CN110227084A - Medical anti-x-ray radiation disinfecting gel and preparation method thereof - Google Patents
Medical anti-x-ray radiation disinfecting gel and preparation method thereof Download PDFInfo
- Publication number
- CN110227084A CN110227084A CN201910599190.6A CN201910599190A CN110227084A CN 110227084 A CN110227084 A CN 110227084A CN 201910599190 A CN201910599190 A CN 201910599190A CN 110227084 A CN110227084 A CN 110227084A
- Authority
- CN
- China
- Prior art keywords
- ray radiation
- medical anti
- disinfecting gel
- powder
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention discloses a kind of medical anti-x-ray radiation disinfecting gels and preparation method thereof, the medical anti-x-ray radiation disinfecting gel consists of the following compositions by mass percentage: ethyl alcohol 40%~60%, triclosan 0.1%~1.0%, barium sulfate 30%~58%, zinc oxide 0%~9%, titanium dioxide 0%~9%, thickener 0.1%~1.0%, skin care moisturizer 0.1%~1.0%.Preparation method includes: 1) procedure for preparation；2) sterilization process；3) mixed processes: disinfecting gel and radiation protection particle are sufficiently mixed in an aseptic environment, are stirred 0.5~3 hour, are obtained medical anti-x-ray radiation disinfecting gel.The present invention organically combines the particle with radiation proof function with disinfectant, so that whole process reduces x-ray radiation to operator not by the harm of protective garment protection zone while reaching hand disinfection in surgical procedure.
Description
Technical field
The present invention relates to a kind of anti-x-ray radiation gels, particularly relate to the medical anti-x-ray radiation disinfecting gel of one kind and its preparation
Method.
Background technique
Demand with the development and many patients of modern medical techniques to minimally-invasive treatment, intervention operation have become clinical doctor
The important component in work is treated, the total quantity of all kinds of intervention operations presents geometric growth in world wide in recent years.
By the interventions such as cardiovascular and cerebrovascular disease, tumor embolism, all kinds of radiographies operation for, patient's whole process all under the perspective of C arm machine x-ray,
Carry out fine surgical procedure.X-ray is mainly radiation injury to the injury of human body, and Toluidine blue O medical personnel is often due to long
Time contact with X-ray and have a negative impact to its health.At the same time, with the rapid growth of current intervention amount for surgical, operation
The harm of X-ray radiation suffered by the occupational staffs such as doctor, nurse, technician has become very important in Minimally Interventional Therapy ask
Topic.
Currently, lead shield, protective glass are generally leaned in intervention operation, and it is worn on x-ray protection clothing with patient, protection
Skirt etc., to reduce injury of the x-ray radiation to medical personnel as far as possible.However, for the patient hand nearest away from x-ray transmitting bulb
Portion and forearm, upper arm region, the blind area often protected, and x-ray can be penetrated from side to trunk through patient's upper arm.There is research
Show to intervene worker's side hand skin irradiation integral dose close from radioactive source up to 120-1400mGy, has pole to health
It is big to influence.The often heavier mass however, traditional anti-x-ray radiation lead is tucked inside the sleeve, and the accurate operation of patient can be hindered when wearing, it influences
Surgical procedure, therefore it is difficult to large-scale promotion in clinical application.
Summary of the invention
It can reduce x-ray radiation the purpose of the present invention is to provide one kind and injure and have both the medical of skin degerming effect and prevent
X-ray radiation disinfecting gel and preparation method thereof.
To achieve the above object, medical anti-x-ray radiation disinfecting gel provided by the present invention, by mass percentage by following
At being grouped as: ethyl alcohol 40%~60%, triclosan 0.1%~1.0%, barium sulfate 30%~58%, zinc oxide 0%~9%, two
Titanium oxide 0%~9%, thickener 0.1%~1.0%, skin care moisturizer 0.1%~1.0%.Preferred mass percentage are as follows: second
Alcohol 40%~50%, triclosan 0.2%~0.3%, barium sulfate 45%~58%, zinc oxide 1%~4%, titanium dioxide 1%~
4%, thickener 0.1%~0.5%, skin care moisturizer 0.5%~1.0%.
The each component effect of the medical anti-x-ray radiation disinfecting gel is as follows:
1) ethyl alcohol, triclosan can quickly kill escherichia coli, Candida albicans, golden yellow glucose coccus, Pseudomonas aeruginosa
Equal multiple-microorganisms, it is contemplated that the requirement of bactericidal effect broad spectrum activity and its stability between radiation protection particle, in gel
Disinfection composition selects ethyl alcohol and triclosan.
2) ultra-fine barium sulfate, zinc oxide (optional), titanium oxide are (optional) has chemical characteristic relatively stable, to human skin
The features such as nontoxic, safe and non-stimulating.Barium sulfate has the ability of good anti-x-ray radiation, and which constitute the masters of disinfecting gel
Will anti-radiation components, thus play effectively prevent scattering x-ray be transmitted through the regions such as patient's hand, forearm, upper arm.Titanium oxide and
Zinc oxide has the characteristic of certain radiation protection and reflective portion ray, in combination with zinc oxide its to skin have convergence, moisturizing,
The effects of skin care, adds titanium oxide, zinc oxide in ultra-fine barium sulfate particle, to reach radiation protection after making three kinds of ingredient mixing
Coordination enhancement effect.
3) use of thickener can effectively prevent splash and the drippage of disinfectant, while disinfecting gel also not can be improved clearly not
Stick greasy feel and stability；Skin care moisturizer can effectively protect the hand skin of patient, is further reduced long-time service disinfection
Stimulation and adverse effect of the ingredient to hand skin.
Preferably, the barium sulfate, zinc oxide and titanium dioxide are all made of superfine nano powder, i.e., the partial size of three is in 1 μ
M mass fraction below is >=90%.It selects superfines that it can be made stronger to the protective capacities of x-ray radiation, while can also make
Gel is more evenly distributed when smearing skin.
Preferably, the thickener is Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, card
One of wave nurse ULTREZ21 or a variety of.
Preferably, the skin care moisturizer is sorbierite, butanediol, dipropylene glycol, one in isopropyl myristate
Kind is a variety of.
Invention also provides the preparation methods of aforementioned medical anti-x-ray radiation disinfecting gel, it is characterised in that: including such as
Lower step:
1) procedure for preparation: barium sulfate powder, Zinc oxide powder and titania powder are dried and dehydrated respectively, ground
Mill, and 12500 meshes are crossed, make each powder in 1 μm of mass fraction >=90% below；
2) sterilization process: ultra-fine barium sulfate powder, Zinc oxide powder, titania powder are respectively charged into sterile chamber
High-temperature sterilization is carried out, thoroughly to its natural cooling after sterilizing；
3) mixed processes: ethyl alcohol, triclosan, thickener and skin care moisturizer are sufficiently mixed and are prepared by mass percentage
Disinfecting gel, at the same barium sulfate powder, Zinc oxide powder, titania powder be sufficiently mixed by mass percentage be prepared into it is anti-
Disinfecting gel and radiation protection particle are sufficiently mixed by radiation particle in an aseptic environment, are stirred 0.5~3 hour, are obtained medical anti-
X-ray radiation disinfecting gel.
Preferably, in step 1), drying and dehydrating temperature is 150 ± 10 DEG C, and the time is 12 ± 2h.
Preferably, in step 2), sterilising temp is 200~250 DEG C, and the time is 2~3 hours.
Compared with prior art, the beneficial effects of the present invention are:
1) particle with radiation proof function is organically combined with disinfectant, to reach hand disinfection in surgical procedure
Meanwhile whole process reduces x-ray radiation to operator not by the harm of protective garment protection zone.
2) the radiation protection disinfecting gel is for traditional radiation-proof oversleeve, lighter and do not influence the fine behaviour that performs the operation
Make, the function of hand disinfection has been taken into account while radiation protection, is easier to be widely applied in clinical position.
3) the radiation protection disinfecting gel is nontoxic to patient's skin to have no stimulation without toxic metals such as lead.
4) present invention proposes medical anti-this completely new product of x-ray radiation disinfecting gel in a creative way, which has both outer
The double effects of section disinfection and anti-x-ray radiation, it is convenient to be applicable in, and protection effect is good, provides for vast Toluidine blue O medical personnel
More fully occupational protection.
Detailed description of the invention
Fig. 1 is to penetrate to be coated with the X-ray spoke after the artificial skin of each embodiment and comparative example gel at away from transmitting tube 1.5m
Penetrate dosage histogram.
Fig. 2 is to penetrate to be coated with the X-ray spoke after the artificial skin of each embodiment and comparative example gel at away from transmitting tube 2.0m
Penetrate dosage histogram.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
Embodiment 1~15
Medical anti-x-ray radiation disinfecting gel, consists of the following compositions: ethyl alcohol by mass percentage provided by each embodiment
40%~60%, triclosan 0.1%~1.0%, barium sulfate 30%~58%, zinc oxide 0%~9%, titanium dioxide 0%~
9%, thickener 0.1%~1.0%, skin care moisturizer 0.1%~1.0%, see Table 1 for details for specific proportion.In view of thickener and shield
Skin moisturizer influences very little to properties of product, and in each embodiment, thickener is all made of Acritamer 940, and skin care moisturizer is all made of
Sorbierite.
Above-mentioned medical anti-x-ray radiation disinfecting gel, is prepared using following steps:
1) procedure for preparation: by barium sulfate powder, Zinc oxide powder (optional, to be free of the component when being 0% in table 1) and dioxy
To change titanium powder (optional, to be free of the component when being 0% in table 1) to be dried and dehydrated respectively, drying and dehydrating temperature is 150 DEG C, when
Between be 12, then ground respectively, cross 12500 meshes, make each powder in 1 μm of mass fraction >=95% below；
2) sterilization process: ultra-fine barium sulfate powder, Zinc oxide powder, titania powder are respectively charged into sterile chamber
High-temperature sterilization is carried out, sterilising temp is 200 DEG C, and the time is 3 hours, thoroughly to its natural cooling after sterilizing；
3) mixed processes: ethyl alcohol, triclosan, thickener and skin care moisturizer are sufficiently mixed and are prepared by mass percentage
Disinfecting gel, at the same barium sulfate powder, Zinc oxide powder, titania powder be sufficiently mixed by mass percentage be prepared into it is anti-
Disinfecting gel and radiation protection particle are sufficiently mixed by radiation particle in an aseptic environment, are stirred 2 hours, are obtained medical anti-x-ray spoke
Penetrate disinfecting gel.
Each embodiment of table 1, comparative example component formula table
Comparative example 1~2
Comparative example 1~2 is common disinfecting gel, and concrete component and proportion are shown in Table 1.
Test example
1) bactericidal effect is tested
The practical disinfection and sterilization of the disinfecting gel of anti-x-ray radiation disinfecting gel and comparative example to the above various embodiments preparation
Effect is tested, and takes the gel of each embodiment of 10ml, comparative example preparation mixed to configured corresponding bacteria suspension 0.5ml respectively
Even, effect samples to be seeded in culture dish afterwards to the predetermined time (being shown in Table 2) cultivates, and calculates clump count and killing rate, assesses it
Bactericidal effect, acquired results see the table below 2.
Each embodiment comparative example gelatification of table 2 is in the bactericidal effect of different microorganisms
2) radiation-proof effect is tested
The practical radiation protection effect of the disinfecting gel of anti-x-ray radiation disinfecting gel and comparative example to the above various embodiments preparation
Fruit is tested, by intervening operating room contrast machine (U.S. GE medical blood vessel radiography X-ray production apparatus in simulation surgical procedure
Innova IGS 540) operator (at transmitting tube 1.5m) and assistant by x-ray transmitting tube position (at transmitting tube 2.0m),
Under the environment such as same illumination time, transmitted intensity (rated tube voltage 125kV, rated tube current 1000mA), measurement is each respectively
After group is applied to artificial skin above, the x-ray radiation dosage penetrated under area coverage, to detect the anti-x-ray of radiation protection disinfecting gel
Radiation effect, acquired results are shown in Fig. 1 (at transmitting tube 1.5m) and Fig. 2 respectively (at transmitting tube 2.0m).
3) test result analysis
From table 2 it can be seen that anti-x-ray radiation disinfecting gel prepared by various embodiments of the present invention, can effectively kill large intestine
The microorganisms such as angstrom uncommon bacterium, staphylococcus aureus and Candida albicans, have reached the standard of " disinfection technology standard ", Disinfection Effect
Reliably.
It can be seen that anti-x-ray radiation disinfecting gel prepared by various embodiments of the present invention from Fig. 1 and Fig. 2, penetrated in test
X-ray radiation dosage be significantly lower than each comparative example, not increasing patient's hand weight bearing sense and under the premise of do not influence accurate operation,
Achieve the effect that effective protection x-ray radiation, provides more fully occupational protection for vast Toluidine blue O medical personnel.
Claims (8)
1. a kind of medical anti-x-ray radiation disinfecting gel, it is characterised in that: consist of the following compositions by mass percentage: ethyl alcohol
40%~60%, triclosan 0.1%~1.0%, barium sulfate 30%~58%, zinc oxide 0%~9%, titanium dioxide 0%~
9%, thickener 0.1%~1.0%, skin care moisturizer 0.1%~1.0%.
2. medical anti-x-ray radiation disinfecting gel according to claim 1, it is characterised in that: by mass percentage by following
At being grouped as: ethyl alcohol 40%~50%, triclosan 0.2%~0.3%, barium sulfate 45%~58%, zinc oxide 1%~4%, two
Titanium oxide 1%~4%, thickener 0.1%~0.5%, skin care moisturizer 0.5%~1.0%.
3. medical anti-x-ray radiation disinfecting gel according to claim 1, it is characterised in that: the barium sulfate, zinc oxide and
Titanium dioxide partial size 1 μm of mass fraction below >=90%.
4. medical anti-x-ray radiation disinfecting gel described in any one of claim 1 to 3, it is characterised in that: the thickening
Agent be one of Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, carbomer ULTREZ21 or
It is a variety of.
5. medical anti-x-ray radiation disinfecting gel described in any one of claim 1 to 3, it is characterised in that: the skin care
Moisturizer is one of sorbierite, butanediol, dipropylene glycol, isopropyl myristate or a variety of.
6. a kind of preparation method of such as medical anti-x-ray radiation disinfecting gel according to any one of claims 1 to 5, feature
It is: includes the following steps:
1) procedure for preparation: barium sulfate powder, Zinc oxide powder and titania powder being dried and dehydrated respectively, ground, and
12500 meshes are crossed, make each powder in 1 μm of mass fraction >=90% below；
2) sterilization process: ultra-fine barium sulfate powder, Zinc oxide powder, titania powder are respectively charged into sterile chamber and carried out
High-temperature sterilization, thoroughly to its natural cooling after sterilizing；
3) mixed processes: ethyl alcohol, triclosan, thickener and skin care moisturizer are sufficiently mixed are prepared into disinfection by mass percentage
Gel, while barium sulfate powder, Zinc oxide powder, titania powder being sufficiently mixed are prepared into radiation protection by mass percentage
Disinfecting gel and radiation protection particle are sufficiently mixed by particle in an aseptic environment, are stirred 0.5~3 hour, are obtained medical anti-x-ray
Radiosterilization gel.
7. the preparation method of medical anti-x-ray radiation disinfecting gel according to claim 6, it is characterised in that: in step 1),
Drying and dehydrating temperature is 150 ± 10 DEG C, and the time is 12 ± 2h.
8. the preparation method of medical anti-x-ray radiation disinfecting gel according to claim 6 or 7, it is characterised in that: step 2)
In, sterilising temp is 200~250 DEG C, and the time is 2~3 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910599190.6A CN110227084A (en) | 2019-07-04 | 2019-07-04 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910599190.6A CN110227084A (en) | 2019-07-04 | 2019-07-04 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110227084A true CN110227084A (en) | 2019-09-13 |
Family
ID=67856721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910599190.6A Pending CN110227084A (en) | 2019-07-04 | 2019-07-04 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110227084A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480221A (en) * | 2003-07-09 | 2004-03-10 | 中国医学科学院生物医学工程研究所 | Washing free gel for disinfection |
| WO2005086641A2 (en) * | 2004-02-27 | 2005-09-22 | Hydromer, Inc. | Anti-infectious hydrogel compositions |
| CN101588722A (en) * | 2007-01-23 | 2009-11-25 | 默克专利股份有限公司 | The antimicrobial compositions that comprises zinc oxide, barium sulfate and silver ion |
| CN103251721A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Radiation-proof skin-care gel and preparation method thereof |
| US20150313811A1 (en) * | 2010-01-07 | 2015-11-05 | Bloxr Solutions, Llc | Radiation protection system |
| CN105535020A (en) * | 2016-01-25 | 2016-05-04 | 苏州爱瑞德医疗科技有限公司 | Medical X-ray protective cream and preparation method thereof |
-
2019
- 2019-07-04 CN CN201910599190.6A patent/CN110227084A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480221A (en) * | 2003-07-09 | 2004-03-10 | 中国医学科学院生物医学工程研究所 | Washing free gel for disinfection |
| WO2005086641A2 (en) * | 2004-02-27 | 2005-09-22 | Hydromer, Inc. | Anti-infectious hydrogel compositions |
| CN101588722A (en) * | 2007-01-23 | 2009-11-25 | 默克专利股份有限公司 | The antimicrobial compositions that comprises zinc oxide, barium sulfate and silver ion |
| US20150313811A1 (en) * | 2010-01-07 | 2015-11-05 | Bloxr Solutions, Llc | Radiation protection system |
| CN103251721A (en) * | 2013-05-08 | 2013-08-21 | 山西省肿瘤研究所 | Radiation-proof skin-care gel and preparation method thereof |
| CN105535020A (en) * | 2016-01-25 | 2016-05-04 | 苏州爱瑞德医疗科技有限公司 | Medical X-ray protective cream and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 姜凤举著: "《实用医学影像检查与临床诊断》", 31 May 2019, 吉林科学技术出版社 * |
| 张秀娥等: "抗辐射凝胶制剂成型工艺的实验研究", 《医学信息》 * |
| 曾武涛等主编: "《心血管病最新诊断与防治策略》", 30 September 2011, 人民军医出版社 * |
| 王杏著: "《纳米二氧化钛的生产与应用》", 31 July 2014, 贵州科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1113599C (en) | Antimicrobial treatment for herpes simplex virus and other infectious diseases | |
| CN103961371B (en) | A kind of dental treatment thing with multi-efficiency and compositions thereof | |
| RU2524635C2 (en) | Antimicrobial/antibacterial medical devices, coated with traditional preparations of chinese medicine | |
| CN106466319A (en) | Antimicrobial compositions and using method | |
| CN106259509A (en) | A kind of natural plant disinfectant and preparation method thereof | |
| CN106860911A (en) | A kind of surface of metal titanium antimicrobial composite coating and preparation method thereof | |
| CN107028848A (en) | A kind of disinfection solution of disposable hand natural green | |
| US3337405A (en) | Product for dental use including a silver complex and methods for such use | |
| CN106822894A (en) | A kind of photosensitive agent prescription for optical dynamic therapy periodontitis and its preparation method and application | |
| CN112516031B (en) | Plant extraction multi-effect composition and preparation method thereof | |
| CN110227084A (en) | Medical anti-x-ray radiation disinfecting gel and preparation method thereof | |
| CN104798823A (en) | Bactericide for clinical laboratory | |
| CN104815096A (en) | Nano composite skin disinfection emulsion and preparation method of same | |
| KR20060086570A (en) | Nano silver conten endodontic treatment gutta percher cone | |
| CN105687021A (en) | Foot powder for preventing tinea pedis | |
| CN108514543A (en) | A kind of Chinese medicine mosquito repellent liquid | |
| CN108324648A (en) | A kind of composition of anti-acne | |
| Marín-Correa et al. | Nanosilver gel as an endodontic alternative against Enterococcus faecalis in an in vitro root canal system in Mexican dental specimens | |
| CN109248161A (en) | It is a kind of to prepare anti-desensitizing paste formula and processing technology using tea tree oil extract terpinene-4-alcohol and phosphoric acid silico-calcium sodium | |
| JP3279351B2 (en) | Manufacturing method of external sterilizing cloth | |
| CN108728691A (en) | It is a kind of applied to the superelevation anti-microbial property titanium alloy of medical implant and its preparation | |
| CN102068506A (en) | Sterilizing and antimicrobial Chinese medicinal disinfectant | |
| CN102552650A (en) | Skin antibacterial agent and preparation method thereof | |
| CN106619739A (en) | Artificial collection method of body surface mucus of giant salamander | |
| CN105796564B (en) | A kind of pharmaceutical composition for preventing and treating tooth body infections of dental pulp |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |