力特生物医药有限公司 | 一种含有小分子肽、白藜芦醇和花青素的饮料及其制备方法 |
| CN111387393B (zh) * | 2020-05-07 | 2022-09-20 | 北京维泰力特生物医药有限公司 | 一种含有小分子肽、白藜芦醇和花青素的饮料及其制备方法 |
| CN114081188A (zh) * | 2021-12-02 | 2022-02-25 | 丛志甲 | 一种骨肽复合食品的组方及制备方法 |
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