CN110366560A - 抗b7-h4抗体、其抗原结合片段及其医药用途 - Google Patents
抗b7-h4抗体、其抗原结合片段及其医药用途 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
一种抗B7‑H4的抗体、其抗原结合片段及其医药用途。一种包含所述抗B7‑H4抗体CDR区的嵌合抗体、人源化抗体，以及包含抗B7‑H4抗体及其抗原结合片段的药物组合物，以及其作为抗癌药物的用途。一种人源化的抗B7‑H4抗体，及其在制备用于治疗B7‑H4介导的疾病或病症的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (34)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310820681.5A CN116693686A (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810142118 | 2018-02-11 | ||
| CN2018101421186 | 2018-02-11 | ||
| PCT/CN2019/074397 WO2019154315A1 (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202310820681.5A Division CN116693686A (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
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| Publication Number | Publication Date |
|---|---|
| CN110366560A true CN110366560A (zh) | 2019-10-22 |
| CN110366560B CN110366560B (zh) | 2023-07-28 |
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| CN201980001361.9A Active CN110366560B (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
| CN202310820681.5A Pending CN116693686A (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202310820681.5A Pending CN116693686A (zh) | 2018-02-11 | 2019-02-01 | 抗b7-h4抗体、其抗原结合片段及其医药用途 |
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| Country | Link |
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| US (1) | US11472882B2 (zh) |
| EP (1) | EP3753951A4 (zh) |
| JP (2) | JP7393337B2 (zh) |
| KR (1) | KR20200119846A (zh) |
| CN (2) | CN110366560B (zh) |
| AU (1) | AU2019218319A1 (zh) |
| BR (1) | BR112020015736A2 (zh) |
| CA (1) | CA3089246A1 (zh) |
| MX (1) | MX2020008181A (zh) |
| TW (1) | TWI823895B (zh) |
| WO (1) | WO2019154315A1 (zh) |
| ZA (1) | ZA202004701B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022039490A1 (en) * | 2020-08-18 | 2022-02-24 | Abl Bio, Inc. | Anti-b7-h4/anti-4-1bb bispecific antibodies and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112351797B (zh) * | 2019-06-06 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 抗b7-h4抗体-药物偶联物及其医药用途 |
| BR112023013263A2 (pt) | 2021-01-04 | 2023-12-12 | Mersana Therapeutics Inc | Conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmos |
| MX2023011310A (es) | 2021-03-26 | 2023-10-05 | Innate Pharma | Anclajes de citocina para proteinas de celulas nk de union a nkp46. |
| BR112023025331A2 (pt) | 2021-06-09 | 2024-02-27 | Innate Pharma | Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| WO2023283345A1 (en) * | 2021-07-07 | 2023-01-12 | Incyte Corporation | Anti-b7-h4 antibodies and uses thereof |
| AR127806A1 (es) * | 2021-12-01 | 2024-02-28 | Kadmon Corp Llc | Anticuerpos b7-h4 y proteínas de fusión de anticuerpo b7-h4 / il-15 |
| TW202342516A (zh) * | 2021-12-23 | 2023-11-01 | 愛爾蘭商普羅希那生物科學有限公司 | 識別分選蛋白的抗體 |
| WO2023186015A1 (zh) * | 2022-03-30 | 2023-10-05 | 映恩生物制药（苏州）有限公司 | B7h4抗体药物偶联物及其用途 |
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| WO2013025779A1 (en) * | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
| CN103981150A (zh) * | 2014-03-28 | 2014-08-13 | 苏州大学 | 抗人b7-h4单克隆抗体及其制备和应用 |
| WO2019169212A1 (en) * | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
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| US20030091580A1 (en) * | 2001-06-18 | 2003-05-15 | Mitcham Jennifer L. | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6858710B2 (en) * | 1998-12-17 | 2005-02-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| CL2008003526A1 (es) * | 2007-11-30 | 2010-01-11 | Medarex Inc | Conjugado de anticuerpo-molécula asociada que comprende un anticuerpo monoclonal humano anti b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8 humana; composición que lo comprende; método in vitro de inhibición de célula tumoral que expresa b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8; y uso para tratar cancer. |
| CA2894879A1 (en) * | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | B7-h4 specific antibodies, and compositions and methods of use thereof |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| BR112015022019A2 (pt) * | 2013-03-14 | 2017-08-29 | Genentech Inc | Anticorpos isolados, ácido nucleico, célula hospedeira, método de produção de anticorpos, imunoconjugado, formulação farmacêutica, métodos de tratamento de indivíduos, de inibição da proliferação de células, de detecção de b7-h4 humano e de detecção de câncer |
| CN113698488A (zh) * | 2014-09-12 | 2021-11-26 | 基因泰克公司 | 抗-b7-h4抗体及免疫缀合物 |
| EP3274369A4 (en) * | 2015-03-27 | 2018-10-17 | University of Southern California | Car t-cells for the treatment of b7-h4 expressing solid tumors |
| CN107299085B (zh) * | 2017-05-26 | 2020-09-29 | 广东医科大学 | 分泌抗人b7-h4胞外单克隆抗体杂交瘤细胞株和抗人b7-h4单克隆抗体及其应用 |
| KR102227515B1 (ko) | 2018-12-18 | 2021-03-12 | 주식회사 포스코 | 제올라이트 및 그 제조방법 |
-
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- 2019-02-01 AU AU2019218319A patent/AU2019218319A1/en active Pending
- 2019-02-01 CA CA3089246A patent/CA3089246A1/en active Pending
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- 2019-02-01 EP EP19750949.0A patent/EP3753951A4/en active Pending
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- 2019-02-01 CN CN202310820681.5A patent/CN116693686A/zh active Pending
- 2019-02-01 WO PCT/CN2019/074397 patent/WO2019154315A1/zh unknown
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Patent Citations (3)
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|---|---|---|---|---|
| WO2013025779A1 (en) * | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
| CN103981150A (zh) * | 2014-03-28 | 2014-08-13 | 苏州大学 | 抗人b7-h4单克隆抗体及其制备和应用 |
| WO2019169212A1 (en) * | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022039490A1 (en) * | 2020-08-18 | 2022-02-24 | Abl Bio, Inc. | Anti-b7-h4/anti-4-1bb bispecific antibodies and use thereof |
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| EP3753951A4 (en) | 2022-03-16 |
| RU2020124155A (ru) | 2022-03-11 |
| TW201934581A (zh) | 2019-09-01 |
| US20210032347A1 (en) | 2021-02-04 |
| TWI823895B (zh) | 2023-12-01 |
| EP3753951A1 (en) | 2020-12-23 |
| CN110366560B (zh) | 2023-07-28 |
| BR112020015736A2 (pt) | 2020-12-08 |
| CN116693686A (zh) | 2023-09-05 |
| WO2019154315A1 (zh) | 2019-08-15 |
| MX2020008181A (es) | 2020-09-18 |
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| JP2021513331A (ja) | 2021-05-27 |
| KR20200119846A (ko) | 2020-10-20 |
| CA3089246A1 (en) | 2019-08-15 |
| US11472882B2 (en) | 2022-10-18 |
| JP2024026132A (ja) | 2024-02-28 |
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