BR112023013263A2 - Conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmos - Google Patents
Conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmosInfo
- Publication number
- BR112023013263A2 BR112023013263A2 BR112023013263A BR112023013263A BR112023013263A2 BR 112023013263 A2 BR112023013263 A2 BR 112023013263A2 BR 112023013263 A BR112023013263 A BR 112023013263A BR 112023013263 A BR112023013263 A BR 112023013263A BR 112023013263 A2 BR112023013263 A2 BR 112023013263A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- methods
- drug conjugates
- conjugates targeting
- targeting
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title abstract 2
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 title 1
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 239000012502 diagnostic product Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- Pulmonology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmos. a presente invenção refere-se, de forma geral, a conjugados de anticorpo-fármaco compreendendo anticorpos monoclonais que se ligam especificamente ao b7-h4 humano na forma solúvel, ou ligados à membrana (isto é, quando expressos na superfície celular) e a métodos de uso desses conjugados como produtos terapêuticos e/ou diagnósticos.
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US202163133707P | 2021-01-04 | 2021-01-04 | |
US202163172968P | 2021-04-09 | 2021-04-09 | |
PCT/US2022/011119 WO2022147532A1 (en) | 2021-01-04 | 2022-01-04 | B7h4-targeted antibody-drug conjugates and methods of use thereof |
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CA3203721A1 (en) | 2021-01-04 | 2022-07-07 | Timothy B. Lowinger | B7h4-targeted antibody-drug conjugates and methods of use thereof |
WO2023225559A1 (en) | 2022-05-17 | 2023-11-23 | Mersana Therapeutics, Inc. | B7-h4-targeted antibody-drug conjugates for the treatment of cancer |
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EP4271713A1 (en) | 2023-11-08 |
CO2023010206A2 (es) | 2023-08-09 |
AU2022205057A1 (en) | 2023-07-13 |
TW202241954A (zh) | 2022-11-01 |
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US11964024B2 (en) | 2024-04-23 |
MX2023008000A (es) | 2023-07-13 |
US20220233707A1 (en) | 2022-07-28 |
KR20230137339A (ko) | 2023-10-04 |
CL2023001966A1 (es) | 2024-02-09 |
CA3203721A1 (en) | 2022-07-07 |
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