CN110320293A - 一种测定苯酞类化合物中残留溶剂的方法 - Google Patents
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Abstract
Description
名称 | 丁苯酞称样量mg | 本底量ug | 加入量ug | 测得量ug | 回收率% |
正庚烷 | 1024.7 | 0 | 4995 | 3745 | 75.0 |
名称 | 丁苯酞称样量mg | 本底量ug | 加入量ug | 测得量ug | 回收率% |
正庚烷 | 1011.2 | 0 | 4866 | 3193 | 65.6 |
名称 | 丁苯酞称样量mg | 本底量ug | 加入量ug | 测得量ug | 回收率% |
正庚烷 | 1024.6 | 0 | 4906 | 4293 | 87.5 |
名称 | 甲醇 | 乙腈 | 二氯甲烷 | 乙酸乙酯 | 四氢呋喃 |
平均回收率% | 103.2 | 102.9 | 104.9 | 100.1 | 95.1 |
RSD% | 3.66 | 3.55 | 4.37 | 3.96 | 3.76 |
名称 | A-样1 | A-样2 | A-样3 | A-样4 | A-样5 | A-样6 | A平均 | RSD% |
甲醇 | 358.12 | 331.4 | 333.71 | 360.67 | 323.18 | 320.34 | 337.90 | 5.15 |
乙腈 | 69.55 | 63.96 | 64.21 | 69.74 | 61.66 | 61.58 | 65.12 | 5.65 |
二氯甲烷 | 50.58 | 45.5 | 46.6 | 50.63 | 44.65 | 43.75 | 46.95 | 6.35 |
乙酸乙酯 | 1427.56 | 1274.19 | 1309.58 | 1424.17 | 1258.68 | 1222.91 | 1319.52 | 6.59 |
四氢呋喃 | 381.67 | 340.78 | 352.02 | 381.29 | 338.72 | 327.5 | 353.66 | 6.48 |
正庚烷 | 10250.02 | 9141.65 | 9521.74 | 10213.49 | 9206.62 | 8793.86 | 9521.23 | 6.27 |
名称 | 甲醇% | 乙腈% | 二氯甲烷% | 乙酸乙酯% | 四氢呋喃% | 正庚烷% |
丁苯酞样品1 | 未检出 | 未检出 | 未检出 | 未检出 | 未检出 | 0.00007 |
丁苯酞样品2 | 未检出 | 未检出 | 未检出 | 0.003 | 未检出 | 0.0004 |
丁苯酞样品3 | 未检出 | 未检出 | 未检出 | 0.001 | 未检出 | 0.0001 |
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Cited By (12)
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CN111289654A (zh) * | 2020-03-19 | 2020-06-16 | 陕西省食品药品监督检验研究院 | 一种盐酸尼卡地平原料中甲醇、丙酮、三氯甲烷和甲苯四种残留溶剂的检测方法 |
CN111351874A (zh) * | 2020-03-16 | 2020-06-30 | 山东省药学科学院 | 一种异丁司特原料药中残留溶剂的检测方法 |
CN111855837A (zh) * | 2020-06-29 | 2020-10-30 | 武汉九州钰民医药科技有限公司 | 一种头孢噻肟钠中残留溶剂的检测方法及应用 |
CN112557531A (zh) * | 2020-11-27 | 2021-03-26 | 衢州康鹏化学有限公司 | 一种顶空气相色谱检测硫酸乙烯酯中残留溶剂的方法 |
CN112684044A (zh) * | 2020-12-17 | 2021-04-20 | 山东省药学科学院 | 一种拉帕替尼原料药中残留溶剂的检测方法 |
CN112730685A (zh) * | 2020-12-28 | 2021-04-30 | 浙江工业大学 | 一种乙酸乙酯和石油醚混合溶剂的回收与分析测试方法 |
CN112964813A (zh) * | 2019-12-13 | 2021-06-15 | 金陵药业股份有限公司 | 一种盐酸法舒地尔中有机溶剂残留量的测定方法 |
CN113607843A (zh) * | 2021-07-30 | 2021-11-05 | 河北省药品医疗器械检验研究院(河北省化妆品检验研究中心) | 一种检测西罗莫司原料药中残留溶剂的方法 |
CN113960229A (zh) * | 2021-10-22 | 2022-01-21 | 云南中烟工业有限责任公司 | 一种烟用爆珠精油中甲醇含量的测定方法 |
CN114216992A (zh) * | 2021-12-27 | 2022-03-22 | 兰晟生物医药(苏州)有限公司 | 顶空气相色谱法测定左旋盐酸去甲基苯环壬酯中残留溶剂的方法 |
CN114965791A (zh) * | 2022-06-14 | 2022-08-30 | 江苏慧聚药业股份有限公司 | 一种顶空气相色谱法测定普乐沙福中残留的方法 |
CN115097027A (zh) * | 2022-06-08 | 2022-09-23 | 河北常山生化药业股份有限公司 | 枸橼酸西地那非原料药中残留溶剂的气相色谱检测方法 |
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CN114216992A (zh) * | 2021-12-27 | 2022-03-22 | 兰晟生物医药(苏州)有限公司 | 顶空气相色谱法测定左旋盐酸去甲基苯环壬酯中残留溶剂的方法 |
CN115097027A (zh) * | 2022-06-08 | 2022-09-23 | 河北常山生化药业股份有限公司 | 枸橼酸西地那非原料药中残留溶剂的气相色谱检测方法 |
CN114965791A (zh) * | 2022-06-14 | 2022-08-30 | 江苏慧聚药业股份有限公司 | 一种顶空气相色谱法测定普乐沙福中残留的方法 |
CN114965791B (zh) * | 2022-06-14 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 一种顶空气相色谱法测定普乐沙福中残留的方法 |
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